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The map label for this gene is atoC [H]

Identifier: 116694148

GI number: 116694148

Start: 217651

End: 219015

Strand: Direct

Name: atoC [H]

Synonym: H16_B0193

Alternate gene names: 116694148

Gene position: 217651-219015 (Clockwise)

Preceding gene: 116694147

Following gene: 116694150

Centisome position: 7.47

GC content: 67.03

Gene sequence:

>1365_bases
ATGAAGACAGACCGCTGGGCCTACGAAAACCTTGAAGTCTACGTGTGGGAAGGCAAGTACGAGATCGCCGACCGCGTCAC
GCGTTTCCTGGCGCCGCTGGGCGTGGACGTTATCCGCGCCGGCGCACTCGAAGCCTTGCCTGCCGAGCCGCGCCTGAAGC
CCTGCATCGCGGTGATCAGCGTGTCGGTGATCGGCGCGGCGCGCTTTTCGCTGGACTGGGAGGCCGCGCACGGCATGCCG
GTGATCTGGGTGGCAGGCCCCGGCCGCGAGGCCGATCCCGGGCGCTTTCCGCCGGAGTACGCGCATATTCTTGCCGATGA
CTTCACCGGCGCCGACCTGCGCAGCCAGATCGGCAAGCTGCTGCCGCAACTGCTGGCCACGGACGCGCCCGGCGAGCGCG
AGGCCGATCTGGTGGCCGGCTCGCCGGCGATGCGCCAGTTGCTGCAGCATGTGGAAACCTTCGCCGACTTCGGCAGCAAC
GTGATGCTGTATGGCGAAACCGGCGCGGGCAAGGAACGCATCGCGCGCCTGTTCCATGAGCGCAATGGCACCTACGGAAA
GGGGCCGTTCGTCGCGGTCAACTGCGGTGCGATCCCTGACGGCTTGTTCGAGTCGCAGTTCTTCGGCCATGCCAAGGGCG
CGTTCACCGGCGCCTCGTTCGCGCACCGTGGCTATTTCGAGCAGGCCAACGGCGGCACGCTGTTTCTCGATGAAATCGGC
GACCTGCCGCTGTTCCAGCAGGTCAAGCTGCTGCGCGTGCTGGAAGAGAACGTGATCACCCGGCTGGGATCGACCCTGGC
GGTCAAGCTGGATTTCCGGCTGGTGGCGGCGACCAACAAGGACCTGCGCGACGCGGTGCGACAGGGGCGTTTCCGCGCCG
ACCTGTTCTTCCGCCTGGCGGTGATCGAGATGCGCATCCCCAGCCTGGAAGAGCGTGGCCAGGCCGACAAGGTGGCACTG
CTGCAGTCCTTCCTGCGCCATATGCTGGGGGAATCCGGCTTCGACGCGCTGCCGCCGATGCCTGACTGGCTCAAGGGCGC
GGTTGGCACCGCCTATTTCACCGGCAATGTGCGCGAGCTGCGCAACCTGGCCGAGCGTGTGGGCATCACAGTGCAGCAGA
CCGGGCACTGGGACGAAGAGCGCATCCGGCCGCTGTTCCGCTCGCTGCATCCGGGTGCGTTCGATGGCGGCGAGCGCAAC
GACCTGCGTGCCGATACGGAAGAGCGCCGCCGCATCCTGGCCGCGCTCGATGCCAATGGCTGGCGGCGGCAGGACACGGC
GGCAAGCCTGGGCATCAGCCGCAAGGTGCTGTGGGAAAAGATGCGCAAGTACCAGATCGCCGACAGCGAGGCCGAGCCGG
TCTGA

Upstream 100 bases:

>100_bases
TAGGCACCGCCGACCTCTGGGTCCACAGCATCGACTGCAACAATGCCGAACTGGTGTACTGAGCCATGATTGCGCCAAAC
CGCCTGATGGCAGAAATCGA

Downstream 100 bases:

>100_bases
CTGCACGGCTCAGAACACGCGCATCAGGACACGCCTCAGGGCAGGCGGATCTCCTTCACGTCGAAGTGCGATTCGCCGAT
CAGCTCCTTGTCGTATTCGC

Product: PspF family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKTDRWAYENLEVYVWEGKYEIADRVTRFLAPLGVDVIRAGALEALPAEPRLKPCIAVISVSVIGAARFSLDWEAAHGMP
VIWVAGPGREADPGRFPPEYAHILADDFTGADLRSQIGKLLPQLLATDAPGEREADLVAGSPAMRQLLQHVETFADFGSN
VMLYGETGAGKERIARLFHERNGTYGKGPFVAVNCGAIPDGLFESQFFGHAKGAFTGASFAHRGYFEQANGGTLFLDEIG
DLPLFQQVKLLRVLEENVITRLGSTLAVKLDFRLVAATNKDLRDAVRQGRFRADLFFRLAVIEMRIPSLEERGQADKVAL
LQSFLRHMLGESGFDALPPMPDWLKGAVGTAYFTGNVRELRNLAERVGITVQQTGHWDEERIRPLFRSLHPGAFDGGERN
DLRADTEERRRILAALDANGWRRQDTAASLGISRKVLWEKMRKYQIADSEAEPV

Sequences:

>Translated_454_residues
MKTDRWAYENLEVYVWEGKYEIADRVTRFLAPLGVDVIRAGALEALPAEPRLKPCIAVISVSVIGAARFSLDWEAAHGMP
VIWVAGPGREADPGRFPPEYAHILADDFTGADLRSQIGKLLPQLLATDAPGEREADLVAGSPAMRQLLQHVETFADFGSN
VMLYGETGAGKERIARLFHERNGTYGKGPFVAVNCGAIPDGLFESQFFGHAKGAFTGASFAHRGYFEQANGGTLFLDEIG
DLPLFQQVKLLRVLEENVITRLGSTLAVKLDFRLVAATNKDLRDAVRQGRFRADLFFRLAVIEMRIPSLEERGQADKVAL
LQSFLRHMLGESGFDALPPMPDWLKGAVGTAYFTGNVRELRNLAERVGITVQQTGHWDEERIRPLFRSLHPGAFDGGERN
DLRADTEERRRILAALDANGWRRQDTAASLGISRKVLWEKMRKYQIADSEAEPV
>Mature_454_residues
MKTDRWAYENLEVYVWEGKYEIADRVTRFLAPLGVDVIRAGALEALPAEPRLKPCIAVISVSVIGAARFSLDWEAAHGMP
VIWVAGPGREADPGRFPPEYAHILADDFTGADLRSQIGKLLPQLLATDAPGEREADLVAGSPAMRQLLQHVETFADFGSN
VMLYGETGAGKERIARLFHERNGTYGKGPFVAVNCGAIPDGLFESQFFGHAKGAFTGASFAHRGYFEQANGGTLFLDEIG
DLPLFQQVKLLRVLEENVITRLGSTLAVKLDFRLVAATNKDLRDAVRQGRFRADLFFRLAVIEMRIPSLEERGQADKVAL
LQSFLRHMLGESGFDALPPMPDWLKGAVGTAYFTGNVRELRNLAERVGITVQQTGHWDEERIRPLFRSLHPGAFDGGERN
DLRADTEERRRILAALDANGWRRQDTAASLGISRKVLWEKMRKYQIADSEAEPV

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=317, Percent_Identity=40.3785488958991, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1790437, Length=308, Percent_Identity=38.3116883116883, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI87082117, Length=363, Percent_Identity=39.1184573002755, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1789233, Length=342, Percent_Identity=35.3801169590643, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1786524, Length=321, Percent_Identity=38.006230529595, Blast_Score=181, Evalue=6e-47,
Organism=Escherichia coli, GI87082152, Length=260, Percent_Identity=42.3076923076923, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1790299, Length=228, Percent_Identity=43.421052631579, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788905, Length=238, Percent_Identity=42.436974789916, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1789087, Length=231, Percent_Identity=43.2900432900433, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI87081872, Length=327, Percent_Identity=33.0275229357798, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1787583, Length=343, Percent_Identity=30.3206997084548, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789828, Length=234, Percent_Identity=35.8974358974359, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI87081858, Length=314, Percent_Identity=29.9363057324841, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50402; Mature: 50402

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTDRWAYENLEVYVWEGKYEIADRVTRFLAPLGVDVIRAGALEALPAEPRLKPCIAVIS
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHH
VSVIGAARFSLDWEAAHGMPVIWVAGPGREADPGRFPPEYAHILADDFTGADLRSQIGKL
HHHHHHHHEECCCHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
LPQLLATDAPGEREADLVAGSPAMRQLLQHVETFADFGSNVMLYGETGAGKERIARLFHE
HHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
RNGTYGKGPFVAVNCGAIPDGLFESQFFGHAKGAFTGASFAHRGYFEQANGGTLFLDEIG
CCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCEEEECCCC
DLPLFQQVKLLRVLEENVITRLGSTLAVKLDFRLVAATNKDLRDAVRQGRFRADLFFRLA
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHCCCHHHHHHHHHH
VIEMRIPSLEERGQADKVALLQSFLRHMLGESGFDALPPMPDWLKGAVGTAYFTGNVREL
HHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEECCHHHH
RNLAERVGITVQQTGHWDEERIRPLFRSLHPGAFDGGERNDLRADTEERRRILAALDANG
HHHHHHHCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
WRRQDTAASLGISRKVLWEKMRKYQIADSEAEPV
CCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKTDRWAYENLEVYVWEGKYEIADRVTRFLAPLGVDVIRAGALEALPAEPRLKPCIAVIS
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHH
VSVIGAARFSLDWEAAHGMPVIWVAGPGREADPGRFPPEYAHILADDFTGADLRSQIGKL
HHHHHHHHEECCCHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
LPQLLATDAPGEREADLVAGSPAMRQLLQHVETFADFGSNVMLYGETGAGKERIARLFHE
HHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
RNGTYGKGPFVAVNCGAIPDGLFESQFFGHAKGAFTGASFAHRGYFEQANGGTLFLDEIG
CCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCCEEEECCCC
DLPLFQQVKLLRVLEENVITRLGSTLAVKLDFRLVAATNKDLRDAVRQGRFRADLFFRLA
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHHHHHHHCCCHHHHHHHHHH
VIEMRIPSLEERGQADKVALLQSFLRHMLGESGFDALPPMPDWLKGAVGTAYFTGNVREL
HHHHCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCEEEECCHHHH
RNLAERVGITVQQTGHWDEERIRPLFRSLHPGAFDGGERNDLRADTEERRRILAALDANG
HHHHHHHCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
WRRQDTAASLGISRKVLWEKMRKYQIADSEAEPV
CCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]