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The map label for this gene is dapA4 [H]

Identifier: 116695767

GI number: 116695767

Start: 2070235

End: 2071149

Strand: Direct

Name: dapA4 [H]

Synonym: H16_B1831

Alternate gene names: 116695767

Gene position: 2070235-2071149 (Clockwise)

Preceding gene: 116695766

Following gene: 116695768

Centisome position: 71.08

GC content: 67.76

Gene sequence:

>915_bases
ATGAACAACAAGCTTACCGCCGCCGACCTGCGCGGCATCTTCCCCGCCATCCCGACGCCCGTGACGGCCGACGACAGGAT
CGACCAGGACGCCACGCGCAAGCTGATGGCCTACCTGCTGGCCAACGGCGTTGCCGGCGTGGTGCCGCTGGGCGGCACCG
GCGAATACGGTGCCCTGTCGCGCGAGGAGCGCGTCCGCATGGCAGCCCTTTGTGTCGAAGCAGCGGCTGGCCAGGTTCCC
GTCATTCCCGGCGTGCTCGACCCGGGGTTCCACGATGCGCTGGATGCGGGCAAGGCCTTTGCCGGCGTCGGCGCCTCTGC
CCTGATGGTGCTGACGCCCTATTACACCTCGCCGACCCAGCAAGGCATCCGCGACTACTTCCTGCGCTATGCCGACGCCT
CGCCGGTGCCGGTCATGATCTACGAGATCCCCTACCGCACGCGGATCGCGATCGCGCCCGAGGTGCTGCACGAGCTGTCG
CGCCACGAAAACATCATCGGCATGAAAGCCTGCAACACCGACATGTACCACTTCCTCAAGGTGGTGGCGGGTGTCGACGA
CAGCTTCAGCGTGTTCAGCGGCGAGGACAGCCTGTTCCCGCTGCACATGGCGGCGGGTGCCAGGGGTGGCGTGGTCGTGA
CCGCCTCCGTGCTGCCGCGCACCTGGCGCACCATCTATGAGCTCGGCGTGGCCGGCAATACCGCGCAAGCGGTACGCCTG
CACCGCCAGCTGATTCCGTTGCTGGACCTGGCCTTCTCCGAAACCAATCCTGGGCCGCTGAAATCCGTGCTCGACCTGGT
GGGCGTGACCGCGCCTAAGGTGCTGGCACCGCTGGTAGCGCCGGCACCCGGGCTGCAGGCACAGCTGCGTGCCGAACTGA
CGCAGCGGCTGCAAGCCGAGGCCGCCCTCGCCTGA

Upstream 100 bases:

>100_bases
TTGCCGCGGTGTCTACCTGCCTGTTCGTCTTCGTTACCCTCCTGATCACCTGCGCCGAGCGCTTGCGCCGCAAGAGCGCC
GGGCGCTGAGAACCTTATCC

Downstream 100 bases:

>100_bases
GGCGCCGACGATCATGCTGCCGGCCATCAAGGACTATCGGGACCTGGCGCGGCGCCGGCTGTCGCGCTTCGCCTTCGACT
ATCTGGAGGGAGGCGCGGAG

Product: dihydrodipicolinate synthase (DapA)

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNNKLTAADLRGIFPAIPTPVTADDRIDQDATRKLMAYLLANGVAGVVPLGGTGEYGALSREERVRMAALCVEAAAGQVP
VIPGVLDPGFHDALDAGKAFAGVGASALMVLTPYYTSPTQQGIRDYFLRYADASPVPVMIYEIPYRTRIAIAPEVLHELS
RHENIIGMKACNTDMYHFLKVVAGVDDSFSVFSGEDSLFPLHMAAGARGGVVVTASVLPRTWRTIYELGVAGNTAQAVRL
HRQLIPLLDLAFSETNPGPLKSVLDLVGVTAPKVLAPLVAPAPGLQAQLRAELTQRLQAEAALA

Sequences:

>Translated_304_residues
MNNKLTAADLRGIFPAIPTPVTADDRIDQDATRKLMAYLLANGVAGVVPLGGTGEYGALSREERVRMAALCVEAAAGQVP
VIPGVLDPGFHDALDAGKAFAGVGASALMVLTPYYTSPTQQGIRDYFLRYADASPVPVMIYEIPYRTRIAIAPEVLHELS
RHENIIGMKACNTDMYHFLKVVAGVDDSFSVFSGEDSLFPLHMAAGARGGVVVTASVLPRTWRTIYELGVAGNTAQAVRL
HRQLIPLLDLAFSETNPGPLKSVLDLVGVTAPKVLAPLVAPAPGLQAQLRAELTQRLQAEAALA
>Mature_304_residues
MNNKLTAADLRGIFPAIPTPVTADDRIDQDATRKLMAYLLANGVAGVVPLGGTGEYGALSREERVRMAALCVEAAAGQVP
VIPGVLDPGFHDALDAGKAFAGVGASALMVLTPYYTSPTQQGIRDYFLRYADASPVPVMIYEIPYRTRIAIAPEVLHELS
RHENIIGMKACNTDMYHFLKVVAGVDDSFSVFSGEDSLFPLHMAAGARGGVVVTASVLPRTWRTIYELGVAGNTAQAVRL
HRQLIPLLDLAFSETNPGPLKSVLDLVGVTAPKVLAPLVAPAPGLQAQLRAELTQRLQAEAALA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=28.2758620689655, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788823, Length=264, Percent_Identity=29.5454545454545, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI87082415, Length=242, Percent_Identity=28.9256198347107, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=26.9387755102041, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789620, Length=266, Percent_Identity=22.9323308270677, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32309; Mature: 32309

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKLTAADLRGIFPAIPTPVTADDRIDQDATRKLMAYLLANGVAGVVPLGGTGEYGALS
CCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
REERVRMAALCVEAAAGQVPVIPGVLDPGFHDALDAGKAFAGVGASALMVLTPYYTSPTQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCHHHHCCCCCEEEEEECCCCCCHH
QGIRDYFLRYADASPVPVMIYEIPYRTRIAIAPEVLHELSRHENIIGMKACNTDMYHFLK
HHHHHHHHHHCCCCCCCEEEEECCCCEEEEECHHHHHHHHHCCCEEEEECCCHHHHHHHH
VVAGVDDSFSVFSGEDSLFPLHMAAGARGGVVVTASVLPRTWRTIYELGVAGNTAQAVRL
HHHCCCCCCEEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHH
HRQLIPLLDLAFSETNPGPLKSVLDLVGVTAPKVLAPLVAPAPGLQAQLRAELTQRLQAE
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AALA
HCCC
>Mature Secondary Structure
MNNKLTAADLRGIFPAIPTPVTADDRIDQDATRKLMAYLLANGVAGVVPLGGTGEYGALS
CCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
REERVRMAALCVEAAAGQVPVIPGVLDPGFHDALDAGKAFAGVGASALMVLTPYYTSPTQ
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCHHHHCCCCCEEEEEECCCCCCHH
QGIRDYFLRYADASPVPVMIYEIPYRTRIAIAPEVLHELSRHENIIGMKACNTDMYHFLK
HHHHHHHHHHCCCCCCCEEEEECCCCEEEEECHHHHHHHHHCCCEEEEECCCHHHHHHHH
VVAGVDDSFSVFSGEDSLFPLHMAAGARGGVVVTASVLPRTWRTIYELGVAGNTAQAVRL
HHHCCCCCCEEECCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHH
HRQLIPLLDLAFSETNPGPLKSVLDLVGVTAPKVLAPLVAPAPGLQAQLRAELTQRLQAE
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
AALA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA