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The map label for this gene is fabG [C]

Identifier: 116694581

GI number: 116694581

Start: 703879

End: 704670

Strand: Direct

Name: fabG [C]

Synonym: H16_B0630

Alternate gene names: 116694581

Gene position: 703879-704670 (Clockwise)

Preceding gene: 116694580

Following gene: 116694582

Centisome position: 24.17

GC content: 68.43

Gene sequence:

>792_bases
ATGCTGTTGAAAGACAAGGTCGTCATCGTGTCGGGAATCGGTCCCGGGCTGGGCGTCAAGCTGGCCGTTGAGGCGGCGCG
CGAAGGCGCCCGCGCCGTTGCCATCGCCGCGCGCACCGCGGCGAAGCTGGACGACGCCCAAGCCCGCATCGATGCACTAG
GCGCCGACTGCGAAGTGCTCAAGGTGGTGACCGACATCACCGACCGGGCCCAGTCCCGGCACCTGGCCGGCGAGACCATG
CGCCGCTTCGGCCGCATCGATGCGCTGGTCAACAGCGCCTTCCAGCATGGCAACTTCCCCGAGCCGGTGGAAGCGGCCGA
CCTGGATGTCTGGCGCCAGGTGTTCGACACTAACGTGTTCGGCACCATGACGCTGACGCAGGAAGTGGCGGCGCTGATGA
AGCCGCAGGGCGGCGGCGCCATTGTCATGATCAACACCCAGGCCACGCGCAAGCCGATGCCCGGCGAATCCGGCTACGCG
ACGTCCAAGGGCGCGCTGGCGGTGGCGGTCAAGTACCTGGCGCGCGAACTGGGCCCGCATGGCATCCGCGCCAACAGCAT
CTTCATGGGCTGGATGTGGGGCGAGCCGGTGCAGGGCTATGTGCGCCACGCCGCGGCCGAGCAGGGCGTGAGCGAGGACA
CCGTGATCGCGCCGGTGACCGCGCAGATTGCGCTGGGCCGCATGCCGACCGACGACGACTGCGCGCGCGCTGCGCTGTTT
CTCGTGTCAGACTACGCTAGGGCCATCACCGGCGCTTCGCTCGATGCCAACGGCGGCGATTTCATGCCCTGA

Upstream 100 bases:

>100_bases
GAGCCAGGAACAACTGGAACGCGATTTCGCCGGCTACCGCGCACGGCACATCCTGAAGCAAAACTAAGACTGCGCACTGC
GCATCACAGGAGACAACACC

Downstream 100 bases:

>100_bases
GTCCTGACCACACCAATGACACGCTACTTTGCCTTCAACGGCGACGCCGACGGCCTGTGCGCCCTGCAGCAGCTGCGCCT
GGCGCAGCCCGGCGACGCCA

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORFC [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MLLKDKVVIVSGIGPGLGVKLAVEAAREGARAVAIAARTAAKLDDAQARIDALGADCEVLKVVTDITDRAQSRHLAGETM
RRFGRIDALVNSAFQHGNFPEPVEAADLDVWRQVFDTNVFGTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGESGYA
TSKGALAVAVKYLARELGPHGIRANSIFMGWMWGEPVQGYVRHAAAEQGVSEDTVIAPVTAQIALGRMPTDDDCARAALF
LVSDYARAITGASLDANGGDFMP

Sequences:

>Translated_263_residues
MLLKDKVVIVSGIGPGLGVKLAVEAAREGARAVAIAARTAAKLDDAQARIDALGADCEVLKVVTDITDRAQSRHLAGETM
RRFGRIDALVNSAFQHGNFPEPVEAADLDVWRQVFDTNVFGTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGESGYA
TSKGALAVAVKYLARELGPHGIRANSIFMGWMWGEPVQGYVRHAAAEQGVSEDTVIAPVTAQIALGRMPTDDDCARAALF
LVSDYARAITGASLDANGGDFMP
>Mature_263_residues
MLLKDKVVIVSGIGPGLGVKLAVEAAREGARAVAIAARTAAKLDDAQARIDALGADCEVLKVVTDITDRAQSRHLAGETM
RRFGRIDALVNSAFQHGNFPEPVEAADLDVWRQVFDTNVFGTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGESGYA
TSKGALAVAVKYLARELGPHGIRANSIFMGWMWGEPVQGYVRHAAAEQGVSEDTVIAPVTAQIALGRMPTDDDCARAALF
LVSDYARAITGASLDANGGDFMP

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=262, Percent_Identity=28.6259541984733, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=28.4046692607004, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI7705925, Length=269, Percent_Identity=28.6245353159851, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=27.7566539923954, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI15277342, Length=271, Percent_Identity=27.6752767527675, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI126723191, Length=187, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI59889578, Length=237, Percent_Identity=32.0675105485232, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7706318, Length=204, Percent_Identity=30.3921568627451, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=24.5210727969349, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI4503301, Length=242, Percent_Identity=28.5123966942149, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40254992, Length=256, Percent_Identity=29.6875, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=263, Percent_Identity=28.5171102661597, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1787905, Length=259, Percent_Identity=31.2741312741313, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082100, Length=264, Percent_Identity=26.8939393939394, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=27.5862068965517, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786812, Length=265, Percent_Identity=28.3018867924528, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789378, Length=195, Percent_Identity=31.2820512820513, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI87082160, Length=264, Percent_Identity=26.8939393939394, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI2367175, Length=262, Percent_Identity=29.0076335877863, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=30.7086614173228, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=263, Percent_Identity=29.277566539924, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=259, Percent_Identity=27.027027027027, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=29.5019157088123, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=185, Percent_Identity=30.8108108108108, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=260, Percent_Identity=25.7692307692308, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=27.5735294117647, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534694, Length=264, Percent_Identity=28.030303030303, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=28.3582089552239, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=27.5092936802974, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=201, Percent_Identity=28.3582089552239, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=28.1021897810219, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=193, Percent_Identity=28.4974093264249, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=263, Percent_Identity=28.1368821292776, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=192, Percent_Identity=30.2083333333333, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=276, Percent_Identity=27.8985507246377, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=188, Percent_Identity=29.2553191489362, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=27.4074074074074, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=215, Percent_Identity=29.7674418604651, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324126, Length=260, Percent_Identity=25, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=217, Percent_Identity=29.4930875576037, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=31.6602316602317, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI23397609, Length=265, Percent_Identity=31.6981132075472, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571526, Length=263, Percent_Identity=31.9391634980989, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357041, Length=260, Percent_Identity=32.3076923076923, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24644339, Length=272, Percent_Identity=27.2058823529412, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639444, Length=263, Percent_Identity=26.2357414448669, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27778; Mature: 27778

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLKDKVVIVSGIGPGLGVKLAVEAAREGARAVAIAARTAAKLDDAQARIDALGADCEVL
CCCCCCEEEEECCCCCCCHHEEHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
KVVTDITDRAQSRHLAGETMRRFGRIDALVNSAFQHGNFPEPVEAADLDVWRQVFDTNVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
GTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGESGYATSKGALAVAVKYLARELGPH
EEHHHHHHHHHHHCCCCCCEEEEEECHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
GIRANSIFMGWMWGEPVQGYVRHAAAEQGVSEDTVIAPVTAQIALGRMPTDDDCARAALF
CCEECEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCHHHHEECCCCCCHHHHHHHHH
LVSDYARAITGASLDANGGDFMP
HHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLLKDKVVIVSGIGPGLGVKLAVEAAREGARAVAIAARTAAKLDDAQARIDALGADCEVL
CCCCCCEEEEECCCCCCCHHEEHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
KVVTDITDRAQSRHLAGETMRRFGRIDALVNSAFQHGNFPEPVEAADLDVWRQVFDTNVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCC
GTMTLTQEVAALMKPQGGGAIVMINTQATRKPMPGESGYATSKGALAVAVKYLARELGPH
EEHHHHHHHHHHHCCCCCCEEEEEECHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
GIRANSIFMGWMWGEPVQGYVRHAAAEQGVSEDTVIAPVTAQIALGRMPTDDDCARAALF
CCEECEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECCHHHHEECCCCCCHHHHHHHHH
LVSDYARAITGASLDANGGDFMP
HHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8868443 [H]