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The map label for this gene is moaE [H]

Identifier: 113968620

GI number: 113968620

Start: 296798

End: 297265

Strand: Direct

Name: moaE [H]

Synonym: Shewmr4_0276

Alternate gene names: 113968620

Gene position: 296798-297265 (Clockwise)

Preceding gene: 113968619

Following gene: 113968621

Centisome position: 6.31

GC content: 52.56

Gene sequence:

>468_bases
ATGCGCTTACTGCCAAATGTGCGGGTTCAAACCGTCGATTTTAATGTGGCCGACGAGTACCACCAATTAGCCCAAGACAA
TAGCGATGGCGCCGTTGTGACTTTTGTTGGCAAAGTGCGCGACTTTAACGACGGTTCAGTGGTGACGGACCTGACCTTAG
AACACTATCCCGGTATGACGGAGCGTGTGCTCGAGCAAATCGTGGCCGAGGCGCGTGAGCGTTGGCCACTCAATAAAGTT
ACGGTTATCCACCGTGTGGGCACTATGGCGCTGGGTGAGCAAATTGTGTTTATCGGCGTCACCAGTGCCCATCGCAAGGC
GGCCTTTGCTGCCTGCGAATTCTTAATCGACTTTTTGAAAACCAAAGCCCCTTTCTGGAAATTAGAAGCCGGGGACAAGG
GCAAGAATTGGGTCGAAGCCAAGGACGCCGATGAGCAAGCGGCGAAATTGTGGCAACACAAAGACTAA

Upstream 100 bases:

>100_bases
AAATTGCTGGTGGCGGTGAATCAAACCATCAGCCAATGGGATACCCGAGTGAGCGATGGTGATGAAGTCGCCTTCTTCCC
GCCTGTGACTGGAGGTTGAT

Downstream 100 bases:

>100_bases
CGTAAGACTGAGTCAGTCGTAGGCGAGAGTGAGGGTGAGTTTATGCACAGTGTGACAGGGTTAGGCAAAATCTGGAGTTT
AGTATTTGCTCTCGGCTTGT

Product: molybdopterin synthase subunit MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MRLLPNVRVQTVDFNVADEYHQLAQDNSDGAVVTFVGKVRDFNDGSVVTDLTLEHYPGMTERVLEQIVAEARERWPLNKV
TVIHRVGTMALGEQIVFIGVTSAHRKAAFAACEFLIDFLKTKAPFWKLEAGDKGKNWVEAKDADEQAAKLWQHKD

Sequences:

>Translated_155_residues
MRLLPNVRVQTVDFNVADEYHQLAQDNSDGAVVTFVGKVRDFNDGSVVTDLTLEHYPGMTERVLEQIVAEARERWPLNKV
TVIHRVGTMALGEQIVFIGVTSAHRKAAFAACEFLIDFLKTKAPFWKLEAGDKGKNWVEAKDADEQAAKLWQHKD
>Mature_155_residues
MRLLPNVRVQTVDFNVADEYHQLAQDNSDGAVVTFVGKVRDFNDGSVVTDLTLEHYPGMTERVLEQIVAEARERWPLNKV
TVIHRVGTMALGEQIVFIGVTSAHRKAAFAACEFLIDFLKTKAPFWKLEAGDKGKNWVEAKDADEQAAKLWQHKD

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=120, Percent_Identity=36.6666666666667, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1787003, Length=138, Percent_Identity=61.5942028985507, Blast_Score=184, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17509279, Length=127, Percent_Identity=37.007874015748, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356259, Length=126, Percent_Identity=37.3015873015873, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 17481; Mature: 17481

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLPNVRVQTVDFNVADEYHQLAQDNSDGAVVTFVGKVRDFNDGSVVTDLTLEHYPGMT
CCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCEECCCCCEEEEEEHHHCCCHH
ERVLEQIVAEARERWPLNKVTVIHRVGTMALGEQIVFIGVTSAHRKAAFAACEFLIDFLK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHH
TKAPFWKLEAGDKGKNWVEAKDADEQAAKLWQHKD
CCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MRLLPNVRVQTVDFNVADEYHQLAQDNSDGAVVTFVGKVRDFNDGSVVTDLTLEHYPGMT
CCCCCCCEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCEECCCCCEEEEEEHHHCCCHH
ERVLEQIVAEARERWPLNKVTVIHRVGTMALGEQIVFIGVTSAHRKAAFAACEFLIDFLK
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHH
TKAPFWKLEAGDKGKNWVEAKDADEQAAKLWQHKD
CCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]