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The map label for this gene is tcmN [H]

Identifier: 113476665

GI number: 113476665

Start: 4777278

End: 4778384

Strand: Reverse

Name: tcmN [H]

Synonym: Tery_3121

Alternate gene names: 113476665

Gene position: 4778384-4777278 (Counterclockwise)

Preceding gene: 113476666

Following gene: 113476664

Centisome position: 61.66

GC content: 29.63

Gene sequence:

>1107_bases
ATGATGAAAAAGATAGAAATTTCTTCTCATAATGTTCATACAGATTTACAAACGTTGCAGTTAATTAATAGTAATCAAGA
CTCCTTAAAAATGGATGATTTAGTCTTGCTATTACATGGCCACTTAGCATTTCAAAATCTTTATGCTGGTTGTGAACTTG
GTGTATTTGAATTACTATTCAATCAAGGAGATTTATCAGCTCTAGAAATTAGTACAAAATTAAAACTTGAAGATTATCCT
ACTAAAGCTTTATTGTTAGCTTTAACAGGATTAAAATTACTAATAAAAGTTGAAAATAAATATCATAATAGTCTAGTAAT
TCAGATGTTATTCCTGGAAAAAACTTGGCAAGAATTTTATGATGTAGTTCTTTTTGAAGCAAAAATTGTATATCGTGGTT
GTATAGATTATGTAGAATCTTTACGTCAAAATACAAACGTTGGTTTACGTCGGTTTGAAGGCAAAGGAGAAGATTTATAT
AATCGTTTACATCAAAATACAGGACTAGACCAAGTATTTTATAACTTTATGGGTTCATGGTCAAAATTAGTTAATCCTTT
ACTATTTGAAAATGTTGACTTTTCTAACTTCAAAAATATTGTAGATGTTGGTGGTGGAGACGCAACAAATTCAATAGCTT
TAGCCAAAGCTTTTCCCGATGTAAATATTACATTGATGGATATTCCTGATAGTTGTAAAATTGCTCAAAAAAATATTGAA
CAAAACCAATTAAGTGACAGAATAACAGTATTTAAATCTAATATTTTTGTAGATGAATTTCTTCAAAATCAAGATTGTTT
TCTCTTTATTCATGTCTTAGTAATTTGGTCATTAGATAAAAATACCATTTTATTACGACGAGCTTATGAAGCACTTAACC
CCGGTGGCTCTGTTGTTATTTTTAACATGATGAGTAATGATTATGAAGATGGACCCTTGATGGGAGCCTTAGATTCATCT
TACTTTGTTTCTATTCCTCATGAGGGTGGTATGATTTACTCTTGGAAAGATCATGAGCAATGTTTAAAAGATGCAGGATT
TACAAAAATAAAACGTATTCCCTGTAATTTTTGGGCTCCTAGTGGAATTATTGTAGCTACTAAATAA

Upstream 100 bases:

>100_bases
GCATAAAAGAAAGGGTTATTATTGTTCATATCTGACAGCTAATAGCTGATTGCTTACAAAAAATTAATTTACCAATAACA
AAATCAACAAGGATAATTTG

Downstream 100 bases:

>100_bases
ATACTAGTATCCGCTCAATAAATTGGGGAAAGAAGAGAAAAAGTACACCTAGTGTTGTAAAATATGACTCATGAGGCAAA
AACTATCATCAGAGAAATTA

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MMKKIEISSHNVHTDLQTLQLINSNQDSLKMDDLVLLLHGHLAFQNLYAGCELGVFELLFNQGDLSALEISTKLKLEDYP
TKALLLALTGLKLLIKVENKYHNSLVIQMLFLEKTWQEFYDVVLFEAKIVYRGCIDYVESLRQNTNVGLRRFEGKGEDLY
NRLHQNTGLDQVFYNFMGSWSKLVNPLLFENVDFSNFKNIVDVGGGDATNSIALAKAFPDVNITLMDIPDSCKIAQKNIE
QNQLSDRITVFKSNIFVDEFLQNQDCFLFIHVLVIWSLDKNTILLRRAYEALNPGGSVVIFNMMSNDYEDGPLMGALDSS
YFVSIPHEGGMIYSWKDHEQCLKDAGFTKIKRIPCNFWAPSGIIVATK

Sequences:

>Translated_368_residues
MMKKIEISSHNVHTDLQTLQLINSNQDSLKMDDLVLLLHGHLAFQNLYAGCELGVFELLFNQGDLSALEISTKLKLEDYP
TKALLLALTGLKLLIKVENKYHNSLVIQMLFLEKTWQEFYDVVLFEAKIVYRGCIDYVESLRQNTNVGLRRFEGKGEDLY
NRLHQNTGLDQVFYNFMGSWSKLVNPLLFENVDFSNFKNIVDVGGGDATNSIALAKAFPDVNITLMDIPDSCKIAQKNIE
QNQLSDRITVFKSNIFVDEFLQNQDCFLFIHVLVIWSLDKNTILLRRAYEALNPGGSVVIFNMMSNDYEDGPLMGALDSS
YFVSIPHEGGMIYSWKDHEQCLKDAGFTKIKRIPCNFWAPSGIIVATK
>Mature_368_residues
MMKKIEISSHNVHTDLQTLQLINSNQDSLKMDDLVLLLHGHLAFQNLYAGCELGVFELLFNQGDLSALEISTKLKLEDYP
TKALLLALTGLKLLIKVENKYHNSLVIQMLFLEKTWQEFYDVVLFEAKIVYRGCIDYVESLRQNTNVGLRRFEGKGEDLY
NRLHQNTGLDQVFYNFMGSWSKLVNPLLFENVDFSNFKNIVDVGGGDATNSIALAKAFPDVNITLMDIPDSCKIAQKNIE
QNQLSDRITVFKSNIFVDEFLQNQDCFLFIHVLVIWSLDKNTILLRRAYEALNPGGSVVIFNMMSNDYEDGPLMGALDSS
YFVSIPHEGGMIYSWKDHEQCLKDAGFTKIKRIPCNFWAPSGIIVATK

Specific function: The N-terminal domain enhances the formation of an early, partially cyclized intermediate, while the C-terminal domain catalyzes the 3-O-methylation of one or more later intermediates in the biosynthetic pathway. Catalyzes the methylation of tetracenomyci

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI291045181, Length=273, Percent_Identity=23.4432234432234, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI291045183, Length=273, Percent_Identity=23.4432234432234, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI117553627, Length=273, Percent_Identity=23.4432234432234, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI283549144, Length=317, Percent_Identity=24.2902208201893, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI157168360, Length=317, Percent_Identity=24.2902208201893, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001077
- InterPro:   IPR005031
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00891 Methyltransf_2; PF03364 Polyketide_cyc [H]

EC number: NA

Molecular weight: Translated: 41876; Mature: 41876

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKIEISSHNVHTDLQTLQLINSNQDSLKMDDLVLLLHGHLAFQNLYAGCELGVFELLF
CCEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHEEEEHHHHHHHHHHHCCCCHHHHHHHH
NQGDLSALEISTKLKLEDYPTKALLLALTGLKLLIKVENKYHNSLVIQMLFLEKTWQEFY
CCCCCEEEEEEEEEEECCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHH
DVVLFEAKIVYRGCIDYVESLRQNTNVGLRRFEGKGEDLYNRLHQNTGLDQVFYNFMGSW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCH
SKLVNPLLFENVDFSNFKNIVDVGGGDATNSIALAKAFPDVNITLMDIPDSCKIAQKNIE
HHHCCHHHHCCCCHHHCCHHEECCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHCCH
QNQLSDRITVFKSNIFVDEFLQNQDCFLFIHVLVIWSLDKNTILLRRAYEALNPGGSVVI
HHHHHHHHEEHHHHCHHHHHHCCCCHHHHEEEHHHHCCCCCEEHHHHHHHHHCCCCCEEE
FNMMSNDYEDGPLMGALDSSYFVSIPHEGGMIYSWKDHEQCLKDAGFTKIKRIPCNFWAP
EEECCCCCCCCCEEEECCCCEEEEECCCCCEEEEECCHHHHHHHCCCCEEEECCCCCCCC
SGIIVATK
CCEEEEEC
>Mature Secondary Structure
MMKKIEISSHNVHTDLQTLQLINSNQDSLKMDDLVLLLHGHLAFQNLYAGCELGVFELLF
CCEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHEEEEHHHHHHHHHHHCCCCHHHHHHHH
NQGDLSALEISTKLKLEDYPTKALLLALTGLKLLIKVENKYHNSLVIQMLFLEKTWQEFY
CCCCCEEEEEEEEEEECCCCHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHH
DVVLFEAKIVYRGCIDYVESLRQNTNVGLRRFEGKGEDLYNRLHQNTGLDQVFYNFMGSW
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCH
SKLVNPLLFENVDFSNFKNIVDVGGGDATNSIALAKAFPDVNITLMDIPDSCKIAQKNIE
HHHCCHHHHCCCCHHHCCHHEECCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHHCCH
QNQLSDRITVFKSNIFVDEFLQNQDCFLFIHVLVIWSLDKNTILLRRAYEALNPGGSVVI
HHHHHHHHEEHHHHCHHHHHHCCCCHHHHEEEHHHHCCCCCEEHHHHHHHHHCCCCCEEE
FNMMSNDYEDGPLMGALDSSYFVSIPHEGGMIYSWKDHEQCLKDAGFTKIKRIPCNFWAP
EEECCCCCCCCCEEEECCCCEEEEECCCCCEEEEECCHHHHHHHCCCCEEEECCCCCCCC
SGIIVATK
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1548230; 2684656 [H]