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The map label for this gene is pepQ [H]

Identifier: 113968365

GI number: 113968365

Start: 23767

End: 25086

Strand: Direct

Name: pepQ [H]

Synonym: Shewmr4_0019

Alternate gene names: 113968365

Gene position: 23767-25086 (Clockwise)

Preceding gene: 113968356

Following gene: 113968366

Centisome position: 0.51

GC content: 49.09

Gene sequence:

>1320_bases
ATGGATCACTTGGCTCATCACTATCATGCCCACATCGCCGAGCTTAATCGTCGAGTCGCTGAAATTGTATCGCGTGAAGC
ATTATCAGGTTTAGTGATCCACTCGGGTCAGCCACATCGAATGTTTTTGGACGACATTAATTATCCTTTTAAAGCCAATC
CCCACTTCAAGGCTTGGTTACCTGTGTTGGATAACCCTAACTGCTGGTTAGTAGTAAACGGTCGCGATAAGCCACAACTG
ATTTTTTATCACCCTGTGGACTTTTGGCATAAGGTGTCTGACGTGCCGGAGATGTTCTGGACCGAGCATTTTGAGATCAA
GTTACTCACTAAGGCCGATAAGGTTGCCGAGCTATTGCCTAGCGATATCACCAACTGGGCTTATTTAGGTGAGCATTTAG
ATGTGGCTGAGGTACTGGGTTTCACCAGTCGCAATCCTGACTCTGTGATGAGCTATCTGCATTTCCACCGTACCACTAAA
ACCGAATATGAACTCGAATGTATGCGCCGTGCGAACCAGATCGCGGTGCAAGGGCATTTAGCGGCTAAAAATGCCTTCTA
TAACGGTGCCAGCGAGTTTGAAATTCAGCAGCAGTATTTATCTGCCGTGGGACAGGGCGAGAACGAAGTGCCCTACGGTA
ATATCATTGCCTTAAACCAAAATGCGGCGATTTTGCATTACACCGCGCTCGAGCATCAAAATCCGGCGCGGCGCTTATCT
TTTTTAATCGATGCGGGCGCCAGTTATTTTGGCTACGCGTCGGATATCACGCGTACCTATGCGTTTGAGAAGAATCGTTT
CGATGAATTGATCACTGCCATGAACAAGGCGCAGCTCGAACTGATCGATATGATGCGCCCAGGTGTGCGTTATCCCGATT
TACACTTGGCTACCCATGGCAAAGTCGCGCAAATGCTGTTGGATTTTGAGTTAGCCACGGGCGATGCCCAAGGCTTAGTC
GACCAAGGCATAACCAGCGCCTTCTTCCCCCACGGACTCGGCCATATGTTAGGCTTGCAAGTACATGATGTGGGAGGTTT
TGCCTTCGATGAGCGTGGTACCCATATTCCGGCCCCTGAGGCCCATCCGTTCCTGCGTTGCACCCGCATTTTAGCGCCAA
ACCAAGTGCTAACGATGGAGCCAGGATTATACATTATCGATACTTTACTCAATGAGCTAAAACAAGATAGCCGTGACCAG
CAGATCAATTGGCGCACCGTTGATGAGTTGCGACCTTTCGGTGGTATCCGTATCGAGGACAATGTGATTGTGCATCAGGA
TCGAAACGAAAATATGACCCGCGAGCTGGGCTTAGCGTGA

Upstream 100 bases:

>100_bases
TGAAATCACAGGGCGTTAGCGAAGGAAAACACTGAGCCTGTATGGCTTAGTCAGATTTGCGGTTTTTTTATTAACTATCG
TTCATTACAGGATATGACAC

Downstream 100 bases:

>100_bases
GTTTAGGGAGAGCGAGTGCTCGAAAGTTATCTGATACCGAGTGAAAGTGTGCAGATAGAAGAAGAGATAAAGCATAGCCG
CTTTATCTCTTTTCTATTTC

Product: proline dipeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYHPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLPSDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHGKVAQMLLDFELATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFAFDERGTHIPAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRDQ
QINWRTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLA

Sequences:

>Translated_439_residues
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYHPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLPSDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHGKVAQMLLDFELATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFAFDERGTHIPAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRDQ
QINWRTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLA
>Mature_439_residues
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWLPVLDNPNCWLVVNGRDKPQL
IFYHPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLPSDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTK
TEYELECMRRANQIAVQGHLAAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHGKVAQMLLDFELATGDAQGLV
DQGITSAFFPHGLGHMLGLQVHDVGGFAFDERGTHIPAPEAHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRDQ
QINWRTVDELRPFGGIRIEDNVIVHQDRNENMTRELGLA

Specific function: Splits dipeptides with a prolyl residue in the C- terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=444, Percent_Identity=28.8288288288288, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI260593665, Length=288, Percent_Identity=34.0277777777778, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI260593663, Length=440, Percent_Identity=27.0454545454545, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI11559925, Length=283, Percent_Identity=25.4416961130742, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790282, Length=443, Percent_Identity=49.6613995485327, Blast_Score=453, Evalue=1e-129,
Organism=Escherichia coli, GI1789275, Length=292, Percent_Identity=31.1643835616438, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1788728, Length=278, Percent_Identity=27.6978417266187, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=451, Percent_Identity=29.490022172949, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321118, Length=290, Percent_Identity=32.7586206896552, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21357079, Length=456, Percent_Identity=26.5350877192982, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI19920384, Length=291, Percent_Identity=29.553264604811, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR001131
- InterPro:   IPR022846 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 50007; Mature: 50007

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEHHCCCCCCCCCCCCEEEE
PVLDNPNCWLVVNGRDKPQLIFYHPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLP
EEECCCCEEEEECCCCCCCEEEECCHHHHHHHHCCHHHHCCCCEEEEEEECHHHHHHHHH
SDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTKTEYELECMRRANQIAVQGHL
HHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEH
AAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEECCCCCHHHHHH
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHG
HHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCH
KVAQMLLDFELATGDAQGLVDQGITSAFFPHGLGHMLGLQVHDVGGFAFDERGTHIPAPE
HHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCHHHHHCEEEEECCCEEECCCCCCCCCCC
AHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRDQQINWRTVDELRPFGGIRIED
CCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCCCCEEEEC
NVIVHQDRNENMTRELGLA
CEEEECCCCCCHHHHHCCC
>Mature Secondary Structure
MDHLAHHYHAHIAELNRRVAEIVSREALSGLVIHSGQPHRMFLDDINYPFKANPHFKAWL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEHHCCCCCCCCCCCCEEEE
PVLDNPNCWLVVNGRDKPQLIFYHPVDFWHKVSDVPEMFWTEHFEIKLLTKADKVAELLP
EEECCCCEEEEECCCCCCCEEEECCHHHHHHHHCCHHHHCCCCEEEEEEECHHHHHHHHH
SDITNWAYLGEHLDVAEVLGFTSRNPDSVMSYLHFHRTTKTEYELECMRRANQIAVQGHL
HHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEH
AAKNAFYNGASEFEIQQQYLSAVGQGENEVPYGNIIALNQNAAILHYTALEHQNPARRLS
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEEEEECCCCCHHHHHH
FLIDAGASYFGYASDITRTYAFEKNRFDELITAMNKAQLELIDMMRPGVRYPDLHLATHG
HHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCH
KVAQMLLDFELATGDAQGLVDQGITSAFFPHGLGHMLGLQVHDVGGFAFDERGTHIPAPE
HHHHHHHHHHCCCCCHHHHHHHCCHHHHHHCCHHHHHCEEEEECCCEEECCCCCCCCCCC
AHPFLRCTRILAPNQVLTMEPGLYIIDTLLNELKQDSRDQQINWRTVDELRPFGGIRIED
CCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCEEHHHCCCCCCEEEEC
NVIVHQDRNENMTRELGLA
CEEEECCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA