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The map label for this gene is gyaR [H]

Identifier: 116696497

GI number: 116696497

Start: 2889476

End: 2890411

Strand: Direct

Name: gyaR [H]

Synonym: H16_B2561

Alternate gene names: 116696497

Gene position: 2889476-2890411 (Clockwise)

Preceding gene: 116696495

Following gene: 116696503

Centisome position: 99.21

GC content: 69.98

Gene sequence:

>936_bases
ATGAAGCCCACGCTGCTGATCCTGACCCAAGTCGCCACCCACCACCGCGACGCCATTGCCGAACGATTCGAGATCCTCTA
CGCGCCAGACGCCGAAGGCCGCGCCGCGCAGATCGCCACGCAGGGCGAACGCATCCGCGCGGTACTGACCATCGGCTCCA
CCGGCCTGACCGCGGCGGAGATCGACGCGATGCCGGCACTGGAACTGGTGTGCGCACTGGGCGCGGGCTTCGAGAACATC
GCCGTGGCCCACGCCCGCGCACGCGGCATCGCCGTGGCCAATGGCGCCGGCACCAACGACAGCTGCGTGGCCGACCACGC
CTTCGCGCTGCTGCTGGCGACCGTGCGCGCCGTGCCGCAGCTGGACGCGGCCACGCGCGCAGGCACCTGGCGCACTGCAC
TGCCGCTGCGGCCCAATGTCTCTGGCAAGCGGCTGGGGATCGTCGGGCTGGGCACCATCGGCCGGCGTATTGCCCGGCGC
GGCGAAGGCTTCGACCTGGAGATCGGCTATCACAACCGCAAGCCGCGCGAAGATGCCGGGTACCGGTACTTCGACAGCAT
CGGTGCGCTGGCCGCTTGGGCGGACTACCTGGTGATCGCCACGCCGGGCGGGGCAGGTACGCGGCACCTGGTCGATGCAA
GCGTGCTGGCGGCGCTCGGGCCGGCCGGGTTCCTCGTCAATATCGCGCGCGGCAGCGTGGTGGATACCGAAGCGCTGGCT
TCAGCGCTGCGCGCTGGCAAGCTTGGCGGGGCGGGGCTGGATGTCTATGAGAGCGAGCCGGCGCCGCCGGTGGTGTTGTT
CGACTGTCCTAACGTCGTGCTGACGCCGCATGTGGCTGGCTGGTCGCCGGAGGCCATCACGGCGTCCGTGACGCAGTTCC
TGGAGAATGCGCGGCGGCATTTTGCTGGGGAGGGGTTGTTGACGCCGGTGGACTGA

Upstream 100 bases:

>100_bases
CTAGAATGTGACGTCTGCCCGCTATCCGCGTGACGGACTCCGGGTGCATCCCACCCGCTGTCACCCTTCTCCGACTCCAT
CGCCTGCTCCGCTGTCCCCC

Downstream 100 bases:

>100_bases
GGGGCAAGCTCTTGCATTGGACAACGGTACGCCGACAACAGCCCAAGCAGCAGCTAAGATCTACCCGGCCCCAAACACCA
CCCTCACCCTCAACCCCGGC

Product: lactate dehydrogenase or related dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKPTLLILTQVATHHRDAIAERFEILYAPDAEGRAAQIATQGERIRAVLTIGSTGLTAAEIDAMPALELVCALGAGFENI
AVAHARARGIAVANGAGTNDSCVADHAFALLLATVRAVPQLDAATRAGTWRTALPLRPNVSGKRLGIVGLGTIGRRIARR
GEGFDLEIGYHNRKPREDAGYRYFDSIGALAAWADYLVIATPGGAGTRHLVDASVLAALGPAGFLVNIARGSVVDTEALA
SALRAGKLGGAGLDVYESEPAPPVVLFDCPNVVLTPHVAGWSPEAITASVTQFLENARRHFAGEGLLTPVD

Sequences:

>Translated_311_residues
MKPTLLILTQVATHHRDAIAERFEILYAPDAEGRAAQIATQGERIRAVLTIGSTGLTAAEIDAMPALELVCALGAGFENI
AVAHARARGIAVANGAGTNDSCVADHAFALLLATVRAVPQLDAATRAGTWRTALPLRPNVSGKRLGIVGLGTIGRRIARR
GEGFDLEIGYHNRKPREDAGYRYFDSIGALAAWADYLVIATPGGAGTRHLVDASVLAALGPAGFLVNIARGSVVDTEALA
SALRAGKLGGAGLDVYESEPAPPVVLFDCPNVVLTPHVAGWSPEAITASVTQFLENARRHFAGEGLLTPVD
>Mature_311_residues
MKPTLLILTQVATHHRDAIAERFEILYAPDAEGRAAQIATQGERIRAVLTIGSTGLTAAEIDAMPALELVCALGAGFENI
AVAHARARGIAVANGAGTNDSCVADHAFALLLATVRAVPQLDAATRAGTWRTALPLRPNVSGKRLGIVGLGTIGRRIARR
GEGFDLEIGYHNRKPREDAGYRYFDSIGALAAWADYLVIATPGGAGTRHLVDASVLAALGPAGFLVNIARGSVVDTEALA
SALRAGKLGGAGLDVYESEPAPPVVLFDCPNVVLTPHVAGWSPEAITASVTQFLENARRHFAGEGLLTPVD

