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The map label for this gene is grpE

Identifier: 113475421

GI number: 113475421

Start: 2664454

End: 2665182

Strand: Direct

Name: grpE

Synonym: Tery_1749

Alternate gene names: 113475421

Gene position: 2664454-2665182 (Clockwise)

Preceding gene: 113475415

Following gene: 113475422

Centisome position: 34.38

GC content: 39.09

Gene sequence:

>729_bases
ATGGCAGGAGAGAACTCCTCTACAGAAACAAAAAATCAAGAAATAAATGAGAAGACTCCAGAGGTTCAAACTTTTGAAAC
TAATGTAGAATTCGAGTCATCTCAAAAGGTTGAAAGTGATACAGAACTTTCTGCAGATAATGCCTCTATAGATACAGATA
TTCAGAGCACTGAATCAACCTCAAAAGAAAAAGATCAGGTCTTATTGAAAGAGGCTTATGAATTATTACAAACTCAGTTA
GAAACTACCAAGTATCAACTAGAAGAAAAAGAGAGTCAATACAAAAGGCTAGGCGCAGACTTTGACAACTTCCGTAAACG
GACACAAAAAGAAAAGGAAGACTTGGATACACAAGTCAAGTGTTCTACAATCATGGAACTATTACCAGTAATTGACAACT
TTGAGCGTGCTCGCTCCCATATTAAACCTGCAAATGATGGAGAAATGGCTATCCATAAAAGCTATCAGAGCGTCTATAAG
CAAATGGTAGACTCTTTGAAACGCTTAGGAGTTTCTGTTATGCGCCCTGAAGGTCAAGAATTTGATCCTAATCTACATGA
GGCAGTAATGCGAGAGGCAACCGCAGAACATCCAGAAGGAACCGTAATAGAAGAATTGGTACGAGGTTATATTCTAGGTG
AGCGTGTACTCCGACACGCTATGGTTAAAGTAGCAACAGCACCAGATACAGATGCTGAGACCGAAAATCAAACAGATCCA
GAAAGTTGA

Upstream 100 bases:

>100_bases
TGTTGATTATGATACGATTAATCATAGTAAAAACAACTATAAAATAAACAATACACCACAATATAAATACTAATAGCCCT
AAGTATCAGGAGAGAATTAA

Downstream 100 bases:

>100_bases
TACTGGTTAGTGATTTTTTATTGAATTATTCTGCTTTAAGTTGTATTCATATCTATCCAAAATCAGCTACAAGAGAAACA
CATATGCTAATAGAAAATTT

Product: heat shock protein GrpE

Products: NA

Alternate protein names: HSP-70 cofactor

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MAGENSSTETKNQEINEKTPEVQTFETNVEFESSQKVESDTELSADNASIDTDIQSTESTSKEKDQVLLKEAYELLQTQL
ETTKYQLEEKESQYKRLGADFDNFRKRTQKEKEDLDTQVKCSTIMELLPVIDNFERARSHIKPANDGEMAIHKSYQSVYK
QMVDSLKRLGVSVMRPEGQEFDPNLHEAVMREATAEHPEGTVIEELVRGYILGERVLRHAMVKVATAPDTDAETENQTDP
ES

Sequences:

>Translated_242_residues
MAGENSSTETKNQEINEKTPEVQTFETNVEFESSQKVESDTELSADNASIDTDIQSTESTSKEKDQVLLKEAYELLQTQL
ETTKYQLEEKESQYKRLGADFDNFRKRTQKEKEDLDTQVKCSTIMELLPVIDNFERARSHIKPANDGEMAIHKSYQSVYK
QMVDSLKRLGVSVMRPEGQEFDPNLHEAVMREATAEHPEGTVIEELVRGYILGERVLRHAMVKVATAPDTDAETENQTDP
ES
>Mature_241_residues
AGENSSTETKNQEINEKTPEVQTFETNVEFESSQKVESDTELSADNASIDTDIQSTESTSKEKDQVLLKEAYELLQTQLE
TTKYQLEEKESQYKRLGADFDNFRKRTQKEKEDLDTQVKCSTIMELLPVIDNFERARSHIKPANDGEMAIHKSYQSVYKQ
MVDSLKRLGVSVMRPEGQEFDPNLHEAVMREATAEHPEGTVIEELVRGYILGERVLRHAMVKVATAPDTDAETENQTDPE
S

Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with dnaK and grpE. It is the nucleotide exchange factor for dnaK and may function as a thermosensor. Unfolded

COG id: COG0576

COG function: function code O; Molecular chaperone GrpE (heat shock protein)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the grpE family

Homologues:

Organism=Escherichia coli, GI1788967, Length=132, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: 2359 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GRPE_TRIEI (Q114R5)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721482.1
- ProteinModelPortal:   Q114R5
- SMR:   Q114R5
- STRING:   Q114R5
- GeneID:   4242592
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1749
- NMPDR:   fig|203124.1.peg.481
- eggNOG:   COG0576
- HOGENOM:   HBG732630
- OMA:   SAPQQDD
- ProtClustDB:   PRK14143
- BioCyc:   TERY203124:TERY_1749-MONOMER
- GO:   GO:0005739
- HAMAP:   MF_01151
- InterPro:   IPR000740
- InterPro:   IPR013805
- InterPro:   IPR009012
- Gene3D:   G3DSA:3.90.20.20
- Gene3D:   G3DSA:2.30.22.10
- PANTHER:   PTHR21237
- PRINTS:   PR00773

Pfam domain/function: PF01025 GrpE; SSF51064 GrpE_head

EC number: NA

Molecular weight: Translated: 27555; Mature: 27423

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS01071 GRPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGENSSTETKNQEINEKTPEVQTFETNVEFESSQKVESDTELSADNASIDTDIQSTEST
CCCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
SKEKDQVLLKEAYELLQTQLETTKYQLEEKESQYKRLGADFDNFRKRTQKEKEDLDTQVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
CSTIMELLPVIDNFERARSHIKPANDGEMAIHKSYQSVYKQMVDSLKRLGVSVMRPEGQE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
FDPNLHEAVMREATAEHPEGTVIEELVRGYILGERVLRHAMVKVATAPDTDAETENQTDP
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
ES
CC
>Mature Secondary Structure 
AGENSSTETKNQEINEKTPEVQTFETNVEFESSQKVESDTELSADNASIDTDIQSTEST
CCCCCCCCCHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
SKEKDQVLLKEAYELLQTQLETTKYQLEEKESQYKRLGADFDNFRKRTQKEKEDLDTQVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
CSTIMELLPVIDNFERARSHIKPANDGEMAIHKSYQSVYKQMVDSLKRLGVSVMRPEGQE
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCC
FDPNLHEAVMREATAEHPEGTVIEELVRGYILGERVLRHAMVKVATAPDTDAETENQTDP
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
ES
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA