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The map label for this gene is ptrB [C]

Identifier: 113476697

GI number: 113476697

Start: 4820301

End: 4822412

Strand: Reverse

Name: ptrB [C]

Synonym: Tery_3157

Alternate gene names: 113476697

Gene position: 4822412-4820301 (Counterclockwise)

Preceding gene: 113476698

Following gene: 113476695

Centisome position: 62.22

GC content: 33.24

Gene sequence:

>2112_bases
ATGAAAGAGAAAAAACAACCTTTAACATATCCTATCACTGAGAAAACAGATACAGTAGAAAATTATCACGGTGTTGAAGT
TGCAGATCCTTATCGATGGTTAGAAGACCCTAACTTAGAAAAAACTAAAGAGTGGGTAAAATCTCAAAATGAAATTACTT
TTAACTATTTGGCAGAAATTTCCGAAGGAGAAACTATCAAAAAACGACTAACTAAAATCTGGGATTATGAAAAATATAGT
GTCCCATTTAAAGAAGGCGATCGCTACTTCTATTATAAAAATGATGGTTTACAAAATCAAAGTATATTATATACATTGCC
TACTCTAGATGCAGAACCAAAAGTTTTGATAGATCCTAACCAATTCTCAGAAGATGGAACAGTCGCTCTTTCAGGAATTG
CTATTAGTAAAGATGGCAAATATATCGCCTATGGTATTTCCAAGTCTGGTTCAGACTGGCAAGAATGGCGCATCAAAAAT
ATTGATACTGGAGAACATTTCCCGGATGTTTTGCAATGGATTAAATTCTATATACCAACTTGGAAAAATGATAATCAGGG
TCTGTTTTATAGTCGTTACGAACAACCAAAAGAAGGGAAGTTAAAAGATACTAACTATTTACATAAGGTTTACTATCATA
GTTTAGGAACTTCTCAAGATAATGATGTACTAATTTATGAAAAACCTGAACAAAAAGAATGGAGTTTTAATTGTCATGTC
ACAGAAGATAATAAGTATTTAATTATTACAGTTTGGCAAAGTACAGAACGCAAAAATCTAGTTTTTTATCAGGATTTAAG
TATACCAAATGCGCCAATAGTGGAACTTATTAGCGAATTTGAAGCTGAATACCTTTTGATAGATAATTATCAGAATATTT
TTTGGTTTTTCACAGATTTAAATGCTCCAAAAAGACGAGTTATTGCCATTGATATTAACAACCCTCCATCTCCTTCTTTA
GTGAGAGGAGAAAATCAAAATAAATGGCAAGAAATTATTCCTGAAGCTACAGATGCATTGCAAGGGATAGGAACACTTAA
TAATCAGTTTGTTACTTTCTATTTAAAAGATGCTCATACTCAGATAAAAATATTTAATCTTGATGGTTCCCCAGTCAGAA
ATGTAGAATTACCTGGCATTGGTTCAGTAGTTGGTTTTTATGGTAGACGTCACGACACAAGCACATTTTATAGTTATGTT
AGTTTCACAACTCCCTCAACTATTTATCATTACGATATGGTGAGTGGTGAAAGTAAAATTTATCGTCAGTCAAATGTAGA
TTTTAATCCTAATCAATTTGAAACAAAGCAAGTTTTTTATAGTAGTAAGGATGGTACAAGCATCCCCATGTTTATTACTC
ATAAAAAAGGTGTAAAACTAGATGGCAATAACCCAACTATTCTTTATGGATATGGAGGATTTAATATTTCTCTGACTCCT
AACTTTTCTATTAGTAGATTAATTTGGTTAGAGATGGGGGGAGTCTACGCAGTGCCCAATATTCGTGGAGGTGGAGAATA
TGGTGAAGGGTGGCATCAAGCAGGAATAAAACAACAAAAACAAAATGTATTTGATGATTTTATTAGTGCTGCTGAATGGT
TGATAGAAAATAATTGGTCTTCTTCTCCAAAGTTAGCTATTACTGGTGCTAGTAATGGTGGTTTATTAGTAGGTGCTTGT
ATAACTCAAAGACCAGAATTATTTGGTGCTGCTTTACCCGCAGTAGGAGTAATGGATATGTTACGTTTCCATAAATTTAC
TATTGGTTGGGCATGGACTGCTGAGTATGGTTCCCCAGATGATCCCGAAGAATTTAAAGCTTTATATGCTTATTCTCCTC
TACATAATTTAAAGCCAAAAACATCTTATCCTCCAACTTTTATTACTACTGCTGACCATGATGATCGGGTTGTTCCAGCT
CATAGTTTTAAGTTTATTTCTACCTTACAAGAAGTTCATATAGGAGATCATCCAGTGTTAATTAGAATTGAAACTAAAGC
AGGTCATGGAGCCGGAAAACCTACTACGAAAATAATTGCAGAAATTACAGATGAATTTGCTTTTTTGCTGAGAAACCTTA
AGATAGAATTACCTGAAAATTTTGGTAATTAA

Upstream 100 bases:

>100_bases
TTTAGCATTTTAGCGAGAATGTCAAAGCTAAATTTATAAAAAACTTGATCAAAGGTAAATTTACTTCTAAGATTAAACTA
ATCATTCACTATTCAATAAT

Downstream 100 bases:

>100_bases
TTTAAGTAAAATATAGTTGAATTAGGAGTGTTTTATTGAATTTTACTTGGGTTCTAACTGCTAAAAATAAAGAGCTAATT
CATAAACAAAATATTAAACT

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 703; Mature: 703

Protein sequence:

>703_residues
MKEKKQPLTYPITEKTDTVENYHGVEVADPYRWLEDPNLEKTKEWVKSQNEITFNYLAEISEGETIKKRLTKIWDYEKYS
VPFKEGDRYFYYKNDGLQNQSILYTLPTLDAEPKVLIDPNQFSEDGTVALSGIAISKDGKYIAYGISKSGSDWQEWRIKN
IDTGEHFPDVLQWIKFYIPTWKNDNQGLFYSRYEQPKEGKLKDTNYLHKVYYHSLGTSQDNDVLIYEKPEQKEWSFNCHV
TEDNKYLIITVWQSTERKNLVFYQDLSIPNAPIVELISEFEAEYLLIDNYQNIFWFFTDLNAPKRRVIAIDINNPPSPSL
VRGENQNKWQEIIPEATDALQGIGTLNNQFVTFYLKDAHTQIKIFNLDGSPVRNVELPGIGSVVGFYGRRHDTSTFYSYV
SFTTPSTIYHYDMVSGESKIYRQSNVDFNPNQFETKQVFYSSKDGTSIPMFITHKKGVKLDGNNPTILYGYGGFNISLTP
NFSISRLIWLEMGGVYAVPNIRGGGEYGEGWHQAGIKQQKQNVFDDFISAAEWLIENNWSSSPKLAITGASNGGLLVGAC
ITQRPELFGAALPAVGVMDMLRFHKFTIGWAWTAEYGSPDDPEEFKALYAYSPLHNLKPKTSYPPTFITTADHDDRVVPA
HSFKFISTLQEVHIGDHPVLIRIETKAGHGAGKPTTKIIAEITDEFAFLLRNLKIELPENFGN

Sequences:

>Translated_703_residues
MKEKKQPLTYPITEKTDTVENYHGVEVADPYRWLEDPNLEKTKEWVKSQNEITFNYLAEISEGETIKKRLTKIWDYEKYS
VPFKEGDRYFYYKNDGLQNQSILYTLPTLDAEPKVLIDPNQFSEDGTVALSGIAISKDGKYIAYGISKSGSDWQEWRIKN
IDTGEHFPDVLQWIKFYIPTWKNDNQGLFYSRYEQPKEGKLKDTNYLHKVYYHSLGTSQDNDVLIYEKPEQKEWSFNCHV
TEDNKYLIITVWQSTERKNLVFYQDLSIPNAPIVELISEFEAEYLLIDNYQNIFWFFTDLNAPKRRVIAIDINNPPSPSL
VRGENQNKWQEIIPEATDALQGIGTLNNQFVTFYLKDAHTQIKIFNLDGSPVRNVELPGIGSVVGFYGRRHDTSTFYSYV
SFTTPSTIYHYDMVSGESKIYRQSNVDFNPNQFETKQVFYSSKDGTSIPMFITHKKGVKLDGNNPTILYGYGGFNISLTP
NFSISRLIWLEMGGVYAVPNIRGGGEYGEGWHQAGIKQQKQNVFDDFISAAEWLIENNWSSSPKLAITGASNGGLLVGAC
ITQRPELFGAALPAVGVMDMLRFHKFTIGWAWTAEYGSPDDPEEFKALYAYSPLHNLKPKTSYPPTFITTADHDDRVVPA
HSFKFISTLQEVHIGDHPVLIRIETKAGHGAGKPTTKIIAEITDEFAFLLRNLKIELPENFGN
>Mature_703_residues
MKEKKQPLTYPITEKTDTVENYHGVEVADPYRWLEDPNLEKTKEWVKSQNEITFNYLAEISEGETIKKRLTKIWDYEKYS
VPFKEGDRYFYYKNDGLQNQSILYTLPTLDAEPKVLIDPNQFSEDGTVALSGIAISKDGKYIAYGISKSGSDWQEWRIKN
IDTGEHFPDVLQWIKFYIPTWKNDNQGLFYSRYEQPKEGKLKDTNYLHKVYYHSLGTSQDNDVLIYEKPEQKEWSFNCHV
TEDNKYLIITVWQSTERKNLVFYQDLSIPNAPIVELISEFEAEYLLIDNYQNIFWFFTDLNAPKRRVIAIDINNPPSPSL
VRGENQNKWQEIIPEATDALQGIGTLNNQFVTFYLKDAHTQIKIFNLDGSPVRNVELPGIGSVVGFYGRRHDTSTFYSYV
SFTTPSTIYHYDMVSGESKIYRQSNVDFNPNQFETKQVFYSSKDGTSIPMFITHKKGVKLDGNNPTILYGYGGFNISLTP
NFSISRLIWLEMGGVYAVPNIRGGGEYGEGWHQAGIKQQKQNVFDDFISAAEWLIENNWSSSPKLAITGASNGGLLVGAC
ITQRPELFGAALPAVGVMDMLRFHKFTIGWAWTAEYGSPDDPEEFKALYAYSPLHNLKPKTSYPPTFITTADHDDRVVPA
HSFKFISTLQEVHIGDHPVLIRIETKAGHGAGKPTTKIIAEITDEFAFLLRNLKIELPENFGN

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=714, Percent_Identity=45.6582633053221, Blast_Score=645, Evalue=0.0,
Organism=Homo sapiens, GI284172420, Length=579, Percent_Identity=21.7616580310881, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI284172413, Length=579, Percent_Identity=21.7616580310881, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI70778815, Length=579, Percent_Identity=21.7616580310881, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI284172438, Length=576, Percent_Identity=21.3541666666667, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI284172431, Length=576, Percent_Identity=21.3541666666667, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI108860686, Length=256, Percent_Identity=27.734375, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI108860692, Length=257, Percent_Identity=27.6264591439689, Blast_Score=97, Evalue=6e-20,
Organism=Escherichia coli, GI1788150, Length=693, Percent_Identity=26.1183261183261, Blast_Score=231, Evalue=8e-62,
Organism=Drosophila melanogaster, GI24583414, Length=719, Percent_Identity=44.923504867872, Blast_Score=610, Evalue=1e-175,
Organism=Drosophila melanogaster, GI221510989, Length=728, Percent_Identity=42.3076923076923, Blast_Score=563, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 80460; Mature: 80460

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKKQPLTYPITEKTDTVENYHGVEVADPYRWLEDPNLEKTKEWVKSQNEITFNYLAEI
CCCCCCCCCCCCCCCCCCHHCCCCCEECCCHHHCCCCCHHHHHHHHHCCCCEEEEEEEEC
SEGETIKKRLTKIWDYEKYSVPFKEGDRYFYYKNDGLQNQSILYTLPTLDAEPKVLIDPN
CCCHHHHHHHHHHHCCCCEECCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEECCC
QFSEDGTVALSGIAISKDGKYIAYGISKSGSDWQEWRIKNIDTGEHFPDVLQWIKFYIPT
CCCCCCCEEEEEEEEECCCCEEEEEECCCCCCHHHEEECCCCCCCCHHHHHHHHHHHCCC
WKNDNQGLFYSRYEQPKEGKLKDTNYLHKVYYHSLGTSQDNDVLIYEKPEQKEWSFNCHV
CCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEE
TEDNKYLIITVWQSTERKNLVFYQDLSIPNAPIVELISEFEAEYLLIDNYQNIFWFFTDL
ECCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCEEEEEEEEC
NAPKRRVIAIDINNPPSPSLVRGENQNKWQEIIPEATDALQGIGTLNNQFVTFYLKDAHT
CCCCEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
QIKIFNLDGSPVRNVELPGIGSVVGFYGRRHDTSTFYSYVSFTTPSTIYHYDMVSGESKI
EEEEEECCCCCCCEEECCCCHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCE
YRQSNVDFNPNQFETKQVFYSSKDGTSIPMFITHKKGVKLDGNNPTILYGYGGFNISLTP
EECCCCCCCCCCEEEEEEEEECCCCCCCCEEEEECCCEEECCCCCEEEEEECCEEEEECC
NFSISRLIWLEMGGVYAVPNIRGGGEYGEGWHQAGIKQQKQNVFDDFISAAEWLIENNWS
CCCEEEEEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SSPKLAITGASNGGLLVGACITQRPELFGAALPAVGVMDMLRFHKFTIGWAWTAEYGSPD
CCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCC
DPEEFKALYAYSPLHNLKPKTSYPPTFITTADHDDRVVPAHSFKFISTLQEVHIGDHPVL
CHHHHHEEEEECCHHCCCCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHHCCCCCCEE
IRIETKAGHGAGKPTTKIIAEITDEFAFLLRNLKIELPENFGN
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCEEECCCCCCC
>Mature Secondary Structure
MKEKKQPLTYPITEKTDTVENYHGVEVADPYRWLEDPNLEKTKEWVKSQNEITFNYLAEI
CCCCCCCCCCCCCCCCCCHHCCCCCEECCCHHHCCCCCHHHHHHHHHCCCCEEEEEEEEC
SEGETIKKRLTKIWDYEKYSVPFKEGDRYFYYKNDGLQNQSILYTLPTLDAEPKVLIDPN
CCCHHHHHHHHHHHCCCCEECCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEECCC
QFSEDGTVALSGIAISKDGKYIAYGISKSGSDWQEWRIKNIDTGEHFPDVLQWIKFYIPT
CCCCCCCEEEEEEEEECCCCEEEEEECCCCCCHHHEEECCCCCCCCHHHHHHHHHHHCCC
WKNDNQGLFYSRYEQPKEGKLKDTNYLHKVYYHSLGTSQDNDVLIYEKPEQKEWSFNCHV
CCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEE
TEDNKYLIITVWQSTERKNLVFYQDLSIPNAPIVELISEFEAEYLLIDNYQNIFWFFTDL
ECCCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCEEEEEEEEC
NAPKRRVIAIDINNPPSPSLVRGENQNKWQEIIPEATDALQGIGTLNNQFVTFYLKDAHT
CCCCEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
QIKIFNLDGSPVRNVELPGIGSVVGFYGRRHDTSTFYSYVSFTTPSTIYHYDMVSGESKI
EEEEEECCCCCCCEEECCCCHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCE
YRQSNVDFNPNQFETKQVFYSSKDGTSIPMFITHKKGVKLDGNNPTILYGYGGFNISLTP
EECCCCCCCCCCEEEEEEEEECCCCCCCCEEEEECCCEEECCCCCEEEEEECCEEEEECC
NFSISRLIWLEMGGVYAVPNIRGGGEYGEGWHQAGIKQQKQNVFDDFISAAEWLIENNWS
CCCEEEEEEEECCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SSPKLAITGASNGGLLVGACITQRPELFGAALPAVGVMDMLRFHKFTIGWAWTAEYGSPD
CCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCC
DPEEFKALYAYSPLHNLKPKTSYPPTFITTADHDDRVVPAHSFKFISTLQEVHIGDHPVL
CHHHHHEEEEECCHHCCCCCCCCCCEEEEECCCCCCEECCCCHHHHHHHHHHCCCCCCEE
IRIETKAGHGAGKPTTKIIAEITDEFAFLLRNLKIELPENFGN
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]