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The map label for this gene is cynR [H]

Identifier: 116694857

GI number: 116694857

Start: 1031682

End: 1032575

Strand: Direct

Name: cynR [H]

Synonym: H16_B0911

Alternate gene names: 116694857

Gene position: 1031682-1032575 (Clockwise)

Preceding gene: 116694851

Following gene: 116694862

Centisome position: 35.42

GC content: 71.03

Gene sequence:

>894_bases
ATGGAGACGCGGGATATCGAATACATCCTCGCCGTGGCGGCGCACGGCGGCATCGGCCGTGCCGCCGACGCGCTGGGAAT
CAGCCAGCCGGCGCTGACCAAGGCGGTGCAGCGGGTGGAGACCCAGGCCGGGCTGCCGCTGTTCGAGCGCACCGCCAACG
GCATGACCGCCACCTACGCCGGCACGCGCTTCCTGGAGCGGGCGCGGCGCATCCAGCTGGAATACGAGGACGGCATCAAG
GAGATGCTGGGCATCCGCACCGGCGAGCAGGGCATCCTGCGCGTGGGCTATTCGCCGTCGATCCCGGGCAACGTGATCCT
GGGCGCTTGCCGGCAACTGGTGCGCGAGCGTCCCGTGGCACGGCTGCGGCTGCGCCGCAGGCTGGCGCGCGACCTGCTGG
ACCTGCTGGCGGCGGGGGAACTGGATGTGGCGGTGGCACCGGCGCCGTTGGCAGCCTCATCGACCGGCCTGGCGGTGCAG
CCGCTCTTTGACGACCGGCTGGTGGTGGTGGCGGACGAGGGCCATGCCTTGCTGCAGCGGCGCAAGCTGCGGCTGGCGGA
CCTGGCGGACCAGGAATGGCTGCTGCCCGAAGGGCATATCACGCTGCGCCAGCAGGTGGACGCGGCGTTCCGCCAGCGCG
GCCTGCCGGAGCCGCAGCCGCGCATCGAGATCGACTTTGGCAGCAGTTCGCTGTTTGCGCTGATGCAGGGCACGCAGATG
CTGAGCATCGCCAATGAAGGCGGCGATGCCATGCAGCACGGCCTGCGCGTGCTGCCGCTGGGCGTGGAGGAGCTGGACCT
GCGCCGGAACATCGGCGTGATCTCGCGCGAGGGCGCCTACCTGTCGCCGCTGGCGCAGCGCCTGACGGTGCTGCTGAGCG
AGCACAGCCGCTGA

Upstream 100 bases:

>100_bases
GCGCTTTTACGTGTGCTCGTGCGCCGTAGTCTGTAAGATGGCTGGCATCACCACAATGAAGTATTGGCTATAAAGCCATA
ACCATCAGGAATGTGAGGCA

Downstream 100 bases:

>100_bases
GGCAGCGGCAGGGCCACGCGGTTATTGCAGCGGGATCTTGGCCACCTCCGCCAGCCGCTTCCAGCGCTGGATCTCGTCCT
TCTGGTACTGCAGCATTTCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
METRDIEYILAVAAHGGIGRAADALGISQPALTKAVQRVETQAGLPLFERTANGMTATYAGTRFLERARRIQLEYEDGIK
EMLGIRTGEQGILRVGYSPSIPGNVILGACRQLVRERPVARLRLRRRLARDLLDLLAAGELDVAVAPAPLAASSTGLAVQ
PLFDDRLVVVADEGHALLQRRKLRLADLADQEWLLPEGHITLRQQVDAAFRQRGLPEPQPRIEIDFGSSSLFALMQGTQM
LSIANEGGDAMQHGLRVLPLGVEELDLRRNIGVISREGAYLSPLAQRLTVLLSEHSR

Sequences:

>Translated_297_residues
METRDIEYILAVAAHGGIGRAADALGISQPALTKAVQRVETQAGLPLFERTANGMTATYAGTRFLERARRIQLEYEDGIK
EMLGIRTGEQGILRVGYSPSIPGNVILGACRQLVRERPVARLRLRRRLARDLLDLLAAGELDVAVAPAPLAASSTGLAVQ
PLFDDRLVVVADEGHALLQRRKLRLADLADQEWLLPEGHITLRQQVDAAFRQRGLPEPQPRIEIDFGSSSLFALMQGTQM
LSIANEGGDAMQHGLRVLPLGVEELDLRRNIGVISREGAYLSPLAQRLTVLLSEHSR
>Mature_297_residues
METRDIEYILAVAAHGGIGRAADALGISQPALTKAVQRVETQAGLPLFERTANGMTATYAGTRFLERARRIQLEYEDGIK
EMLGIRTGEQGILRVGYSPSIPGNVILGACRQLVRERPVARLRLRRRLARDLLDLLAAGELDVAVAPAPLAASSTGLAVQ
PLFDDRLVVVADEGHALLQRRKLRLADLADQEWLLPEGHITLRQQVDAAFRQRGLPEPQPRIEIDFGSSSLFALMQGTQM
LSIANEGGDAMQHGLRVLPLGVEELDLRRNIGVISREGAYLSPLAQRLTVLLSEHSR

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=263, Percent_Identity=30.7984790874525, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790399, Length=295, Percent_Identity=29.1525423728814, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789506, Length=206, Percent_Identity=25.7281553398058, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787879, Length=201, Percent_Identity=29.8507462686567, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87081904, Length=224, Percent_Identity=30.3571428571429, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787601, Length=289, Percent_Identity=23.1833910034602, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI145693105, Length=298, Percent_Identity=22.8187919463087, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787530, Length=225, Percent_Identity=24.4444444444444, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI2367136, Length=196, Percent_Identity=28.0612244897959, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788887, Length=188, Percent_Identity=29.7872340425532, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788297, Length=218, Percent_Identity=27.0642201834862, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32511; Mature: 32511

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METRDIEYILAVAAHGGIGRAADALGISQPALTKAVQRVETQAGLPLFERTANGMTATYA
CCCCHHEEEEEEHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEHHH
GTRFLERARRIQLEYEDGIKEMLGIRTGEQGILRVGYSPSIPGNVILGACRQLVRERPVA
HHHHHHHHHHEECHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHH
RLRLRRRLARDLLDLLAAGELDVAVAPAPLAASSTGLAVQPLFDDRLVVVADEGHALLQR
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHH
RKLRLADLADQEWLLPEGHITLRQQVDAAFRQRGLPEPQPRIEIDFGSSSLFALMQGTQM
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHCCCCE
LSIANEGGDAMQHGLRVLPLGVEELDLRRNIGVISREGAYLSPLAQRLTVLLSEHSR
EEEECCCCHHHHCCCEEEECCHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
METRDIEYILAVAAHGGIGRAADALGISQPALTKAVQRVETQAGLPLFERTANGMTATYA
CCCCHHEEEEEEHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEHHH
GTRFLERARRIQLEYEDGIKEMLGIRTGEQGILRVGYSPSIPGNVILGACRQLVRERPVA
HHHHHHHHHHEECHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHH
RLRLRRRLARDLLDLLAAGELDVAVAPAPLAASSTGLAVQPLFDDRLVVVADEGHALLQR
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCEEEEECCCCEEEEECCCHHHHHH
RKLRLADLADQEWLLPEGHITLRQQVDAAFRQRGLPEPQPRIEIDFGSSSLFALMQGTQM
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHCCCCE
LSIANEGGDAMQHGLRVLPLGVEELDLRRNIGVISREGAYLSPLAQRLTVLLSEHSR
EEEECCCCHHHHCCCEEEECCHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]