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The map label for this gene is hutU [H]

Identifier: 113968444

GI number: 113968444

Start: 109241

End: 110911

Strand: Direct

Name: hutU [H]

Synonym: Shewmr4_0099

Alternate gene names: 113968444

Gene position: 109241-110911 (Clockwise)

Preceding gene: 113968443

Following gene: 113968445

Centisome position: 2.32

GC content: 55.06

Gene sequence:

>1671_bases
ATGGACAAGCGACACGACCCAAGCCGCCGCATTATTGCGCCCCATGGTAGCCAATTAAGCTGCAAAAGCTGGTTAACCGA
AGCGCCAATGCGCATGTTAATGAACAACTTACATCCAGATGTGGCCGAGCGCCCAGAGGATTTAGTGGTTTACGGTGGTA
TCGGCCGCGCGGCCCGCGACTGGGACTGCTACGACAAGATTATCGAAGTACTAAAACGCCTCGAAGACGACGAAACCTTA
ATGGTGCAATCGGGTAAACCTGTGGGCGTATTCCGTACCCACGCCGATGCTCCGCGCGTGCTGATTGCTAACTCTAACCT
AGTGCCACATTGGGCAAACTGGGAACACTTCAACGAGTTAGATAAGCAAGGTCTGGCGATGTATGGCCAGATGACTGCGG
GTTCGTGGATTTATATCGGGACTCAGGGCATTGTCCAAGGTACCTACGAAACCTTCGTTGCCGTGGCAAAACAACACTTT
GGCGGTGTGGCTGCCGGTAAGTGGATCCTCACCGGTGGTTTAGGTGGTATGGGCGGCGCGCAAACGCTGGCCGGTACTAT
GGCTGGCTTCTCTGTGCTTGCCTGTGAAGTCGATGAAACCCGTATCGATTTTCGTCTGCGTACCCGTTATGTGGATAAAA
AGGCCACTTCATTAGACGAAGCCTTGGCTATGATCAACGACGCCAATGCCTCGGGCAAACCCGTATCTGTGGGCCTGCTG
GCTAACGCCGCCGATATCTTTGCCGAATTGGTGAAGCGTGGCATTACTCCTGATGTTGTCACCGACCAAACCTCTGCCCA
CGATCCGCTGAACGGCTATTTGCCACAGGGCTGGACCATGGCGCAAGCGGCTGACATGCGTAAAACCGATGAAGCCGCCG
TCGTTAAAGCGGCTAAAGCCTCAATGGCGGTACAGGTGCAAGCCATGCTGGATCTGCAAGCGGCAGGCGCGGCGACCTTA
GACTATGGTAACAACATTCGCCAAATGGCCTTCGAAACTGGCGTTAAAAACGCGTTCGATTTCCCTGGTTTTGTGCCTGC
TTATATTCGCCCACTCTTCTGCGAAGGTATCGGCCCGTTCCGTTGGGTAGCCCTGTCTGGCGATCCTGAGGATATCTACA
AGACCGACGCCAAAGTGAAGGAGCTGATCCCCGACAATCCTCATTTGCACAACTGGTTAGATATGGCCCGTGAACGTATC
GCCTTCCAAGGTCTACCTGCGCGTATCTGCTGGGTGGGCCTAAAGGACCGTGCGCGTTTAGCCCAAGCCTTTAACGAGAT
GGTGAAAAACGGCGAGCTGTCGGCGCCCATCGTCATTGGTCGTGACCACTTAGACTCAGGCTCAGTCGCCAGCCCTAACC
GTGAAACCGAATCTATGATGGACGGTTCAGACGCAGTATCTGACTGGCCATTACTGAACGCTCTGCTAAACACTGCCAGC
GGCGCGACTTGGGTGTCGCTGCACCACGGCGGTGGCGTAGGCATGGGCTTTAGCCAACACTCGGGTGTAGTGATCGTGTG
TGACGGTACTGAGGCCGCCGCTAAACGTGTTGGCCGCGTACTGTGGAACGACCCTGCGACAGGCGTGATGCGCCATGCGG
ATGCGGGTTACGAGATCGCGAAAAACTGCGCAAAAGAGCAGGGCTTAGATCTGCCCATGCTTAAAGACTAG

Upstream 100 bases:

>100_bases
TTATGGCATTCATCCGATGTTTAGCGGCAAAAACACAATAAAAACAATAGCACTTAGCCGAATGGCGAGTGAGTTCAACA
GGTTGAAAGAGGACATCTCA

Downstream 100 bases:

>100_bases
CTATTCAACAAACCGTGAAAAACAACGACAAGAATACGGATGTAAAAATGAAATCAGTCAATCATTTAGTATTAACGCCC
GGCAGTTTAAGTCTGGCGCA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MDKRHDPSRRIIAPHGSQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLKRLEDDETL
MVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKQGLAMYGQMTAGSWIYIGTQGIVQGTYETFVAVAKQHF
GGVAAGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMINDANASGKPVSVGLL
ANAADIFAELVKRGITPDVVTDQTSAHDPLNGYLPQGWTMAQAADMRKTDEAAVVKAAKASMAVQVQAMLDLQAAGAATL
DYGNNIRQMAFETGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPARICWVGLKDRARLAQAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMMDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTEAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMLKD

Sequences:

>Translated_556_residues
MDKRHDPSRRIIAPHGSQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLKRLEDDETL
MVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKQGLAMYGQMTAGSWIYIGTQGIVQGTYETFVAVAKQHF
GGVAAGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMINDANASGKPVSVGLL
ANAADIFAELVKRGITPDVVTDQTSAHDPLNGYLPQGWTMAQAADMRKTDEAAVVKAAKASMAVQVQAMLDLQAAGAATL
DYGNNIRQMAFETGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPARICWVGLKDRARLAQAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMMDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTEAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMLKD
>Mature_556_residues
MDKRHDPSRRIIAPHGSQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARDWDCYDKIIEVLKRLEDDETL
MVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNELDKQGLAMYGQMTAGSWIYIGTQGIVQGTYETFVAVAKQHF
GGVAAGKWILTGGLGGMGGAQTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMINDANASGKPVSVGLL
ANAADIFAELVKRGITPDVVTDQTSAHDPLNGYLPQGWTMAQAADMRKTDEAAVVKAAKASMAVQVQAMLDLQAAGAATL
DYGNNIRQMAFETGVKNAFDFPGFVPAYIRPLFCEGIGPFRWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERI
AFQGLPARICWVGLKDRARLAQAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMMDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTEAAAKRVGRVLWNDPATGVMRHADAGYEIAKNCAKEQGLDLPMLKD

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=562, Percent_Identity=33.9857651245552, Blast_Score=299, Evalue=6e-81,
Organism=Homo sapiens, GI260306182, Length=206, Percent_Identity=38.3495145631068, Blast_Score=152, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71997891, Length=560, Percent_Identity=33.9285714285714, Blast_Score=308, Evalue=6e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60297; Mature: 60297

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKRHDPSRRIIAPHGSQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARD
CCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCCCCC
WDCYDKIIEVLKRLEDDETLMVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHH
DKQGLAMYGQMTAGSWIYIGTQGIVQGTYETFVAVAKQHFGGVAAGKWILTGGLGGMGGA
HHHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCH
QTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMINDANASGKPVSVGLL
HHHHHHHHCCEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHH
ANAADIFAELVKRGITPDVVTDQTSAHDPLNGYLPQGWTMAQAADMRKTDEAAVVKAAKA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHH
SMAVQVQAMLDLQAAGAATLDYGNNIRQMAFETGVKNAFDFPGFVPAYIRPLFCEGIGPF
HHHEEEHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPARICWVGLKDRARL
EEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
AQAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMMDGSDAVSDWPLLNALLNTAS
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTEAAAKRVGRVLWNDPATGVMRHADAGYEIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHH
KNCAKEQGLDLPMLKD
HHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDKRHDPSRRIIAPHGSQLSCKSWLTEAPMRMLMNNLHPDVAERPEDLVVYGGIGRAARD
CCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCEEEECCCCCCCCC
WDCYDKIIEVLKRLEDDETLMVQSGKPVGVFRTHADAPRVLIANSNLVPHWANWEHFNEL
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCHHHHHH
DKQGLAMYGQMTAGSWIYIGTQGIVQGTYETFVAVAKQHFGGVAAGKWILTGGLGGMGGA
HHHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCH
QTLAGTMAGFSVLACEVDETRIDFRLRTRYVDKKATSLDEALAMINDANASGKPVSVGLL
HHHHHHHHCCEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHH
ANAADIFAELVKRGITPDVVTDQTSAHDPLNGYLPQGWTMAQAADMRKTDEAAVVKAAKA
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHH
SMAVQVQAMLDLQAAGAATLDYGNNIRQMAFETGVKNAFDFPGFVPAYIRPLFCEGIGPF
HHHEEEHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPEDIYKTDAKVKELIPDNPHLHNWLDMARERIAFQGLPARICWVGLKDRARL
EEEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
AQAFNEMVKNGELSAPIVIGRDHLDSGSVASPNRETESMMDGSDAVSDWPLLNALLNTAS
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHSGVVIVCDGTEAAAKRVGRVLWNDPATGVMRHADAGYEIA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHH
KNCAKEQGLDLPMLKD
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA