Click here to switch to the map view.

The map label for this gene is purK [H]

Identifier: 113475175

GI number: 113475175

Start: 2235212

End: 2236372

Strand: Direct

Name: purK [H]

Synonym: Tery_1473

Alternate gene names: 113475175

Gene position: 2235212-2236372 (Clockwise)

Preceding gene: 113475171

Following gene: 113475176

Centisome position: 28.84

GC content: 36.09

Gene sequence:

>1161_bases
ATGGTAAAAATGAAAATGAATGAAGAGGAAAAAAAACAACAAAACAAAATTCAGCGAGTGGGTGTTGTTGGTGGTGGTCA
ATTAGCATGGATGATGGGGGATGCAGCAAAAAAACTAGGAGTAGATTTAATTATTCAAACTCCTCATCAAGATGACCCAG
CAGTATCTATTGCAAAGGATATAATTTTGGCAGAAATTGATGACCCTCAGGCAACTACTAAGTTAGCAAATATTTGTGAT
GTGATTACCTTTGAGAATGAGTTTATTAATATAGATGAGTTATCATATCTTGCTGAAAAGAATGTAATTTTTCGTCCTAG
TTTATCTGTGTTGAAGCCGTTATTAGATAAATATGAACAGTTATGTTATTTACGATATTTGGGTTTACCTGTACCGAACT
TTTGGGAGTGGGGAATAGAGATTGAGCCTTTATCTTTCCCTTTGGTATTGAAAGCTCGTCGTCATGGTTATGACGGTCAG
GGTACTTTTATTATTAAGAATATTGAGAGTTTAAAATCTCAGGGAAATTCAGAATTTTTCATACAAGAATTTATTCCTTT
TGAACGAGAGGTTGCTGTTATTGCTGCTCGTGGAGTTACTGGGGAAGTTAAGGTTTATCCTGTGGTAGAAACTCAACAAG
AAAACCAGGTTTGCCAGCGGGTTTTTGTACCTGATGAAAATTTAGAATTAGTAACAGAAATTGAAGAGATCGCTCAGACT
CTCCTTAATAGTTTAGAAGTAGTAGGAGTATTTGGGATAGAAATGTTTATTACTAAAGACAAGAAGGTTTTAATTAATGA
AATTGCTCCAAGAACTCATAACTCTGGTCATTACAGTTTGGATGCTTGTGAAGTTTCCCAGTTTGAACAACATTTACGGG
CTGTTTGTGGTTTACCTTTAGGTAATACTACTCTCAAAGTAAGGAGAGCGGTGATGGTAAATTTATTGGGTTATGAATTT
GGGGAAAATTACTACTTGACAAAACGGCAAATGTTAGAAAAAATTCCTCATGCTTCGGTTTGGTGGTATGGCAAAACAGA
ATCTCGCCCAGGACGGAAGTTAGGTCATGTGACTGTTTTGCTAGATGAGGAAAATTTTGAAATTATGGGTCGCAAGGGTG
AGGCGATCGCTAATAAAATAGAGAATATCTGGTACACCTAA

Upstream 100 bases:

>100_bases
GATTACTATAGGTAATTATAAATTATTTCTTTGCTTTCCTTTTGCTAACTAAGGAAATAATAATAAAATTTTTATTTGTA
AAATACAAAAGCTTAAATTA

Downstream 100 bases:

>100_bases
AGCTTGCTGTTGCCTCTTTTAGACACTTTATGACTTTTGACTTTTAAATTTTGAAGTTTGACTGCATAAAGGGGGGTGAC
AGAAAAAAAATAACCGCTAT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MVKMKMNEEEKKQQNKIQRVGVVGGGQLAWMMGDAAKKLGVDLIIQTPHQDDPAVSIAKDIILAEIDDPQATTKLANICD
VITFENEFINIDELSYLAEKNVIFRPSLSVLKPLLDKYEQLCYLRYLGLPVPNFWEWGIEIEPLSFPLVLKARRHGYDGQ
GTFIIKNIESLKSQGNSEFFIQEFIPFEREVAVIAARGVTGEVKVYPVVETQQENQVCQRVFVPDENLELVTEIEEIAQT
LLNSLEVVGVFGIEMFITKDKKVLINEIAPRTHNSGHYSLDACEVSQFEQHLRAVCGLPLGNTTLKVRRAVMVNLLGYEF
GENYYLTKRQMLEKIPHASVWWYGKTESRPGRKLGHVTVLLDEENFEIMGRKGEAIANKIENIWYT

Sequences:

>Translated_386_residues
MVKMKMNEEEKKQQNKIQRVGVVGGGQLAWMMGDAAKKLGVDLIIQTPHQDDPAVSIAKDIILAEIDDPQATTKLANICD
VITFENEFINIDELSYLAEKNVIFRPSLSVLKPLLDKYEQLCYLRYLGLPVPNFWEWGIEIEPLSFPLVLKARRHGYDGQ
GTFIIKNIESLKSQGNSEFFIQEFIPFEREVAVIAARGVTGEVKVYPVVETQQENQVCQRVFVPDENLELVTEIEEIAQT
LLNSLEVVGVFGIEMFITKDKKVLINEIAPRTHNSGHYSLDACEVSQFEQHLRAVCGLPLGNTTLKVRRAVMVNLLGYEF
GENYYLTKRQMLEKIPHASVWWYGKTESRPGRKLGHVTVLLDEENFEIMGRKGEAIANKIENIWYT
>Mature_386_residues
MVKMKMNEEEKKQQNKIQRVGVVGGGQLAWMMGDAAKKLGVDLIIQTPHQDDPAVSIAKDIILAEIDDPQATTKLANICD
VITFENEFINIDELSYLAEKNVIFRPSLSVLKPLLDKYEQLCYLRYLGLPVPNFWEWGIEIEPLSFPLVLKARRHGYDGQ
GTFIIKNIESLKSQGNSEFFIQEFIPFEREVAVIAARGVTGEVKVYPVVETQQENQVCQRVFVPDENLELVTEIEEIAQT
LLNSLEVVGVFGIEMFITKDKKVLINEIAPRTHNSGHYSLDACEVSQFEQHLRAVCGLPLGNTTLKVRRAVMVNLLGYEF
GENYYLTKRQMLEKIPHASVWWYGKTESRPGRKLGHVTVLLDEENFEIMGRKGEAIANKIENIWYT

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=352, Percent_Identity=29.5454545454545, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788155, Length=305, Percent_Identity=24.5901639344262, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324702, Length=366, Percent_Identity=34.6994535519126, Blast_Score=206, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 43948; Mature: 43948

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKMKMNEEEKKQQNKIQRVGVVGGGQLAWMMGDAAKKLGVDLIIQTPHQDDPAVSIAKD
CEECCCCHHHHHHHHHHHEEEEECCCEEEEEECHHHHHCCCEEEEECCCCCCCHHHHHHH
IILAEIDDPQATTKLANICDVITFENEFINIDELSYLAEKNVIFRPSLSVLKPLLDKYEQ
EEEEECCCCHHHHHHHHHHHHEEECCCEECHHHHHHHHHCCEEECCCHHHHHHHHHHHHH
LCYLRYLGLPVPNFWEWGIEIEPLSFPLVLKARRHGYDGQGTFIIKNIESLKSQGNSEFF
HHHHHHHCCCCCCHHHCCEEECCCCCCEEEEEHHCCCCCCCEEEEEEHHHHHCCCCCEEE
IQEFIPFEREVAVIAARGVTGEVKVYPVVETQQENQVCQRVFVPDENLELVTEIEEIAQT
HHHHCCCCCCEEEEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
LLNSLEVVGVFGIEMFITKDKKVLINEIAPRTHNSGHYSLDACEVSQFEQHLRAVCGLPL
HHHHHHEEEEEEEEEEEECCCHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCC
GNTTLKVRRAVMVNLLGYEFGENYYLTKRQMLEKIPHASVWWYGKTESRPGRKLGHVTVL
CCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCEEEEECCCCCCCCCEECEEEEE
LDEENFEIMGRKGEAIANKIENIWYT
EECCCCEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MVKMKMNEEEKKQQNKIQRVGVVGGGQLAWMMGDAAKKLGVDLIIQTPHQDDPAVSIAKD
CEECCCCHHHHHHHHHHHEEEEECCCEEEEEECHHHHHCCCEEEEECCCCCCCHHHHHHH
IILAEIDDPQATTKLANICDVITFENEFINIDELSYLAEKNVIFRPSLSVLKPLLDKYEQ
EEEEECCCCHHHHHHHHHHHHEEECCCEECHHHHHHHHHCCEEECCCHHHHHHHHHHHHH
LCYLRYLGLPVPNFWEWGIEIEPLSFPLVLKARRHGYDGQGTFIIKNIESLKSQGNSEFF
HHHHHHHCCCCCCHHHCCEEECCCCCCEEEEEHHCCCCCCCEEEEEEHHHHHCCCCCEEE
IQEFIPFEREVAVIAARGVTGEVKVYPVVETQQENQVCQRVFVPDENLELVTEIEEIAQT
HHHHCCCCCCEEEEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
LLNSLEVVGVFGIEMFITKDKKVLINEIAPRTHNSGHYSLDACEVSQFEQHLRAVCGLPL
HHHHHHEEEEEEEEEEEECCCHHHHHHCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCC
GNTTLKVRRAVMVNLLGYEFGENYYLTKRQMLEKIPHASVWWYGKTESRPGRKLGHVTVL
CCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCEEEEECCCCCCCCCEECEEEEE
LDEENFEIMGRKGEAIANKIENIWYT
EECCCCEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA