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The map label for this gene is moaA [H]

Identifier: 113968617

GI number: 113968617

Start: 294920

End: 295933

Strand: Direct

Name: moaA [H]

Synonym: Shewmr4_0273

Alternate gene names: 113968617

Gene position: 294920-295933 (Clockwise)

Preceding gene: 113968614

Following gene: 113968618

Centisome position: 6.27

GC content: 49.01

Gene sequence:

>1014_bases
ATGCACTCGCCTCCCACACTTGGAAAGGTGATCATGTCTCAATTACAAGACAATTTTGGTCGTAAATTTCATTACTTACG
AATGTCAGTCACTGACGTTTGTAACTTCAAATGCAGTTATTGTCTCCCCGATGGTTATCATCCGAATGGTAGACAACAGT
TCTTATCTCTCAGTGAGATAGAAAATCTTGTGTCCGCATTTAGCCAGGTTGGCACTCAAAAAATCCGTATCACTGGCGGC
GAACCCACGCTGCGTAAAGATTTTACCGATATCATTCGAGTGGTCGCCGACAATCCTCGAATTCATACCGTAGCCACTAC
TACTAATGGGTATAGGCTCGAGAAGCATGCCCAAGAGTGGTTCGACGCAGGGCTACGCCGTATCAATGTGTCGGTGGACA
GCTTAGATCCTAAGATGTTTTACCAGATCACTGGCGAGAATAAGTTCGATGAGGTGATGCGTGGCATAGATGCCGCCTTA
TCCGCGGGCTTTGAACGGGTGAAGGTCAACGCGGTATTGCTCAAAGGCATGAACGATAAAGATTTACCGCGCTTTTTAAA
TTGGATTAAGCACACGCCTATCGATCTGCGTTTTATTGAGTTGATGGAAACAGGCCTTGGTCGCGAGTATTTTCAGGCTC
ACCATTTGGCTGGTGCCGATATTAAAGCGCTGTTGCAAGCTGAGGGCTGGCAATTAGATACGCCTCGCGCCGACGATGGC
CCTGCGCAAAACTTCAGCCACAGTGACTTTAAGGGCCGTATCGGCTTGATCATGCCCTACGCCACTAACTTCTGCGCGAG
CTGTAATCGCTTGCGGGTCTCGGCCAAGGGTAAGCTGCACTTGTGCCTCTTTACCGAGTCTGGCATCGATTTGCGTGATC
TACTGCAACACCCGAGTCAGCAAGCGGAATTAATCGAGCGGTTACACGGTCAACTGGCGCAGAAGAAGGAAACCCATTAT
CTGCATCAGGGCATTACTGGCGTGACGCAACATCTAGCCTCGATTGGCGGTTAA

Upstream 100 bases:

>100_bases
GGCTTATAATCACGAATGACGGTTCTCCGAGCTTGCCTACCTAAGTCGACAGATATGGGGGTGTAGCCGTGGCAATAAGG
CCACTGGGGTGAGTAAAGAA

Downstream 100 bases:

>100_bases
TCTAACTTAGGTCTTAGTCTGCTTATCGCGTTATCTTTCATTAGGTTAAATTTCGCGATGGCGCTTAACTTCCCTATGCT
TGAATTTGGCATCAGTTTAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MHSPPTLGKVIMSQLQDNFGRKFHYLRMSVTDVCNFKCSYCLPDGYHPNGRQQFLSLSEIENLVSAFSQVGTQKIRITGG
EPTLRKDFTDIIRVVADNPRIHTVATTTNGYRLEKHAQEWFDAGLRRINVSVDSLDPKMFYQITGENKFDEVMRGIDAAL
SAGFERVKVNAVLLKGMNDKDLPRFLNWIKHTPIDLRFIELMETGLGREYFQAHHLAGADIKALLQAEGWQLDTPRADDG
PAQNFSHSDFKGRIGLIMPYATNFCASCNRLRVSAKGKLHLCLFTESGIDLRDLLQHPSQQAELIERLHGQLAQKKETHY
LHQGITGVTQHLASIGG

Sequences:

>Translated_337_residues
MHSPPTLGKVIMSQLQDNFGRKFHYLRMSVTDVCNFKCSYCLPDGYHPNGRQQFLSLSEIENLVSAFSQVGTQKIRITGG
EPTLRKDFTDIIRVVADNPRIHTVATTTNGYRLEKHAQEWFDAGLRRINVSVDSLDPKMFYQITGENKFDEVMRGIDAAL
SAGFERVKVNAVLLKGMNDKDLPRFLNWIKHTPIDLRFIELMETGLGREYFQAHHLAGADIKALLQAEGWQLDTPRADDG
PAQNFSHSDFKGRIGLIMPYATNFCASCNRLRVSAKGKLHLCLFTESGIDLRDLLQHPSQQAELIERLHGQLAQKKETHY
LHQGITGVTQHLASIGG
>Mature_337_residues
MHSPPTLGKVIMSQLQDNFGRKFHYLRMSVTDVCNFKCSYCLPDGYHPNGRQQFLSLSEIENLVSAFSQVGTQKIRITGG
EPTLRKDFTDIIRVVADNPRIHTVATTTNGYRLEKHAQEWFDAGLRRINVSVDSLDPKMFYQITGENKFDEVMRGIDAAL
SAGFERVKVNAVLLKGMNDKDLPRFLNWIKHTPIDLRFIELMETGLGREYFQAHHLAGADIKALLQAEGWQLDTPRADDG
PAQNFSHSDFKGRIGLIMPYATNFCASCNRLRVSAKGKLHLCLFTESGIDLRDLLQHPSQQAELIERLHGQLAQKKETHY
LHQGITGVTQHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=306, Percent_Identity=34.9673202614379, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI22027536, Length=306, Percent_Identity=34.9673202614379, Blast_Score=198, Evalue=6e-51,
Organism=Escherichia coli, GI1786999, Length=329, Percent_Identity=57.7507598784195, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI32566331, Length=307, Percent_Identity=35.8306188925081, Blast_Score=197, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI32566329, Length=307, Percent_Identity=35.8306188925081, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=36.1563517915309, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI28574488, Length=322, Percent_Identity=33.5403726708075, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI28574490, Length=312, Percent_Identity=33.6538461538462, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37990; Mature: 37990

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSPPTLGKVIMSQLQDNFGRKFHYLRMSVTDVCNFKCSYCLPDGYHPNGRQQFLSLSEI
CCCCCHHHHHHHHHHHHHHCCEEEEEEEEHHHHHCCCEEEECCCCCCCCHHHHHHHHHHH
ENLVSAFSQVGTQKIRITGGEPTLRKDFTDIIRVVADNPRIHTVATTTNGYRLEKHAQEW
HHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEHHHHHHHH
FDAGLRRINVSVDSLDPKMFYQITGENKFDEVMRGIDAALSAGFERVKVNAVLLKGMNDK
HHHHHHEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCC
DLPRFLNWIKHTPIDLRFIELMETGLGREYFQAHHLAGADIKALLQAEGWQLDTPRADDG
CHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
PAQNFSHSDFKGRIGLIMPYATNFCASCNRLRVSAKGKLHLCLFTESGIDLRDLLQHPSQ
CCCCCCCCCCCCCEEEEECHHHHHHHCCCCEEEECCCCEEEEEEECCCCCHHHHHHCCCH
QAELIERLHGQLAQKKETHYLHQGITGVTQHLASIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHSPPTLGKVIMSQLQDNFGRKFHYLRMSVTDVCNFKCSYCLPDGYHPNGRQQFLSLSEI
CCCCCHHHHHHHHHHHHHHCCEEEEEEEEHHHHHCCCEEEECCCCCCCCHHHHHHHHHHH
ENLVSAFSQVGTQKIRITGGEPTLRKDFTDIIRVVADNPRIHTVATTTNGYRLEKHAQEW
HHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEHHHHHHHH
FDAGLRRINVSVDSLDPKMFYQITGENKFDEVMRGIDAALSAGFERVKVNAVLLKGMNDK
HHHHHHEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHEEEEEEEEECCCCC
DLPRFLNWIKHTPIDLRFIELMETGLGREYFQAHHLAGADIKALLQAEGWQLDTPRADDG
CHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
PAQNFSHSDFKGRIGLIMPYATNFCASCNRLRVSAKGKLHLCLFTESGIDLRDLLQHPSQ
CCCCCCCCCCCCCEEEEECHHHHHHHCCCCEEEECCCCEEEEEEECCCCCHHHHHHCCCH
QAELIERLHGQLAQKKETHYLHQGITGVTQHLASIGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA