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The map label for this gene is hutC [H]

Identifier: 113968443

GI number: 113968443

Start: 108410

End: 109117

Strand: Direct

Name: hutC [H]

Synonym: Shewmr4_0098

Alternate gene names: 113968443

Gene position: 108410-109117 (Clockwise)

Preceding gene: 113968441

Following gene: 113968444

Centisome position: 2.3

GC content: 55.51

Gene sequence:

>708_bases
TTGGCTACGCCTAAGTTTGCAGAAATTAAGCAATATATCATTGGCTGTATCGAGTCTGGTGAGTGGGAAGAAAATGCCCG
TGTCCCCTCGGAAAATCAGCTAGCCGAACTGTTTGTCTGTAGCCGTATGACGGCGCGTCGCGCCTTGACCGAGCTGACAG
ACAACGGCGTGCTTGAGCGTTCGCAGGGGCTGGGCACCTTTGTGGCCGGGCGAAAGTCGCAATCCTCGATGTTGGCAATC
CGCAACATTGCCGACGAAATCAAAGACCGTGGTCATGGTTACAGTGTGCAGCAGTTAGCACTTAAACAAGTGAATGCCAC
CGCGCCTATCGCCATCGCACTGGCGCTGGAGCTCGGAAGTCCGGTGTTTCATTCGGTGTTAGTGCATTGCGAGCAGGGCG
TGCCGCTCCAAGTCGAGGAGCGTTATGTGAATCCTGCCTTTGCGCCCGACTATTTGGCGCAGGACTTTAGCGAGCAGACG
CCCCATGAGTACCTGTCGCAGGTGGCTCCGCTGACCGAGGCGCACCACACCATCGAAGCCATTATCGCCAGTAGCGAATT
GCAGCAGAGGTTAGCCATTCCGGCGACTGAACCCTGTTTACAGATTTCACGCCGCACTTGGTCGCGCCAAGGGGTGGTGA
GTTTTGCCAAATTAGTACACCCGGGGAGCCGCTTTAAGCTCGGCGGACACCTGACATTCAATAAATAG

Upstream 100 bases:

>100_bases
ATTGTAGCCGCAATTTTGAACGTTTGAAAGTGGCTCAGTGTTTTGGTGTGTGAGTACCTACCATGCCAAACCTAGGTAGA
TTTGATCTTGAGGAAGTGTT

Downstream 100 bases:

>100_bases
CGTACGCAAACAGCGGTGAAGGCTTATGGCATTCATCCGATGTTTAGCGGCAAAAACACAATAAAAACAATAGCACTTAG
CCGAATGGCGAGTGAGTTCA

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MATPKFAEIKQYIIGCIESGEWEENARVPSENQLAELFVCSRMTARRALTELTDNGVLERSQGLGTFVAGRKSQSSMLAI
RNIADEIKDRGHGYSVQQLALKQVNATAPIAIALALELGSPVFHSVLVHCEQGVPLQVEERYVNPAFAPDYLAQDFSEQT
PHEYLSQVAPLTEAHHTIEAIIASSELQQRLAIPATEPCLQISRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFNK

Sequences:

>Translated_235_residues
MATPKFAEIKQYIIGCIESGEWEENARVPSENQLAELFVCSRMTARRALTELTDNGVLERSQGLGTFVAGRKSQSSMLAI
RNIADEIKDRGHGYSVQQLALKQVNATAPIAIALALELGSPVFHSVLVHCEQGVPLQVEERYVNPAFAPDYLAQDFSEQT
PHEYLSQVAPLTEAHHTIEAIIASSELQQRLAIPATEPCLQISRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFNK
>Mature_234_residues
ATPKFAEIKQYIIGCIESGEWEENARVPSENQLAELFVCSRMTARRALTELTDNGVLERSQGLGTFVAGRKSQSSMLAIR
NIADEIKDRGHGYSVQQLALKQVNATAPIAIALALELGSPVFHSVLVHCEQGVPLQVEERYVNPAFAPDYLAQDFSEQTP
HEYLSQVAPLTEAHHTIEAIIASSELQQRLAIPATEPCLQISRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFNK

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=146, Percent_Identity=28.7671232876712, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790118, Length=218, Percent_Identity=23.394495412844, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786950, Length=212, Percent_Identity=24.0566037735849, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 25948; Mature: 25817

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPKFAEIKQYIIGCIESGEWEENARVPSENQLAELFVCSRMTARRALTELTDNGVLER
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
SQGLGTFVAGRKSQSSMLAIRNIADEIKDRGHGYSVQQLALKQVNATAPIAIALALELGS
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCC
PVFHSVLVHCEQGVPLQVEERYVNPAFAPDYLAQDFSEQTPHEYLSQVAPLTEAHHTIEA
HHHHHHHHHHCCCCCEEHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHH
IIASSELQQRLAIPATEPCLQISRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFNK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECC
>Mature Secondary Structure 
ATPKFAEIKQYIIGCIESGEWEENARVPSENQLAELFVCSRMTARRALTELTDNGVLER
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
SQGLGTFVAGRKSQSSMLAIRNIADEIKDRGHGYSVQQLALKQVNATAPIAIALALELGS
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCC
PVFHSVLVHCEQGVPLQVEERYVNPAFAPDYLAQDFSEQTPHEYLSQVAPLTEAHHTIEA
HHHHHHHHHHCCCCCEEHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHH
IIASSELQQRLAIPATEPCLQISRRTWSRQGVVSFAKLVHPGSRFKLGGHLTFNK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]