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The map label for this gene is acmD

Identifier: 116694284

GI number: 116694284

Start: 370886

End: 371866

Strand: Direct

Name: acmD

Synonym: H16_B0330

Alternate gene names: NA

Gene position: 370886-371866 (Clockwise)

Preceding gene: 116694279

Following gene: 116694285

Centisome position: 12.73

GC content: 65.24

Gene sequence:

>981_bases
ATGCCTGTCATCGATGTCCACACCCACATCTTCACAAAGCCCTGGCTGGAGCTGCTCAAGCGCAAGGGCGGCCTCTACAA
CATCCAGCAGCGCCCCGACGGCCAGCACGAGGTATTCCGTGGCGACACGCCCGTGGTCATCCCACAGAAAGGACACTTCG
ACTACGATCTGCGCATCCAGCACATGGACGCGGCCGGCATCGATATCTCAGTCATGTCGCTGACTTGCCCCAATGTGTTC
TGGGGCGACGAGGAAACCAGCTGCGAAGCGGCGCGCGAATCCAACGATTCGCTGGCGCAGGCGCAGGCCGATCACCCGAG
CCGGCTGCGTTGGTTCACGTCGCTGCCGTGGGAATACCCGCAGCGCGCGCTCGACGAGCTCAAGCGCACCTGCGACAACG
GTGCGAGCGGCGTCATGGTGCTGGCCAACATCGCCGGCCGCAGCCTGACCGACCCGGCCTTCGCACCCATCTGGGCCGAA
ATCGACCGCCGCGCGCTGCCGGTGCTGGTGCACCCCACCGACCCGCCGGGCGCCGACCTGATGGACATGACCAAGTTCGA
CCTGAGCTGGTCGGTGGGCTTCATGTTCGACACCACGCTCGCCATCACGCGCATGATCTTCGAGGGCTTCTTCGACCAAT
ACCCCAACCTCAAGATCATCGCCTCGCATGCGGGCGGTGCGTTGCCCTACCTGGCCGGCCGTTTCGGGAAGGGCCACGAG
GTCGAGATCCCCCAGCGGCGCAAGATGCAGCGCACGCCCATCGACTACCTGCGCCACATCCACTACGACTGCATCTCGTA
CAGTCCGGCTTCGCTGGAGTTCCTGATCTCGGTCGTCGGCGCCGACCGGGTGATGTTCGGCACCGACTGGCCGCACCAGG
TTCACGACACGCGCGGGTCCTTCGCCAATACCGAGCGGCTGCCCGCCGCGCAGCGCGACGCCGTGCGTTCGGGCAATGCC
ATGCGAGTATTCGGTTTCTGA

Upstream 100 bases:

>100_bases
TTACTTATCCTGGTATCAAGATATCTGCCAATACGTTTATGCCAGATCACTACAGTAGTGTCTAGACATCCGTCACTCAC
ACACCACAGGAGCCCCCTAG

Downstream 100 bases:

>100_bases
TCGACTTCGGCTGACCAAGGAGACTCTCAGCATGTTGAAGCGACGCGTTTTCAATCGGGTGGCTGCAACCATGGCGCTGG
CCGCCGCGCTGCCCATGGGC

Product: amidohydrolase, similiar to 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Products: 2-aminomuconate semialdehyde; CO2

Alternate protein names: Amidohydrolase; Metal-Dependent Hydrolase; Amidohydrolase/Decarboxylase; Amidohydrolase Family Protein; Hydrolase; 2-Amino-3-Carboxylmuconate-6-Semialdehyde Decarboxylase; O-Pyrocatechuate Decarboxylase; 2-Amino-3-Carboxymuconate-6-Semialdehyde Decarboxylase; 2-Amino-3-Carboxymuconate 6-Semialdehyde Decarboxylase; 4-Oxalomesaconate Hydratase; 2-Amino-3-Carboxymuconate-6- Semialdehyde Decarboxylase; Tryptophan 2 3-Dioxygenase; Decarboxylase; 2 3-Dihydroxybenzoic Acid Decarboxylase; Amidohydrolase Family; Amidase; 5-Carboxyvanillate Decarboxylase; Twin-Arginine Translocation Pathway Signal; Metal-Dependent Hydrolase Of TIM-Barrel Fold; Barh Protein; Amidohydrolase 2 Family Protein; Metal Dependent Hydrolase; 5-Carboxy-2-Hydroxymuconate-6-Semialdehyde Decarboxylase

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MPVIDVHTHIFTKPWLELLKRKGGLYNIQQRPDGQHEVFRGDTPVVIPQKGHFDYDLRIQHMDAAGIDISVMSLTCPNVF
WGDEETSCEAARESNDSLAQAQADHPSRLRWFTSLPWEYPQRALDELKRTCDNGASGVMVLANIAGRSLTDPAFAPIWAE
IDRRALPVLVHPTDPPGADLMDMTKFDLSWSVGFMFDTTLAITRMIFEGFFDQYPNLKIIASHAGGALPYLAGRFGKGHE
VEIPQRRKMQRTPIDYLRHIHYDCISYSPASLEFLISVVGADRVMFGTDWPHQVHDTRGSFANTERLPAAQRDAVRSGNA
MRVFGF

Sequences:

>Translated_326_residues
MPVIDVHTHIFTKPWLELLKRKGGLYNIQQRPDGQHEVFRGDTPVVIPQKGHFDYDLRIQHMDAAGIDISVMSLTCPNVF
WGDEETSCEAARESNDSLAQAQADHPSRLRWFTSLPWEYPQRALDELKRTCDNGASGVMVLANIAGRSLTDPAFAPIWAE
IDRRALPVLVHPTDPPGADLMDMTKFDLSWSVGFMFDTTLAITRMIFEGFFDQYPNLKIIASHAGGALPYLAGRFGKGHE
VEIPQRRKMQRTPIDYLRHIHYDCISYSPASLEFLISVVGADRVMFGTDWPHQVHDTRGSFANTERLPAAQRDAVRSGNA
MRVFGF
>Mature_325_residues
PVIDVHTHIFTKPWLELLKRKGGLYNIQQRPDGQHEVFRGDTPVVIPQKGHFDYDLRIQHMDAAGIDISVMSLTCPNVFW
GDEETSCEAARESNDSLAQAQADHPSRLRWFTSLPWEYPQRALDELKRTCDNGASGVMVLANIAGRSLTDPAFAPIWAEI
DRRALPVLVHPTDPPGADLMDMTKFDLSWSVGFMFDTTLAITRMIFEGFFDQYPNLKIIASHAGGALPYLAGRFGKGHEV
EIPQRRKMQRTPIDYLRHIHYDCISYSPASLEFLISVVGADRVMFGTDWPHQVHDTRGSFANTERLPAAQRDAVRSGNAM
RVFGF

Specific function: Unknown

COG id: COG2159

COG function: function code R; Predicted metal-dependent hydrolase of the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI109715856, Length=335, Percent_Identity=29.2537313432836, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71995651, Length=317, Percent_Identity=27.4447949526814, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.45

Molecular weight: Translated: 36783; Mature: 36652

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVIDVHTHIFTKPWLELLKRKGGLYNIQQRPDGQHEVFRGDTPVVIPQKGHFDYDLRIQ
CCEEECHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEECCCCCEEECCCCCCCEEEEEE
HMDAAGIDISVMSLTCPNVFWGDEETSCEAARESNDSLAQAQADHPSRLRWFTSLPWEYP
EECCCCCEEEEEEEECCCEEECCCCCHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCHHHH
QRALDELKRTCDNGASGVMVLANIAGRSLTDPAFAPIWAEIDRRALPVLVHPTDPPGADL
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCCH
MDMTKFDLSWSVGFMFDTTLAITRMIFEGFFDQYPNLKIIASHAGGALPYLAGRFGKGHE
HHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCCC
VEIPQRRKMQRTPIDYLRHIHYDCISYSPASLEFLISVVGADRVMFGTDWPHQVHDTRGS
CCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHCCCC
FANTERLPAAQRDAVRSGNAMRVFGF
CCCCCCCCCHHHHHHHCCCEEEEECC
>Mature Secondary Structure 
PVIDVHTHIFTKPWLELLKRKGGLYNIQQRPDGQHEVFRGDTPVVIPQKGHFDYDLRIQ
CEEECHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEECCCCCEEECCCCCCCEEEEEE
HMDAAGIDISVMSLTCPNVFWGDEETSCEAARESNDSLAQAQADHPSRLRWFTSLPWEYP
EECCCCCEEEEEEEECCCEEECCCCCHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCHHHH
QRALDELKRTCDNGASGVMVLANIAGRSLTDPAFAPIWAEIDRRALPVLVHPTDPPGADL
HHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCCH
MDMTKFDLSWSVGFMFDTTLAITRMIFEGFFDQYPNLKIIASHAGGALPYLAGRFGKGHE
HHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCCC
VEIPQRRKMQRTPIDYLRHIHYDCISYSPASLEFLISVVGADRVMFGTDWPHQVHDTRGS
CCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCHHHHHCCCC
FANTERLPAAQRDAVRSGNAMRVFGF
CCCCCCCCCHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate

Specific reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA