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The map label for this gene is gdhA [H]

Identifier: 113477718

GI number: 113477718

Start: 6646719

End: 6648005

Strand: Reverse

Name: gdhA [H]

Synonym: Tery_4311

Alternate gene names: 113477718

Gene position: 6648005-6646719 (Counterclockwise)

Preceding gene: 113477720

Following gene: 113477717

Centisome position: 85.78

GC content: 37.61

Gene sequence:

>1287_bases
ATGTCAGATTCTTTGTTTGATGATGCTAGTCGTAGGTTAGAAAGGGCTTTACAATATGTTTCTCTTTCAGAAGATACAAA
AGAACGTCTCAAATACCCTAAAGCTACCTTAATAGTTTCTATTCCTGTCCGGATGGATGATGGCTCATTACGAGTTTTTC
AAGGTTATCGAGTTCGTTATGATGATACAAGAGGACCCACAAAAGGTGGCATTCGTTATCATCCCAATGTGTCTATTGAT
GAAGTAAAGTCTTTGGCTTTTTGGATGACTTTTAAATGTGCTGTTGTCAGTTTGCCTTTTGGAGGGGCCAAAGGTGGCAT
TACTGTTAATCCTAAAGAATTATCTCGGATGGAATTGGAACGTTTGAGTCGGGGGTATATTGATGCGATCGCTGATTTTA
TCGGTCCTGATACCGATATTCCTGCACCGGATATGTATACTAACCCCATGATAATGGGTTGGATGATGGATGAATACAGC
ATTATTCGCAGACAACTAAGTCCGGCAGTTATTACGGGTAAACCTGTGAGCATCGGTGGTAGTTTGGGAAGAAATACTGC
AACGGCAATGGGTGCTTTTTTTGCTATTGAAACTATTATGCCGAAGTTTGAATATACTCCTGAAAAAACTACAGTAGCAA
TACAAGGGTTTGGTAATGCCGGGGCGTTTTTAGCTGAGTTACTATGTCTTCATGGTTATAAGGTTGTTGCTGTTAGTGAT
TCTCAGGGAGGTATTTATTCTGCACAAGGTTTAGATATTCCAAGTATTCGTCAATATAAGGAAGTTAATAAACAGATACA
AGCAGTTTATTGCAAGGATAGTGTTTGCAATATTGTTGAGCATACAGTTTTGACTAATGAAGAACTTTTAGCTTTGGATG
TTGATATTTTAATTCCTGCTGCTTTGGAGAATCAAATTACTGAGGAAAATGTCAAAGATATTCAGGCAAAGTTTATTTTT
GAAGCTGCTAATGGTCCGACTACTTCTGGTGCAGATAAAATTTTAGAAGACCGTGGAGTTTATGTATTTCCTGATATTTT
GATAAATGCTGGTGGTGTGACTGTCAGTTATTTTGAGTGGGTACAAAATCGTAGTGGTTTGTATTGGACTTTGGATGAAG
TTAATCAAAAATTGAAAGCAAAAATGGTCGCAGAAACAGAGAATATTTGGCAAATATCTCAGGAGTTATCTATTTCTATG
CGAACTGCTGCTTATGTGCATGGTTTAGATAGATTAGGACAAGCAATTAATGCTAAAGGAACTAGAGCTTTTTATGCCAA
AAGGTAG

Upstream 100 bases:

>100_bases
TCCAGGTAAAAAAAGCACTTGCCAATATCAGTCAATGCTTTAAAAGTTAATCAGCAAGCCCTAAATACCAACATAATTTT
ATTTATAGAAAGAGGTATTG

Downstream 100 bases:

>100_bases
TTCAGTTATTAGTTATGAGTTCAAAGTTTCTTGAATCTGCTATTTGTAAGTCATGGACTCTTTGGTTAATTAGGGCTTGC
TGATTAAATATAAAAGCATT

Product: glutamate dehydrogenase (NADP)

Products: NA

Alternate protein names: NADP-GDH [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSDSLFDDASRRLERALQYVSLSEDTKERLKYPKATLIVSIPVRMDDGSLRVFQGYRVRYDDTRGPTKGGIRYHPNVSID
EVKSLAFWMTFKCAVVSLPFGGAKGGITVNPKELSRMELERLSRGYIDAIADFIGPDTDIPAPDMYTNPMIMGWMMDEYS
IIRRQLSPAVITGKPVSIGGSLGRNTATAMGAFFAIETIMPKFEYTPEKTTVAIQGFGNAGAFLAELLCLHGYKVVAVSD
SQGGIYSAQGLDIPSIRQYKEVNKQIQAVYCKDSVCNIVEHTVLTNEELLALDVDILIPAALENQITEENVKDIQAKFIF
EAANGPTTSGADKILEDRGVYVFPDILINAGGVTVSYFEWVQNRSGLYWTLDEVNQKLKAKMVAETENIWQISQELSISM
RTAAYVHGLDRLGQAINAKGTRAFYAKR

Sequences:

>Translated_428_residues
MSDSLFDDASRRLERALQYVSLSEDTKERLKYPKATLIVSIPVRMDDGSLRVFQGYRVRYDDTRGPTKGGIRYHPNVSID
EVKSLAFWMTFKCAVVSLPFGGAKGGITVNPKELSRMELERLSRGYIDAIADFIGPDTDIPAPDMYTNPMIMGWMMDEYS
IIRRQLSPAVITGKPVSIGGSLGRNTATAMGAFFAIETIMPKFEYTPEKTTVAIQGFGNAGAFLAELLCLHGYKVVAVSD
SQGGIYSAQGLDIPSIRQYKEVNKQIQAVYCKDSVCNIVEHTVLTNEELLALDVDILIPAALENQITEENVKDIQAKFIF
EAANGPTTSGADKILEDRGVYVFPDILINAGGVTVSYFEWVQNRSGLYWTLDEVNQKLKAKMVAETENIWQISQELSISM
RTAAYVHGLDRLGQAINAKGTRAFYAKR
>Mature_427_residues
SDSLFDDASRRLERALQYVSLSEDTKERLKYPKATLIVSIPVRMDDGSLRVFQGYRVRYDDTRGPTKGGIRYHPNVSIDE
VKSLAFWMTFKCAVVSLPFGGAKGGITVNPKELSRMELERLSRGYIDAIADFIGPDTDIPAPDMYTNPMIMGWMMDEYSI
IRRQLSPAVITGKPVSIGGSLGRNTATAMGAFFAIETIMPKFEYTPEKTTVAIQGFGNAGAFLAELLCLHGYKVVAVSDS
QGGIYSAQGLDIPSIRQYKEVNKQIQAVYCKDSVCNIVEHTVLTNEELLALDVDILIPAALENQITEENVKDIQAKFIFE
AANGPTTSGADKILEDRGVYVFPDILINAGGVTVSYFEWVQNRSGLYWTLDEVNQKLKAKMVAETENIWQISQELSISMR
TAAYVHGLDRLGQAINAKGTRAFYAKR

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=341, Percent_Identity=43.6950146627566, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI4885281, Length=342, Percent_Identity=44.1520467836257, Blast_Score=266, Evalue=3e-71,
Organism=Escherichia coli, GI1788059, Length=377, Percent_Identity=30.2387267904509, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17544676, Length=374, Percent_Identity=38.7700534759358, Blast_Score=247, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6324951, Length=413, Percent_Identity=32.2033898305085, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319256, Length=423, Percent_Identity=30.7328605200946, Blast_Score=156, Evalue=6e-39,
Organism=Drosophila melanogaster, GI45549226, Length=381, Percent_Identity=39.6325459317585, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI45553475, Length=381, Percent_Identity=39.6325459317585, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24649283, Length=363, Percent_Identity=38.5674931129477, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24649460, Length=288, Percent_Identity=41.6666666666667, Blast_Score=215, Evalue=4e-56,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.4 [H]

Molecular weight: Translated: 47468; Mature: 47337

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSLFDDASRRLERALQYVSLSEDTKERLKYPKATLIVSIPVRMDDGSLRVFQGYRVRY
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEEEECCCCEEEEECEEEEE
DDTRGPTKGGIRYHPNVSIDEVKSLAFWMTFKCAVVSLPFGGAKGGITVNPKELSRMELE
CCCCCCCCCCEEECCCCCHHHHHHHHHHHEEEEEEEEECCCCCCCCEEECHHHHHHHHHH
RLSRGYIDAIADFIGPDTDIPAPDMYTNPMIMGWMMDEYSIIRRQLSPAVITGKPVSIGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCEEEECCCEECCC
SLGRNTATAMGAFFAIETIMPKFEYTPEKTTVAIQGFGNAGAFLAELLCLHGYKVVAVSD
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCEEEEEEEC
SQGGIYSAQGLDIPSIRQYKEVNKQIQAVYCKDSVCNIVEHTVLTNEELLALDVDILIPA
CCCCEEEECCCCCCHHHHHHHHHHHHEEEEECHHHHHHHHHHHCCCCCEEEEEEHEEECH
ALENQITEENVKDIQAKFIFEAANGPTTSGADKILEDRGVYVFPDILINAGGVTVSYFEW
HHHHHHHHHHHHHHEEEEEEEECCCCCCCCHHHHHHCCCCEEECHHEEECCCCEEHHHHH
VQNRSGLYWTLDEVNQKLKAKMVAETENIWQISQELSISMRTAAYVHGLDRLGQAINAKG
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TRAFYAKR
CEEEEECC
>Mature Secondary Structure 
SDSLFDDASRRLERALQYVSLSEDTKERLKYPKATLIVSIPVRMDDGSLRVFQGYRVRY
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEEEEEECCCCEEEEECEEEEE
DDTRGPTKGGIRYHPNVSIDEVKSLAFWMTFKCAVVSLPFGGAKGGITVNPKELSRMELE
CCCCCCCCCCEEECCCCCHHHHHHHHHHHEEEEEEEEECCCCCCCCEEECHHHHHHHHHH
RLSRGYIDAIADFIGPDTDIPAPDMYTNPMIMGWMMDEYSIIRRQLSPAVITGKPVSIGG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCEEEECCCEECCC
SLGRNTATAMGAFFAIETIMPKFEYTPEKTTVAIQGFGNAGAFLAELLCLHGYKVVAVSD
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCEEEEEEEC
SQGGIYSAQGLDIPSIRQYKEVNKQIQAVYCKDSVCNIVEHTVLTNEELLALDVDILIPA
CCCCEEEECCCCCCHHHHHHHHHHHHEEEEECHHHHHHHHHHHCCCCCEEEEEEHEEECH
ALENQITEENVKDIQAKFIFEAANGPTTSGADKILEDRGVYVFPDILINAGGVTVSYFEW
HHHHHHHHHHHHHHEEEEEEEECCCCCCCCHHHHHHCCCCEEECHHEEECCCCEEHHHHH
VQNRSGLYWTLDEVNQKLKAKMVAETENIWQISQELSISMRTAAYVHGLDRLGQAINAKG
HHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TRAFYAKR
CEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7787182; 8590279; 8905231 [H]