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The map label for this gene is cobD [H]

Identifier: 113475529

GI number: 113475529

Start: 2846024

End: 2847016

Strand: Direct

Name: cobD [H]

Synonym: Tery_1861

Alternate gene names: 113475529

Gene position: 2846024-2847016 (Clockwise)

Preceding gene: 113475528

Following gene: 113475534

Centisome position: 36.72

GC content: 35.95

Gene sequence:

>993_bases
GTGACTTATAACTATACTTTCATTGTTATTTTTATAGCTGCTTGTCTAGATTATTTGATTGGCGATCCTTGGAGTTGGCC
ACATCCTGTAAAAGTTATGGGATGGATAATTACTCATTACACTCAAATGATTTTTCAACTCAGTAAAAATTATAGAGAGA
ACTTCCCTAGCTTTGTACTGAGATTTGCTGGTATTTTACTAACAATCACTCTTGTTTTCGGTAGTGGAGTTATCAGTTGG
TTAATTGTTCAAGCTTTACGAATAAATTTTGTCCAATTTCCTTTATTAACTGTAATATTAGAAAGCATTCTATTAGCTAG
CTGTTTTGCTGGTAAAAGTTTAAATACTGCAGCTAAAGACGTACTTAAACCTGCCCTAGGTGGTAATTTAATTCAAGCAC
GCCAAAATTTAAGTTTATATGTAGGTAGAGATACAGAAAATTTATCAATTTCAGAAATATTTCGCGCAGTTTTGGAAACA
GTCACAGAAAATGCTACAGATGGGGTAATAGCACCATTATTTTATGCTTTAGTAGGAGCAATAATACCTGATGTAGGCAG
TATACCTTTGGCCTTTGCGTACAAAGCTGCCAGTACATTAGACTCAATGGTAGGCTACAAAGAAGCACCTTATACTCATA
TAGGATGGTTTAGTGCCAAACTAGAAGATATTTTAACCTGGTTACCTTGTCGCTTAAATGTATTGACTATAGCGTTCCTC
TCTGGCAAACCTCTATATGTTTGCAAAATATGTCAAAGGGATGCAGTCAAAGACCCAAGTCCTAATGCTGGTTGGAGTGA
ATGTGCCTATGCTGCAACATTGGGAGTACAAATGGGTGGTGCCAACTCTTACAAGGGGACGGTTAAATATAAACCACTAT
TGGGAGAAGCGACTCATCCAATTACAGCAGAAACTATTGATCGGGCATTACAGTTAACTCGTTACTGTTTTTTAATCTGG
TTAGGATTATTTTTTATAATACTAGGCATTTAG

Upstream 100 bases:

>100_bases
AGTTTTTGATAGTTTAAGTCTAAAGTTGTAAAAGTTAATCAGTGGTTAAATGATTAGCAAGAATTATTCACTCAAATAAA
TTTACAATTATTGAATTACT

Downstream 100 bases:

>100_bases
GGTATGAACATTGGTAAATTCTGTTTGCCTAGCATTTGAGCACCAAAAACTAAGTAATTTTAGTTATTATCAGTACTGAT
CCCTGAAGTCAAGCCTTAAA

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTYNYTFIVIFIAACLDYLIGDPWSWPHPVKVMGWIITHYTQMIFQLSKNYRENFPSFVLRFAGILLTITLVFGSGVISW
LIVQALRINFVQFPLLTVILESILLASCFAGKSLNTAAKDVLKPALGGNLIQARQNLSLYVGRDTENLSISEIFRAVLET
VTENATDGVIAPLFYALVGAIIPDVGSIPLAFAYKAASTLDSMVGYKEAPYTHIGWFSAKLEDILTWLPCRLNVLTIAFL
SGKPLYVCKICQRDAVKDPSPNAGWSECAYAATLGVQMGGANSYKGTVKYKPLLGEATHPITAETIDRALQLTRYCFLIW
LGLFFIILGI

Sequences:

>Translated_330_residues
MTYNYTFIVIFIAACLDYLIGDPWSWPHPVKVMGWIITHYTQMIFQLSKNYRENFPSFVLRFAGILLTITLVFGSGVISW
LIVQALRINFVQFPLLTVILESILLASCFAGKSLNTAAKDVLKPALGGNLIQARQNLSLYVGRDTENLSISEIFRAVLET
VTENATDGVIAPLFYALVGAIIPDVGSIPLAFAYKAASTLDSMVGYKEAPYTHIGWFSAKLEDILTWLPCRLNVLTIAFL
SGKPLYVCKICQRDAVKDPSPNAGWSECAYAATLGVQMGGANSYKGTVKYKPLLGEATHPITAETIDRALQLTRYCFLIW
LGLFFIILGI
>Mature_329_residues
TYNYTFIVIFIAACLDYLIGDPWSWPHPVKVMGWIITHYTQMIFQLSKNYRENFPSFVLRFAGILLTITLVFGSGVISWL
IVQALRINFVQFPLLTVILESILLASCFAGKSLNTAAKDVLKPALGGNLIQARQNLSLYVGRDTENLSISEIFRAVLETV
TENATDGVIAPLFYALVGAIIPDVGSIPLAFAYKAASTLDSMVGYKEAPYTHIGWFSAKLEDILTWLPCRLNVLTIAFLS
GKPLYVCKICQRDAVKDPSPNAGWSECAYAATLGVQMGGANSYKGTVKYKPLLGEATHPITAETIDRALQLTRYCFLIWL
GLFFIILGI

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 36486; Mature: 36355

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYNYTFIVIFIAACLDYLIGDPWSWPHPVKVMGWIITHYTQMIFQLSKNYRENFPSFVL
CCEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFAGILLTITLVFGSGVISWLIVQALRINFVQFPLLTVILESILLASCFAGKSLNTAAKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VLKPALGGNLIQARQNLSLYVGRDTENLSISEIFRAVLETVTENATDGVIAPLFYALVGA
HHHHHHCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
IIPDVGSIPLAFAYKAASTLDSMVGYKEAPYTHIGWFSAKLEDILTWLPCRLNVLTIAFL
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHEEEEE
SGKPLYVCKICQRDAVKDPSPNAGWSECAYAATLGVQMGGANSYKGTVKYKPLLGEATHP
CCCCEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCCCC
ITAETIDRALQLTRYCFLIWLGLFFIILGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TYNYTFIVIFIAACLDYLIGDPWSWPHPVKVMGWIITHYTQMIFQLSKNYRENFPSFVL
CEEHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFAGILLTITLVFGSGVISWLIVQALRINFVQFPLLTVILESILLASCFAGKSLNTAAKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
VLKPALGGNLIQARQNLSLYVGRDTENLSISEIFRAVLETVTENATDGVIAPLFYALVGA
HHHHHHCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
IIPDVGSIPLAFAYKAASTLDSMVGYKEAPYTHIGWFSAKLEDILTWLPCRLNVLTIAFL
HHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHEEEEE
SGKPLYVCKICQRDAVKDPSPNAGWSECAYAATLGVQMGGANSYKGTVKYKPLLGEATHP
CCCCEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCEEEECCCCCCCCCC
ITAETIDRALQLTRYCFLIWLGLFFIILGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]