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The map label for this gene is thyX [H]

Identifier: 113475735

GI number: 113475735

Start: 3249986

End: 3251362

Strand: Direct

Name: thyX [H]

Synonym: Tery_2082

Alternate gene names: 113475735

Gene position: 3249986-3251362 (Clockwise)

Preceding gene: 113475733

Following gene: 113475736

Centisome position: 41.93

GC content: 30.94

Gene sequence:

>1377_bases
ATGCAGCAAGCAAGAACTCATAGAATAGGTTGCTGTTTGTCGGGCAATACAAAAGTTAGATTTAGGTATTCGTCTTCATC
CCAAGAAGCGAAATATTATGAGGAAACAATTGAAAAATTAGCTAACTTATGGCATTACGGGAGCAAAAATCAATATACTT
CTAAAGATGCAAAATGTATGCAAGAAAATATATCTAGCCGTAATATTTTTACTCTAGATACCCAAACTAACCAAATTGTT
TCTAGCAAAATTACCAACATATATATTAATGGTGAAAAAGAAACTTACACAATAAAAACTGTTTCTGGTAAGGAAATAAG
AGCTACCCTAGAACACCAGTTTTGGACTAACCAAGGGTGGAAACGATTAAAAGATTTTAATAACAGCACTCAATTATGTG
AAGTGCAATTAGCTGGAAATAAAGTTACTCCACAAGAAGTTAAATTTCTCGAAAAAGAAATGTTTAATGAAAAGTGGATC
CCAGTAAGAAATTATGACGGATATAAAATTTATAGCTTAGATATTTTGAATTCTTACCTTATTCAAAAAGAGAATAAAGA
GCATTCACGGAGCAAATCTAAAAATTGTTTACTTCCCAATTTAAATTATGGAATTAGGTATGATCGACTTTCAGAAGTAA
ATATAAATAGATTAGTAATGGAAAACTTGAAATTATTAGGAGAATACAAGGAACTTGAAGTCAGACATTTAAATGAGAAT
AGTTTTAACAACAAGCCAAAAAAATTTGCCTGGAATTCTAGCAAAAGCGACCAAATTGACAATATCAATAACAATAGTTT
CTCTGATAATTCTGGTGTTTTTGTAGAGATAGAATCTATTGAAAAATTTGGCAAAGAAATTACTTATGATCTTGAAGTCG
AACACCCAGAACATAATTTTATAGCCAATGGTTTAGTTGTTCATAATTCTTTCGATGTACAAAGTTATCGGTTTTGTTCG
GGAAAAGTTATTGCAGTAGCAGATGGAAAAACTGATATAGAAACTGCTTTTTACTTACGTCCAGTCGGAGAATATTCTGA
CCGCAAAGGTAAAAAATATTATTATTCCGCCGAACAACGAGAAAAAGATTTATATTGGTGTTTAGAAGCAGCTAAGAAAT
ACAAACTTGATATGGAACTTGGAATGTCTGAAGAACATGCCAGAGGAAAAATTCCTTTTGATTATCGTCAGCATTTTGTT
GTCAGTTTTAATTGTCGTAGTTTGCTACATTTTTTAGATTTACGTTTTAAAAAGAATGCTCAATTAGAAATTCAAAAACT
TTGTGAATTAATGTGGCCTCATTTTCAAGATTGGGTTCCCAATATAGCAGAATGGTATGAAAAAAATAGACTTAAAAAAG
GCAAATTAGCACCTTAA

Upstream 100 bases:

>100_bases
TCACGTCCGGTTCTGAAGACAAGTCGGATCAGGTAACTTATCTGGCTTAGTTTAACACCCTCAAATTACTTTTAATTGTG
GATTTTTTCCCCATAGTGTT

Downstream 100 bases:

>100_bases
AAACAACCCTAAAAATAACTGATAAATGATAACTAAAATCACACATTTTTCAACGATAATCTAAAATCAACGAAACTCCC
TATTCTCAATAAACTCCCTA

Product: thymidylate synthase, flavin-dependent

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MQQARTHRIGCCLSGNTKVRFRYSSSSQEAKYYEETIEKLANLWHYGSKNQYTSKDAKCMQENISSRNIFTLDTQTNQIV
SSKITNIYINGEKETYTIKTVSGKEIRATLEHQFWTNQGWKRLKDFNNSTQLCEVQLAGNKVTPQEVKFLEKEMFNEKWI
PVRNYDGYKIYSLDILNSYLIQKENKEHSRSKSKNCLLPNLNYGIRYDRLSEVNINRLVMENLKLLGEYKELEVRHLNEN
SFNNKPKKFAWNSSKSDQIDNINNNSFSDNSGVFVEIESIEKFGKEITYDLEVEHPEHNFIANGLVVHNSFDVQSYRFCS
GKVIAVADGKTDIETAFYLRPVGEYSDRKGKKYYYSAEQREKDLYWCLEAAKKYKLDMELGMSEEHARGKIPFDYRQHFV
VSFNCRSLLHFLDLRFKKNAQLEIQKLCELMWPHFQDWVPNIAEWYEKNRLKKGKLAP

Sequences:

>Translated_458_residues
MQQARTHRIGCCLSGNTKVRFRYSSSSQEAKYYEETIEKLANLWHYGSKNQYTSKDAKCMQENISSRNIFTLDTQTNQIV
SSKITNIYINGEKETYTIKTVSGKEIRATLEHQFWTNQGWKRLKDFNNSTQLCEVQLAGNKVTPQEVKFLEKEMFNEKWI
PVRNYDGYKIYSLDILNSYLIQKENKEHSRSKSKNCLLPNLNYGIRYDRLSEVNINRLVMENLKLLGEYKELEVRHLNEN
SFNNKPKKFAWNSSKSDQIDNINNNSFSDNSGVFVEIESIEKFGKEITYDLEVEHPEHNFIANGLVVHNSFDVQSYRFCS
GKVIAVADGKTDIETAFYLRPVGEYSDRKGKKYYYSAEQREKDLYWCLEAAKKYKLDMELGMSEEHARGKIPFDYRQHFV
VSFNCRSLLHFLDLRFKKNAQLEIQKLCELMWPHFQDWVPNIAEWYEKNRLKKGKLAP
>Mature_458_residues
MQQARTHRIGCCLSGNTKVRFRYSSSSQEAKYYEETIEKLANLWHYGSKNQYTSKDAKCMQENISSRNIFTLDTQTNQIV
SSKITNIYINGEKETYTIKTVSGKEIRATLEHQFWTNQGWKRLKDFNNSTQLCEVQLAGNKVTPQEVKFLEKEMFNEKWI
PVRNYDGYKIYSLDILNSYLIQKENKEHSRSKSKNCLLPNLNYGIRYDRLSEVNINRLVMENLKLLGEYKELEVRHLNEN
SFNNKPKKFAWNSSKSDQIDNINNNSFSDNSGVFVEIESIEKFGKEITYDLEVEHPEHNFIANGLVVHNSFDVQSYRFCS
GKVIAVADGKTDIETAFYLRPVGEYSDRKGKKYYYSAEQREKDLYWCLEAAKKYKLDMELGMSEEHARGKIPFDYRQHFV
VSFNCRSLLHFLDLRFKKNAQLEIQKLCELMWPHFQDWVPNIAEWYEKNRLKKGKLAP

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 53978; Mature: 53978

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS50817 INTEIN_N_TER ; PS50818 INTEIN_C_TER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQARTHRIGCCLSGNTKVRFRYSSSSQEAKYYEETIEKLANLWHYGSKNQYTSKDAKCM
CCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
QENISSRNIFTLDTQTNQIVSSKITNIYINGEKETYTIKTVSGKEIRATLEHQFWTNQGW
HHCCCCCCEEEEECCCHHHHHCCCEEEEECCCCEEEEEEEECCCHHHHHHHHHHHCCCHH
KRLKDFNNSTQLCEVQLAGNKVTPQEVKFLEKEMFNEKWIPVRNYDGYKIYSLDILNSYL
HHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEECCCCCEEEEEEHHHHHHH
IQKENKEHSRSKSKNCLLPNLNYGIRYDRLSEVNINRLVMENLKLLGEYKELEVRHLNEN
HCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCHHHEEEEECCCC
SFNNKPKKFAWNSSKSDQIDNINNNSFSDNSGVFVEIESIEKFGKEITYDLEVEHPEHNF
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCEEEEEEECCCCCCE
IANGLVVHNSFDVQSYRFCSGKVIAVADGKTDIETAFYLRPVGEYSDRKGKKYYYSAEQR
EECCEEEECCCCCCEEEECCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEECCHHH
EKDLYWCLEAAKKYKLDMELGMSEEHARGKIPFDYRQHFVVSFNCRSLLHFLDLRFKKNA
CHHHHHHHHHHHHEEEEEECCCCCHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCC
QLEIQKLCELMWPHFQDWVPNIAEWYEKNRLKKGKLAP
CCHHHHHHHHHCCCHHHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQQARTHRIGCCLSGNTKVRFRYSSSSQEAKYYEETIEKLANLWHYGSKNQYTSKDAKCM
CCCCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
QENISSRNIFTLDTQTNQIVSSKITNIYINGEKETYTIKTVSGKEIRATLEHQFWTNQGW
HHCCCCCCEEEEECCCHHHHHCCCEEEEECCCCEEEEEEEECCCHHHHHHHHHHHCCCHH
KRLKDFNNSTQLCEVQLAGNKVTPQEVKFLEKEMFNEKWIPVRNYDGYKIYSLDILNSYL
HHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCEECCCCCEEEEEEHHHHHHH
IQKENKEHSRSKSKNCLLPNLNYGIRYDRLSEVNINRLVMENLKLLGEYKELEVRHLNEN
HCCCCCHHHHHCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHCCHHHEEEEECCCC
SFNNKPKKFAWNSSKSDQIDNINNNSFSDNSGVFVEIESIEKFGKEITYDLEVEHPEHNF
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCCEEEEEEECCCCCCE
IANGLVVHNSFDVQSYRFCSGKVIAVADGKTDIETAFYLRPVGEYSDRKGKKYYYSAEQR
EECCEEEECCCCCCEEEECCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCEEEECCHHH
EKDLYWCLEAAKKYKLDMELGMSEEHARGKIPFDYRQHFVVSFNCRSLLHFLDLRFKKNA
CHHHHHHHHHHHHEEEEEECCCCCHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHCCCCC
QLEIQKLCELMWPHFQDWVPNIAEWYEKNRLKKGKLAP
CCHHHHHHHHHCCCHHHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA