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The map label for this gene is gabT [H]

Identifier: 116694926

GI number: 116694926

Start: 1105569

End: 1106840

Strand: Direct

Name: gabT [H]

Synonym: H16_B0981

Alternate gene names: 116694926

Gene position: 1105569-1106840 (Clockwise)

Preceding gene: 116694922

Following gene: 116694927

Centisome position: 37.96

GC content: 67.77

Gene sequence:

>1272_bases
ATGACCATGAAAAACCTCGAACTGAACCAACGCCGTACCCTCGCGACGCCGCGCGGCGTGGGCGTGATGTGCGATTTCTA
CGCCGACCGCGCCGAGAACGCCACGCTGTGGGACGTGGAAGGCCGTGCCTACACGGACTTCGCCGCCGGCATCGCCGTGC
TCAACACGGGCCATCGCCACCCGCGCGTGATGCAGGCCATCGCCGCGCAGCTGGAGCGTTTCACGCATACCGCCTACCAG
ATCGTGCCCTACCAGGGCTATGTCACGCTGGCCGAGCGCATCAACGCGCTGGTGCCGATCCAGGGCCTGAACAAGACGGC
CCTGTTCACCACCGGCGCAGAGGCCGTGGAGAATGCCATCAAGATCGCCCGTGCGCATACCGGCCGCCCCGGCGTGATCG
CCTTCTCGGGCGCCTTCCATGGACGCACGCTGCTGGGCATGGCGCTGACCGGCAAGGTGGCGCCGTACAAGATCGGGTTT
GGCCCGTTCCCCTCCGACATCTACCACGCTCCGTTCCCCAGCGCGCTGCATGGCGTCAGCACTGAGCGGGCGCTGCAGGC
GCTTGAAGGCCTGTTCAAGACCGATATCGATCCGGCCCGCGTGGCCGCGATCATCGTTGAGCCGGTGCAGGGCGAAGGCG
GCTTCCAGGCGGCGCCGGCCGATTTCATGCGGGGGCTGCGGGCCGTATGCGATCAGCACGGCATCGTGCTGATCGCCGAT
GAAGTGCAGACCGGCTTTGGCCGTACCGGCAAGATGTTCGCGATGTCGCACCATGACGTGGAGCCGGACCTGATCACCAT
GGCCAAGAGCCTGGCCGGCGGCATGCCGCTGTCGGCGGTCAGCGGCCGGGCCGCGATCATGGATGCACCGCTGCCCGGCG
GCCTCGGCGGCACCTATGCCGGTAATCCGCTGGCGGTGGCGGCGGCGCACGCGGTCATCGACGTCATCGAGGAAGAAAAG
CTGTGCGAGCGCTCTGCCAGCCTGGGCCAGCAGTTGCGCGAGCACCTGCTGGCGCAGCGCAAGCACTGCCCCGCAATGGC
CGAGGTGCGCGGGCTGGGTTCGATGGTTGCCGCCGAATTCTGCGATCCCGCCACAGGCCAGCCCAGCGCCGAGCATGCCA
AGCGCGTGCAGACGCGTGCGCTGGAAGCCGGACTGGTGCTGCTGACCTGCGGCACCTACGGCAATGTCATCCGCTTCCTT
TATCCGCTCACCATCCCGCAGGCGCAGTTCGACGCGGCGCTGGCGGTGCTGACCCAGGCGCTGGCCGAATAA

Upstream 100 bases:

>100_bases
ATTATAGGGCCAAGGCCGGTTGAAATGGCTGGCATCGCTGGGCCCCTGCCAGCGGTGCCCGTTTCGCGAGTCGGCCGGTG
CCGACAGTCCTTACCGCACA

Downstream 100 bases:

>100_bases
GGGGAACACATGGAACTCCAACATACCGCGCTGTTGCGCAGCCATTGCCTGATCGACGGGGAATGGACCGGGGCGCAAAG
CGGCGCAGAGCTCGCCGTCT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MTMKNLELNQRRTLATPRGVGVMCDFYADRAENATLWDVEGRAYTDFAAGIAVLNTGHRHPRVMQAIAAQLERFTHTAYQ
IVPYQGYVTLAERINALVPIQGLNKTALFTTGAEAVENAIKIARAHTGRPGVIAFSGAFHGRTLLGMALTGKVAPYKIGF
GPFPSDIYHAPFPSALHGVSTERALQALEGLFKTDIDPARVAAIIVEPVQGEGGFQAAPADFMRGLRAVCDQHGIVLIAD
EVQTGFGRTGKMFAMSHHDVEPDLITMAKSLAGGMPLSAVSGRAAIMDAPLPGGLGGTYAGNPLAVAAAHAVIDVIEEEK
LCERSASLGQQLREHLLAQRKHCPAMAEVRGLGSMVAAEFCDPATGQPSAEHAKRVQTRALEAGLVLLTCGTYGNVIRFL
YPLTIPQAQFDAALAVLTQALAE

Sequences:

>Translated_423_residues
MTMKNLELNQRRTLATPRGVGVMCDFYADRAENATLWDVEGRAYTDFAAGIAVLNTGHRHPRVMQAIAAQLERFTHTAYQ
IVPYQGYVTLAERINALVPIQGLNKTALFTTGAEAVENAIKIARAHTGRPGVIAFSGAFHGRTLLGMALTGKVAPYKIGF
GPFPSDIYHAPFPSALHGVSTERALQALEGLFKTDIDPARVAAIIVEPVQGEGGFQAAPADFMRGLRAVCDQHGIVLIAD
EVQTGFGRTGKMFAMSHHDVEPDLITMAKSLAGGMPLSAVSGRAAIMDAPLPGGLGGTYAGNPLAVAAAHAVIDVIEEEK
LCERSASLGQQLREHLLAQRKHCPAMAEVRGLGSMVAAEFCDPATGQPSAEHAKRVQTRALEAGLVLLTCGTYGNVIRFL
YPLTIPQAQFDAALAVLTQALAE
>Mature_422_residues
TMKNLELNQRRTLATPRGVGVMCDFYADRAENATLWDVEGRAYTDFAAGIAVLNTGHRHPRVMQAIAAQLERFTHTAYQI
VPYQGYVTLAERINALVPIQGLNKTALFTTGAEAVENAIKIARAHTGRPGVIAFSGAFHGRTLLGMALTGKVAPYKIGFG
PFPSDIYHAPFPSALHGVSTERALQALEGLFKTDIDPARVAAIIVEPVQGEGGFQAAPADFMRGLRAVCDQHGIVLIADE
VQTGFGRTGKMFAMSHHDVEPDLITMAKSLAGGMPLSAVSGRAAIMDAPLPGGLGGTYAGNPLAVAAAHAVIDVIEEEKL
CERSASLGQQLREHLLAQRKHCPAMAEVRGLGSMVAAEFCDPATGQPSAEHAKRVQTRALEAGLVLLTCGTYGNVIRFLY
PLTIPQAQFDAALAVLTQALAE

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=32.9238329238329, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI13994255, Length=419, Percent_Identity=30.7875894988067, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=33.5403726708075, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=29.6912114014252, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI24119277, Length=398, Percent_Identity=27.3869346733668, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=29.9492385786802, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=28.978622327791, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI188536080, Length=459, Percent_Identity=27.8867102396514, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI38679950, Length=459, Percent_Identity=27.8867102396514, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI38679946, Length=459, Percent_Identity=27.8867102396514, Blast_Score=122, Evalue=5e-28,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=69.5961995249406, Blast_Score=603, Evalue=1e-174,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=54.047619047619, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=35.0617283950617, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1788044, Length=400, Percent_Identity=36.25, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI145693181, Length=401, Percent_Identity=35.4114713216958, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1786349, Length=342, Percent_Identity=32.4561403508772, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1786991, Length=443, Percent_Identity=28.4424379232506, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=409, Percent_Identity=32.0293398533007, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=30.2540415704388, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=29.8165137614679, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=33.2203389830508, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=426, Percent_Identity=26.9953051643192, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323470, Length=408, Percent_Identity=32.843137254902, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324432, Length=413, Percent_Identity=30.7506053268765, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324386, Length=326, Percent_Identity=24.5398773006135, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=437, Percent_Identity=25.1716247139588, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=31.9410319410319, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI28574759, Length=415, Percent_Identity=31.3253012048193, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161085790, Length=413, Percent_Identity=30.7506053268765, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=29.9760191846523, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI281366494, Length=399, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24667139, Length=399, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24667143, Length=399, Percent_Identity=28.5714285714286, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 44986; Mature: 44855

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKNLELNQRRTLATPRGVGVMCDFYADRAENATLWDVEGRAYTDFAAGIAVLNTGHRH
CCCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCEEEECCCCEEHHHHHHHHHCCCCCCC
PRVMQAIAAQLERFTHTAYQIVPYQGYVTLAERINALVPIQGLNKTALFTTGAEAVENAI
HHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHCCCEEECCCCCCEEEEECCHHHHHHHH
KIARAHTGRPGVIAFSGAFHGRTLLGMALTGKVAPYKIGFGPFPSDIYHAPFPSALHGVS
HHHHHCCCCCCEEEEECCCCCCCCEEHHHCCCCCCEEECCCCCCCCCCCCCCCHHHHCCC
TERALQALEGLFKTDIDPARVAAIIVEPVQGEGGFQAAPADFMRGLRAVCDQHGIVLIAD
HHHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
EVQTGFGRTGKMFAMSHHDVEPDLITMAKSLAGGMPLSAVSGRAAIMDAPLPGGLGGTYA
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHCCCCEEEEECCCCCCCCCCCC
GNPLAVAAAHAVIDVIEEEKLCERSASLGQQLREHLLAQRKHCPAMAEVRGLGSMVAAEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CDPATGQPSAEHAKRVQTRALEAGLVLLTCGTYGNVIRFLYPLTIPQAQFDAALAVLTQA
CCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LAE
HCC
>Mature Secondary Structure 
TMKNLELNQRRTLATPRGVGVMCDFYADRAENATLWDVEGRAYTDFAAGIAVLNTGHRH
CCCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCEEEECCCCEEHHHHHHHHHCCCCCCC
PRVMQAIAAQLERFTHTAYQIVPYQGYVTLAERINALVPIQGLNKTALFTTGAEAVENAI
HHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHCCCEEECCCCCCEEEEECCHHHHHHHH
KIARAHTGRPGVIAFSGAFHGRTLLGMALTGKVAPYKIGFGPFPSDIYHAPFPSALHGVS
HHHHHCCCCCCEEEEECCCCCCCCEEHHHCCCCCCEEECCCCCCCCCCCCCCCHHHHCCC
TERALQALEGLFKTDIDPARVAAIIVEPVQGEGGFQAAPADFMRGLRAVCDQHGIVLIAD
HHHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEC
EVQTGFGRTGKMFAMSHHDVEPDLITMAKSLAGGMPLSAVSGRAAIMDAPLPGGLGGTYA
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHCCCCEEEEECCCCCCCCCCCC
GNPLAVAAAHAVIDVIEEEKLCERSASLGQQLREHLLAQRKHCPAMAEVRGLGSMVAAEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CDPATGQPSAEHAKRVQTRALEAGLVLLTCGTYGNVIRFLYPLTIPQAQFDAALAVLTQA
CCCCCCCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LAE
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]