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The map label for this gene is serA3 [H]

Identifier: 116694417

GI number: 116694417

Start: 525088

End: 526044

Strand: Direct

Name: serA3 [H]

Synonym: H16_B0466

Alternate gene names: 116694417

Gene position: 525088-526044 (Clockwise)

Preceding gene: 116694416

Following gene: 116694421

Centisome position: 18.03

GC content: 63.11

Gene sequence:

>957_bases
ATGCCAATTTCTGAAGACACCCCCTCGGGCGCGCTGGCTTTCTACAGCGCCTTCGACGATTTCGACACGTGGAAGCGCGC
GCTCCAGGCCCAGCTCCCGAACCTGAAAGTCATTCACTCCAGCAAAATCACCCGGCCAGCCGACATTCACTACGCGCTCG
CCTGGAAACCGCCGGAGAATTTCTTTGCCGAAATGACGAACCTGCGCCTGATCGTCAATCTGGGAGCGGGGGTTGATTCA
CTGGTCCAGCGGCAGGATCTTCCCCAAGGCATTCCCATCACGCGGCTCACGGACCCGCAGATGGCGCGCATGATGGCGGG
ATACGTGCTGTTCTCCGTGCTGCGGCACGCCCGGGACATCCCGTACTTCGAGCAGGCGCAGCGGCGGGGTGAGTGGGCCT
ACCGTCATCCCCGTTCTCCGGAAGACATCCGCGTGGCGGTTCTGGGGCTCGGTCAGCTGGGCGCGAAAGCGGCCCACGAA
CTGCAGCGCCAGGGGTTCAAGGTGATCGGCTGGTCGCGCAGCCCGGCGCAGATCGAAGGCGTGGAATGCTTTGCCGGACT
GGAAACGCTCGACACCGTGCTAGGACAGGCGGACATTGTCGTCGTGATGCTGCCGCTCACGCCGCAGACGGCTGGCATCC
TGGATCGGGCGCGACTCGAGCAGCTGCCGCGAGGCGCGGCCTTCATCAACGTTGCGCGGGGCGCACTGGTCGATCAGGCG
GCGCTTACGGACCTGCTCCAAAGCGGCCACATTGGCGGGGCAACCTTGGACGTTTTCGAGCGCGAACCTTTGCCTGCCGG
GGATCCGCTGTGGAGCATGCCTAATGTGCTGATCACACCCCATCTGGCTTCGGTGGCGATTCCGTCGTCTGCGGCGAGGC
AGATTGCGGAGAATATTGTTCGGGTTTCTGCCGGCGAATCGCCGGATAACATCATTGATCCAGCACGCGGATATTGA

Upstream 100 bases:

>100_bases
GAAGGGCAGAGCAGCGGTCTGATTTCCATGCGCACGCGGAACGGCAGCAGGATGTACTCTCGCTGCCGTCCTTGCCATTA
TTCTCAAGGCAGTTGCCAAG

Downstream 100 bases:

>100_bases
GGTATGGGCTACGTCCGGTGCAATGCGCCGGACGCGTGGAAGGGATGAGAGACGCGATCAAAATGGAGCGAAGCGGTTCT
GGCTAGGGGGCGAAGCAGGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MPISEDTPSGALAFYSAFDDFDTWKRALQAQLPNLKVIHSSKITRPADIHYALAWKPPENFFAEMTNLRLIVNLGAGVDS
LVQRQDLPQGIPITRLTDPQMARMMAGYVLFSVLRHARDIPYFEQAQRRGEWAYRHPRSPEDIRVAVLGLGQLGAKAAHE
LQRQGFKVIGWSRSPAQIEGVECFAGLETLDTVLGQADIVVVMLPLTPQTAGILDRARLEQLPRGAAFINVARGALVDQA
ALTDLLQSGHIGGATLDVFEREPLPAGDPLWSMPNVLITPHLASVAIPSSAARQIAENIVRVSAGESPDNIIDPARGY

Sequences:

>Translated_318_residues
MPISEDTPSGALAFYSAFDDFDTWKRALQAQLPNLKVIHSSKITRPADIHYALAWKPPENFFAEMTNLRLIVNLGAGVDS
LVQRQDLPQGIPITRLTDPQMARMMAGYVLFSVLRHARDIPYFEQAQRRGEWAYRHPRSPEDIRVAVLGLGQLGAKAAHE
LQRQGFKVIGWSRSPAQIEGVECFAGLETLDTVLGQADIVVVMLPLTPQTAGILDRARLEQLPRGAAFINVARGALVDQA
ALTDLLQSGHIGGATLDVFEREPLPAGDPLWSMPNVLITPHLASVAIPSSAARQIAENIVRVSAGESPDNIIDPARGY
>Mature_317_residues
PISEDTPSGALAFYSAFDDFDTWKRALQAQLPNLKVIHSSKITRPADIHYALAWKPPENFFAEMTNLRLIVNLGAGVDSL
VQRQDLPQGIPITRLTDPQMARMMAGYVLFSVLRHARDIPYFEQAQRRGEWAYRHPRSPEDIRVAVLGLGQLGAKAAHEL
QRQGFKVIGWSRSPAQIEGVECFAGLETLDTVLGQADIVVVMLPLTPQTAGILDRARLEQLPRGAAFINVARGALVDQAA
LTDLLQSGHIGGATLDVFEREPLPAGDPLWSMPNVLITPHLASVAIPSSAARQIAENIVRVSAGESPDNIIDPARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557497, Length=334, Percent_Identity=28.7425149700599, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI61743967, Length=334, Percent_Identity=28.7425149700599, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI23308577, Length=254, Percent_Identity=29.1338582677165, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI6912396, Length=224, Percent_Identity=29.4642857142857, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI145580578, Length=300, Percent_Identity=28.3333333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI4557499, Length=300, Percent_Identity=28.3333333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI145580575, Length=235, Percent_Identity=31.063829787234, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI87081824, Length=312, Percent_Identity=36.8589743589744, Blast_Score=191, Evalue=7e-50,
Organism=Escherichia coli, GI87082289, Length=268, Percent_Identity=30.2238805970149, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1789279, Length=190, Percent_Identity=28.4210526315789, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787645, Length=183, Percent_Identity=27.8688524590164, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=272, Percent_Identity=32.3529411764706, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324055, Length=176, Percent_Identity=32.9545454545455, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=288, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=235, Percent_Identity=24.2553191489362, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=196, Percent_Identity=26.530612244898, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=240, Percent_Identity=25, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=157, Percent_Identity=28.0254777070064, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=261, Percent_Identity=29.5019157088123, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28571528, Length=167, Percent_Identity=34.7305389221557, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585514, Length=257, Percent_Identity=29.5719844357977, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28574282, Length=257, Percent_Identity=29.5719844357977, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28574286, Length=306, Percent_Identity=25.4901960784314, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45552429, Length=257, Percent_Identity=29.5719844357977, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI45551003, Length=257, Percent_Identity=29.5719844357977, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574284, Length=257, Percent_Identity=29.5719844357977, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24585516, Length=249, Percent_Identity=26.5060240963855, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=29.2307692307692, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=29.2307692307692, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=29.2307692307692, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=29.2307692307692, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 34748; Mature: 34617

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISEDTPSGALAFYSAFDDFDTWKRALQAQLPNLKVIHSSKITRPADIHYALAWKPPEN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCHH
FFAEMTNLRLIVNLGAGVDSLVQRQDLPQGIPITRLTDPQMARMMAGYVLFSVLRHARDI
HHHHHHCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PYFEQAQRRGEWAYRHPRSPEDIRVAVLGLGQLGAKAAHELQRQGFKVIGWSRSPAQIEG
CHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCCCCCC
VECFAGLETLDTVLGQADIVVVMLPLTPQTAGILDRARLEQLPRGAAFINVARGALVDQA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ALTDLLQSGHIGGATLDVFEREPLPAGDPLWSMPNVLITPHLASVAIPSSAARQIAENIV
HHHHHHHCCCCCCCEEEHHCCCCCCCCCCCCCCCCEEECCCHHHHCCCCHHHHHHHHHHH
RVSAGESPDNIIDPARGY
HHCCCCCCCHHCCCCCCC
>Mature Secondary Structure 
PISEDTPSGALAFYSAFDDFDTWKRALQAQLPNLKVIHSSKITRPADIHYALAWKPPEN
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEECCCHH
FFAEMTNLRLIVNLGAGVDSLVQRQDLPQGIPITRLTDPQMARMMAGYVLFSVLRHARDI
HHHHHHCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PYFEQAQRRGEWAYRHPRSPEDIRVAVLGLGQLGAKAAHELQRQGFKVIGWSRSPAQIEG
CHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCCCCCC
VECFAGLETLDTVLGQADIVVVMLPLTPQTAGILDRARLEQLPRGAAFINVARGALVDQA
HHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
ALTDLLQSGHIGGATLDVFEREPLPAGDPLWSMPNVLITPHLASVAIPSSAARQIAENIV
HHHHHHHCCCCCCCEEEHHCCCCCCCCCCCCCCCCEEECCCHHHHCCCCHHHHHHHHHHH
RVSAGESPDNIIDPARGY
HHCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA