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The map label for this gene is paaG [C]

Identifier: 116694355

GI number: 116694355

Start: 459583

End: 460419

Strand: Direct

Name: paaG [C]

Synonym: H16_B0402

Alternate gene names: 116694355

Gene position: 459583-460419 (Clockwise)

Preceding gene: 116694354

Following gene: 116694356

Centisome position: 15.78

GC content: 68.34

Gene sequence:

>837_bases
ATGCAAAGAGAGACGATCCCCTTGCGCGAAGCCCGGCTCGAAATCGGGGACGGCATCGCGGAGCTCATCCATGACCGGCC
GGAACGTCGCAACCCGATGTCGCTGACGCTGCGCCAGGACTACACCGACATGCTGGACCGCGTGGAGCGCGACCCCGAGA
TCCGCGCGCTCATCATCACCGGTTCGGGCGGCTCGTTCTGCGCGGGGGGCGACCTCGGCGACCTGAAGAGCCGTGTCGAG
CAGCCCGATGCGCCGCAGAATTCGCCCGACGCGATGCGGCGTCGCCTGCTCGCGCTGCATGACCGGGTCGCGCGGCTGCG
CAACCTGGAAATGCCTGTCATCGCCGCGGTCGATGGGCCGGCGCTCGGCGCCGGCATGGGGCTGGCGCTGGTGGCCGACT
TCGTGCTGGCGTCGCCGCGCGCATTCTTCGGCATGTCGTTTGCCAAGGTGGGGCTGGTGCCGGACATGGCTTCGGCCTAC
TTCCTGCCGCGCGTGGTCGGCATGTCGATGGCCAAGGAACTGATGCTGACGGCCCGCAAGGTCGGTGCCGAGGAGGCAAA
GCAGCTCGGCATCGTTCATGCGATCTATCCGCACGAGACGCTGGCCGAGCAGGCGCGGCAGTTCGCGCTGCGCTTCGTCG
ACGCGCCCCCGCAGGCGATGGGCGCGATGAAGCGCATGCTGAACAGCAGCTTCGAGACGAGCTACGGCGCGTTCGTGGAG
CTGGAGGCGAATGCACAGGCGGTGGCGTCCACCACGGCTTACCATGCCGACGCCTTGCGCCGCTTTGCCGAGGGCAAGCC
GTTGCGGTATGACTGGGACCGGGTGGCGAAGGGGTGA

Upstream 100 bases:

>100_bases
TGCCAGGAACTGGTCTCGCGCATGATGGCCGAGTGCCGCACTGCGCTGTGCGAGACGCTGGCGCGGTTCGACGACTGACG
ATTCACCAAGGAGGCAACCC

Downstream 100 bases:

>100_bases
CAGCTTGCCGCCTGTTGCGGTAATGACAAGGCCAGCGCCTGGGCGTTGGCCATTTTGCATTTCGGACGTTGCAAAGAACG
GCTTGCCACCGATTGCTTGC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: 4-CBA-CoA dehalogenase; 4-CBCoA dehalogenase; 4-chlorobenzoyl-CoA dehalogenase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MQRETIPLREARLEIGDGIAELIHDRPERRNPMSLTLRQDYTDMLDRVERDPEIRALIITGSGGSFCAGGDLGDLKSRVE
QPDAPQNSPDAMRRRLLALHDRVARLRNLEMPVIAAVDGPALGAGMGLALVADFVLASPRAFFGMSFAKVGLVPDMASAY
FLPRVVGMSMAKELMLTARKVGAEEAKQLGIVHAIYPHETLAEQARQFALRFVDAPPQAMGAMKRMLNSSFETSYGAFVE
LEANAQAVASTTAYHADALRRFAEGKPLRYDWDRVAKG

Sequences:

>Translated_278_residues
MQRETIPLREARLEIGDGIAELIHDRPERRNPMSLTLRQDYTDMLDRVERDPEIRALIITGSGGSFCAGGDLGDLKSRVE
QPDAPQNSPDAMRRRLLALHDRVARLRNLEMPVIAAVDGPALGAGMGLALVADFVLASPRAFFGMSFAKVGLVPDMASAY
FLPRVVGMSMAKELMLTARKVGAEEAKQLGIVHAIYPHETLAEQARQFALRFVDAPPQAMGAMKRMLNSSFETSYGAFVE
LEANAQAVASTTAYHADALRRFAEGKPLRYDWDRVAKG
>Mature_278_residues
MQRETIPLREARLEIGDGIAELIHDRPERRNPMSLTLRQDYTDMLDRVERDPEIRALIITGSGGSFCAGGDLGDLKSRVE
QPDAPQNSPDAMRRRLLALHDRVARLRNLEMPVIAAVDGPALGAGMGLALVADFVLASPRAFFGMSFAKVGLVPDMASAY
FLPRVVGMSMAKELMLTARKVGAEEAKQLGIVHAIYPHETLAEQARQFALRFVDAPPQAMGAMKRMLNSSFETSYGAFVE
LEANAQAVASTTAYHADALRRFAEGKPLRYDWDRVAKG

Specific function: Dehalogenates 4-chlorobenzoyl-CoA, 4-iodobenzoyl-CoA and 4-bromobenzoyl-CoA, but not 4-fluorobenzoyl-CoA. Inactive towards crotonyl-CoA, alpha-methylcrotonyl-CoA and beta-methylcrotonyl- CoA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=218, Percent_Identity=30.7339449541284, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI70995211, Length=181, Percent_Identity=33.7016574585635, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI45643119, Length=211, Percent_Identity=26.5402843601896, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI260275230, Length=211, Percent_Identity=26.5402843601896, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI260274832, Length=211, Percent_Identity=26.5402843601896, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI37594469, Length=203, Percent_Identity=29.5566502463054, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI37594471, Length=203, Percent_Identity=29.5566502463054, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=30.6201550387597, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI68989263, Length=212, Percent_Identity=30.188679245283, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI116235487, Length=150, Percent_Identity=28.6666666666667, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4757966, Length=197, Percent_Identity=22.3350253807107, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI51538581, Length=197, Percent_Identity=22.3350253807107, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI25453481, Length=197, Percent_Identity=22.3350253807107, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI51538573, Length=197, Percent_Identity=22.3350253807107, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI4757968, Length=200, Percent_Identity=23, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI49355787, Length=200, Percent_Identity=23, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI213417737, Length=219, Percent_Identity=24.2009132420091, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI157694516, Length=219, Percent_Identity=24.2009132420091, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI221307494, Length=150, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI20127408, Length=209, Percent_Identity=25.3588516746411, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI221136756, Length=150, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI221136753, Length=150, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI31542718, Length=203, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI157694520, Length=196, Percent_Identity=24.4897959183673, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787660, Length=249, Percent_Identity=35.7429718875502, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI221142681, Length=216, Percent_Identity=33.7962962962963, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1787659, Length=216, Percent_Identity=31.4814814814815, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788597, Length=230, Percent_Identity=28.2608695652174, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790281, Length=190, Percent_Identity=28.4210526315789, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788682, Length=200, Percent_Identity=28.5, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082183, Length=244, Percent_Identity=24.1803278688525, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=260, Percent_Identity=29.2307692307692, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17535521, Length=205, Percent_Identity=28.2926829268293, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=251, Percent_Identity=28.6852589641434, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17536985, Length=217, Percent_Identity=29.9539170506912, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17554946, Length=247, Percent_Identity=27.5303643724696, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17560910, Length=221, Percent_Identity=28.0542986425339, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534483, Length=218, Percent_Identity=25.6880733944954, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17549921, Length=207, Percent_Identity=27.536231884058, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17540306, Length=243, Percent_Identity=27.1604938271605, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25141363, Length=212, Percent_Identity=27.8301886792453, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=255, Percent_Identity=27.0588235294118, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653477, Length=255, Percent_Identity=27.0588235294118, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24653139, Length=198, Percent_Identity=31.8181818181818, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19920382, Length=213, Percent_Identity=30.0469483568075, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24654903, Length=207, Percent_Identity=27.536231884058, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357171, Length=239, Percent_Identity=27.6150627615063, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28571730, Length=147, Percent_Identity=31.9727891156463, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28571729, Length=147, Percent_Identity=31.9727891156463, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24650670, Length=214, Percent_Identity=25.2336448598131, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =3.8.1.7 [H]

Molecular weight: Translated: 30526; Mature: 30526

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRETIPLREARLEIGDGIAELIHDRPERRNPMSLTLRQDYTDMLDRVERDPEIRALIIT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCCEEEEEEE
GSGGSFCAGGDLGDLKSRVEQPDAPQNSPDAMRRRLLALHDRVARLRNLEMPVIAAVDGP
CCCCCEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
ALGAGMGLALVADFVLASPRAFFGMSFAKVGLVPDMASAYFLPRVVGMSMAKELMLTARK
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAEEAKQLGIVHAIYPHETLAEQARQFALRFVDAPPQAMGAMKRMLNSSFETSYGAFVE
HCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEE
LEANAQAVASTTAYHADALRRFAEGKPLRYDWDRVAKG
EECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
>Mature Secondary Structure
MQRETIPLREARLEIGDGIAELIHDRPERRNPMSLTLRQDYTDMLDRVERDPEIRALIIT
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHHHCCCCCEEEEEEE
GSGGSFCAGGDLGDLKSRVEQPDAPQNSPDAMRRRLLALHDRVARLRNLEMPVIAAVDGP
CCCCCEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
ALGAGMGLALVADFVLASPRAFFGMSFAKVGLVPDMASAYFLPRVVGMSMAKELMLTARK
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAEEAKQLGIVHAIYPHETLAEQARQFALRFVDAPPQAMGAMKRMLNSSFETSYGAFVE
HCHHHHHHCCCCEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEE
LEANAQAVASTTAYHADALRRFAEGKPLRYDWDRVAKG
EECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1351742; 1610806 [H]