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The map label for this gene is hprA [H]

Identifier: 116694562

GI number: 116694562

Start: 681945

End: 682901

Strand: Direct

Name: hprA [H]

Synonym: H16_B0611

Alternate gene names: 116694562

Gene position: 681945-682901 (Clockwise)

Preceding gene: 116694560

Following gene: 116694563

Centisome position: 23.41

GC content: 65.1

Gene sequence:

>957_bases
ATGAAGATCGTATTCCTGGACCGTTCCACCATCTCGCCGCAGGTCACGCTGCCAGCGCTGCCGTTCCCGCATGAGCTCCA
ACTCTACGGGGAAACGCCTGACGAGGACGTCGCCGCGCGCATCGCCGCCGCGGACGTGGTCATCACCAACAAGGTGAAGC
TGGATGCCCGCCAGCTTGAGCAGGCACCGAACCTGAAGCTCATCGCCATTGCGGCGACCGGCACCGATGTTGTCGACCTG
CAAGCCTGTGCCGCCCGCGGCATCGTCGTCTCCAATATCCGCAACTATGCCGTCCATACGGTGCCGGAACATACATTTGC
CCTGATCGTCGCGCTGCGGCGAAGCCTGGCCGCCTACCACGATGCGGTCCGGCGCGGCCGCTGGCAGGAATCCGGATCCT
TCTGCTTCTTCGACTACCCGATCAAGGACTTGCACGGGTCGGTGCTTGGCATCATCGGCGACGGCGTGCTCGGCCAGTCG
GTGGCCAGGATGGCGAGTGCGCTGGGCATGCAGCCGCTGTTTGCGGCCCACAAGGGACGCGAGGGCATGGGCCCGCTCTA
CACGCCTTTCGACGAGGTGCTGCGCCGTAGCGACATCATCACCTTGCATTGCCCGCTGGTGGCGCAGACACGCAACCTGA
TCGACACCGCGGAGTTCTCGAAGATGGAGCGGCGCCCGTTGCTGATCAACACCGCCCGAGGCGGGCTGGTCAATGAAGCG
GCGCTGGTGGAAGCGCTGCAATCCGGAAAGGTGGCCGGGGCCGGCTTCGACGTTGCGACGCAGGAGCCGCCCGGCGCGGA
ACACCCGTTCCATCAGTTGAAGGATGCGCCGAACTTCATCCTGACCCCGCACGTTGCATGGGCCAGCGACGAGGCCGTGC
AAGGCCTGGCCGACCAGCTTATCGACAATATCTGTGCCTTCGCGCAAGGCGCGCCCAGGAACGTGGTGGCCGCATGA

Upstream 100 bases:

>100_bases
CTGCCGCCCTTCGACCGCAGCCCGTCCCTACGCGCCAGTGTGACAAGCCGTGCCTCACATCGGCACGCTGCGGGGGGCCC
GCAACCTGGATGTCATGGCA

Downstream 100 bases:

>100_bases
CGTGCCCGCCGGACGAAGGATGGTGCCGACAATGAAAGCAGCAGGACTCAAGGTGCTGGTTGCACCTGACTCGTTCAAAG
GCAGCCTCAGCGCGACCGAG

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: GDH; Glyoxylate reductase; Hydroxypyruvate dehydrogenase; NADH-dependent hydroxypyruvate reductase; HPR; HPR-A [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKIVFLDRSTISPQVTLPALPFPHELQLYGETPDEDVAARIAAADVVITNKVKLDARQLEQAPNLKLIAIAATGTDVVDL
QACAARGIVVSNIRNYAVHTVPEHTFALIVALRRSLAAYHDAVRRGRWQESGSFCFFDYPIKDLHGSVLGIIGDGVLGQS
VARMASALGMQPLFAAHKGREGMGPLYTPFDEVLRRSDIITLHCPLVAQTRNLIDTAEFSKMERRPLLINTARGGLVNEA
ALVEALQSGKVAGAGFDVATQEPPGAEHPFHQLKDAPNFILTPHVAWASDEAVQGLADQLIDNICAFAQGAPRNVVAA

Sequences:

>Translated_318_residues
MKIVFLDRSTISPQVTLPALPFPHELQLYGETPDEDVAARIAAADVVITNKVKLDARQLEQAPNLKLIAIAATGTDVVDL
QACAARGIVVSNIRNYAVHTVPEHTFALIVALRRSLAAYHDAVRRGRWQESGSFCFFDYPIKDLHGSVLGIIGDGVLGQS
VARMASALGMQPLFAAHKGREGMGPLYTPFDEVLRRSDIITLHCPLVAQTRNLIDTAEFSKMERRPLLINTARGGLVNEA
ALVEALQSGKVAGAGFDVATQEPPGAEHPFHQLKDAPNFILTPHVAWASDEAVQGLADQLIDNICAFAQGAPRNVVAA
>Mature_318_residues
MKIVFLDRSTISPQVTLPALPFPHELQLYGETPDEDVAARIAAADVVITNKVKLDARQLEQAPNLKLIAIAATGTDVVDL
QACAARGIVVSNIRNYAVHTVPEHTFALIVALRRSLAAYHDAVRRGRWQESGSFCFFDYPIKDLHGSVLGIIGDGVLGQS
VARMASALGMQPLFAAHKGREGMGPLYTPFDEVLRRSDIITLHCPLVAQTRNLIDTAEFSKMERRPLLINTARGGLVNEA
ALVEALQSGKVAGAGFDVATQEPPGAEHPFHQLKDAPNFILTPHVAWASDEAVQGLADQLIDNICAFAQGAPRNVVAA

Specific function: Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=34.4961240310078, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=34.4961240310078, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=35.6589147286822, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=35.6589147286822, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI23308577, Length=265, Percent_Identity=30.5660377358491, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=35.5212355212355, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI6912396, Length=267, Percent_Identity=30.7116104868914, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI87082289, Length=281, Percent_Identity=31.3167259786477, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1789279, Length=285, Percent_Identity=29.8245614035088, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787645, Length=260, Percent_Identity=26.1538461538462, Blast_Score=105, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17532191, Length=279, Percent_Identity=32.258064516129, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=271, Percent_Identity=31.7343173431734, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=282, Percent_Identity=29.7872340425532, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=272, Percent_Identity=29.7794117647059, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=296, Percent_Identity=29.0540540540541, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=29.2682926829268, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=117, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24646446, Length=271, Percent_Identity=32.4723247232472, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=271, Percent_Identity=32.4723247232472, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=271, Percent_Identity=32.4723247232472, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=271, Percent_Identity=32.4723247232472, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=271, Percent_Identity=32.4723247232472, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI19921140, Length=288, Percent_Identity=29.1666666666667, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571528, Length=266, Percent_Identity=31.5789473684211, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=26.5873015873016, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574286, Length=297, Percent_Identity=26.2626262626263, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585514, Length=266, Percent_Identity=25.5639097744361, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574282, Length=266, Percent_Identity=25.5639097744361, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45552429, Length=266, Percent_Identity=25.5639097744361, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551003, Length=266, Percent_Identity=25.5639097744361, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574284, Length=266, Percent_Identity=25.5639097744361, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.29 [H]

Molecular weight: Translated: 34263; Mature: 34263

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVFLDRSTISPQVTLPALPFPHELQLYGETPDEDVAARIAAADVVITNKVKLDARQLE
CEEEEEECCCCCCCEEECCCCCCCCEEEECCCCCHHHHHHHHHHEEEEECCEECCHHHHH
QAPNLKLIAIAATGTDVVDLQACAARGIVVSNIRNYAVHTVPEHTFALIVALRRSLAAYH
CCCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHH
DAVRRGRWQESGSFCFFDYPIKDLHGSVLGIIGDGVLGQSVARMASALGMQPLFAAHKGR
HHHHHCCCCCCCCEEEEECCHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHCCC
EGMGPLYTPFDEVLRRSDIITLHCPLVAQTRNLIDTAEFSKMERRPLLINTARGGLVNEA
CCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHH
ALVEALQSGKVAGAGFDVATQEPPGAEHPFHQLKDAPNFILTPHVAWASDEAVQGLADQL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHH
IDNICAFAQGAPRNVVAA
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKIVFLDRSTISPQVTLPALPFPHELQLYGETPDEDVAARIAAADVVITNKVKLDARQLE
CEEEEEECCCCCCCEEECCCCCCCCEEEECCCCCHHHHHHHHHHEEEEECCEECCHHHHH
QAPNLKLIAIAATGTDVVDLQACAARGIVVSNIRNYAVHTVPEHTFALIVALRRSLAAYH
CCCCEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHH
DAVRRGRWQESGSFCFFDYPIKDLHGSVLGIIGDGVLGQSVARMASALGMQPLFAAHKGR
HHHHHCCCCCCCCEEEEECCHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHHHCCC
EGMGPLYTPFDEVLRRSDIITLHCPLVAQTRNLIDTAEFSKMERRPLLINTARGGLVNEA
CCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHH
ALVEALQSGKVAGAGFDVATQEPPGAEHPFHQLKDAPNFILTPHVAWASDEAVQGLADQL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHH
IDNICAFAQGAPRNVVAA
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144463; 1729225; 1657886 [H]