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The map label for this gene is ytnA [H]

Identifier: 116696101

GI number: 116696101

Start: 2451528

End: 2452907

Strand: Direct

Name: ytnA [H]

Synonym: H16_B2165

Alternate gene names: 116696101

Gene position: 2451528-2452907 (Clockwise)

Preceding gene: 116696100

Following gene: 116696102

Centisome position: 84.17

GC content: 66.52

Gene sequence:

>1380_bases
ATGAGTGCAAGCGCAGAACATCTGCAACGCGGCCTGGGCGAACGGCATATCCGGCTGATGGCGCTGGGTTCGGCCATCGG
CGTGGGCCTGTTCCTGGGCGCCGGCAATGCCATCAAGATGGCCGGCCCCGCCATCATGCTGGGCTACCTGATCGGCGGCG
CGGTGATCTTCCTGATCATGCGCGCGCTGGGCGAAATGGCCGTGCACAACCCGGTGGCCGGCTCGTTCTGCCGCTACGCG
CAGGACCACATGGGCCCGCTGGCCGGCTACCTGACCGGCTGGAACTACTGGTTCCTGTGGCTGGTGACCTGCGTGGCGGA
GATCACCGCCGTGGCCATCTACATGGGCATGTGGTTCCCCGACGTGCCGCGCTGGATCTGGGCGCTGGCCGCGCTGGCGG
CAATGGGCTCGGTCAACCTGATGGCGGTCAAGGCCTATGGCGAGTTCGAGTTCTGGTTCGCCATGATCAAGATCGTCACC
ATCGTGCTGATGCTGATCGGCGGCGGCGCCATGATCGTGTTCGGCTTTGGCAACGGCGGTATCGCCACCGGCATCTCGAA
CCTGTGGGCGCACGGCGGTTTCATGCCCAACGGCGCCTCCGGCGTGCTGATGTCGCTGCAGATGGTGATGTTCGCCTACC
TCGGCGTGGAGATGATCGGCCTGACCGCCGGCGAGGCGCGCAACCCGAAGAAGTCGATCCCTGACGCGATCAACTCGGTG
TTCTGGCGCATCCTGATCTTCTACGTGGGTGCGCTGTTCGTGATCCTGTCGCTGTACCCGTGGAACGAGATCGGCGCCCA
GGGCAGCCCCTTCGTGCTGACTTTCGAGCGGCTGGGCATCAAGACCGCCGCCGGCATCATCAACTTCGTGGTGCTGACCG
CGGCGCTGTCGTCGTGCAATGGCGGCATCTTCAGCACCGGGCGCATGCTGTACAACCTGGCGCAGCAGGGCCAGGCGCCG
CAGGCCTTTGCCAAGGTCGACCGCAATGGCGTGCCGCGCCGCGCGCTGCTGGTGTCGATCGCCGCGCTGCTGTGCGGCGT
GCTGCTCAATTACCTGGTGCCCGAGCAGGTCTTCGTCTGGGTGACGGCGATTTCCACCTTCGGCGCGGTCTGGACCTGGG
CCATCATCCTGGTCACGCAGATCCAGTTCCGCCGCAGCCTGTCGGCGGCCGAGCGCAAGGCGCTGGCCTTCCGCATGCCG
TTCTGGCCCTATGGCTCCTACATCGCGCTGGCCTTCCTGGCGCTGGTGGTGGCGCTGATGGCCTACTTCCCGGAGACCCG
CGTGGCGCTGTACGTGGGCCCGGGCTGGCTGGTGCTGCTGACGGTGTGCTACTACGCGCTGGACATGCGCTCGCGCGGGC
CAGTCAGCTACCGCGCCTGA

Upstream 100 bases:

>100_bases
TATTTTCCGTTTACGGCCCGCCGCGGACGAGAAAATAGCTGCTCCCGCCGGCCCCACGAAGGCCGGCGCGGCCTTTCTGA
TGACACGGAGACAACGACAC

Downstream 100 bases:

>100_bases
GCTTGCCGTAGCCAGCGGGGTGCGCCGGCCGGCGCGCCTCGCTACAATGGCTCCCGGGCAATCCAACGCCAGGGGGCCGA
ATGTCCGAGACCACTGAGGT

Product: amino acid ABC transporter permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSASAEHLQRGLGERHIRLMALGSAIGVGLFLGAGNAIKMAGPAIMLGYLIGGAVIFLIMRALGEMAVHNPVAGSFCRYA
QDHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGMWFPDVPRWIWALAALAAMGSVNLMAVKAYGEFEFWFAMIKIVT
IVLMLIGGGAMIVFGFGNGGIATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEARNPKKSIPDAINSV
FWRILIFYVGALFVILSLYPWNEIGAQGSPFVLTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGQAP
QAFAKVDRNGVPRRALLVSIAALLCGVLLNYLVPEQVFVWVTAISTFGAVWTWAIILVTQIQFRRSLSAAERKALAFRMP
FWPYGSYIALAFLALVVALMAYFPETRVALYVGPGWLVLLTVCYYALDMRSRGPVSYRA

Sequences:

>Translated_459_residues
MSASAEHLQRGLGERHIRLMALGSAIGVGLFLGAGNAIKMAGPAIMLGYLIGGAVIFLIMRALGEMAVHNPVAGSFCRYA
QDHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGMWFPDVPRWIWALAALAAMGSVNLMAVKAYGEFEFWFAMIKIVT
IVLMLIGGGAMIVFGFGNGGIATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEARNPKKSIPDAINSV
FWRILIFYVGALFVILSLYPWNEIGAQGSPFVLTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGQAP
QAFAKVDRNGVPRRALLVSIAALLCGVLLNYLVPEQVFVWVTAISTFGAVWTWAIILVTQIQFRRSLSAAERKALAFRMP
FWPYGSYIALAFLALVVALMAYFPETRVALYVGPGWLVLLTVCYYALDMRSRGPVSYRA
>Mature_458_residues
SASAEHLQRGLGERHIRLMALGSAIGVGLFLGAGNAIKMAGPAIMLGYLIGGAVIFLIMRALGEMAVHNPVAGSFCRYAQ
DHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGMWFPDVPRWIWALAALAAMGSVNLMAVKAYGEFEFWFAMIKIVTI
VLMLIGGGAMIVFGFGNGGIATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEARNPKKSIPDAINSVF
WRILIFYVGALFVILSLYPWNEIGAQGSPFVLTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGQAPQ
AFAKVDRNGVPRRALLVSIAALLCGVLLNYLVPEQVFVWVTAISTFGAVWTWAIILVTQIQFRRSLSAAERKALAFRMPF
WPYGSYIALAFLALVVALMAYFPETRVALYVGPGWLVLLTVCYYALDMRSRGPVSYRA

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=316, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI258614003, Length=437, Percent_Identity=22.1967963386728, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI258614005, Length=437, Percent_Identity=22.1967963386728, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI258645169, Length=389, Percent_Identity=23.6503856041131, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI114326544, Length=359, Percent_Identity=22.8412256267409, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI114326550, Length=359, Percent_Identity=22.8412256267409, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI110347453, Length=354, Percent_Identity=25.4237288135593, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786602, Length=439, Percent_Identity=56.0364464692483, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=50.5494505494505, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=45.43429844098, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1786302, Length=449, Percent_Identity=45.6570155902004, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1790653, Length=440, Percent_Identity=42.9545454545455, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI87081915, Length=453, Percent_Identity=41.280353200883, Blast_Score=343, Evalue=9e-96,
Organism=Escherichia coli, GI87081708, Length=444, Percent_Identity=39.6396396396396, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=36.3431151241535, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1788480, Length=431, Percent_Identity=37.122969837587, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87081869, Length=233, Percent_Identity=23.175965665236, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790575, Length=280, Percent_Identity=26.0714285714286, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI2367353, Length=360, Percent_Identity=25.5555555555556, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082023, Length=285, Percent_Identity=23.859649122807, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=363, Percent_Identity=24.5179063360882, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=444, Percent_Identity=23.4234234234234, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=466, Percent_Identity=32.1888412017167, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6320772, Length=438, Percent_Identity=32.4200913242009, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322892, Length=434, Percent_Identity=33.6405529953917, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6324990, Length=446, Percent_Identity=31.390134529148, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6324924, Length=457, Percent_Identity=32.1663019693654, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6319824, Length=438, Percent_Identity=30.1369863013699, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6320717, Length=441, Percent_Identity=29.9319727891156, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=436, Percent_Identity=31.8807339449541, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=409, Percent_Identity=33.4963325183374, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321629, Length=402, Percent_Identity=28.6069651741293, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319543, Length=403, Percent_Identity=30.0248138957816, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6320251, Length=439, Percent_Identity=28.7015945330296, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=405, Percent_Identity=29.1358024691358, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=403, Percent_Identity=30.272952853598, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6321053, Length=429, Percent_Identity=28.9044289044289, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319608, Length=445, Percent_Identity=27.1910112359551, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324981, Length=428, Percent_Identity=27.1028037383178, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320364, Length=507, Percent_Identity=24.65483234714, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24667468, Length=359, Percent_Identity=25.3481894150418, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221512776, Length=340, Percent_Identity=21.7647058823529, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666159, Length=340, Percent_Identity=21.7647058823529, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24668806, Length=421, Percent_Identity=23.2779097387173, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21356285, Length=421, Percent_Identity=23.2779097387173, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24668802, Length=421, Percent_Identity=23.2779097387173, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI161077963, Length=414, Percent_Identity=24.1545893719807, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281366235, Length=358, Percent_Identity=23.463687150838, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007820, Length=358, Percent_Identity=23.463687150838, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49803; Mature: 49672

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASAEHLQRGLGERHIRLMALGSAIGVGLFLGAGNAIKMAGPAIMLGYLIGGAVIFLIM
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHH
RALGEMAVHNPVAGSFCRYAQDHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGMWFP
HHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVPRWIWALAALAAMGSVNLMAVKAYGEFEFWFAMIKIVTIVLMLIGGGAMIVFGFGNGG
CHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
IATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEARNPKKSIPDAINSV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHCCHHHHHHH
FWRILIFYVGALFVILSLYPWNEIGAQGSPFVLTFERLGIKTAAGIINFVVLTAALSSCN
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHCC
GGIFSTGRMLYNLAQQGQAPQAFAKVDRNGVPRRALLVSIAALLCGVLLNYLVPEQVFVW
CCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHH
VTAISTFGAVWTWAIILVTQIQFRRSLSAAERKALAFRMPFWPYGSYIALAFLALVVALM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHH
AYFPETRVALYVGPGWLVLLTVCYYALDMRSRGPVSYRA
HHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SASAEHLQRGLGERHIRLMALGSAIGVGLFLGAGNAIKMAGPAIMLGYLIGGAVIFLIM
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHH
RALGEMAVHNPVAGSFCRYAQDHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGMWFP
HHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVPRWIWALAALAAMGSVNLMAVKAYGEFEFWFAMIKIVTIVLMLIGGGAMIVFGFGNGG
CHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCC
IATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEARNPKKSIPDAINSV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHCCHHHHHHH
FWRILIFYVGALFVILSLYPWNEIGAQGSPFVLTFERLGIKTAAGIINFVVLTAALSSCN
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHCC
GGIFSTGRMLYNLAQQGQAPQAFAKVDRNGVPRRALLVSIAALLCGVLLNYLVPEQVFVW
CCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHH
VTAISTFGAVWTWAIILVTQIQFRRSLSAAERKALAFRMPFWPYGSYIALAFLALVVALM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHH
AYFPETRVALYVGPGWLVLLTVCYYALDMRSRGPVSYRA
HHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]