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The map label for this gene is fabR [H]

Identifier: 113968522

GI number: 113968522

Start: 198095

End: 198709

Strand: Direct

Name: fabR [H]

Synonym: Shewmr4_0177

Alternate gene names: 113968522

Gene position: 198095-198709 (Clockwise)

Preceding gene: 113968518

Following gene: 113968524

Centisome position: 4.21

GC content: 52.52

Gene sequence:

>615_bases
ATGGGTATTCGTGCACAGCAAAAAGAGAAAACTCGGCGGGCATTAGTCGATGCGGCGTTTAACCAGCTCAGTGCTGAACG
AAGTTTCTCTAGCTTAAGCTTGCGTGAGGTGGCGAGGGAAGCCAACATTGCGCCCACATCCTTTTATCGTCATTTTAAGG
ATATGAATGAGCTTGGGTTGACCATGGTCGACGAAGGCGGGCTCACCCTAAGACAGATGATGCGAAAGGGGCGGCAACGT
GCCGAAGCCGGGGGCAGCGTGATCCGTATTTCTGTGGATACCTTTATGGAAGTGCTTGATTCTAATCCAAACGTTTTCAG
AATCTTATTACATGAGCGCTCTGGTACCTCGGCAGCCTTCCGCGCGGCGGTAGCCCGCGAGATTGAACATTTTATCTCGG
AACTTGCCCATTACACCGAAGCGACGGCGGGTCGTACGCCTATGCTGGCCAGAGCACAGGCTGAAGCGTTAGTGACCTTA
GTGTTTAACGCCGGAGCGTCGGCACTGGATATGAAGCGCGCCGATCGTAAAGTGCTCGCCGATCAACTGGTGATGCAATT
ACGTATGGTGGCTAAGGGCGCCGAAGCCTTACAACATAAGGTTGAGCATCGTTAA

Upstream 100 bases:

>100_bases
ATTTAGCCTAGCAATCTTGTTTGGTCAAGGTGGATGGGGCTGTGTTTCAGACGCAAAAGCGGTATTATCGCGTCATTACA
TTCAGTTAGCGGATTGAAGA

Downstream 100 bases:

>100_bases
GTGAGATTGTGATTTAGCCCCAAAACAAAGGAGCCAATGGCTCCTTTGTTTTTAGGTACATAGAGTCGCTTAACGACGCT
CAAGCAGTACACCTGTTTCC

Product: DNA-binding transcriptional repressor FabR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELGLTMVDEGGLTLRQMMRKGRQR
AEAGGSVIRISVDTFMEVLDSNPNVFRILLHERSGTSAAFRAAVAREIEHFISELAHYTEATAGRTPMLARAQAEALVTL
VFNAGASALDMKRADRKVLADQLVMQLRMVAKGAEALQHKVEHR

Sequences:

>Translated_204_residues
MGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELGLTMVDEGGLTLRQMMRKGRQR
AEAGGSVIRISVDTFMEVLDSNPNVFRILLHERSGTSAAFRAAVAREIEHFISELAHYTEATAGRTPMLARAQAEALVTL
VFNAGASALDMKRADRKVLADQLVMQLRMVAKGAEALQHKVEHR
>Mature_203_residues
GIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELGLTMVDEGGLTLRQMMRKGRQRA
EAGGSVIRISVDTFMEVLDSNPNVFRILLHERSGTSAAFRAAVAREIEHFISELAHYTEATAGRTPMLARAQAEALVTLV
FNAGASALDMKRADRKVLADQLVMQLRMVAKGAEALQHKVEHR

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=194, Percent_Identity=70.1030927835051, Blast_Score=272, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 22727; Mature: 22596

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELGL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
TMVDEGGLTLRQMMRKGRQRAEAGGSVIRISVDTFMEVLDSNPNVFRILLHERSGTSAAF
EEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCEEEEEEECCCCCHHHH
RAAVAREIEHFISELAHYTEATAGRTPMLARAQAEALVTLVFNAGASALDMKRADRKVLA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DQLVMQLRMVAKGAEALQHKVEHR
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GIRAQQKEKTRRALVDAAFNQLSAERSFSSLSLREVAREANIAPTSFYRHFKDMNELGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
TMVDEGGLTLRQMMRKGRQRAEAGGSVIRISVDTFMEVLDSNPNVFRILLHERSGTSAAF
EEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCEEEEEEECCCCCHHHH
RAAVAREIEHFISELAHYTEATAGRTPMLARAQAEALVTLVFNAGASALDMKRADRKVLA
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DQLVMQLRMVAKGAEALQHKVEHR
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA