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The map label for this gene is aceE [H]

Identifier: 113968772

GI number: 113968772

Start: 475419

End: 478085

Strand: Direct

Name: aceE [H]

Synonym: Shewmr4_0428

Alternate gene names: 113968772

Gene position: 475419-478085 (Clockwise)

Preceding gene: 113968771

Following gene: 113968773

Centisome position: 10.1

GC content: 49.08

Gene sequence:

>2667_bases
ATGTCTGAAGATATGCTACAAGACTTAGATCCGTTAGAGACTCAGGAATGGGTTGACGCCCTGCAAGCAGTATTAGAACA
GGAAGGCCCTGAGCGCGCCCATTTCTTATTAGAGAAACTGATCGATAAAGCCCGTCGCAATGGCACACACTTGCCTTACA
CTGCGACCACGGCCTATTTGAACACTATTCCAGCGGGTCAAGAGCCGCACATGCCTGGCAACCAAGAGATGGAACGTCGC
ATTCGCGCCATCATCCGTTGGAACGCCTTAGCTATGGTTCTGCGTGGTTCTAAGAAAGATTTAGAGTTAGGCGGCCATAT
TTCGAGTTTCGCGTCGAGCGCAACCATTTATGACGTGTGTTTCAACCACTTCTTCCGCGCGCCAAACGAGAAAGACGGCG
GCGACTTAGTGTATTTCCAAGGCCATATTGCCCCAGGTATCTACGCGCGTTCATTCTTGGAAGGCCGTTTAACTGAAGAC
CAACTGGCTAACTTCCGTCAAGAAGTGGATGGCAAAGGTTTATCTTCTTATCCGCACCCTAAGTTGATGCCTGACTACTG
GCAATTCCCAACGGTTTCGATGGGCTTAGGTCCAATCCAAGCGATTTACCAAGCGCGCTTCTTAAAATACCTGACTGACC
GTGGTCTGAAAGATTGTTCTGATCAAACCGTTTACTGCTTCTTAGGTGACGGTGAGTGTGACGAGCCAGAAGCTTTAGGT
GCTATCGGTTTAGCCGCCCGTGAAGAATTAGACAACCTAGTCTTCATCATCAACTGTAACCTGCAACGTCTGGACGGCCC
AGTACGCGGTAACGGTAAGATCATCCAAGAACTGGAAGGCGAATTCCGCGGCGCTGGCTGGGAAGTGGTTAAAGTGATTT
GGGGTCGTTACTGGGATCCATTATTAGCCCGTGATACCAGCGGTAAGTTACTGCAGTTAATGGAAGAAACCGTTGACGGT
GAATACCAAAACTGTAAAGCCAAAGGTGGCGCTTATACTCGCGAACACTTCTTCGGCAAATATCCAGAAACCGCCGAAAT
GGTAGCGAACATGTCAGATGATGACATTTGGCGCTTAAACCGTGGTGGTCATGACCCAGTTAAAGTTTACGCGGCATTAG
ACCATGCGCGTAAGACTAAAGGTCGCCCAACTGTGATCCTAGCGAAAACCGTTAAAGGTTACGGCCTCGGTGATGCGGGT
GAAGGTAAAAACATCGCACACAACGTGAAGAAAATGGGTATCGAGTCTATCCGTTACTTCCGCGATCGTTTCAATATCCC
AATTCCAGACGATCAATTAGAAGATCTGCCGTTCTACCACCCAGGTCCAGATTCGGAAGAAGTGAAGTACATGATGAGCC
GTCGTGCCGAGCTGCACGGCAGTGTGCCACAACGTCGTGAGAAGTTCAGCGAAGAGCTGGAAATTCCATCACTGAAGATT
TTCGACTCGATTCTGCAGGGTTCTAACGGCCGTGAAATTTCGTCAACGATGGCGTTTGTTCGCGTACTGACGGCACTGTT
AAAAGACAAGAAGATTGGCAAAAACATCGTGCCAATTATTCCTGACGAAGCGCGTACCTTCGGTATGGAAGGTCTGTTCC
GTCAAGTGGGTATTTATGCTCACGAAGGCCAAAAATACGTTCCGCAAGACTCTGACCAAGTGGCTTACTACCGTGAAGAT
AAGTCAGGCCAAGTACTGCAGGAAGGTATTAACGAATTAGGTGCTATGTCATCTTGGGTATCGGCAGCGACCAGCTACTC
AGTGAACGATGTGCCAATGATCCCATTCTACATCTACTACTCAATGTTCGGTTTCCAACGTATTGGCGACATGGCTTGGG
CTGCGGGTGATATGCGTGCTCGCGGCTTCTTAGTCGGTGGTACTTCTGGCCGTACAACCTTAAACGGTGAAGGTCTGCAG
CATCAGGACGGTCACAGCCACGTACTGGCTAACACCATTCCTAACTGTATTACCTACGATCCAACTTACGGTTATGAAAT
TGCCGTTGTGGTACAAGATGGTATTCGTCGTATGTACGGCGAGAATCAAGAAGATATCTTCTACTACCTGACCACAATGA
ACGAAAACTACGAGCAGCCAGCCATGCCAGAAGGCGCAGAAGTTGGCATCGTTAAAGGTATCTACAAGTTAGAAACCGTT
GCCGGCTCGGGTAAAGGCAAAGTTCAGTTAATGAGCTGTGGCACCATTCTTGAGCAAACACGCAAAGCGGCTCAAGCACT
GGCAAAAGACTTCGGTATCACTGCCGACGTATTCAGCGTAACCAGCTTCAACGAACTGACTCGCGATGGTCAAGCGGTTG
AGCGTTGGAACATGCTGCACCCAACTGAAACGCCAAAACAAGCGTATATCAGCCAAGTGATCTCCAGTGATGCGCCTGCA
ATCGCAGCGACTGACTACATGAAGATCTACGGTGAGCAGTTACGTGCATACATGCCAACCGATTACAAAGTGTTAGGTAC
TGACGGTTTCGGTCGTTCAGACAGCCGTGACAACCTGCGTCACCACTTCGAAGTGGACGCTAAGTTCATCGTTATCGCGG
CACTGAAGTCACTGGTTGATCGTAAAGAGCTGCCTGTTGATGTGTTAGCGAATGCCATCAAGGAATACGGCATCGACGCT
GACAAGATCAATCCACAGTACGCGTAA

Upstream 100 bases:

>100_bases
GTTTAAAGAGTGGCGCTTAAGTTCCCGACTTTAGCACTCGCTAAAGCGGAATATGCCGCAAACACCATTCATTATCATGT
ATATAGAGAAGGACAGTGTC

Downstream 100 bases:

>100_bases
GAGGCAATAAAAATGGCTGAATTAAAAGAAGTTTTTGTTCCTGATATCGGCGGCGATGAAGTACAGGTTATCGAAATCTG
TGCTTCTGTGGGCGATACCT

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 888; Mature: 887

Protein sequence:

>888_residues
MSEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERR
IRAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTED
QLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSDQTVYCFLGDGECDEPEALG
AIGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDPLLARDTSGKLLQLMEETVDG
EYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAG
EGKNIAHNVKKMGIESIRYFRDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAELHGSVPQRREKFSEELEIPSLKI
FDSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYRED
KSGQVLQEGINELGAMSSWVSAATSYSVNDVPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQ
HQDGHSHVLANTIPNCITYDPTYGYEIAVVVQDGIRRMYGENQEDIFYYLTTMNENYEQPAMPEGAEVGIVKGIYKLETV
AGSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLHPTETPKQAYISQVISSDAPA
IAATDYMKIYGEQLRAYMPTDYKVLGTDGFGRSDSRDNLRHHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDA
DKINPQYA

Sequences:

>Translated_888_residues
MSEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERR
IRAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTED
QLANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSDQTVYCFLGDGECDEPEALG
AIGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDPLLARDTSGKLLQLMEETVDG
EYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAG
EGKNIAHNVKKMGIESIRYFRDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAELHGSVPQRREKFSEELEIPSLKI
FDSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYRED
KSGQVLQEGINELGAMSSWVSAATSYSVNDVPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQ
HQDGHSHVLANTIPNCITYDPTYGYEIAVVVQDGIRRMYGENQEDIFYYLTTMNENYEQPAMPEGAEVGIVKGIYKLETV
AGSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLHPTETPKQAYISQVISSDAPA
IAATDYMKIYGEQLRAYMPTDYKVLGTDGFGRSDSRDNLRHHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDA
DKINPQYA
>Mature_887_residues
SEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYLNTIPAGQEPHMPGNQEMERRI
RAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVCFNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTEDQ
LANFRQEVDGKGLSSYPHPKLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSDQTVYCFLGDGECDEPEALGA
IGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDPLLARDTSGKLLQLMEETVDGE
YQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLNRGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAGE
GKNIAHNVKKMGIESIRYFRDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAELHGSVPQRREKFSEELEIPSLKIF
DSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYAHEGQKYVPQDSDQVAYYREDK
SGQVLQEGINELGAMSSWVSAATSYSVNDVPMIPFYIYYSMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQH
QDGHSHVLANTIPNCITYDPTYGYEIAVVVQDGIRRMYGENQEDIFYYLTTMNENYEQPAMPEGAEVGIVKGIYKLETVA
GSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLHPTETPKQAYISQVISSDAPAI
AATDYMKIYGEQLRAYMPTDYKVLGTDGFGRSDSRDNLRHHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDAD
KINPQYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=890, Percent_Identity=66.5168539325843, Blast_Score=1277, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99509; Mature: 99378

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYL
CCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
NTIPAGQEPHMPGNQEMERRIRAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVC
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHH
FNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTEDQLANFRQEVDGKGLSSYPHP
HHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSDQTVYCFLGDGECDEPEALG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHH
AIGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDP
HHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCH
LLARDTSGKLLQLMEETVDGEYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLN
HHHCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCEEECC
RGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAGEGKNIAHNVKKMGIESIRYF
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAELHGSVPQRREKFSEELEIPSLKI
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
FDSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCEEE
HEGQKYVPQDSDQVAYYREDKSGQVLQEGINELGAMSSWVSAATSYSVNDVPMIPFYIYY
ECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQHQDGHSHVLANTIPNCITYD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEHHHHCCCCEECC
PTYGYEIAVVVQDGIRRMYGENQEDIFYYLTTMNENYEQPAMPEGAEVGIVKGIYKLETV
CCCCEEEEEEEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AGSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLH
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCC
PTETPKQAYISQVISSDAPAIAATDYMKIYGEQLRAYMPTDYKVLGTDGFGRSDSRDNLR
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHH
HHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDADKINPQYA
HHEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
SEDMLQDLDPLETQEWVDALQAVLEQEGPERAHFLLEKLIDKARRNGTHLPYTATTAYL
CHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHH
NTIPAGQEPHMPGNQEMERRIRAIIRWNALAMVLRGSKKDLELGGHISSFASSATIYDVC
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCHHHHHHH
FNHFFRAPNEKDGGDLVYFQGHIAPGIYARSFLEGRLTEDQLANFRQEVDGKGLSSYPHP
HHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
KLMPDYWQFPTVSMGLGPIQAIYQARFLKYLTDRGLKDCSDQTVYCFLGDGECDEPEALG
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHH
AIGLAAREELDNLVFIINCNLQRLDGPVRGNGKIIQELEGEFRGAGWEVVKVIWGRYWDP
HHHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCH
LLARDTSGKLLQLMEETVDGEYQNCKAKGGAYTREHFFGKYPETAEMVANMSDDDIWRLN
HHHCCCCHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCCEEECC
RGGHDPVKVYAALDHARKTKGRPTVILAKTVKGYGLGDAGEGKNIAHNVKKMGIESIRYF
CCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
RDRFNIPIPDDQLEDLPFYHPGPDSEEVKYMMSRRAELHGSVPQRREKFSEELEIPSLKI
HHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHH
FDSILQGSNGREISSTMAFVRVLTALLKDKKIGKNIVPIIPDEARTFGMEGLFRQVGIYA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCEEE
HEGQKYVPQDSDQVAYYREDKSGQVLQEGINELGAMSSWVSAATSYSVNDVPMIPFYIYY
ECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRIGDMAWAAGDMRARGFLVGGTSGRTTLNGEGLQHQDGHSHVLANTIPNCITYD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCEEHHHHCCCCEECC
PTYGYEIAVVVQDGIRRMYGENQEDIFYYLTTMNENYEQPAMPEGAEVGIVKGIYKLETV
CCCCEEEEEEEHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AGSGKGKVQLMSCGTILEQTRKAAQALAKDFGITADVFSVTSFNELTRDGQAVERWNMLH
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHCCCC
PTETPKQAYISQVISSDAPAIAATDYMKIYGEQLRAYMPTDYKVLGTDGFGRSDSRDNLR
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHH
HHFEVDAKFIVIAALKSLVDRKELPVDVLANAIKEYGIDADKINPQYA
HHEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]