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The map label for this gene is cqsS [H]

Identifier: 116694537

GI number: 116694537

Start: 658837

End: 660255

Strand: Direct

Name: cqsS [H]

Synonym: H16_B0586

Alternate gene names: 116694537

Gene position: 658837-660255 (Clockwise)

Preceding gene: 116694536

Following gene: 116694539

Centisome position: 22.62

GC content: 68.43

Gene sequence:

>1419_bases
ATGTACGCAGCCTTGCCCGCCTTCGTCTCGTCGATCTTCCTCGGTTACGGCCTCTATGTGCTGGTGACCAAGGGCGTGAC
GCGCGTCTCCACTTCGTTCTTCCTGCTGTGCGTGACCACCTTCGCCTGGCAGGGCACGTGGGTGTTCCTGTTCCAGGCCT
CGCATCCCGATGTGTCGCTGATGCTGGCCCGGCTCGGCTACCTCTTCATCCTGTTCCTGCCGACCACCTTCTACCACTTC
ATCGCCGAAGTCACCGAGTGCCGCCGCGAGCGGCCGTTGCTGCTGGCCTCGTACGGCCTGAGCCTGGTGCTGGCGGTGCT
GCTGCTGACCACCGACCAGGTGGTCTCCGGCTACTACAGCTATTTCTTTGGCGACTATCCCAGGGCCGGCCCGCTGCATC
CGCTGCACCTGGTGCAGACGGTGCTGGTGGCGCTGCGCAGCGCCTGGCTGCTGGTGGCGGCGCGGCGCAATGCAACCGCC
GAACGCCGCAAGCGCTACAAGCTGTGCCTGGTGGCGGTGGCGCTCTATTCGCTGGCGGCGGTGGACTACGCCGTCAACTA
TGGCGCGGCCTTCTATCCGCCGGGCGTGGTGTTCGTGGCGGCAAGCCTGGGCATCCTGGCGGTCAGCGTGGTGCGCTACG
ACCTGATGCATCCGTATTCGCTGGCCGCCACCGTGGCGCACGAGGTGCGCACGCCGCTGGCGACCATCCGCATGCAGGCG
CAGGAGCTGGCGCGCACCTGGCCGCAGGTGCTGCATGGCTACCGGCTGGCGGTCCAGCAGGGGCTGTGCGAGGACCGCAT
GCGGCCCGGGCAGCTTGAGCGCGTGTCGAGCCTGGTCGGCGCCATCACGCGGGAAGTCGATGGCACCAGCACCGTGATCG
ACATGGCGCTGGCCTCGGTCACGCTGGAGCGGCTGGACCGCAGCAGCTTTGCCCCGCACGGCATTGCCGACTGCGTGCAT
GCGGCGCTGGAGCGCTACCCGTTCCAGGGCGAGGAGCGCGGCTGCGTGCAGGTGCGCGGCATCGACCAGGGCTGGCGCTT
TGTCGGCTCCGACACGCTGCTGGTCTACGTGCTGTTCAATCTGCTGAAGAACGCGCTGCATGCGATCCGCGCGGCCGGCG
GCGGCCGCATCGACATCACCGGCGCGACCGAGGGCCAGTACCACGTGATCCGCTTTCGCGACACCGGCCCGGGCATTGCG
GCCGACGTCATGCCGCGCATCTTCGATCCGTTCTTCTCCACCAAGGCGCATGGCACCGGTGCCGGCCTCGGCCTGGCCTT
CTGCCGGCGCGTGATCGAGACCTTCGGCGGGCGCATTGAGTGCGAGTCGGTGCCGGCCGTGCATACCACCTTTACCCTCA
GCCTGCCGCGCTTCACCGCCATGGCCGACAGCCGGCTGCGCACCAGCACCGCCGGCTGA

Upstream 100 bases:

>100_bases
AGCTCTGAATGCAACCGAATGATGCACGCGCCACCCGCGCAGGGCATAACATGTCGCGTCGCCGACCCTGCCATCCGCCC
GGCTTGCCTTCGCGCTCCGC

Downstream 100 bases:

>100_bases
GCCACGGCCGGCGGTGCCGGATTCAGACCCGCGCGGGGTCAGCCGCGCCTGGCTCAGCTGGCCAGTGCCGGCAGCGCCAG
TTCATATTCCCTGACCCGTT

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MYAALPAFVSSIFLGYGLYVLVTKGVTRVSTSFFLLCVTTFAWQGTWVFLFQASHPDVSLMLARLGYLFILFLPTTFYHF
IAEVTECRRERPLLLASYGLSLVLAVLLLTTDQVVSGYYSYFFGDYPRAGPLHPLHLVQTVLVALRSAWLLVAARRNATA
ERRKRYKLCLVAVALYSLAAVDYAVNYGAAFYPPGVVFVAASLGILAVSVVRYDLMHPYSLAATVAHEVRTPLATIRMQA
QELARTWPQVLHGYRLAVQQGLCEDRMRPGQLERVSSLVGAITREVDGTSTVIDMALASVTLERLDRSSFAPHGIADCVH
AALERYPFQGEERGCVQVRGIDQGWRFVGSDTLLVYVLFNLLKNALHAIRAAGGGRIDITGATEGQYHVIRFRDTGPGIA
ADVMPRIFDPFFSTKAHGTGAGLGLAFCRRVIETFGGRIECESVPAVHTTFTLSLPRFTAMADSRLRTSTAG

Sequences:

>Translated_472_residues
MYAALPAFVSSIFLGYGLYVLVTKGVTRVSTSFFLLCVTTFAWQGTWVFLFQASHPDVSLMLARLGYLFILFLPTTFYHF
IAEVTECRRERPLLLASYGLSLVLAVLLLTTDQVVSGYYSYFFGDYPRAGPLHPLHLVQTVLVALRSAWLLVAARRNATA
ERRKRYKLCLVAVALYSLAAVDYAVNYGAAFYPPGVVFVAASLGILAVSVVRYDLMHPYSLAATVAHEVRTPLATIRMQA
QELARTWPQVLHGYRLAVQQGLCEDRMRPGQLERVSSLVGAITREVDGTSTVIDMALASVTLERLDRSSFAPHGIADCVH
AALERYPFQGEERGCVQVRGIDQGWRFVGSDTLLVYVLFNLLKNALHAIRAAGGGRIDITGATEGQYHVIRFRDTGPGIA
ADVMPRIFDPFFSTKAHGTGAGLGLAFCRRVIETFGGRIECESVPAVHTTFTLSLPRFTAMADSRLRTSTAG
>Mature_472_residues
MYAALPAFVSSIFLGYGLYVLVTKGVTRVSTSFFLLCVTTFAWQGTWVFLFQASHPDVSLMLARLGYLFILFLPTTFYHF
IAEVTECRRERPLLLASYGLSLVLAVLLLTTDQVVSGYYSYFFGDYPRAGPLHPLHLVQTVLVALRSAWLLVAARRNATA
ERRKRYKLCLVAVALYSLAAVDYAVNYGAAFYPPGVVFVAASLGILAVSVVRYDLMHPYSLAATVAHEVRTPLATIRMQA
QELARTWPQVLHGYRLAVQQGLCEDRMRPGQLERVSSLVGAITREVDGTSTVIDMALASVTLERLDRSSFAPHGIADCVH
AALERYPFQGEERGCVQVRGIDQGWRFVGSDTLLVYVLFNLLKNALHAIRAAGGGRIDITGATEGQYHVIRFRDTGPGIA
ADVMPRIFDPFFSTKAHGTGAGLGLAFCRRVIETFGGRIECESVPAVHTTFTLSLPRFTAMADSRLRTSTAG

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=238, Percent_Identity=32.3529411764706, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=31.4285714285714, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=27.0491803278689, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790567, Length=103, Percent_Identity=38.8349514563107, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788393, Length=262, Percent_Identity=24.8091603053435, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51925; Mature: 51925

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCHHHHHHHHHHHCCCCC
>Mature Secondary Structure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CHHHHHHHHHHHHHHCCEEEECCCCCEEEEEEEECCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]