Click here to switch to the map view.

The map label for this gene is hemH

Identifier: 113477720

GI number: 113477720

Start: 6650853

End: 6652016

Strand: Reverse

Name: hemH

Synonym: Tery_4313

Alternate gene names: 113477720

Gene position: 6652016-6650853 (Counterclockwise)

Preceding gene: 113477728

Following gene: 113477718

Centisome position: 85.83

GC content: 38.06

Gene sequence:

>1164_bases
ATGAGTCGTGTTGGAATATTATTACTTAATTTAGGTGGGCCAGAACAACTTGAAGATGTACGTCCCTTTCTTTTCAATTT
GTTTTCTGATCCAGAAATTATTCGTCTACCCTTTCCTTGGCTACAGAAACCTTTGGCATGGTTCATTTCCACTATGCGTT
TTCAAAAGTCTCAGGAAAATTATAAAGAAATTGGCGGTGGCTCTCCATTAAGATCAATTACAGAAGAGCAAGCTCTGGCT
ATTCAACAACAGTTAGAACAAAAAGGACTACTGACTCAAATGTATATAGGAATGCGTTACTGGCATCCTTTTACAGAAGA
AGCTCTCACTAGAATTAAGCGCGAGCAAGTAGAAAAGTTAGTAATCCTACCACTATATCCTCAATATTCTATCAGCACAA
GTGGTTCAAGTTTTAGATTGCTTGATAAACTTTGGGAAAAAGACTCAGAACTGAAGAAAATTGAATACACTGTTATTCCC
TCTTGGCATCAACGACCAGGATATGTTCAGGCAATGGTAGAATTAATTACTCAACAATTAGACCAATCTCCCAACCCAGA
TCAAGTACATATCTTTTTCAGCGCTCATGGTGTACCGGTCAGCTATGTTGAAGAAGCCGGAGACCCTTATCAGGCAGAAA
TTGAAGAGTGTGTAGATAAGATAATGAAAACTTTGAATTGCTCTAACCCTCATACTTTAGCTTATCAAAGTCGGGTTGGC
CCAGTGGAATGGTTGAAGCCTTACACCGAAGATGCTATCGAAGAATTGGCTGCTGGTGGAGTTAAAGATTTATTGGTAGT
TCCTATTAGTTTTGTTTCTGAACATATTGAGACTCTACAAGAAATTGACATAGAATATCGTGAACTAGCAGAAGAAGCTG
GAATTAGTAATTTTTACCGAGTACCTGCTCTGAATACTCACCCAGTATTTATTAATGATTTAGCAGATTTGGTTATGGAA
GCTTTAGATGCTCCAAGCCGTGATTTTTCTGATGCTATTCAGATGAAAAAAATTATTAAAATGTATCCCCAAGAAAGATG
GCAATGGGGCTTAACTACTACAGCAGAAGTCTGGAATGGACGATTAGCAATGGTGGGCTTTATGGCTTTGTTGTTGGAGT
TGATTACTGGTTATGGTCCCTTACACTTTGCTGGTTTATTATAA

Upstream 100 bases:

>100_bases
GGCTTATGGTTGACTCTACATTATTCAGAAAATATAATTAAAAAAATATAAATATTTTAAGTTTGGTAACAAATATCAAA
ATGGGAGCCTGATTAACACT

Downstream 100 bases:

>100_bases
ATCTGGGGGCATTGGGCCCCTTGCTTCTATTAATCTTAATCAAAATTACTACTATGAGTTTGTGGCTGAAGACTACTCCC
TCGTTTTGTTTTTCCTTGAT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSRVGILLLNLGGPEQLEDVRPFLFNLFSDPEIIRLPFPWLQKPLAWFISTMRFQKSQENYKEIGGGSPLRSITEEQALA
IQQQLEQKGLLTQMYIGMRYWHPFTEEALTRIKREQVEKLVILPLYPQYSISTSGSSFRLLDKLWEKDSELKKIEYTVIP
SWHQRPGYVQAMVELITQQLDQSPNPDQVHIFFSAHGVPVSYVEEAGDPYQAEIEECVDKIMKTLNCSNPHTLAYQSRVG
PVEWLKPYTEDAIEELAAGGVKDLLVVPISFVSEHIETLQEIDIEYRELAEEAGISNFYRVPALNTHPVFINDLADLVME
ALDAPSRDFSDAIQMKKIIKMYPQERWQWGLTTTAEVWNGRLAMVGFMALLLELITGYGPLHFAGLL

Sequences:

>Translated_387_residues
MSRVGILLLNLGGPEQLEDVRPFLFNLFSDPEIIRLPFPWLQKPLAWFISTMRFQKSQENYKEIGGGSPLRSITEEQALA
IQQQLEQKGLLTQMYIGMRYWHPFTEEALTRIKREQVEKLVILPLYPQYSISTSGSSFRLLDKLWEKDSELKKIEYTVIP
SWHQRPGYVQAMVELITQQLDQSPNPDQVHIFFSAHGVPVSYVEEAGDPYQAEIEECVDKIMKTLNCSNPHTLAYQSRVG
PVEWLKPYTEDAIEELAAGGVKDLLVVPISFVSEHIETLQEIDIEYRELAEEAGISNFYRVPALNTHPVFINDLADLVME
ALDAPSRDFSDAIQMKKIIKMYPQERWQWGLTTTAEVWNGRLAMVGFMALLLELITGYGPLHFAGLL
>Mature_386_residues
SRVGILLLNLGGPEQLEDVRPFLFNLFSDPEIIRLPFPWLQKPLAWFISTMRFQKSQENYKEIGGGSPLRSITEEQALAI
QQQLEQKGLLTQMYIGMRYWHPFTEEALTRIKREQVEKLVILPLYPQYSISTSGSSFRLLDKLWEKDSELKKIEYTVIPS
WHQRPGYVQAMVELITQQLDQSPNPDQVHIFFSAHGVPVSYVEEAGDPYQAEIEECVDKIMKTLNCSNPHTLAYQSRVGP
VEWLKPYTEDAIEELAAGGVKDLLVVPISFVSEHIETLQEIDIEYRELAEEAGISNFYRVPALNTHPVFINDLADLVMEA
LDAPSRDFSDAIQMKKIIKMYPQERWQWGLTTTAEVWNGRLAMVGFMALLLELITGYGPLHFAGLL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=328, Percent_Identity=40.8536585365854, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI60499025, Length=328, Percent_Identity=40.8536585365854, Blast_Score=230, Evalue=2e-60,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=29.1925465838509, Blast_Score=119, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324750, Length=332, Percent_Identity=37.6506024096386, Blast_Score=205, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17864156, Length=328, Percent_Identity=37.8048780487805, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=35.7976653696498, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45552018, Length=188, Percent_Identity=38.2978723404255, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_TRIEI (Q10WR6)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_723781.1
- ProteinModelPortal:   Q10WR6
- SMR:   Q10WR6
- STRING:   Q10WR6
- GeneID:   4245965
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_4313
- NMPDR:   fig|203124.1.peg.3124
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   WLQKPLA
- PhylomeDB:   Q10WR6
- ProtClustDB:   PRK00035
- BioCyc:   TERY203124:TERY_4313-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 44320; Mature: 44189

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVGILLLNLGGPEQLEDVRPFLFNLFSDPEIIRLPFPWLQKPLAWFISTMRFQKSQEN
CCCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
YKEIGGGSPLRSITEEQALAIQQQLEQKGLLTQMYIGMRYWHPFTEEALTRIKREQVEKL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHE
VILPLYPQYSISTSGSSFRLLDKLWEKDSELKKIEYTVIPSWHQRPGYVQAMVELITQQL
EEEECCCCCEECCCCCHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHH
DQSPNPDQVHIFFSAHGVPVSYVEEAGDPYQAEIEECVDKIMKTLNCSNPHTLAYQSRVG
CCCCCCCEEEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
PVEWLKPYTEDAIEELAAGGVKDLLVVPISFVSEHIETLQEIDIEYRELAEEAGISNFYR
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEE
VPALNTHPVFINDLADLVMEALDAPSRDFSDAIQMKKIIKMYPQERWQWGLTTTAEVWNG
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHCC
RLAMVGFMALLLELITGYGPLHFAGLL
HHHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure 
SRVGILLLNLGGPEQLEDVRPFLFNLFSDPEIIRLPFPWLQKPLAWFISTMRFQKSQEN
CCEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
YKEIGGGSPLRSITEEQALAIQQQLEQKGLLTQMYIGMRYWHPFTEEALTRIKREQVEKL
HHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHE
VILPLYPQYSISTSGSSFRLLDKLWEKDSELKKIEYTVIPSWHQRPGYVQAMVELITQQL
EEEECCCCCEECCCCCHHHHHHHHHCCCCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHH
DQSPNPDQVHIFFSAHGVPVSYVEEAGDPYQAEIEECVDKIMKTLNCSNPHTLAYQSRVG
CCCCCCCEEEEEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCC
PVEWLKPYTEDAIEELAAGGVKDLLVVPISFVSEHIETLQEIDIEYRELAEEAGISNFYR
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEE
VPALNTHPVFINDLADLVMEALDAPSRDFSDAIQMKKIIKMYPQERWQWGLTTTAEVWNG
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHCC
RLAMVGFMALLLELITGYGPLHFAGLL
HHHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA