Click here to switch to the map view.

The map label for this gene is lysP [H]

Identifier: 116696408

GI number: 116696408

Start: 2795391

End: 2796842

Strand: Direct

Name: lysP [H]

Synonym: H16_B2472

Alternate gene names: 116696408

Gene position: 2795391-2796842 (Clockwise)

Preceding gene: 116696404

Following gene: 116696409

Centisome position: 95.98

GC content: 65.98

Gene sequence:

>1452_bases
ATGATCGCCATCGGCGGCTCGATCGGCACGGGGCTGTTCGTGGCCTCGGGTGCCACCATCGCACAGGCCGGCCCCGGCGG
CGCGCTGGCCGCCTATATCCTGATCGGGGCGATGGTCTATTTCCTGATGACCAGCCTGGGCGAGCTGGCGGCCTATATGC
CGGTGTCGGGCTCGTTCGCCACCTATGGCGCGCGCTATGTCGATGAAGGCTTCGGCTTCGCGCTCGGCTGGAACTATTGG
TACAACTGGGCGGTGACCATCGCGGTGGAACTGGCCGCGGCCCAGCTGGTGATGCAGTACTGGTTCCCCGACACGCCGGG
CGTGCTGTGGAGCGCGCTGTTCCTGGGCCTGATGTTCCTGCTCAACGCGATCTCGGTGCGCGGCTTCGGCGAGGCCGAGT
ACTGGTGCGCGCTGGTCAAGGTGGTGACGGTGATCGCCTTTATCGGCATCGGCACGCTGATGATCTTCGGCATCCTGCGC
GGCGACGTGTCGGCCTCCCACGGACTGGCCAACCTGACCACCGGCGACGCGCCCTTCGTCGGCGGCCTGCCGGCGCTGAT
CGGCGTGGCCATGATCGCCGGCTTCTCGTTCCAGGGCACCGAGCTGATCGGCGTCGCCGCCGGCGAATCGGCCGATCCGG
CCAAGAACATCCCGCGCGCGGTGCGCCAGGTGTTCTGGCGCATCCTGCTGTTCTATGTGCTGGCGATCCTGATCATCGGC
ATCCTGATCCCCTACACCGACCCGAACCTGCTCAAGAACGACGTGCAGACCGTGGGCGTCAGCCCGTTCACGCTGGTGTT
CCGCCATGCGGGCCTGGCCTTTGCGGCAGGCGTGATGAACGCGGTGATCCTGACCGCGGTGCTGTCGGCCGGCAATTCTG
GCATGTATGCCTCCACCCGCATGCTGTACAACCTGGCCACCGAAGGCCGCGCGCCGCGCATCTTTGCGCAGCTCACGCGC
AACGGCGTGCCGCTGATGGCGCTGCTGGCCACTACCGCGGTGGGCGCGCTGTGCTTTCTCACCTCGTTGTTCGAAAGCAG
GTCGGTCTACCTGTGGCTGCTGAACCTGTCCGGCATGACCGGATTTATCGCGTGGCTGGGCATTGCGGTCAGCCATTACC
GCTTCCGCAAGGGCTTTGTCGCGCAAGGGCTGGACCTGGACCGGCTGCCTTACCGCTCGCCGTTCTTCCCCTACGGGCCG
ATCTTCGCCTTTGCGCTGTGCCTGATCGTGACGCTTGGGCAGAACTACCAGGCTTTCACCAGCGGCAAGATCGACTGGGT
CAGCGTGGCCGCCACCTATATCGGCATCCCGATCTTCCTCCTGATCTGGCTGGGCTATCGCATTGCGCGCAAGACGCGCT
TCGTGTCCTATGCCGAGATGCAATTCCCCGCCCTGCCGGCCAGACGCGATGCCGCCCCGGCGCGCGCCGCCGTGCCGGCA
ATCGGTGAATAA

Upstream 100 bases:

>100_bases
CCCAGACCGGATCCTGATGTCAAGCCAACCTTCCCAGCCCACCTCTTCCGGCGCCCCCGCGCCGACGCTGCGCCGCACCC
TGCGGGCACGCCATCTCACC

Downstream 100 bases:

>100_bases
GCGCCATTCCCGCGCGCTTCACAACCAGCAGTACACAAGAGCAAGAAAGCACAAGCACAACAACAACAAGGAGCATCGCT
TTGAAGAGAGCAATCCGCAT

Product: amino acid ABC transporter permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MIAIGGSIGTGLFVASGATIAQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVSGSFATYGARYVDEGFGFALGWNYW
YNWAVTIAVELAAAQLVMQYWFPDTPGVLWSALFLGLMFLLNAISVRGFGEAEYWCALVKVVTVIAFIGIGTLMIFGILR
GDVSASHGLANLTTGDAPFVGGLPALIGVAMIAGFSFQGTELIGVAAGESADPAKNIPRAVRQVFWRILLFYVLAILIIG
ILIPYTDPNLLKNDVQTVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRIFAQLTR
NGVPLMALLATTAVGALCFLTSLFESRSVYLWLLNLSGMTGFIAWLGIAVSHYRFRKGFVAQGLDLDRLPYRSPFFPYGP
IFAFALCLIVTLGQNYQAFTSGKIDWVSVAATYIGIPIFLLIWLGYRIARKTRFVSYAEMQFPALPARRDAAPARAAVPA
IGE

Sequences:

>Translated_483_residues
MIAIGGSIGTGLFVASGATIAQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVSGSFATYGARYVDEGFGFALGWNYW
YNWAVTIAVELAAAQLVMQYWFPDTPGVLWSALFLGLMFLLNAISVRGFGEAEYWCALVKVVTVIAFIGIGTLMIFGILR
GDVSASHGLANLTTGDAPFVGGLPALIGVAMIAGFSFQGTELIGVAAGESADPAKNIPRAVRQVFWRILLFYVLAILIIG
ILIPYTDPNLLKNDVQTVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRIFAQLTR
NGVPLMALLATTAVGALCFLTSLFESRSVYLWLLNLSGMTGFIAWLGIAVSHYRFRKGFVAQGLDLDRLPYRSPFFPYGP
IFAFALCLIVTLGQNYQAFTSGKIDWVSVAATYIGIPIFLLIWLGYRIARKTRFVSYAEMQFPALPARRDAAPARAAVPA
IGE
>Mature_483_residues
MIAIGGSIGTGLFVASGATIAQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVSGSFATYGARYVDEGFGFALGWNYW
YNWAVTIAVELAAAQLVMQYWFPDTPGVLWSALFLGLMFLLNAISVRGFGEAEYWCALVKVVTVIAFIGIGTLMIFGILR
GDVSASHGLANLTTGDAPFVGGLPALIGVAMIAGFSFQGTELIGVAAGESADPAKNIPRAVRQVFWRILLFYVLAILIIG
ILIPYTDPNLLKNDVQTVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRIFAQLTR
NGVPLMALLATTAVGALCFLTSLFESRSVYLWLLNLSGMTGFIAWLGIAVSHYRFRKGFVAQGLDLDRLPYRSPFFPYGP
IFAFALCLIVTLGQNYQAFTSGKIDWVSVAATYIGIPIFLLIWLGYRIARKTRFVSYAEMQFPALPARRDAAPARAAVPA
IGE

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=463, Percent_Identity=76.2419006479482, Blast_Score=714, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=416, Percent_Identity=42.7884615384615, Blast_Score=320, Evalue=2e-88,
Organism=Escherichia coli, GI1786789, Length=412, Percent_Identity=36.1650485436893, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI48994972, Length=423, Percent_Identity=36.6430260047281, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1786302, Length=390, Percent_Identity=35.8974358974359, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081915, Length=405, Percent_Identity=36.0493827160494, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1789017, Length=426, Percent_Identity=32.8638497652582, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1790653, Length=383, Percent_Identity=34.4647519582245, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786602, Length=393, Percent_Identity=33.0788804071247, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI87081869, Length=197, Percent_Identity=26.3959390862944, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=465, Percent_Identity=36.5591397849462, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6324061, Length=465, Percent_Identity=35.9139784946237, Blast_Score=317, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6324059, Length=468, Percent_Identity=36.965811965812, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6324990, Length=477, Percent_Identity=32.7044025157233, Blast_Score=284, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6322892, Length=466, Percent_Identity=37.1244635193133, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6324924, Length=468, Percent_Identity=33.3333333333333, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6324553, Length=459, Percent_Identity=35.0762527233115, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6322967, Length=461, Percent_Identity=33.8394793926247, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6321629, Length=484, Percent_Identity=30.1652892561983, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319824, Length=461, Percent_Identity=29.5010845986985, Blast_Score=229, Evalue=8e-61,
Organism=Saccharomyces cerevisiae, GI6320717, Length=459, Percent_Identity=28.7581699346405, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6324981, Length=459, Percent_Identity=33.1154684095861, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321053, Length=454, Percent_Identity=30.6167400881057, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6319542, Length=460, Percent_Identity=28.4782608695652, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6320251, Length=462, Percent_Identity=27.2727272727273, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6319543, Length=458, Percent_Identity=28.82096069869, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6319608, Length=483, Percent_Identity=28.7784679089027, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320364, Length=522, Percent_Identity=25.6704980842912, Blast_Score=162, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51723; Mature: 51723

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIGGSIGTGLFVASGATIAQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVSGSFA
CEEECCCCCCCCEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
TYGARYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMQYWFPDTPGVLWSALFLGLMFL
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LNAISVRGFGEAEYWCALVKVVTVIAFIGIGTLMIFGILRGDVSASHGLANLTTGDAPFV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GGLPALIGVAMIAGFSFQGTELIGVAAGESADPAKNIPRAVRQVFWRILLFYVLAILIIG
CCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILIPYTDPNLLKNDVQTVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGMYASTR
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MLYNLATEGRAPRIFAQLTRNGVPLMALLATTAVGALCFLTSLFESRSVYLWLLNLSGMT
HHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHH
GFIAWLGIAVSHYRFRKGFVAQGLDLDRLPYRSPFFPYGPIFAFALCLIVTLGQNYQAFT
HHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECC
SGKIDWVSVAATYIGIPIFLLIWLGYRIARKTRFVSYAEMQFPALPARRDAAPARAAVPA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCC
IGE
CCC
>Mature Secondary Structure
MIAIGGSIGTGLFVASGATIAQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVSGSFA
CEEECCCCCCCCEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
TYGARYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMQYWFPDTPGVLWSALFLGLMFL
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LNAISVRGFGEAEYWCALVKVVTVIAFIGIGTLMIFGILRGDVSASHGLANLTTGDAPFV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
GGLPALIGVAMIAGFSFQGTELIGVAAGESADPAKNIPRAVRQVFWRILLFYVLAILIIG
CCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILIPYTDPNLLKNDVQTVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGMYASTR
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MLYNLATEGRAPRIFAQLTRNGVPLMALLATTAVGALCFLTSLFESRSVYLWLLNLSGMT
HHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHH
GFIAWLGIAVSHYRFRKGFVAQGLDLDRLPYRSPFFPYGPIFAFALCLIVTLGQNYQAFT
HHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECC
SGKIDWVSVAATYIGIPIFLLIWLGYRIARKTRFVSYAEMQFPALPARRDAAPARAAVPA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCC
IGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]