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The map label for this gene is ribD [H]

Identifier: 113475344

GI number: 113475344

Start: 2526786

End: 2527910

Strand: Direct

Name: ribD [H]

Synonym: Tery_1661

Alternate gene names: 113475344

Gene position: 2526786-2527910 (Clockwise)

Preceding gene: 113475336

Following gene: 113475345

Centisome position: 32.6

GC content: 41.51

Gene sequence:

>1125_bases
ATGTTGAAATTTGATGATAGTGAAAATCAAAATCAGCTCGATCCCTTAATTATGGCTCATTGTCTAGAACTAGCCCGACG
TGCTTTGGGTAATACTGCCCCTAATCCTTTGGTGGGTTGTGTTATAATTAAAAATGGCCAAATTATAGGTGAGGGATTTC
ATCCTGGTGCTGGTTATCCTCATGCCGAAGTTTTTGCTCTCACAGAGGCGGGGGAAAAAGCAAGAGGAGCTACTGCCTAC
GTTAATTTAGAACCATGTAATCATTATGGCAGGACACCACCTTGTACAGACGCTTTAATTGCAGCAGGTGTAGCTAGGGT
AGTAATTGGAATGATTGATCCTAATCCTTTGGTTGCAGGTGCTGGTGTGGCCAAGTTGCAGGATGCTGGTATAGAAGTAG
TAGTGGGAGTATTAGAGGCGGAATGTCGCGAACTGAATGAAGCCTTTATTCACCGAATGCTTTACCATTGTCCTTTCGGA
ATTTTGAAATATGCCATGACTCTTGATGGTAAAATTGCTACCACTACAGGTCATAGTGCATGGGTGACATCTCAGGAGGC
AAGGAGTGAAGTGCATAAGTTACGGGCTATTAGCGATGCCGTGATTATTGGAGGTAATACAGTTCGACGAGATAACCCCT
TTTTGACGAGTCGCAGCACTCAAGCTAATAATCCTTTGCGGGTAGTTATGAGTCGTAGTTTAGATTTGCCCACAGAGGCT
AATTTATGGGATGTCAGTGAAGCTCAAACTTTAGTATTTACAGAAATAGATTCTAATCAAGAATTTAAGGAGTATTTAAG
GCAAAAAGGGGTGGAAGTGCTGGAAACTTCGACTTTAACTCCCGCAGTAGTAATGTCTAATCTCTATGATCGCGGATTTC
TTTCTGTACTTTGGGAGTGTGGGGGAACTTTAGCAGCCAGAGCGATGGCTGATGGCGCAGTACAAAAAATTTGGGCTTTT
ATTGCTCCGAAAATTATTGGAGGGGAAATAGCTCCAACACCAGTAGGGAATTTAGGGTTAACTAAAATGACGGAGGCTTT
TGAGTTAGAAAATATTAGTATGCGTACTGTTGGTTGTGATTATTTATTAGAAGGTTATTTGCATCAGAAAAAGGAAAAAT
TTTGA

Upstream 100 bases:

>100_bases
CAACCAGGTTTATTTGCGTAAGTTATATTCTCCTAACCAAATGGGTTCTGTATAATTTCTGAAGATGTCTAATATTTAAC
TTGAAACTAAAAATCTGAAG

Downstream 100 bases:

>100_bases
GTCTTTTTATAAGACATTTACAGCATATTTCAAGTATATGAGTTACAAGTATTAATATTCAAACCTCTCAGGGCTTTTTG
GAAAATGGGGTTTCAGGGGA

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLKFDDSENQNQLDPLIMAHCLELARRALGNTAPNPLVGCVIIKNGQIIGEGFHPGAGYPHAEVFALTEAGEKARGATAY
VNLEPCNHYGRTPPCTDALIAAGVARVVIGMIDPNPLVAGAGVAKLQDAGIEVVVGVLEAECRELNEAFIHRMLYHCPFG
ILKYAMTLDGKIATTTGHSAWVTSQEARSEVHKLRAISDAVIIGGNTVRRDNPFLTSRSTQANNPLRVVMSRSLDLPTEA
NLWDVSEAQTLVFTEIDSNQEFKEYLRQKGVEVLETSTLTPAVVMSNLYDRGFLSVLWECGGTLAARAMADGAVQKIWAF
IAPKIIGGEIAPTPVGNLGLTKMTEAFELENISMRTVGCDYLLEGYLHQKKEKF

Sequences:

>Translated_374_residues
MLKFDDSENQNQLDPLIMAHCLELARRALGNTAPNPLVGCVIIKNGQIIGEGFHPGAGYPHAEVFALTEAGEKARGATAY
VNLEPCNHYGRTPPCTDALIAAGVARVVIGMIDPNPLVAGAGVAKLQDAGIEVVVGVLEAECRELNEAFIHRMLYHCPFG
ILKYAMTLDGKIATTTGHSAWVTSQEARSEVHKLRAISDAVIIGGNTVRRDNPFLTSRSTQANNPLRVVMSRSLDLPTEA
NLWDVSEAQTLVFTEIDSNQEFKEYLRQKGVEVLETSTLTPAVVMSNLYDRGFLSVLWECGGTLAARAMADGAVQKIWAF
IAPKIIGGEIAPTPVGNLGLTKMTEAFELENISMRTVGCDYLLEGYLHQKKEKF
>Mature_374_residues
MLKFDDSENQNQLDPLIMAHCLELARRALGNTAPNPLVGCVIIKNGQIIGEGFHPGAGYPHAEVFALTEAGEKARGATAY
VNLEPCNHYGRTPPCTDALIAAGVARVVIGMIDPNPLVAGAGVAKLQDAGIEVVVGVLEAECRELNEAFIHRMLYHCPFG
ILKYAMTLDGKIATTTGHSAWVTSQEARSEVHKLRAISDAVIIGGNTVRRDNPFLTSRSTQANNPLRVVMSRSLDLPTEA
NLWDVSEAQTLVFTEIDSNQEFKEYLRQKGVEVLETSTLTPAVVMSNLYDRGFLSVLWECGGTLAARAMADGAVQKIWAF
IAPKIIGGEIAPTPVGNLGLTKMTEAFELENISMRTVGCDYLLEGYLHQKKEKF

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=366, Percent_Identity=42.0765027322404, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI145693172, Length=146, Percent_Identity=34.2465753424658, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40609; Mature: 40609

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKFDDSENQNQLDPLIMAHCLELARRALGNTAPNPLVGCVIIKNGQIIGEGFHPGAGYP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEECCCCCCCCCC
HAEVFALTEAGEKARGATAYVNLEPCNHYGRTPPCTDALIAAGVARVVIGMIDPNPLVAG
CCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEC
AGVAKLQDAGIEVVVGVLEAECRELNEAFIHRMLYHCPFGILKYAMTLDGKIATTTGHSA
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCC
WVTSQEARSEVHKLRAISDAVIIGGNTVRRDNPFLTSRSTQANNPLRVVMSRSLDLPTEA
EEECHHHHHHHHHHHHHHCEEEECCCEEECCCCCEECCCCCCCCCCEEEEECCCCCCCCC
NLWDVSEAQTLVFTEIDSNQEFKEYLRQKGVEVLETSTLTPAVVMSNLYDRGFLSVLWEC
CCEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHC
GGTLAARAMADGAVQKIWAFIAPKIIGGEIAPTPVGNLGLTKMTEAFELENISMRTVGCD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECHH
YLLEGYLHQKKEKF
HHHHHHHHHHHCCC
>Mature Secondary Structure
MLKFDDSENQNQLDPLIMAHCLELARRALGNTAPNPLVGCVIIKNGQIIGEGFHPGAGYP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEECCCCCCCCCC
HAEVFALTEAGEKARGATAYVNLEPCNHYGRTPPCTDALIAAGVARVVIGMIDPNPLVAG
CCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEC
AGVAKLQDAGIEVVVGVLEAECRELNEAFIHRMLYHCPFGILKYAMTLDGKIATTTGHSA
CCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEEEEECCCCC
WVTSQEARSEVHKLRAISDAVIIGGNTVRRDNPFLTSRSTQANNPLRVVMSRSLDLPTEA
EEECHHHHHHHHHHHHHHCEEEECCCEEECCCCCEECCCCCCCCCCEEEEECCCCCCCCC
NLWDVSEAQTLVFTEIDSNQEFKEYLRQKGVEVLETSTLTPAVVMSNLYDRGFLSVLWEC
CCEECCCCCEEEEEECCCCHHHHHHHHHCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHC
GGTLAARAMADGAVQKIWAFIAPKIIGGEIAPTPVGNLGLTKMTEAFELENISMRTVGCD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECHH
YLLEGYLHQKKEKF
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]