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The map label for this gene is hcrA [H]

Identifier: 116694694

GI number: 116694694

Start: 837755

End: 840046

Strand: Direct

Name: hcrA [H]

Synonym: H16_B0743

Alternate gene names: 116694694

Gene position: 837755-840046 (Clockwise)

Preceding gene: 116694693

Following gene: 116694695

Centisome position: 28.76

GC content: 69.42

Gene sequence:

>2292_bases
ATGAGCAAGGCCATCGTGGGAAGCTCCACGCCGCAGGTGACCGCGCGGGAAAAGGTCATGGGGCGCGCGCAGTATGCCGG
CGACATCAAGTTGCCCGGCATGCTGCATGCCAAGGTGCTGCGCAGCCCACACCCGCATGCGCGCATCGTGCGCATCGACA
CCTCCGCGGCGAAGGCGCTGCCCGGCGTCAAGCTGGTGGTGACCGGGCACGATGTGCCCGCCCGCAACTGGGGCCCGCAC
CGCAAGGAGCAGCGCATCCTGGCCTGCGGCGTGGTGCGCCACGTCGGCGAGGAAGTGGCCGCGGTGGTGGCGGTCAGCGA
GGAGATCGCGCGTGATGCGCTGGACCTGGTCCGCATCGAGTACGAGGCGCTGCCCGCGCTGCTGACGCCGGAAGCGGCGC
TGGCCGATGGCGCGCCCGAGATCCATGCCGGCACGCGCAATATCGGCCATGAGATGCACATCGTGCGGGGCGACGTGGAT
GCCGCGTTCGAAGCCTGCGCCGCAGTGTATGAGGCCACCTACGACATGCACTCGCAGTACCCGGGCTACCTTGAGCCGAT
GGCCTCGGTGGCGGCGCAGGACGGCAACGGGCGGCTCACGCTGTGGGCCTCGACCCAGTCCGTGTTCCTGGCGCGCGCGC
GGCTGGCCGAGGCGCTGGACCGGCCGGTCTCGACCATCCGCGTGGTGCAGGCGACCACCGGCGGCGGCTTCGGCGCCAAG
ATCGTCGAGGAGAACAACAGCCTGATCTGCGCCTTCCTGGCCAGCCGGCTGGAGCGCCCGGTGCGGCTGGTCAACAACCG
GCTGGAAGACTTCCAGGGCGCGCGCGCCAGCGTGCCGATGAAAGTGTGGCTGCGCATGGGGCTGTCCGCAGACGGCGTGA
TCCTGGCCAAGGATGTGCGCATCGCGGCCGAATGCGGCGCCTACTCCGGGCTTGCCGGTGATGTGATGCACGTCACCGCC
ATGCGCAGCGACAACATGCACCGCGTGCAGAACGTGCGCTCGCATGCGGTCATGGCCTATACCAACAACCCGCCGCGCGG
CGCCTTCCGCGGCTTTGGCGGGCAGCAGATGCAGTTTCCGCTGAACTGCCACCTGACCGTGCTGGCCGGCATGCTCGGCA
TGGACCCGGTGGAGGTGCACAAGCGCAATGCGATCGGCGCGGGCGAGACCAGCGTGCATGGCTGGAAGATCAGCAGCACC
GGCATGGCCGAGTGCCTGGAAATGACCCGCAAGGCCATCGGCTGGGACGAGAAGCGCGCCGCGCCGCGCGGCACCGGCAC
GCGCCGGCGCGGCGTGGGCATTGCCGCGGCCATGCACGTCAGCGGCAACCGCACGCTGGGCAACTGGGACGGCTCGACCA
TCCTGCTCAAGATCAACGAGGACGGGCGCGCGATGCTGCAGACCAGCGAGTGCGACATGGGGCAGGGCGCCAACACCATG
CTCAGCCAGATCTGCGCGCAGGAGCTCGGCATCCCGCTGTCGCACGTGACCGTGATGGCGCCGGATACCGATACCGCGCC
GTTCTGCCTGGGCTCGCTGGCGTCGCGCGTGACCATCATCGCCGGCAATGCGTTGCTGCGTGCCGCGCGCGAGGCGCGCC
AGAAACTGCTGGCACTCGCGGCGGAGAAGCTTGGCGTGGACGCGGAACAACTGGCGATTGCCGATGGCCGCATCGCCGCG
CCGGGCCAGCCCGACAAGTCCGCCACGCTGGCGGAGATCGCGCGGCTGCATATCTTCCGCCACGGCGGCGAGGGCATCCA
CGTGCGCGCCACCTATGACGCGCCCACGGTGATGCACGACGCCGACTACTACGGCAACGTCGCGCCCGCGCACTCCTTCG
CGGCACAGGCGGTGGAAGTGGAAGTCGACACCAGCACCGGCCAGGTCACCGTGATCGACAGCTTTGTCGCCGACGACTGC
GGCAAGGCCATCAACCCGCTCGCCGTGCACGGCCAGACCCACGGCGCGACCGTGCAGGCGATCGGCTGGACCCTGTACGA
GAACCTGCAATACGAGGATGGCCGCCTGATGAACGGCAACTTTGCCGACTACACCATGCCGACCGCCGACGCGGTGCCGA
TGCTGCGCACCGACGTGGTGGAATCGAACGACCCCAACGGCCCCTATGGCGCCAAGGGCGCCAGCGAAACCGCGATCCTG
CCGGGCGCGGCGGCGATCGCCAATGCCGTCTTCGACGCCGTGGGCGTGCGCATCCAGTCGCTGCCGATCACGCCGGAGAA
GGTGCTGGCGGGCCTGCGCGAACTGAAGCAGAAGGAGGCCGTCCATGCGTGA

