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The map label for this gene is pyrD

Identifier: 113475667

GI number: 113475667

Start: 3127156

End: 3128292

Strand: Direct

Name: pyrD

Synonym: Tery_2007

Alternate gene names: 113475667

Gene position: 3127156-3128292 (Clockwise)

Preceding gene: 113475665

Following gene: 113475668

Centisome position: 40.35

GC content: 33.51

Gene sequence:

>1137_bases
GTGTTAAATATTTATCGTTCCGTCCTATTTCCTATTATATTTTCCGGTTTAAAAGCCGATCCAGAATGGGCACATCATCA
AGTCCTAAATATGCTCAGTTTTATAGATACTCACTCCGACTCTCAACTAGTAAATAGTATTAGGACAACAATGGAAAAAT
TATTCTGTTTTAAAGACACTCGTCTAGAGCAAAACTTATGGGAATTAAACTTTAAAAACCCAGTAGGTTTAGCCCCAGGA
TATGATAAAGATGGTCAGGCAATTAATATGTGGCCTCAACTAGGTTTTGGGTTTGCTGAACTTGGTACAGTTACCTTCCA
TCAACAACCAGGAAATGCGCAACCAAGATTATTCCGCTTACCAAAAGATAAAGCCGTCTTAAACAGAATGGGATTTAATA
ATAAAGGAGCTGCCGCCTTAGCTAAGAAATTCCAAATTCAAAACAAAAAAAATTCTTTTTTCTTTCCTTATGGAGTAAAT
ATTGGTAAATCTAAAATCACCCCTTTAGAAGCAGCAGCAACAGATTATTTAGAAAGTTTTAGACTATTAAAAAATTGTGG
AGATTATTTTGTAGTAAATGTATCTTCTCCTAATACCCCAGGGTTACGTTCCCTGCAAAACACTGATAGTTTAAGTAAAA
TTTTAGAAGTTTTGCCAAGAGAAAATGAAAGAAAAAAGCCTATTTTAGTTAAGATTGCACCAGATTTAGAAAATGAAGCG
ATCGCCGCCATAATAGACCTAATTAAAGAATATAAAATATCTGGTATAATTGCTACAAACACAACTATTAATCGTGAAAA
ATTAACAACTAAAATACTTCCAGCAACAGGCAAACCTATTATAGAAGAAGCAGGTGGAATTAGTGGCAAACCATTAACCA
AAAGATCAACAGAAATAATTAAATTTATCTGGCAAGAAACAAAAGGAAAATTACCAATTATTGGGGTAGGTGGTATATTC
ACTTCAGAAGATGCCTGGAATAAAATTACTGCTGGTGCCAGTTTAATTCAAATTTATACAGGATTAGTTTATCAAGGACC
AGGAATAGTCAAACAAATTCTCCAAGGATTACTAAAAAAGCTAGATGAACATGGATTAAACTCCATTTCCGAAGCTGTTG
GTCTAGCAAACAAATAA

Upstream 100 bases:

>100_bases
AACCGACAAACCTTTCCATAAAACTTTAATTATTACATCCCTATTTCCCAACCTCACTAAAATACCTTTTTTGTCAACCC
TAACTACCATTAAAAATAAA

Downstream 100 bases:

>100_bases
GTTATCAATAAAAATATCTAGAAAGTATTTATTCTAGAATTAATTATTATCTATGTTTTCTAAATTTTTTTCACTTAATC
AACCCTTAAATTTGTGGATT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MLNIYRSVLFPIIFSGLKADPEWAHHQVLNMLSFIDTHSDSQLVNSIRTTMEKLFCFKDTRLEQNLWELNFKNPVGLAPG
YDKDGQAINMWPQLGFGFAELGTVTFHQQPGNAQPRLFRLPKDKAVLNRMGFNNKGAAALAKKFQIQNKKNSFFFPYGVN
IGKSKITPLEAAATDYLESFRLLKNCGDYFVVNVSSPNTPGLRSLQNTDSLSKILEVLPRENERKKPILVKIAPDLENEA
IAAIIDLIKEYKISGIIATNTTINREKLTTKILPATGKPIIEEAGGISGKPLTKRSTEIIKFIWQETKGKLPIIGVGGIF
TSEDAWNKITAGASLIQIYTGLVYQGPGIVKQILQGLLKKLDEHGLNSISEAVGLANK

Sequences:

>Translated_378_residues
MLNIYRSVLFPIIFSGLKADPEWAHHQVLNMLSFIDTHSDSQLVNSIRTTMEKLFCFKDTRLEQNLWELNFKNPVGLAPG
YDKDGQAINMWPQLGFGFAELGTVTFHQQPGNAQPRLFRLPKDKAVLNRMGFNNKGAAALAKKFQIQNKKNSFFFPYGVN
IGKSKITPLEAAATDYLESFRLLKNCGDYFVVNVSSPNTPGLRSLQNTDSLSKILEVLPRENERKKPILVKIAPDLENEA
IAAIIDLIKEYKISGIIATNTTINREKLTTKILPATGKPIIEEAGGISGKPLTKRSTEIIKFIWQETKGKLPIIGVGGIF
TSEDAWNKITAGASLIQIYTGLVYQGPGIVKQILQGLLKKLDEHGLNSISEAVGLANK
>Mature_378_residues
MLNIYRSVLFPIIFSGLKADPEWAHHQVLNMLSFIDTHSDSQLVNSIRTTMEKLFCFKDTRLEQNLWELNFKNPVGLAPG
YDKDGQAINMWPQLGFGFAELGTVTFHQQPGNAQPRLFRLPKDKAVLNRMGFNNKGAAALAKKFQIQNKKNSFFFPYGVN
IGKSKITPLEAAATDYLESFRLLKNCGDYFVVNVSSPNTPGLRSLQNTDSLSKILEVLPRENERKKPILVKIAPDLENEA
IAAIIDLIKEYKISGIIATNTTINREKLTTKILPATGKPIIEEAGGISGKPLTKRSTEIIKFIWQETKGKLPIIGVGGIF
TSEDAWNKITAGASLIQIYTGLVYQGPGIVKQILQGLLKKLDEHGLNSISEAVGLANK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=370, Percent_Identity=39.7297297297297, Blast_Score=258, Evalue=8e-69,
Organism=Escherichia coli, GI1787177, Length=353, Percent_Identity=40.7932011331445, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082059, Length=212, Percent_Identity=32.5471698113208, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17509475, Length=329, Percent_Identity=41.0334346504559, Blast_Score=230, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6322633, Length=295, Percent_Identity=23.0508474576271, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281361352, Length=327, Percent_Identity=40.9785932721713, Blast_Score=250, Evalue=1e-66,
Organism=Drosophila melanogaster, GI17137316, Length=327, Percent_Identity=40.9785932721713, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_TRIEI (Q113R9)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721728.1
- ProteinModelPortal:   Q113R9
- SMR:   Q113R9
- STRING:   Q113R9
- GeneID:   4243434
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_2007
- NMPDR:   fig|203124.1.peg.740
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   Q113R9
- ProtClustDB:   PRK05286
- BioCyc:   TERY203124:TERY_2007-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 41911; Mature: 41911

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIYRSVLFPIIFSGLKADPEWAHHQVLNMLSFIDTHSDSQLVNSIRTTMEKLFCFKDT
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RLEQNLWELNFKNPVGLAPGYDKDGQAINMWPQLGFGFAELGTVTFHQQPGNAQPRLFRL
HHHHHHHEECCCCCCCCCCCCCCCCCEEEECHHHCCCHHHHCEEEEECCCCCCCCCEEEC
PKDKAVLNRMGFNNKGAAALAKKFQIQNKKNSFFFPYGVNIGKSKITPLEAAATDYLESF
CCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
RLLKNCGDYFVVNVSSPNTPGLRSLQNTDSLSKILEVLPRENERKKPILVKIAPDLENEA
HHHHCCCCEEEEEECCCCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHH
IAAIIDLIKEYKISGIIATNTTINREKLTTKILPATGKPIIEEAGGISGKPLTKRSTEII
HHHHHHHHHHHHHCEEEEECCCCCHHHHHHEECCCCCCHHHHHCCCCCCCCCCHHHHHHH
KFIWQETKGKLPIIGVGGIFTSEDAWNKITAGASLIQIYTGLVYQGPGIVKQILQGLLKK
HHHHHHCCCCCCEEEECCEECCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LDEHGLNSISEAVGLANK
HHHHCHHHHHHHHCCCCC
>Mature Secondary Structure
MLNIYRSVLFPIIFSGLKADPEWAHHQVLNMLSFIDTHSDSQLVNSIRTTMEKLFCFKDT
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RLEQNLWELNFKNPVGLAPGYDKDGQAINMWPQLGFGFAELGTVTFHQQPGNAQPRLFRL
HHHHHHHEECCCCCCCCCCCCCCCCCEEEECHHHCCCHHHHCEEEEECCCCCCCCCEEEC
PKDKAVLNRMGFNNKGAAALAKKFQIQNKKNSFFFPYGVNIGKSKITPLEAAATDYLESF
CCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
RLLKNCGDYFVVNVSSPNTPGLRSLQNTDSLSKILEVLPRENERKKPILVKIAPDLENEA
HHHHCCCCEEEEEECCCCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHH
IAAIIDLIKEYKISGIIATNTTINREKLTTKILPATGKPIIEEAGGISGKPLTKRSTEII
HHHHHHHHHHHHHCEEEEECCCCCHHHHHHEECCCCCCHHHHHCCCCCCCCCCHHHHHHH
KFIWQETKGKLPIIGVGGIFTSEDAWNKITAGASLIQIYTGLVYQGPGIVKQILQGLLKK
HHHHHHCCCCCCEEEECCEECCCHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
LDEHGLNSISEAVGLANK
HHHHCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA