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The map label for this gene is macA [H]

Identifier: 116696074

GI number: 116696074

Start: 2418176

End: 2419390

Strand: Direct

Name: macA [H]

Synonym: H16_B2138

Alternate gene names: 116696074

Gene position: 2418176-2419390 (Clockwise)

Preceding gene: 116696073

Following gene: 116696075

Centisome position: 83.03

GC content: 69.88

Gene sequence:

>1215_bases
GTGGCTGACCACGACCTGTCCAGGCTGAAAATCGACCGGAGCGCCGCCGCGGCCGGCGCCGGCATCCGCCCCCGGCGCAG
GTGGCTGCGCTATGCAGTGATCGCGCTGGCCGTGCTGGCCCTGGCCGGCATCGCCATGAAGCTGGCCGGGCCGCAGGCGG
TGCAGACCGCCACCGTCACCTCCGCCTATCCCACGCAGAATTTCACCGTGCTCAATGCCACCGGCTATGTCGTGCCGCAG
CGCAAGGCGGCGGTCGCGTCCAAGGCGCAGGGCCGGCTGGAATGGCTGGGCGTGCTGGAAGGCTCGCGCGTGAAGAAGGA
CGAGATCATCGCACGGCTGGAGAGCAAGGACGTCGCCGCCTCGTTCGCGCAGGCCCAGGCACAGGTCCAGGTGGCGCAGG
CCAACCTGGCGCTGCAGCAGGCCGAGCTGAAGGACGCCGAGGTGAACCTGCGCCGCTCGAAGATCCTGATCGTGCCGAAC
GCCATCTCGCGCACCCAGTACGACGCCGACGTGGCGCGCTTTGACAAGGCGCGGGCCTCGGTCAACAGTTCGCGCGCGGC
GATCGCCTCGGCCCAGGCCAATGCCCGCGCGGCCGAGGTCGCGGTGGAGCAGACCGTGGTGCGCGCGCCCTTCGATGGCG
TGGTACTGGTCAAGCATGCCAACGTGGGCGACAACATCACGCCCTTCTCTGCCGCCGCCGACACCAAGGGCGCGATCGTG
ACCATCGCCGACATGGAGACGCTGGAGGTGGAAGCCGATGTCGCCGAATCCAATATCGGCAAGATCCGCGCCAACCAGCC
GTGCGAGCTGCTGCTGGATGCGCTGCCGGGATTGCGGCTGGCGGGGCAAGTGTCGCGCATCGTGCCGACGGTGGACCGCT
CCAAGGCCACCGTGCTGGTCAAGGTGCGCTTTGTCGACCGCGATGCGCGCGTGCTGCCGGACATGAGCGCCAAGATCGCC
TTCCTGTCGCGCACCGCCTCGGCGCAGGACCGCCAGCCGGTGGTGGCGGTGCAGCCCGCCGCCGTGGTCACGCGCCAGGG
CCGGGAGCTGGCCTATGTGGTGAAGGACGGCCGTGCGCATGAGGTGCAGGTCAAGACCGGCGACAAGCTGGGCGAACTGG
TGGCCGTGCAGGGCGTCAAGCCCGGCGACGTGCTGGTGCTGTCGCCGGCCGACAATCTCGGCGACGGCGACCGCATCACC
GTGGCCAAGCCGTAG

Upstream 100 bases:

>100_bases
CCGCACGCCAGCGGTTTGCTCCCCTCTCGCAAGCAATGGACACCCTTTCACTCGCCGCTATACTGGGAGCCCCGCCCATC
ACAGCGAGAGGAAGCGCGCA

Downstream 100 bases:

>100_bases
AGAGGACCACATGAGCGCAGCACCGCTGGTGCAGATCAGCCACCTCGCCAAATCCTACCGGCGCGGCGTGCAGACCGTGC
CGGTGCTGACCGATATTTCG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MADHDLSRLKIDRSAAAAGAGIRPRRRWLRYAVIALAVLALAGIAMKLAGPQAVQTATVTSAYPTQNFTVLNATGYVVPQ
RKAAVASKAQGRLEWLGVLEGSRVKKDEIIARLESKDVAASFAQAQAQVQVAQANLALQQAELKDAEVNLRRSKILIVPN
AISRTQYDADVARFDKARASVNSSRAAIASAQANARAAEVAVEQTVVRAPFDGVVLVKHANVGDNITPFSAAADTKGAIV
TIADMETLEVEADVAESNIGKIRANQPCELLLDALPGLRLAGQVSRIVPTVDRSKATVLVKVRFVDRDARVLPDMSAKIA
FLSRTASAQDRQPVVAVQPAAVVTRQGRELAYVVKDGRAHEVQVKTGDKLGELVAVQGVKPGDVLVLSPADNLGDGDRIT
VAKP

Sequences:

>Translated_404_residues
MADHDLSRLKIDRSAAAAGAGIRPRRRWLRYAVIALAVLALAGIAMKLAGPQAVQTATVTSAYPTQNFTVLNATGYVVPQ
RKAAVASKAQGRLEWLGVLEGSRVKKDEIIARLESKDVAASFAQAQAQVQVAQANLALQQAELKDAEVNLRRSKILIVPN
AISRTQYDADVARFDKARASVNSSRAAIASAQANARAAEVAVEQTVVRAPFDGVVLVKHANVGDNITPFSAAADTKGAIV
TIADMETLEVEADVAESNIGKIRANQPCELLLDALPGLRLAGQVSRIVPTVDRSKATVLVKVRFVDRDARVLPDMSAKIA
FLSRTASAQDRQPVVAVQPAAVVTRQGRELAYVVKDGRAHEVQVKTGDKLGELVAVQGVKPGDVLVLSPADNLGDGDRIT
VAKP
>Mature_403_residues
ADHDLSRLKIDRSAAAAGAGIRPRRRWLRYAVIALAVLALAGIAMKLAGPQAVQTATVTSAYPTQNFTVLNATGYVVPQR
KAAVASKAQGRLEWLGVLEGSRVKKDEIIARLESKDVAASFAQAQAQVQVAQANLALQQAELKDAEVNLRRSKILIVPNA
ISRTQYDADVARFDKARASVNSSRAAIASAQANARAAEVAVEQTVVRAPFDGVVLVKHANVGDNITPFSAAADTKGAIVT
IADMETLEVEADVAESNIGKIRANQPCELLLDALPGLRLAGQVSRIVPTVDRSKATVLVKVRFVDRDARVLPDMSAKIAF
LSRTASAQDRQPVVAVQPAAVVTRQGRELAYVVKDGRAHEVQVKTGDKLGELVAVQGVKPGDVLVLSPADNLGDGDRITV
AKP

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=362, Percent_Identity=25.9668508287293, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081796, Length=323, Percent_Identity=24.1486068111455, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789929, Length=330, Percent_Identity=22.7272727272727, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42856; Mature: 42724

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADHDLSRLKIDRSAAAAGAGIRPRRRWLRYAVIALAVLALAGIAMKLAGPQAVQTATVT
CCCCCCHHEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
SAYPTQNFTVLNATGYVVPQRKAAVASKAQGRLEWLGVLEGSRVKKDEIIARLESKDVAA
ECCCCCCEEEEEECCEEECCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHH
SFAQAQAQVQVAQANLALQQAELKDAEVNLRRSKILIVPNAISRTQYDADVARFDKARAS
HHHHHHHHEEEHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
VNSSRAAIASAQANARAAEVAVEQTVVRAPFDGVVLVKHANVGDNITPFSAAADTKGAIV
CCCCHHHEECCCCCCHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCEE
TIADMETLEVEADVAESNIGKIRANQPCELLLDALPGLRLAGQVSRIVPTVDRSKATVLV
EEECCEEEEEECCCCCCCCCEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEE
KVRFVDRDARVLPDMSAKIAFLSRTASAQDRQPVVAVQPAAVVTRQGRELAYVVKDGRAH
EEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHCCCCEEEEEEECCCEE
EVQVKTGDKLGELVAVQGVKPGDVLVLSPADNLGDGDRITVAKP
EEEEECCCCCCCEEEECCCCCCCEEEECCCCCCCCCCEEEEECC
>Mature Secondary Structure 
ADHDLSRLKIDRSAAAAGAGIRPRRRWLRYAVIALAVLALAGIAMKLAGPQAVQTATVT
CCCCCHHEEECCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
SAYPTQNFTVLNATGYVVPQRKAAVASKAQGRLEWLGVLEGSRVKKDEIIARLESKDVAA
ECCCCCCEEEEEECCEEECCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCHHHHH
SFAQAQAQVQVAQANLALQQAELKDAEVNLRRSKILIVPNAISRTQYDADVARFDKARAS
HHHHHHHHEEEHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHH
VNSSRAAIASAQANARAAEVAVEQTVVRAPFDGVVLVKHANVGDNITPFSAAADTKGAIV
CCCCHHHEECCCCCCHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCEE
TIADMETLEVEADVAESNIGKIRANQPCELLLDALPGLRLAGQVSRIVPTVDRSKATVLV
EEECCEEEEEECCCCCCCCCEEECCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEEE
KVRFVDRDARVLPDMSAKIAFLSRTASAQDRQPVVAVQPAAVVTRQGRELAYVVKDGRAH
EEEEECCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHCCCCEEEEEEECCCEE
EVQVKTGDKLGELVAVQGVKPGDVLVLSPADNLGDGDRITVAKP
EEEEECCCCCCCEEEECCCCCCCEEEECCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]