Upstream 100 bases:

>100_bases
TACGAGCGGCTGGGCAAGGTGATCCGCGACCTCGCGATCACGGCGGAATGACGCAGGGCAGCGCATCGCGTTCATGCAAC
CAGACAAGCAGGAGGCCGGC

Downstream 100 bases:

>100_bases
CTTTGCCTTCCTTGAGCCGGCCACCGTGGCCGAGGCCAGCCAGATGCTGGCCGAGCTGGGCGACAGTTGCCGCATCCTTG
CCGGCGGCACCGCGCTGATG

Product: 4-hydroxybenzoyl-CoA reductase molybdopterin-binding subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MSKAIVGSSTPQVTAREKVMGRAQYAGDIKLPGMLHAKVLRSPHPHARIVRIDTSAAKALPGVKLVVTGHDVPARNWGPH
RKEQRILACGVVRHVGEEVAAVVAVSEEIARDALDLVRIEYEALPALLTPEAALADGAPEIHAGTRNIGHEMHIVRGDVD
AAFEACAAVYEATYDMHSQYPGYLEPMASVAAQDGNGRLTLWASTQSVFLARARLAEALDRPVSTIRVVQATTGGGFGAK
IVEENNSLICAFLASRLERPVRLVNNRLEDFQGARASVPMKVWLRMGLSADGVILAKDVRIAAECGAYSGLAGDVMHVTA
MRSDNMHRVQNVRSHAVMAYTNNPPRGAFRGFGGQQMQFPLNCHLTVLAGMLGMDPVEVHKRNAIGAGETSVHGWKISST
GMAECLEMTRKAIGWDEKRAAPRGTGTRRRGVGIAAAMHVSGNRTLGNWDGSTILLKINEDGRAMLQTSECDMGQGANTM
LSQICAQELGIPLSHVTVMAPDTDTAPFCLGSLASRVTIIAGNALLRAAREARQKLLALAAEKLGVDAEQLAIADGRIAA
PGQPDKSATLAEIARLHIFRHGGEGIHVRATYDAPTVMHDADYYGNVAPAHSFAAQAVEVEVDTSTGQVTVIDSFVADDC
GKAINPLAVHGQTHGATVQAIGWTLYENLQYEDGRLMNGNFADYTMPTADAVPMLRTDVVESNDPNGPYGAKGASETAIL
PGAAAIANAVFDAVGVRIQSLPITPEKVLAGLRELKQKEAVHA

Sequences:

>Translated_763_residues
MSKAIVGSSTPQVTAREKVMGRAQYAGDIKLPGMLHAKVLRSPHPHARIVRIDTSAAKALPGVKLVVTGHDVPARNWGPH
RKEQRILACGVVRHVGEEVAAVVAVSEEIARDALDLVRIEYEALPALLTPEAALADGAPEIHAGTRNIGHEMHIVRGDVD
AAFEACAAVYEATYDMHSQYPGYLEPMASVAAQDGNGRLTLWASTQSVFLARARLAEALDRPVSTIRVVQATTGGGFGAK
IVEENNSLICAFLASRLERPVRLVNNRLEDFQGARASVPMKVWLRMGLSADGVILAKDVRIAAECGAYSGLAGDVMHVTA
MRSDNMHRVQNVRSHAVMAYTNNPPRGAFRGFGGQQMQFPLNCHLTVLAGMLGMDPVEVHKRNAIGAGETSVHGWKISST
GMAECLEMTRKAIGWDEKRAAPRGTGTRRRGVGIAAAMHVSGNRTLGNWDGSTILLKINEDGRAMLQTSECDMGQGANTM
LSQICAQELGIPLSHVTVMAPDTDTAPFCLGSLASRVTIIAGNALLRAAREARQKLLALAAEKLGVDAEQLAIADGRIAA
PGQPDKSATLAEIARLHIFRHGGEGIHVRATYDAPTVMHDADYYGNVAPAHSFAAQAVEVEVDTSTGQVTVIDSFVADDC
GKAINPLAVHGQTHGATVQAIGWTLYENLQYEDGRLMNGNFADYTMPTADAVPMLRTDVVESNDPNGPYGAKGASETAIL
PGAAAIANAVFDAVGVRIQSLPITPEKVLAGLRELKQKEAVHA
>Mature_762_residues
SKAIVGSSTPQVTAREKVMGRAQYAGDIKLPGMLHAKVLRSPHPHARIVRIDTSAAKALPGVKLVVTGHDVPARNWGPHR
KEQRILACGVVRHVGEEVAAVVAVSEEIARDALDLVRIEYEALPALLTPEAALADGAPEIHAGTRNIGHEMHIVRGDVDA
AFEACAAVYEATYDMHSQYPGYLEPMASVAAQDGNGRLTLWASTQSVFLARARLAEALDRPVSTIRVVQATTGGGFGAKI
VEENNSLICAFLASRLERPVRLVNNRLEDFQGARASVPMKVWLRMGLSADGVILAKDVRIAAECGAYSGLAGDVMHVTAM
RSDNMHRVQNVRSHAVMAYTNNPPRGAFRGFGGQQMQFPLNCHLTVLAGMLGMDPVEVHKRNAIGAGETSVHGWKISSTG
MAECLEMTRKAIGWDEKRAAPRGTGTRRRGVGIAAAMHVSGNRTLGNWDGSTILLKINEDGRAMLQTSECDMGQGANTML
SQICAQELGIPLSHVTVMAPDTDTAPFCLGSLASRVTIIAGNALLRAAREARQKLLALAAEKLGVDAEQLAIADGRIAAP
GQPDKSATLAEIARLHIFRHGGEGIHVRATYDAPTVMHDADYYGNVAPAHSFAAQAVEVEVDTSTGQVTVIDSFVADDCG
KAINPLAVHGQTHGATVQAIGWTLYENLQYEDGRLMNGNFADYTMPTADAVPMLRTDVVESNDPNGPYGAKGASETAILP
GAAAIANAVFDAVGVRIQSLPITPEKVLAGLRELKQKEAVHA

Specific function: Catalyzes reductive dehydroxylation of 4-hydroxybenzoyl- CoA. Reaction is not reversible [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To xanthine oxidases [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=771, Percent_Identity=26.0700389105058, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI71773480, Length=775, Percent_Identity=24.7741935483871, Blast_Score=170, Evalue=4e-42,
Organism=Escherichia coli, GI1789230, Length=765, Percent_Identity=34.1176470588235, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1789246, Length=814, Percent_Identity=29.1154791154791, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1786478, Length=768, Percent_Identity=28.6458333333333, Blast_Score=201, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17540638, Length=771, Percent_Identity=23.7354085603113, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17539860, Length=738, Percent_Identity=25.0677506775068, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI32566215, Length=729, Percent_Identity=23.8683127572016, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17737937, Length=740, Percent_Identity=26.4864864864865, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24647193, Length=727, Percent_Identity=23.3837689133425, Blast_Score=113, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017607
- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.3.99.20 [H]

Molecular weight: Translated: 81200; Mature: 81068

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAIVGSSTPQVTAREKVMGRAQYAGDIKLPGMLHAKVLRSPHPHARIVRIDTSAAKAL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEEEEEECHHHHHC
PGVKLVVTGHDVPARNWGPHRKEQRILACGVVRHVGEEVAAVVAVSEEIARDALDLVRIE
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEALPALLTPEAALADGAPEIHAGTRNIGHEMHIVRGDVDAAFEACAAVYEATYDMHSQY
HHHCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
PGYLEPMASVAAQDGNGRLTLWASTQSVFLARARLAEALDRPVSTIRVVQATTGGGFGAK
CCHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEE
IVEENNSLICAFLASRLERPVRLVNNRLEDFQGARASVPMKVWLRMGLSADGVILAKDVR
EEECCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEECCE
IAAECGAYSGLAGDVMHVTAMRSDNMHRVQNVRSHAVMAYTNNPPRGAFRGFGGQQMQFP
EEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCEEEEEECCCCCCHHCCCCCCEEEEC
LNCHLTVLAGMLGMDPVEVHKRNAIGAGETSVHGWKISSTGMAECLEMTRKAIGWDEKRA
CCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHC
APRGTGTRRRGVGIAAAMHVSGNRTLGNWDGSTILLKINEDGRAMLQTSECDMGQGANTM
CCCCCCCCCCCCEEEEEEEECCCCEECCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHH
LSQICAQELGIPLSHVTVMAPDTDTAPFCLGSLASRVTIIAGNALLRAAREARQKLLALA
HHHHHHHHHCCCCHHEEEECCCCCCCHHHHHHHHHCEEEEECHHHHHHHHHHHHHHHHHH
AEKLGVDAEQLAIADGRIAAPGQPDKSATLAEIARLHIFRHGGEGIHVRATYDAPTVMHD
HHHHCCCHHHEEEECCEECCCCCCCCCHHHHHHHHHHHEEECCCEEEEEEECCCCCEEEC
ADYYGNVAPAHSFAAQAVEVEVDTSTGQVTVIDSFVADDCGKAINPLAVHGQTHGATVQA
CCCCCCCCCHHHHHCEEEEEEEECCCCEEEEEEHHHHHHHHHCCCCEEEECCCCCCEEEE
IGWTLYENLQYEDGRLMNGNFADYTMPTADAVPMLRTDVVESNDPNGPYGAKGASETAIL
EHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEC
PGAAAIANAVFDAVGVRIQSLPITPEKVLAGLRELKQKEAVHA
CCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKAIVGSSTPQVTAREKVMGRAQYAGDIKLPGMLHAKVLRSPHPHARIVRIDTSAAKAL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCEEEEEEECHHHHHC
PGVKLVVTGHDVPARNWGPHRKEQRILACGVVRHVGEEVAAVVAVSEEIARDALDLVRIE
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YEALPALLTPEAALADGAPEIHAGTRNIGHEMHIVRGDVDAAFEACAAVYEATYDMHSQY
HHHCCCCCCCCHHHCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCC
PGYLEPMASVAAQDGNGRLTLWASTQSVFLARARLAEALDRPVSTIRVVQATTGGGFGAK
CCHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEE
IVEENNSLICAFLASRLERPVRLVNNRLEDFQGARASVPMKVWLRMGLSADGVILAKDVR
EEECCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEEEEECCE
IAAECGAYSGLAGDVMHVTAMRSDNMHRVQNVRSHAVMAYTNNPPRGAFRGFGGQQMQFP
EEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCEEEEEECCCCCCHHCCCCCCEEEEC
LNCHLTVLAGMLGMDPVEVHKRNAIGAGETSVHGWKISSTGMAECLEMTRKAIGWDEKRA
CCCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHC
APRGTGTRRRGVGIAAAMHVSGNRTLGNWDGSTILLKINEDGRAMLQTSECDMGQGANTM
CCCCCCCCCCCCEEEEEEEECCCCEECCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHH
LSQICAQELGIPLSHVTVMAPDTDTAPFCLGSLASRVTIIAGNALLRAAREARQKLLALA
HHHHHHHHHCCCCHHEEEECCCCCCCHHHHHHHHHCEEEEECHHHHHHHHHHHHHHHHHH
AEKLGVDAEQLAIADGRIAAPGQPDKSATLAEIARLHIFRHGGEGIHVRATYDAPTVMHD
HHHHCCCHHHEEEECCEECCCCCCCCCHHHHHHHHHHHEEECCCEEEEEEECCCCCEEEC
ADYYGNVAPAHSFAAQAVEVEVDTSTGQVTVIDSFVADDCGKAINPLAVHGQTHGATVQA
CCCCCCCCCHHHHHCEEEEEEEECCCCEEEEEEHHHHHHHHHCCCCEEEECCCCCCEEEE
IGWTLYENLQYEDGRLMNGNFADYTMPTADAVPMLRTDVVESNDPNGPYGAKGASETAIL
EHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEC
PGAAAIANAVFDAVGVRIQSLPITPEKVLAGLRELKQKEAVHA
CCHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9490068 [H]