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The map label for this gene is phcA [H]

Identifier: 116696016

GI number: 116696016

Start: 2339457

End: 2340416

Strand: Direct

Name: phcA [H]

Synonym: H16_B2080

Alternate gene names: 116696016

Gene position: 2339457-2340416 (Clockwise)

Preceding gene: 116696015

Following gene: 116696017

Centisome position: 80.32

GC content: 68.02

Gene sequence:

>960_bases
ATGCGTCACGTCAGCACGAAGTTGTTGCATGTCTTTGTCCTGGTCATGGAATACCGGGACCTCAGCGCCGTTGCGGCCTG
CACGCAGGGACGCGTGCCGACGGTGGCCTACAGCCTCGCGCGCTTGCGCGAAATCACCGGCGATCCGCTGTTCGTCAAGC
GCAACGGGATGCTCGAACCCACACCGCATGCGCTGCGCCTGGAGCAGACGGCGCGGCAGATCCTGGCCAAATGGAACCAG
CTGGTGCGCCCCGGCGAGCCTGGCCTGAGCAAGCGCCGTGACGACGGCAGACGCGTTTCGATCGGCTTTTCATCGTCGAT
CGGCGACCCGGTCATCACCGAGATCCTGACCGCACTGTGCGAGCAGTTTCCGCGCGACAGCTTTATCACGCGCCCGGTGA
TCGCCGACGCCACCCTTGCCGGCCATCTCGGCAGCGGCGAACTGGACTGCGCCTTCATCGTCGACAGCGGCCACGATCCC
GAACGCGTGCGCCAGCACAACATCATGGCCACGCCGCGCCGGCTGGTCAGCGCCACGCGCGGCGGCAGCCATGACGAAGG
CGAAAGCGACTGGATCCTGCTGCAGGAAGACTGCGAGGCCGGCAGCCCGCTGCGGGCCTTCCTGAGCCGCCAGGCCAGCA
CTCCGGGGCATCGCGAGACCGTGGTCCCATCATGGCATACCCAGATCACGCTGCTGCATTCGGCCGGGGGCATCTGCCCG
GTGCTGGACTTCAACGTGCCGCTGGTCACGCGCGAGCGCAAGACGCGCCTGCTGGCACCGCCGAGCAGCTTCCCGGAATG
GGCCGCACTGCATTTCTGGGCACCGGAGCGCAGCGGCGACAAGGGCGTGCTGCGCGACATCATGGATGTCGGCAGCGCCG
TGCTGCGCGCCCCTCTCAAGGCCATCGACAGCCGCCGCAACGGCCGCGCCGCAGCCCACGCGCAATCCGCACTGGCGTGA

Upstream 100 bases:

>100_bases
CACCAGGCCGCGCTTGCGCCCTTTGTTTCGACGCAGTGCTGTAGGTGTCGGACCAACAAGAAAATAGAGAAAACAAAGTC
ATGGATCGGGAGAAGTCGGA

Downstream 100 bases:

>100_bases
CGCAACGCCCCGCAGCGGCGGCGCCCGCAAGGCGCTGGCAGCCCCATGGCGCCAGCGCCTTTTTCTTTGGCTGCGCAGAA
GCGGCGGCGTTCTTATTACA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Virulence genes transcriptional regulator phcA [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRHVSTKLLHVFVLVMEYRDLSAVAACTQGRVPTVAYSLARLREITGDPLFVKRNGMLEPTPHALRLEQTARQILAKWNQ
LVRPGEPGLSKRRDDGRRVSIGFSSSIGDPVITEILTALCEQFPRDSFITRPVIADATLAGHLGSGELDCAFIVDSGHDP
ERVRQHNIMATPRRLVSATRGGSHDEGESDWILLQEDCEAGSPLRAFLSRQASTPGHRETVVPSWHTQITLLHSAGGICP
VLDFNVPLVTRERKTRLLAPPSSFPEWAALHFWAPERSGDKGVLRDIMDVGSAVLRAPLKAIDSRRNGRAAAHAQSALA

Sequences:

>Translated_319_residues
MRHVSTKLLHVFVLVMEYRDLSAVAACTQGRVPTVAYSLARLREITGDPLFVKRNGMLEPTPHALRLEQTARQILAKWNQ
LVRPGEPGLSKRRDDGRRVSIGFSSSIGDPVITEILTALCEQFPRDSFITRPVIADATLAGHLGSGELDCAFIVDSGHDP
ERVRQHNIMATPRRLVSATRGGSHDEGESDWILLQEDCEAGSPLRAFLSRQASTPGHRETVVPSWHTQITLLHSAGGICP
VLDFNVPLVTRERKTRLLAPPSSFPEWAALHFWAPERSGDKGVLRDIMDVGSAVLRAPLKAIDSRRNGRAAAHAQSALA
>Mature_319_residues
MRHVSTKLLHVFVLVMEYRDLSAVAACTQGRVPTVAYSLARLREITGDPLFVKRNGMLEPTPHALRLEQTARQILAKWNQ
LVRPGEPGLSKRRDDGRRVSIGFSSSIGDPVITEILTALCEQFPRDSFITRPVIADATLAGHLGSGELDCAFIVDSGHDP
ERVRQHNIMATPRRLVSATRGGSHDEGESDWILLQEDCEAGSPLRAFLSRQASTPGHRETVVPSWHTQITLLHSAGGICP
VLDFNVPLVTRERKTRLLAPPSSFPEWAALHFWAPERSGDKGVLRDIMDVGSAVLRAPLKAIDSRRNGRAAAHAQSALA

Specific function: Regulates the transcription of one or more of the genes involved in virulence [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35026; Mature: 35026

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHVSTKLLHVFVLVMEYRDLSAVAACTQGRVPTVAYSLARLREITGDPLFVKRNGMLEP
CCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCC
TPHALRLEQTARQILAKWNQLVRPGEPGLSKRRDDGRRVSIGFSSSIGDPVITEILTALC
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
EQFPRDSFITRPVIADATLAGHLGSGELDCAFIVDSGHDPERVRQHNIMATPRRLVSATR
HHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHCCCCCCHHHHHHHHC
GGSHDEGESDWILLQEDCEAGSPLRAFLSRQASTPGHRETVVPSWHTQITLLHSAGGICP
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCE
VLDFNVPLVTRERKTRLLAPPSSFPEWAALHFWAPERSGDKGVLRDIMDVGSAVLRAPLK
EEECCCCEEECCCCCEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
AIDSRRNGRAAAHAQSALA
HHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MRHVSTKLLHVFVLVMEYRDLSAVAACTQGRVPTVAYSLARLREITGDPLFVKRNGMLEP
CCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCC
TPHALRLEQTARQILAKWNQLVRPGEPGLSKRRDDGRRVSIGFSSSIGDPVITEILTALC
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHH
EQFPRDSFITRPVIADATLAGHLGSGELDCAFIVDSGHDPERVRQHNIMATPRRLVSATR
HHCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHCCCCCCHHHHHHHHC
GGSHDEGESDWILLQEDCEAGSPLRAFLSRQASTPGHRETVVPSWHTQITLLHSAGGICP
CCCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCE
VLDFNVPLVTRERKTRLLAPPSSFPEWAALHFWAPERSGDKGVLRDIMDVGSAVLRAPLK
EEECCCCEEECCCCCEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
AIDSRRNGRAAAHAQSALA
HHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8366033; 10913109; 11823852 [H]