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The map label for this gene is guaD [H]

Identifier: 113968486

GI number: 113968486

Start: 159200

End: 159673

Strand: Direct

Name: guaD [H]

Synonym: Shewmr4_0141

Alternate gene names: 113968486

Gene position: 159200-159673 (Clockwise)

Preceding gene: 113968485

Following gene: 113968489

Centisome position: 3.38

GC content: 48.73

Gene sequence:

>474_bases
ATGTGTAATCACTTTTTACCTGCGGTGAACCACACCTTGGCGTTGGCGCAAAAGGAAGTCGAAGGTACAGGCCTGCCGTT
TTCGGCTGTGATTGTGGATGAGTCTGGGCGGATTGTGGCTGAAGGGGTGAATCGGGTACAGGCGCTGCATGATTGTACCG
CCCATGCTGAAATCCAAGCGATACGAAAGGCGACTCTGCTACTTAAACAAGTCAGCTTGGAGGGCATGACATTAATTGCT
TCTGGTGAGCCCTGTGGATTTTGTTATATGGCGATACAACTGGCCAAAATCAGTCGGGTCATCGTCTTAGTCGATCGCCA
CGAAGCTTGCCAATATGGCTTTGATTATCGTTGGACCTATCAGCTATTGCAGGAGTCGAAATTGCAAATTGAGATCAGTA
AATGGCCGCAGTTGAATCATCGGCTTCAGCCATTTCGCCAAAGTTCTATTGGGTTAGCCTCAATCGGCATGTAG

Upstream 100 bases:

>100_bases
TTTGCCGATAATCGACATCAGCAATCGTTACAACAGGCTCTGGCAAAGTCCGCTGCCATGGGGTTACAACTAGCACAACA
CTACGCAGGGAAAACGACTG

Downstream 100 bases:

>100_bases
GTCAGTGGTATGGTTTGCGGCAGCATGACTTGCCGCATTCACTAAGGCTTTAAAACGAAGGTCGCTTTTGCACAAAGGTG
TGAGTGCTTCGGCTTTATTG

Product: CMP/dCMP deaminase, zinc-binding

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MCNHFLPAVNHTLALAQKEVEGTGLPFSAVIVDESGRIVAEGVNRVQALHDCTAHAEIQAIRKATLLLKQVSLEGMTLIA
SGEPCGFCYMAIQLAKISRVIVLVDRHEACQYGFDYRWTYQLLQESKLQIEISKWPQLNHRLQPFRQSSIGLASIGM

Sequences:

>Translated_157_residues
MCNHFLPAVNHTLALAQKEVEGTGLPFSAVIVDESGRIVAEGVNRVQALHDCTAHAEIQAIRKATLLLKQVSLEGMTLIA
SGEPCGFCYMAIQLAKISRVIVLVDRHEACQYGFDYRWTYQLLQESKLQIEISKWPQLNHRLQPFRQSSIGLASIGM
>Mature_157_residues
MCNHFLPAVNHTLALAQKEVEGTGLPFSAVIVDESGRIVAEGVNRVQALHDCTAHAEIQAIRKATLLLKQVSLEGMTLIA
SGEPCGFCYMAIQLAKISRVIVLVDRHEACQYGFDYRWTYQLLQESKLQIEISKWPQLNHRLQPFRQSSIGLASIGM

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=93, Percent_Identity=37.6344086021505, Blast_Score=64, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17555996, Length=140, Percent_Identity=35, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17492; Mature: 17492

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNHFLPAVNHTLALAQKEVEGTGLPFSAVIVDESGRIVAEGVNRVQALHDCTAHAEIQA
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
IRKATLLLKQVSLEGMTLIASGEPCGFCYMAIQLAKISRVIVLVDRHEACQYGFDYRWTY
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCEEEEEEECCHHHHCCCCCHHHH
QLLQESKLQIEISKWPQLNHRLQPFRQSSIGLASIGM
HHHHCCCEEEEECCCCCCCCCCCCHHHCCCCEEECCC
>Mature Secondary Structure
MCNHFLPAVNHTLALAQKEVEGTGLPFSAVIVDESGRIVAEGVNRVQALHDCTAHAEIQA
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
IRKATLLLKQVSLEGMTLIASGEPCGFCYMAIQLAKISRVIVLVDRHEACQYGFDYRWTY
HHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCEEEEEEECCHHHHCCCCCHHHH
QLLQESKLQIEISKWPQLNHRLQPFRQSSIGLASIGM
HHHHCCCEEEEECCCCCCCCCCCCHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]