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The map label for this gene is livH [H]

Identifier: 116695973

GI number: 116695973

Start: 2290097

End: 2290960

Strand: Direct

Name: livH [H]

Synonym: H16_B2037

Alternate gene names: 116695973

Gene position: 2290097-2290960 (Clockwise)

Preceding gene: 116695972

Following gene: 116695974

Centisome position: 78.63

GC content: 65.39

Gene sequence:

>864_bases
GTGGCATTGTTCCTTCAACAGTTCCTGAACGGCCTGACGCTGGGAGGCGTCTACAGCCTGGTGGCGCTTGGCCTGACGCT
GGTCTACGGCATCCTGCACGTGCCCAACTTCGCGCATGGCGCCTTCTACATGGCTGGCGCCTATGTGTCGTACTTCCTGA
TGACATCGCTGGGCGTGAACTACTGGCTGGCGATGCTTGGCGCGGCGCTGGTGGTGGCCGTATTGTCGATGGCTGCCGAC
CGGCTGGTGTTCCACCCGCTGCGCAACTCGCCCGAGCTGCACGACATGATCGCAGCGATCGGCATCCTGCTGTTCCTGGA
AGCCGGGGCGCAGGCGCTGTGGGGCGCGGACTTCCACCGCATGCCCACGCCCTATGGCCAGATCGTCGACGTGTTCGGGC
TGACCGCGCCGCTGCAGCGCCTGCTGATCATCGGCGCCGCCTTTGCGCTGATGGTGCTGCTGCACCTGTTCCTGACGCGC
ACCATGACCGGCGCCACCATCATGGCCATGGCGCAGAACCGCGAAGGCGCCGCACTGGTCGGCATCGACGCCACCCGCGT
GACGCTGCTGGTGTTTGCCATCTCCGGCGCGCTTGCCGCAATCGCCGCCACGCTCTACGCCCCGATCAACCTGGTCTACC
CCAGCATGGGCAACCTGGTGATCACCAAGGCCTTCGTCATCATCATCCTGGGCGGCATGGGCAGCATCCCCGGGGCCATC
GTCGGCGGGCTGATCATCGGCATGGCCGAGAGCTTCGGCGGCTTCTACGTTTCCACCGACTACAAGGACATCATCGCCTT
CGTGCTGCTGGTGGTGATCCTGTCGATCCGGCCGCAGGGCCTGTTTGCCGGCAAGACGGCCTGA

Upstream 100 bases:

>100_bases
CCGACTTCCTGACCGTGGCCGCGCCTGGCGCCGCCGCGACGGAACACGCACGGCCTTTGCCGCTGCGTGCCTGGTTTCCC
GAACCGCACGAGGTACCCCT

Downstream 100 bases:

>100_bases
GGAGCACAACACAATGAAAGCACTGCAAGGAAAAACCGGCTGGACGCTGCTGCTTGCGGCGGCCATCGCCTTCCCGCTGA
TCACGCCCAACAGCTACTAC

Product: ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MALFLQQFLNGLTLGGVYSLVALGLTLVYGILHVPNFAHGAFYMAGAYVSYFLMTSLGVNYWLAMLGAALVVAVLSMAAD
RLVFHPLRNSPELHDMIAAIGILLFLEAGAQALWGADFHRMPTPYGQIVDVFGLTAPLQRLLIIGAAFALMVLLHLFLTR
TMTGATIMAMAQNREGAALVGIDATRVTLLVFAISGALAAIAATLYAPINLVYPSMGNLVITKAFVIIILGGMGSIPGAI
VGGLIIGMAESFGGFYVSTDYKDIIAFVLLVVILSIRPQGLFAGKTA

Sequences:

>Translated_287_residues
MALFLQQFLNGLTLGGVYSLVALGLTLVYGILHVPNFAHGAFYMAGAYVSYFLMTSLGVNYWLAMLGAALVVAVLSMAAD
RLVFHPLRNSPELHDMIAAIGILLFLEAGAQALWGADFHRMPTPYGQIVDVFGLTAPLQRLLIIGAAFALMVLLHLFLTR
TMTGATIMAMAQNREGAALVGIDATRVTLLVFAISGALAAIAATLYAPINLVYPSMGNLVITKAFVIIILGGMGSIPGAI
VGGLIIGMAESFGGFYVSTDYKDIIAFVLLVVILSIRPQGLFAGKTA
>Mature_286_residues
ALFLQQFLNGLTLGGVYSLVALGLTLVYGILHVPNFAHGAFYMAGAYVSYFLMTSLGVNYWLAMLGAALVVAVLSMAADR
LVFHPLRNSPELHDMIAAIGILLFLEAGAQALWGADFHRMPTPYGQIVDVFGLTAPLQRLLIIGAAFALMVLLHLFLTRT
MTGATIMAMAQNREGAALVGIDATRVTLLVFAISGALAAIAATLYAPINLVYPSMGNLVITKAFVIIILGGMGSIPGAIV
GGLIIGMAESFGGFYVSTDYKDIIAFVLLVVILSIRPQGLFAGKTA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=295, Percent_Identity=37.6271186440678, Blast_Score=168, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30315; Mature: 30184

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALFLQQFLNGLTLGGVYSLVALGLTLVYGILHVPNFAHGAFYMAGAYVSYFLMTSLGVN
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
YWLAMLGAALVVAVLSMAADRLVFHPLRNSPELHDMIAAIGILLFLEAGAQALWGADFHR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCHHC
MPTPYGQIVDVFGLTAPLQRLLIIGAAFALMVLLHLFLTRTMTGATIMAMAQNREGAALV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEE
GIDATRVTLLVFAISGALAAIAATLYAPINLVYPSMGNLVITKAFVIIILGGMGSIPGAI
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHH
VGGLIIGMAESFGGFYVSTDYKDIIAFVLLVVILSIRPQGLFAGKTA
HHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ALFLQQFLNGLTLGGVYSLVALGLTLVYGILHVPNFAHGAFYMAGAYVSYFLMTSLGVN
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
YWLAMLGAALVVAVLSMAADRLVFHPLRNSPELHDMIAAIGILLFLEAGAQALWGADFHR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCHHC
MPTPYGQIVDVFGLTAPLQRLLIIGAAFALMVLLHLFLTRTMTGATIMAMAQNREGAALV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEE
GIDATRVTLLVFAISGALAAIAATLYAPINLVYPSMGNLVITKAFVIIILGGMGSIPGAI
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHH
VGGLIIGMAESFGGFYVSTDYKDIIAFVLLVVILSIRPQGLFAGKTA
HHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]