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=236, Percent_Identity=31.7796610169492, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI61743967, Length=271, Percent_Identity=29.520295202952, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4557497, Length=271, Percent_Identity=29.520295202952, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI6912396, Length=220, Percent_Identity=31.3636363636364, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI145580578, Length=243, Percent_Identity=29.2181069958848, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI4557499, Length=243, Percent_Identity=29.2181069958848, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=29.2682926829268, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI87082289, Length=297, Percent_Identity=29.2929292929293, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1789279, Length=256, Percent_Identity=30.859375, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787645, Length=247, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081824, Length=226, Percent_Identity=27.4336283185841, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788660, Length=305, Percent_Identity=27.2131147540984, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=264, Percent_Identity=31.0606060606061, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=254, Percent_Identity=29.5275590551181, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=279, Percent_Identity=30.8243727598566, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=29.2307692307692, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=260, Percent_Identity=28.4615384615385, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=247, Percent_Identity=26.7206477732794, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321253, Length=172, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=173, Percent_Identity=27.1676300578035, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24585514, Length=303, Percent_Identity=28.3828382838284, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574282, Length=303, Percent_Identity=28.3828382838284, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45551003, Length=303, Percent_Identity=28.3828382838284, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45552429, Length=303, Percent_Identity=28.3828382838284, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28574284, Length=303, Percent_Identity=28.3828382838284, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI19921140, Length=226, Percent_Identity=32.7433628318584, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646446, Length=255, Percent_Identity=31.7647058823529, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646448, Length=255, Percent_Identity=31.7647058823529, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646452, Length=255, Percent_Identity=31.7647058823529, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646450, Length=255, Percent_Identity=31.7647058823529, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574286, Length=283, Percent_Identity=29.6819787985866, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI62472511, Length=255, Percent_Identity=31.7647058823529, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI28571528, Length=225, Percent_Identity=32.8888888888889, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24585516, Length=223, Percent_Identity=28.6995515695067, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32432; Mature: 32432

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTLLILTQVATHHRDAIAERFEILYAPDAEGRAAQIATQGERIRAVLTIGSTGLTAAE
CCCCEEEHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCEEEEEEEECCCCCCHHH
IDAMPALELVCALGAGFENIAVAHARARGIAVANGAGTNDSCVADHAFALLLATVRAVPQ
HHCCHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
LDAATRAGTWRTALPLRPNVSGKRLGIVGLGTIGRRIARRGEGFDLEIGYHNRKPREDAG
CCHHHCCCCCEEECCCCCCCCCCEEEEEECCHHHHHHHHCCCCCEEEECCCCCCCCCCCC
YRYFDSIGALAAWADYLVIATPGGAGTRHLVDASVLAALGPAGFLVNIARGSVVDTEALA
CHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEECHHHHH
SALRAGKLGGAGLDVYESEPAPPVVLFDCPNVVLTPHVAGWSPEAITASVTQFLENARRH
HHHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHH
FAGEGLLTPVD
HCCCCCCCCCC
>Mature Secondary Structure
MKPTLLILTQVATHHRDAIAERFEILYAPDAEGRAAQIATQGERIRAVLTIGSTGLTAAE
CCCCEEEHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCEEEEEEEECCCCCCHHH
IDAMPALELVCALGAGFENIAVAHARARGIAVANGAGTNDSCVADHAFALLLATVRAVPQ
HHCCHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
LDAATRAGTWRTALPLRPNVSGKRLGIVGLGTIGRRIARRGEGFDLEIGYHNRKPREDAG
CCHHHCCCCCEEECCCCCCCCCCEEEEEECCHHHHHHHHCCCCCEEEECCCCCCCCCCCC
YRYFDSIGALAAWADYLVIATPGGAGTRHLVDASVLAALGPAGFLVNIARGSVVDTEALA
CHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEECHHHHH
SALRAGKLGGAGLDVYESEPAPPVVLFDCPNVVLTPHVAGWSPEAITASVTQFLENARRH
HHHHHCCCCCCCCCCCCCCCCCCEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHH
FAGEGLLTPVD
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA