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The map label for this gene is cueR [H]

Identifier: 113968430

GI number: 113968430

Start: 96964

End: 97317

Strand: Direct

Name: cueR [H]

Synonym: Shewmr4_0085

Alternate gene names: 113968430

Gene position: 96964-97317 (Clockwise)

Preceding gene: 113968426

Following gene: 113968431

Centisome position: 2.06

GC content: 48.31

Gene sequence:

>354_bases
ATGTATATTGGTGCTGTGGCGAAGCAAACTGGCCTGTCGATCAAGGCGATTCGCCTCTACGAGGAGTGGGGACTGATCAG
TGCGCCGATCCGTAAGGGGCGTTATCGCACTTATAGCGCAACCGATATAAAGCAGTTAATGCTGATCAAAGAGGCCAAAA
CCTTAGGTATCAAACTCTCGCAACTTAAAGACTTGTTTACCGAGGGGGAGCAGGCGGCGCAGCTTGAGTCTGTGCAGCAG
TTTTTATTGAATATCAAAGCCGATTTCCAGCGGCAGATTAGCGAATTAGAAGATAAATTAGTCAGGCTCGATGCCTGTAT
TGATGGTTTGGATACCTGTGAATCCCGCGCCTAA

Upstream 100 bases:

>100_bases
AGTATAAAGTGCGAGCGACAAGCCTAAAGCGCGGTGATATGCTGGCTAAGGCTTGGAGGTTTATGATGATTTTTTCAATT
ATTTTAATGGATTAAATACT

Downstream 100 bases:

>100_bases
TTGCATGCTTGACTCTGCCCCTAGGGGCAGAGCTTAAGCTGTTGTCATATTGAATACTCAAGGTTTTTACTATGACAAAA
AAGATTCTGGTGGTTTCTGG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 117; Mature: 117

Protein sequence:

>117_residues
MYIGAVAKQTGLSIKAIRLYEEWGLISAPIRKGRYRTYSATDIKQLMLIKEAKTLGIKLSQLKDLFTEGEQAAQLESVQQ
FLLNIKADFQRQISELEDKLVRLDACIDGLDTCESRA

Sequences:

>Translated_117_residues
MYIGAVAKQTGLSIKAIRLYEEWGLISAPIRKGRYRTYSATDIKQLMLIKEAKTLGIKLSQLKDLFTEGEQAAQLESVQQ
FLLNIKADFQRQISELEDKLVRLDACIDGLDTCESRA
>Mature_117_residues
MYIGAVAKQTGLSIKAIRLYEEWGLISAPIRKGRYRTYSATDIKQLMLIKEAKTLGIKLSQLKDLFTEGEQAAQLESVQQ
FLLNIKADFQRQISELEDKLVRLDACIDGLDTCESRA

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=119, Percent_Identity=36.1344537815126, Blast_Score=68, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 13225; Mature: 13225

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIGAVAKQTGLSIKAIRLYEEWGLISAPIRKGRYRTYSATDIKQLMLIKEAKTLGIKLS
CCCCCCHHHCCCCHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHH
QLKDLFTEGEQAAQLESVQQFLLNIKADFQRQISELEDKLVRLDACIDGLDTCESRA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure
MYIGAVAKQTGLSIKAIRLYEEWGLISAPIRKGRYRTYSATDIKQLMLIKEAKTLGIKLS
CCCCCCHHHCCCCHHHHHHHHHCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHH
QLKDLFTEGEQAAQLESVQQFLLNIKADFQRQISELEDKLVRLDACIDGLDTCESRA
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]