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The map label for this gene is tdcB [H]

Identifier: 116694505

GI number: 116694505

Start: 624419

End: 625384

Strand: Direct

Name: tdcB [H]

Synonym: H16_B0554

Alternate gene names: 116694505

Gene position: 624419-625384 (Clockwise)

Preceding gene: 116694503

Following gene: 116694506

Centisome position: 21.44

GC content: 69.46

Gene sequence:

>966_bases
ATGACCGCCCTGCCTATCTCCTTCGACGACGTCGCCGCCGCACACGAACGCATCCGCGCGGCGGCTCACCGCACCCCGGT
GCTGACCTCCGCCACCGCGAACGTGGCCACCGGCGCGCAGCTGTTCTTCAAGGCCGAGAACTTCCAGCGCATCGGCGCCT
TCAAGTTCCGCGGCGCCTACAACGCCATCGCCCAGTTCACGCCGCAGCAGAAGGCGGGCGGCGTGCTGGCGTTCTCTTCC
GGCAACCATGCGCAGGCGATCGCGCTGTCGGCCCGGTTGCTGGGCGTGCAGGCGGTGATCGTGATGCCGCAGGACGCCCC
CGCGATCAAGATCGAAGCCACGCGCGGCTATGGCGCCGAAGTGGTGCTGTACGACCGCTACCAGGACGATCGCGAAGCGC
TGGGCCGGCGCATCGCCGCCGAGCGCGGCATGACGCTGATCCCGCCGTATGACCATCCGCACGTGATGGCGGGGCAGGGC
ACGGCGGCCAAGGAGCTGTTCGAGGAAACCGGGCCGCTGGACATGCTGGTGGTGTGCCTCGGCGGTGGCGGGCTGCTGTC
GGGCTGCGCGGTGGCGGCCCGGGCGATGTCGCCCGGCTGTGCCGTGTACGGCGTCGAACCCGAGGCCGGCAACGATGGCC
AGCGCAGCCTGCGCAGCGGCGAGATCGTCCGCATCGACACCCCGCGCACCATTGCCGACGGCGCGCAGACGCCGTTCCTG
GGCAACCACACCTTTGCCGTGATCCGCGAGCTGGTGACGGACATCGTCACGGTGTCGGATGCGGAACTGGTCGACACCAT
GAAGTTCTTCGCCGGGCGCATGAAGATCGTGGCTGAGCCCACCGGCTGCCTGGCCGCCGCCGCGGTGCTGCACGGCAAGC
TGGATGTGAAGGGCAAGCGCGTGGGGATCATCATCTCGGGCGGTAATGTCGACCTGGGCGCCTTCGGCAGCTTCCTGCTG
GGCTGA

Upstream 100 bases:

>100_bases
GCACAGGCGGGCCGCGGCATAGCGCCACGCCGGGCCGGCCTGGCTGCAAGGTGGCCCCGGGGCGGGTAAACTGGCCGGTC
CCAGCCTCCTTGCCACCGCC

Downstream 100 bases:

>100_bases
GTCGGGCGGCAGGGAATCCTGGACTGGCCCTGGCCGTCTAACCTGCAATCCGCGACGACAAAGCCAGGGGCGGCCATGAC
GGACAAGCGCCACTATGACG

Product: serine/threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTALPISFDDVAAAHERIRAAAHRTPVLTSATANVATGAQLFFKAENFQRIGAFKFRGAYNAIAQFTPQQKAGGVLAFSS
GNHAQAIALSARLLGVQAVIVMPQDAPAIKIEATRGYGAEVVLYDRYQDDREALGRRIAAERGMTLIPPYDHPHVMAGQG
TAAKELFEETGPLDMLVVCLGGGGLLSGCAVAARAMSPGCAVYGVEPEAGNDGQRSLRSGEIVRIDTPRTIADGAQTPFL
GNHTFAVIRELVTDIVTVSDAELVDTMKFFAGRMKIVAEPTGCLAAAAVLHGKLDVKGKRVGIIISGGNVDLGAFGSFLL
G

Sequences:

>Translated_321_residues
MTALPISFDDVAAAHERIRAAAHRTPVLTSATANVATGAQLFFKAENFQRIGAFKFRGAYNAIAQFTPQQKAGGVLAFSS
GNHAQAIALSARLLGVQAVIVMPQDAPAIKIEATRGYGAEVVLYDRYQDDREALGRRIAAERGMTLIPPYDHPHVMAGQG
TAAKELFEETGPLDMLVVCLGGGGLLSGCAVAARAMSPGCAVYGVEPEAGNDGQRSLRSGEIVRIDTPRTIADGAQTPFL
GNHTFAVIRELVTDIVTVSDAELVDTMKFFAGRMKIVAEPTGCLAAAAVLHGKLDVKGKRVGIIISGGNVDLGAFGSFLL
G
>Mature_320_residues
TALPISFDDVAAAHERIRAAAHRTPVLTSATANVATGAQLFFKAENFQRIGAFKFRGAYNAIAQFTPQQKAGGVLAFSSG
NHAQAIALSARLLGVQAVIVMPQDAPAIKIEATRGYGAEVVLYDRYQDDREALGRRIAAERGMTLIPPYDHPHVMAGQGT
AAKELFEETGPLDMLVVCLGGGGLLSGCAVAARAMSPGCAVYGVEPEAGNDGQRSLRSGEIVRIDTPRTIADGAQTPFLG
NHTFAVIRELVTDIVTVSDAELVDTMKFFAGRMKIVAEPTGCLAAAAVLHGKLDVKGKRVGIIISGGNVDLGAFGSFLLG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=321, Percent_Identity=40.4984423676012, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI19923959, Length=145, Percent_Identity=33.1034482758621, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI33469958, Length=309, Percent_Identity=26.537216828479, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=41.8006430868167, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1790207, Length=302, Percent_Identity=37.7483443708609, Blast_Score=168, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17508781, Length=310, Percent_Identity=33.5483870967742, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI71991565, Length=312, Percent_Identity=32.3717948717949, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=312, Percent_Identity=34.2948717948718, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322631, Length=315, Percent_Identity=62.2222222222222, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6320930, Length=284, Percent_Identity=33.4507042253521, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319788, Length=289, Percent_Identity=24.9134948096886, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355833, Length=315, Percent_Identity=36.1904761904762, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24645328, Length=219, Percent_Identity=35.1598173515982, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 33649; Mature: 33518

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALPISFDDVAAAHERIRAAAHRTPVLTSATANVATGAQLFFKAENFQRIGAFKFRGAY
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCHHCCCEEECCHH
NAIAQFTPQQKAGGVLAFSSGNHAQAIALSARLLGVQAVIVMPQDAPAIKIEATRGYGAE
HHHHHCCCCHHCCCEEEECCCCCCEEEEEHHHEEEEEEEEEECCCCCEEEEEECCCCCCE
VVLYDRYQDDREALGRRIAAERGMTLIPPYDHPHVMAGQGTAAKELFEETGPLDMLVVCL
EEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
GGGGLLSGCAVAARAMSPGCAVYGVEPEAGNDGQRSLRSGEIVRIDTPRTIADGAQTPFL
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCC
GNHTFAVIRELVTDIVTVSDAELVDTMKFFAGRMKIVAEPTGCLAAAAVLHGKLDVKGKR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCEEECCCE
VGIIISGGNVDLGAFGSFLLG
EEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TALPISFDDVAAAHERIRAAAHRTPVLTSATANVATGAQLFFKAENFQRIGAFKFRGAY
CCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCHHCCCEEECCHH
NAIAQFTPQQKAGGVLAFSSGNHAQAIALSARLLGVQAVIVMPQDAPAIKIEATRGYGAE
HHHHHCCCCHHCCCEEEECCCCCCEEEEEHHHEEEEEEEEEECCCCCEEEEEECCCCCCE
VVLYDRYQDDREALGRRIAAERGMTLIPPYDHPHVMAGQGTAAKELFEETGPLDMLVVCL
EEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
GGGGLLSGCAVAARAMSPGCAVYGVEPEAGNDGQRSLRSGEIVRIDTPRTIADGAQTPFL
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCC
GNHTFAVIRELVTDIVTVSDAELVDTMKFFAGRMKIVAEPTGCLAAAAVLHGKLDVKGKR
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCEEECCCE
VGIIISGGNVDLGAFGSFLLG
EEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA