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The map label for this gene is hutH [H]

Identifier: 113968445

GI number: 113968445

Start: 110959

End: 112500

Strand: Direct

Name: hutH [H]

Synonym: Shewmr4_0100

Alternate gene names: 113968445

Gene position: 110959-112500 (Clockwise)

Preceding gene: 113968444

Following gene: 113968446

Centisome position: 2.36

GC content: 53.5

Gene sequence:

>1542_bases
ATGAAATCAGTCAATCATTTAGTATTAACGCCCGGCAGTTTAAGTCTGGCGCAATTGCGTGAAATCAGCCGCCATAAGCT
GACACTCGAACTGGCGCCAGAGGCGATAAACGATATCAACACCAGCGCGCAAATCGTGCAAAAGGTGTTGGATGAAGGTC
GCACCGTTTACGGCATCAACACGGGTTTTGGTCTGCTGGCCAACACTAAGATTGCCCCGGAAGATCTGCAATTACTGCAA
CGCTCTATCGTGTTATCCCACGCTGCGGGCACGGGCCAATACATGCAGGACGCGACCGTGCGCCTGATGATGGTGTTAAA
GATCAACTCCTTAAGCCGTGGCTTCTCGGGTATCCGTTTAGAAGTGATTAATTTCCTTATCAGCCTAGTGAACGCCGAGG
TTTATCCTTGTGTGCCTGAAAAAGGTTCTGTGGGCGCCTCTGGCGACTTAGCGCCGTTAGCCCATATGTGTTTGCCGCTG
TTGGGTGAAGGCGAGATGAGCTATCAAGGTCAGATTATTTCGGCCGCCGAAGGCTTAGAAATCGCCGGCCTCAAGCCTAT
CGATTTAGCCGCGAAGGAAGGCTTAGCCCTGCTCAACGGTACTCAGGCTTCTACTGCTCTGGCGTTGGAAGGTCTGTTCC
ACGCTGAAGACTTGTTTGCTGCAAGCTCAGTGATTGGCGCCATGAGCGTCGAGGCAGCCATGGGTAGTCGCAGTCCGTTT
GACCCACGCATCCATGCGGCTCGTGGTCAGAAAGGACAAATCGATGCGGCCATGGTGTTCCGTCATCTGTTGGGCGAAGA
GTCTGAAATCAGCTTAAGCCACATCAACTGCGAGAAGGTGCAAGATCCTTACTCACTGCGCTGCCAACCACAGGTATTAG
GTGCGTGCTTGACCCAAATCCGCCAAGCGGCCGAGGTGTTAGGCACAGAAGCCAACGGTGTGACCGATAACCCGCTGGTA
TTTCAAGATACTGGCGATATTATCTCCGGTGGTAACTTCCACGCCGAGCCCGTTGCTATGGCAGCCGATAATTTGGCGAT
TGCGATTGCCGAATTAGGCGCGATTGCAGAGCGTCGTATCGCGCTGCTTATCGACTCTAGCCTATCTAAACTGCCACCTT
TCCTGGTTAAAAATGGCGGGGTGAACTCGGGCTTTATGATCGCCCAAGTGACGGCGGCGGCATTGGCCTCTGAAAACAAA
ACCTACGCCCATCCAGCATCGGTCGACAGTTTACCGACCTCGGCCAACCAAGAAGACCATGTGTCTATGGCGACCTTTGC
GGCGCGCCGTTTACGGGATATGAGCGAAAACACCCGTGGCGTGTTAGCTGTTGAGTTATTGGCGGCCGCCCAAGGCTTGG
ATTTCCGCGCGCCATTAATGCCAAGCAAAGCAGTGGCGCAGGCGAAGGCCGAGCTACGCGAAGTGGTTGCCTACTATGAT
AAAGACAGATACTTTGCGCCGGATATCGATGCGGCAACGGATCTGCTTTATACCGCCAGCTTCAATGCTTACTTGCCCCA
AGGCGTATTGCCGAGTCTGTAA

Upstream 100 bases:

>100_bases
CGAAAAACTGCGCAAAAGAGCAGGGCTTAGATCTGCCCATGCTTAAAGACTAGCTATTCAACAAACCGTGAAAAACAACG
ACAAGAATACGGATGTAAAA

Downstream 100 bases:

>100_bases
TGCATAGTTTTTAGCGCCGATAACCCATTTGCGGGTGAAAAGTGCTGAAGCAAGTGACCAATAAAGTGGAAGGCATAGTG
ATTTGCTATGCCTTTTATCT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAINDINTSAQIVQKVLDEGRTVYGINTGFGLLANTKIAPEDLQLLQ
RSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPL
LGEGEMSYQGQIISAAEGLEIAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
DPRIHAARGQKGQIDAAMVFRHLLGEESEISLSHINCEKVQDPYSLRCQPQVLGACLTQIRQAAEVLGTEANGVTDNPLV
FQDTGDIISGGNFHAEPVAMAADNLAIAIAELGAIAERRIALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENK
TYAHPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLMPSKAVAQAKAELREVVAYYD
KDRYFAPDIDAATDLLYTASFNAYLPQGVLPSL

Sequences:

>Translated_513_residues
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAINDINTSAQIVQKVLDEGRTVYGINTGFGLLANTKIAPEDLQLLQ
RSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPL
LGEGEMSYQGQIISAAEGLEIAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
DPRIHAARGQKGQIDAAMVFRHLLGEESEISLSHINCEKVQDPYSLRCQPQVLGACLTQIRQAAEVLGTEANGVTDNPLV
FQDTGDIISGGNFHAEPVAMAADNLAIAIAELGAIAERRIALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENK
TYAHPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLMPSKAVAQAKAELREVVAYYD
KDRYFAPDIDAATDLLYTASFNAYLPQGVLPSL
>Mature_513_residues
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAINDINTSAQIVQKVLDEGRTVYGINTGFGLLANTKIAPEDLQLLQ
RSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRLEVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPL
LGEGEMSYQGQIISAAEGLEIAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
DPRIHAARGQKGQIDAAMVFRHLLGEESEISLSHINCEKVQDPYSLRCQPQVLGACLTQIRQAAEVLGTEANGVTDNPLV
FQDTGDIISGGNFHAEPVAMAADNLAIAIAELGAIAERRIALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENK
TYAHPASVDSLPTSANQEDHVSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLMPSKAVAQAKAELREVVAYYD
KDRYFAPDIDAATDLLYTASFNAYLPQGVLPSL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=487, Percent_Identity=46.8172484599589, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567831, Length=506, Percent_Identity=43.2806324110672, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54423; Mature: 54423

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAINDINTSAQIVQKVLDEGRTVYGIN
CCCCCEEEECCCCCCHHHHHHHHHHEEEEEECCHHHHHCCHHHHHHHHHHHCCCEEEEEC
TGFGLLANTKIAPEDLQLLQRSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRL
CCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEHEEEHHHHHCCCCCHHH
EVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPLLGEGEMSYQGQIISAAEGLE
HHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCE
IAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
ECCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPRIHAARGQKGQIDAAMVFRHLLGEESEISLSHINCEKVQDPYSLRCQPQVLGACLTQI
CCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHHH
RQAAEVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGAIAERRI
HHHHHHHCCCCCCCCCCCEEEECCCCEECCCCCCCCCHHEECCCHHHHHHHHHHHHHHHE
ALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDH
EEEEECHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
VSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLMPSKAVAQAKAELREVVAYYD
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
KDRYFAPDIDAATDLLYTASFNAYLPQGVLPSL
CCCCCCCCCCHHHHEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKSVNHLVLTPGSLSLAQLREISRHKLTLELAPEAINDINTSAQIVQKVLDEGRTVYGIN
CCCCCEEEECCCCCCHHHHHHHHHHEEEEEECCHHHHHCCHHHHHHHHHHHCCCEEEEEC
TGFGLLANTKIAPEDLQLLQRSIVLSHAAGTGQYMQDATVRLMMVLKINSLSRGFSGIRL
CCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHEEHEEEHHHHHCCCCCHHH
EVINFLISLVNAEVYPCVPEKGSVGASGDLAPLAHMCLPLLGEGEMSYQGQIISAAEGLE
HHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCE
IAGLKPIDLAAKEGLALLNGTQASTALALEGLFHAEDLFAASSVIGAMSVEAAMGSRSPF
ECCCCCHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPRIHAARGQKGQIDAAMVFRHLLGEESEISLSHINCEKVQDPYSLRCQPQVLGACLTQI
CCCEECCCCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHHH
RQAAEVLGTEANGVTDNPLVFQDTGDIISGGNFHAEPVAMAADNLAIAIAELGAIAERRI
HHHHHHHCCCCCCCCCCCEEEECCCCEECCCCCCCCCHHEECCCHHHHHHHHHHHHHHHE
ALLIDSSLSKLPPFLVKNGGVNSGFMIAQVTAAALASENKTYAHPASVDSLPTSANQEDH
EEEEECHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
VSMATFAARRLRDMSENTRGVLAVELLAAAQGLDFRAPLMPSKAVAQAKAELREVVAYYD
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
KDRYFAPDIDAATDLLYTASFNAYLPQGVLPSL
CCCCCCCCCCHHHHEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]