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The map label for this gene is boxD [H]

Identifier: 116695853

GI number: 116695853

Start: 2165721

End: 2167268

Strand: Direct

Name: boxD [H]

Synonym: H16_B1917

Alternate gene names: 116695853

Gene position: 2165721-2167268 (Clockwise)

Preceding gene: 116695852

Following gene: 116695854

Centisome position: 74.36

GC content: 69.19

Gene sequence:

>1548_bases
ATGACTGAATTGCTATCCAACTATCTCGGCGGCAAGTGGCAGGCCGGCAGCGGTGCCGGCACGCCCTTGTTCGATCCGGT
GCTGGGCGACGAACTGGTGCGCGTTGACGCCACCGGGCTGGACCTCGCTGCCGGCTTCGCCTTTGCCCGCGAACAGGGCG
GCGCGGCCCTGCGCGCGCTGACCTATCGCCAGCGTGCCGCGTTGCTGGCTGACATCGTCAAGGTGCTGCAGGCCAATCGC
GATGCCTATTACGACATCGCCACGGCCAACAGCGGCACCGTCAGGAACGACTCCGCGGTCGACATCGACGGCGGCATCTT
CACGCTGGGCACCTACGCCAGGCTGGGCGATACGCTCGGCGACCGGCACTACCTGCCGGATGGCGAGGCCGTGCGGCTGG
GCAAGGACCCGTTGTTCCAGTCGCAGCACGTGCTGGTACCGACGCGCGGCGTGGCGCTGTTTATCAATGCCTTCAACTTC
CCGAGCTGGGGATTGTGGGAGAAGGCGGCGCCGGCATTGCTGGCCGGCGTGCCGGTGATCGTCAAACCCGCTACCGCCAC
CGCCTGGCTGACCCAGCGCATGGTGCGCGACGTGGTCGAGGCCGGGGCGCTGCCGGCCGGCGCGTTGTCGGTGGTGTGCG
GCAGCTCGGCCGGCCTGCTGGACCAGTTGCAGCCCTTTGACGTGGTGTCGTTCACCGGTTCGGCCGATACGGCCGCGGTG
ATCCGCTCGCATCCCGCCATCGCGCAACGCTCTGTTCGCGTGAATATCGAAGCGGACAGCATCAATTCCGCCGTGCTGCT
GCCGCAGGACGGCCCCGATACCGCCGCCTTCGACCTGCTGGCGAAGGAAGTCGTGCGCGAGATGACGGTCAAGTCCGGCC
AGAAATGCACCGCGATCCGGCGCGTGTTCGTGCCTGAAGCGCTGTATGGCCTGGCCGCCGAGGCGATCGGCGCACGGCTG
TCGAAAGTGACCGTGGGCAACCCGCGCAACGATACGGTGCGCATGGGTGCGCTGGTCAGCCGTGCGCAGTTCAACGCCGT
GCAAGACGGGCTGGCAACCCTGCGCAAGCACGCACAGGTGCTGCATGACGGCACGCAGCAGGCGCTGGTCGATGCCGATC
CGGCCGTGGCCTGCTGCATCGGCCCGACGCTGCTGGGCGTGGCCGATGCGGACGCCGCCGCCGCGGTGCACGACACCGAA
GTGTTCGGCCCGGTGGCCACGCTGCTGCCCTATCGGGATACCGCCCACGCACTGGCACTCGTGCGCCGTGGACAGGGCTC
GCTGGTGGCATCGCTCTATGGCAGCGACGCGGCCGCGCTCGGTGCGGCCGCCGTCGAGCTGGCCGACAGCCATGGCCGCG
TGCATGTGATCTCGCCCGACGTGGCGCAGCTGCACACCGGCCACGGCAACGTCATGCCGCAATCGCTGCATGGCGGCCCC
GGCCGCGCCGGCGGCGGCGAGGAACTGGGCGGACTGCGCGCCCTGCACTTCTATCACCGGCGCAGCGCCATTCAGGCCAG
TACCGCGGTGCTCGACGAACTCGCCTGA

Upstream 100 bases:

>100_bases
CGCCGGGCAGCGCCCACCGCCCCACCGTCAGCAACGGCCGCGCGCTGGTGCTCTACCTGCTGCCGGAAGGCCGCATCGAC
TTCACGCGCTGAGATTCCCG

Downstream 100 bases:

>100_bases
CCGTTCAAGCCAACCCGCTTCACCGCGCCGCCACGTCCGCATGGCGGCGCGCGGCACACCGTACACCAGCAACGGGGAGA
CACCCATGACCGCCACACCC

Product: aldehyde dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MTELLSNYLGGKWQAGSGAGTPLFDPVLGDELVRVDATGLDLAAGFAFAREQGGAALRALTYRQRAALLADIVKVLQANR
DAYYDIATANSGTVRNDSAVDIDGGIFTLGTYARLGDTLGDRHYLPDGEAVRLGKDPLFQSQHVLVPTRGVALFINAFNF
PSWGLWEKAAPALLAGVPVIVKPATATAWLTQRMVRDVVEAGALPAGALSVVCGSSAGLLDQLQPFDVVSFTGSADTAAV
IRSHPAIAQRSVRVNIEADSINSAVLLPQDGPDTAAFDLLAKEVVREMTVKSGQKCTAIRRVFVPEALYGLAAEAIGARL
SKVTVGNPRNDTVRMGALVSRAQFNAVQDGLATLRKHAQVLHDGTQQALVDADPAVACCIGPTLLGVADADAAAAVHDTE
VFGPVATLLPYRDTAHALALVRRGQGSLVASLYGSDAAALGAAAVELADSHGRVHVISPDVAQLHTGHGNVMPQSLHGGP
GRAGGGEELGGLRALHFYHRRSAIQASTAVLDELA

Sequences:

>Translated_515_residues
MTELLSNYLGGKWQAGSGAGTPLFDPVLGDELVRVDATGLDLAAGFAFAREQGGAALRALTYRQRAALLADIVKVLQANR
DAYYDIATANSGTVRNDSAVDIDGGIFTLGTYARLGDTLGDRHYLPDGEAVRLGKDPLFQSQHVLVPTRGVALFINAFNF
PSWGLWEKAAPALLAGVPVIVKPATATAWLTQRMVRDVVEAGALPAGALSVVCGSSAGLLDQLQPFDVVSFTGSADTAAV
IRSHPAIAQRSVRVNIEADSINSAVLLPQDGPDTAAFDLLAKEVVREMTVKSGQKCTAIRRVFVPEALYGLAAEAIGARL
SKVTVGNPRNDTVRMGALVSRAQFNAVQDGLATLRKHAQVLHDGTQQALVDADPAVACCIGPTLLGVADADAAAAVHDTE
VFGPVATLLPYRDTAHALALVRRGQGSLVASLYGSDAAALGAAAVELADSHGRVHVISPDVAQLHTGHGNVMPQSLHGGP
GRAGGGEELGGLRALHFYHRRSAIQASTAVLDELA
>Mature_514_residues
TELLSNYLGGKWQAGSGAGTPLFDPVLGDELVRVDATGLDLAAGFAFAREQGGAALRALTYRQRAALLADIVKVLQANRD
AYYDIATANSGTVRNDSAVDIDGGIFTLGTYARLGDTLGDRHYLPDGEAVRLGKDPLFQSQHVLVPTRGVALFINAFNFP
SWGLWEKAAPALLAGVPVIVKPATATAWLTQRMVRDVVEAGALPAGALSVVCGSSAGLLDQLQPFDVVSFTGSADTAAVI
RSHPAIAQRSVRVNIEADSINSAVLLPQDGPDTAAFDLLAKEVVREMTVKSGQKCTAIRRVFVPEALYGLAAEAIGARLS
KVTVGNPRNDTVRMGALVSRAQFNAVQDGLATLRKHAQVLHDGTQQALVDADPAVACCIGPTLLGVADADAAAAVHDTEV
FGPVATLLPYRDTAHALALVRRGQGSLVASLYGSDAAALGAAAVELADSHGRVHVISPDVAQLHTGHGNVMPQSLHGGPG
RAGGGEELGGLRALHFYHRRSAIQASTAVLDELA

Specific function: Catalyzes the NADP-dependent oxidation of 3,4- dehydroadipyl-CoA semialdehyde to form cis-3,4-dehydroadipyl-CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361176, Length=517, Percent_Identity=23.21083172147, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI12007648, Length=460, Percent_Identity=22.8260869565217, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI25777724, Length=500, Percent_Identity=24.2, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI153266822, Length=496, Percent_Identity=23.5887096774194, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI25777732, Length=505, Percent_Identity=25.7425742574257, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI115387104, Length=519, Percent_Identity=24.0847784200385, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI25777730, Length=497, Percent_Identity=23.7424547283702, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI25777728, Length=439, Percent_Identity=24.1457858769932, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4507229, Length=456, Percent_Identity=24.3421052631579, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI25777721, Length=468, Percent_Identity=23.5042735042735, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787653, Length=508, Percent_Identity=46.0629921259843, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1789015, Length=436, Percent_Identity=25.9174311926606, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1787715, Length=501, Percent_Identity=24.5508982035928, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87082295, Length=450, Percent_Identity=26.2222222222222, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1786504, Length=524, Percent_Identity=25.1908396946565, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1787684, Length=356, Percent_Identity=25.561797752809, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787558, Length=439, Percent_Identity=25.2847380410023, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081896, Length=488, Percent_Identity=25.4098360655738, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788042, Length=429, Percent_Identity=25.4079254079254, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081926, Length=428, Percent_Identity=23.1308411214953, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551164, Length=511, Percent_Identity=25.6360078277886, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17534447, Length=363, Percent_Identity=26.4462809917355, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI115532534, Length=363, Percent_Identity=26.4462809917355, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25143876, Length=361, Percent_Identity=24.3767313019391, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25143874, Length=361, Percent_Identity=24.3767313019391, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32564151, Length=293, Percent_Identity=27.9863481228669, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562198, Length=505, Percent_Identity=22.7722772277228, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324950, Length=456, Percent_Identity=23.4649122807018, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320917, Length=434, Percent_Identity=23.2718894009217, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6319478, Length=449, Percent_Identity=20.7126948775056, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325196, Length=374, Percent_Identity=23.2620320855615, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323822, Length=383, Percent_Identity=22.7154046997389, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323821, Length=382, Percent_Identity=22.2513089005236, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281362580, Length=389, Percent_Identity=25.4498714652956, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI62472918, Length=389, Percent_Identity=25.4498714652956, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI62472926, Length=389, Percent_Identity=25.4498714652956, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI62472936, Length=389, Percent_Identity=25.4498714652956, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356737, Length=389, Percent_Identity=25.4498714652956, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24650465, Length=488, Percent_Identity=25.6147540983607, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI20129399, Length=442, Percent_Identity=24.6606334841629, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.77 [H]

Molecular weight: Translated: 53621; Mature: 53490

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELLSNYLGGKWQAGSGAGTPLFDPVLGDELVRVDATGLDLAAGFAFAREQGGAALRAL
CHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHH
TYRQRAALLADIVKVLQANRDAYYDIATANSGTVRNDSAVDIDGGIFTLGTYARLGDTLG
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCEEEEHHHHHHHHHCC
DRHYLPDGEAVRLGKDPLFQSQHVLVPTRGVALFINAFNFPSWGLWEKAAPALLAGVPVI
CCCCCCCCCEEEECCCCCCCCCEEEEECCCEEEEEEECCCCCCCCHHHHCCHHHCCCCEE
VKPATATAWLTQRMVRDVVEAGALPAGALSVVCGSSAGLLDQLQPFDVVSFTGSADTAAV
EECCHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCHHHCCCCCCEEEECCCCCHHHH
IRSHPAIAQRSVRVNIEADSINSAVLLPQDGPDTAAFDLLAKEVVREMTVKSGQKCTAIR
HHCCCCHHCCEEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
RVFVPEALYGLAAEAIGARLSKVTVGNPRNDTVRMGALVSRAQFNAVQDGLATLRKHAQV
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHDGTQQALVDADPAVACCIGPTLLGVADADAAAAVHDTEVFGPVATLLPYRDTAHALAL
HHCCCHHHHHCCCCCEEEECCCHHHEECCCCCHHHCCCHHHHHHHHHHCCCCCHHHHHHH
VRRGQGSLVASLYGSDAAALGAAAVELADSHGRVHVISPDVAQLHTGHGNVMPQSLHGGP
HHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCCCCCCCCC
GRAGGGEELGGLRALHFYHRRSAIQASTAVLDELA
CCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TELLSNYLGGKWQAGSGAGTPLFDPVLGDELVRVDATGLDLAAGFAFAREQGGAALRAL
HHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHH
TYRQRAALLADIVKVLQANRDAYYDIATANSGTVRNDSAVDIDGGIFTLGTYARLGDTLG
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCEEEEHHHHHHHHHCC
DRHYLPDGEAVRLGKDPLFQSQHVLVPTRGVALFINAFNFPSWGLWEKAAPALLAGVPVI
CCCCCCCCCEEEECCCCCCCCCEEEEECCCEEEEEEECCCCCCCCHHHHCCHHHCCCCEE
VKPATATAWLTQRMVRDVVEAGALPAGALSVVCGSSAGLLDQLQPFDVVSFTGSADTAAV
EECCHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCCCHHHCCCCCCEEEECCCCCHHHH
IRSHPAIAQRSVRVNIEADSINSAVLLPQDGPDTAAFDLLAKEVVREMTVKSGQKCTAIR
HHCCCCHHCCEEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
RVFVPEALYGLAAEAIGARLSKVTVGNPRNDTVRMGALVSRAQFNAVQDGLATLRKHAQV
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHDGTQQALVDADPAVACCIGPTLLGVADADAAAAVHDTEVFGPVATLLPYRDTAHALAL
HHCCCHHHHHCCCCCEEEECCCHHHEECCCCCHHHCCCHHHHHHHHHHCCCCCHHHHHHH
VRRGQGSLVASLYGSDAAALGAAAVELADSHGRVHVISPDVAQLHTGHGNVMPQSLHGGP
HHCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCCCCCCCCC
GRAGGGEELGGLRALHFYHRRSAIQASTAVLDELA
CCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12399500 [H]