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The map label for this gene is fabR [H]

Identifier: 116694955

GI number: 116694955

Start: 1136983

End: 1137630

Strand: Direct

Name: fabR [H]

Synonym: H16_B1010

Alternate gene names: 116694955

Gene position: 1136983-1137630 (Clockwise)

Preceding gene: 116694953

Following gene: 116694957

Centisome position: 39.04

GC content: 66.67

Gene sequence:

>648_bases
ATGGAAGCCATTGCCGACGGCAAACGCCGCCTGATCGACGCCGCGTTGCGGCTGGCCGCAGCCAAGCGCAGCTTTGCGGC
ACTCAAGCTGCGCGAGATCGCGCGCGAGGCCGGCCTGAACCCCAACACGTTCTACCGGCATTTCAGCGACATGGAAGACC
TGGCCATCACCGCCATGGCCGAGGTAAGCGCCGAACTGCGGCCGATGCTGCGCGCGGTCCGATGGGCCGCTGCCCGCGAC
AACCCGGGTGAAGTGGCCACGCGTGCGTGCGAAGCGCTGTTCCTGTACGCGCAGCATCACCCGGATGCATTCATCGTTGG
TGTGTGCGGGATCACGGGCCCGCAGCCCGCGCTTCGCGTTGCCATTCGCACGGTGCTGGATGACATCGCCGCCGAGATGG
CGGAAGACATCGAGCGGCTGGGGCTGTGTCCCAAGCTCTCACGCCCGGTCATTGACGACGTCTGCGCGTACGTCGTTTCC
TACCTTTTCCATCAATGCGTCGACTACATCGAAGCCGATGCCGCCGGACGGCGCAGGCTGATGGCGCGCTCGGTGCAGTT
GAGTTGCTGGCTGCTGCAGGGCGCGGCAGGGCCGAATGCCCAGCCGGGAGCGAAATCAGGCAGGGAGCGCAAGGCCGTGG
CGGCGTAG

Upstream 100 bases:

>100_bases
ACGTAGACATCTGTCTACCGGCGCAAGCGTAGACAACCGTAGACATGCTGTCAACGAAGCATGTCGGGCAAAAACCGAGT
CCTGCTACTAAACCGCATTC

Downstream 100 bases:

>100_bases
CCTGTTGCGACGAAACACGCAGAAGGAAGAAACTCAGCCGAAGCAGTGGCCGAAGCGAAGGCGTGTGTCCGGGCCAGCAC
TCACCCTGAAATCGTGATGC

Product: TetR/AcrR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MEAIADGKRRLIDAALRLAAAKRSFAALKLREIAREAGLNPNTFYRHFSDMEDLAITAMAEVSAELRPMLRAVRWAAARD
NPGEVATRACEALFLYAQHHPDAFIVGVCGITGPQPALRVAIRTVLDDIAAEMAEDIERLGLCPKLSRPVIDDVCAYVVS
YLFHQCVDYIEADAAGRRRLMARSVQLSCWLLQGAAGPNAQPGAKSGRERKAVAA

Sequences:

>Translated_215_residues
MEAIADGKRRLIDAALRLAAAKRSFAALKLREIAREAGLNPNTFYRHFSDMEDLAITAMAEVSAELRPMLRAVRWAAARD
NPGEVATRACEALFLYAQHHPDAFIVGVCGITGPQPALRVAIRTVLDDIAAEMAEDIERLGLCPKLSRPVIDDVCAYVVS
YLFHQCVDYIEADAAGRRRLMARSVQLSCWLLQGAAGPNAQPGAKSGRERKAVAA
>Mature_215_residues
MEAIADGKRRLIDAALRLAAAKRSFAALKLREIAREAGLNPNTFYRHFSDMEDLAITAMAEVSAELRPMLRAVRWAAARD
NPGEVATRACEALFLYAQHHPDAFIVGVCGITGPQPALRVAIRTVLDDIAAEMAEDIERLGLCPKLSRPVIDDVCAYVVS
YLFHQCVDYIEADAAGRRRLMARSVQLSCWLLQGAAGPNAQPGAKSGRERKAVAA

Specific function: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, fabR directly influences the physical properties of the membrane bilayer [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693209, Length=178, Percent_Identity=30.8988764044944, Blast_Score=87, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23430; Mature: 23430

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAIADGKRRLIDAALRLAAAKRSFAALKLREIAREAGLNPNTFYRHFSDMEDLAITAMA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EVSAELRPMLRAVRWAAARDNPGEVATRACEALFLYAQHHPDAFIVGVCGITGPQPALRV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
AIRTVLDDIAAEMAEDIERLGLCPKLSRPVIDDVCAYVVSYLFHQCVDYIEADAAGRRRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
MARSVQLSCWLLQGAAGPNAQPGAKSGRERKAVAA
HHHHHHHHHHEEECCCCCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MEAIADGKRRLIDAALRLAAAKRSFAALKLREIAREAGLNPNTFYRHFSDMEDLAITAMA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EVSAELRPMLRAVRWAAARDNPGEVATRACEALFLYAQHHPDAFIVGVCGITGPQPALRV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
AIRTVLDDIAAEMAEDIERLGLCPKLSRPVIDDVCAYVVSYLFHQCVDYIEADAAGRRRL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
MARSVQLSCWLLQGAAGPNAQPGAKSGRERKAVAA
HHHHHHHHHHEEECCCCCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA