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The map label for this gene is thrS [H]

Identifier: 113475159

GI number: 113475159

Start: 2203647

End: 2205473

Strand: Reverse

Name: thrS [H]

Synonym: Tery_1457

Alternate gene names: 113475159

Gene position: 2205473-2203647 (Counterclockwise)

Preceding gene: 113475160

Following gene: 113475158

Centisome position: 28.46

GC content: 39.63

Gene sequence:

>1827_bases
ATGTCCAGTTCAGAATCTAGTTCTTCCCCTGAAAAATCAGAAAAAATTCATTTACCCCGCACTAGCGAGTCACAAACTCT
CAAAAAAATTCGTCATACCACATCTCATGTCATGGCTATGGCGGTACAAAAGCTATTTCCCAAAGCCCAAGTAACAATCG
GTCCATGGATTGAAAATGGCTTCTACTACGACTTTGATACCCTAGAATCATTTACAGAAGCTGACCTAAAAGCCATCAAA
AAAGAGATGGTAAAAATCATTAAACGTAATCTACCCGTAATTAGAGAAGAAGTCAGCCGGGAAGAGGCTAAACGTCGAAT
TGAAGAAATTAAAGAACCTTATAAATTAGAAATTCTTGAAGATTTAGAAGACCCAATTACCATTTATCATCTTGGTGAAG
ACTGGTGGGATTTATGTGCAGGCCCTCATATTGAAAGTACAAAGCAAATTAATCCCAAGGCAATTGAGTTAGAAACTGTG
GCAGGTGCTTACTGGCGTGGAGATGAAACCAAAGCCCAATTGCAACGTATTTATGGTACTGCTTGGGAAACTCCAGAACA
ACTGACTGAGTATAAAAGACGTAAGGAAGAAGCTCTCAAAAGGAACCATCGTAAACTAGGTAAAGAATTAGGACTATTTA
TTTTTTCCGATCTTGTTGGACCAGGGTTGCCTCTTTGGACTCCTAAAGGTACAATGTTAAAAAATTCACTGAAAGACTTT
CTTCAACAAGAACAACTGAAACGGGGTTATTTACCTGTAGATACTCCCCATATTGCCAGAATAGATTTATTCAAAACTTC
CGGACATTGGCAAAAGTACAAAGAGGATATGTTCCCGATGATGGCTGAGGATGAACAAGCAGAAGCTCTGGAACAGGGTT
TTGTTTTAAAACCAATGAACTGTCCCTTTCATATCCAAATCTATAAAAATGAACTACGTTCTTATCGAGAGTTGCCAATA
CGACTTGCCGAGTTTGGTACTGTTTACCGCCATGAAAAATCTGGGGAATTAGGTGGTTTAACCCGAGTCCGGGGTTTCAC
TCAAGATGATTCTCATTTATTTGTGACACCCGAACAACTTGATGCTGAGTTTCTCAGTGTGGTGGACCTAACTCTATTTG
TATTTAAAAGTCTACAACTACAGAACTTTAAGGCTAGATTAAGTTTCCGAGACCCTAATTTAGATAAGTATATTGGTTCT
GATGAAGCTTGGGAAAAAGCTGAAGGTGCAATTCGTCGAGCTGTGGAAAAAATGGGTATGGATCATTTTGAGGGTATTGG
TGAAGCTGCATTTTATGGTCCAAAGTTAGATTTTATTTTCCAGGATGCTTTGGAGCGAGAATGGCAGCTGGGGACTGTGC
AGGTAGACTATAATTTACCGGAACGATTTGATTTAGAATATGTAGCAGAAGATGGTACAAGAAAACGTCCGGTGATGATT
CATCGGGCACCTTTTGGTTCCTTGGAAAGGTTGATTGGAATTTTAATTGAGGAGTATGCAGGAGATTTTCCTGTGTGGTT
GGCTCCTACCCAGGTTAAACTTTTACCAGTTAATTCTGAATTTTGGCCTTTTGCTCAAGAAGTTGCGGAGCAGATGCTTC
AAGTAGGTATTCGTGCTGAAGTGGATATGAGTAATGAGCGTTTGGGTAAGTTGATTCGTAATGCTGAGAAGGCAAAAATT
CCTATTATGGCTGTTGTGGGTGCTAAGGAAGTTGAGTCTAATAGTTTGAGTATTCGTACTCGTAGTACTGGTGAATTGGG
AAGTATACCTGTGATGGAGGTAATTCAGAAGATGACAAAGGCGATCGCCAATTATGAAAATTTCTAG

Upstream 100 bases:

>100_bases
TAAAACTTCAAACTCCTACATTGTGATAACCTAACTAAAATTCAATCTAAGTCCATCTCTGTAAAAATATACAATATTAA
AACCTCAGAATAAATAACTA

Downstream 100 bases:

>100_bases
GTCTATGTATACAGAAAATCTAAATCTTCAACTAGGGTAATTTTGCCTTATACTTTGAAGCTAACCTTATGAGGTTATTT
CAGTTATCAGTTATTATTAC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSSSESSSSPEKSEKIHLPRTSESQTLKKIRHTTSHVMAMAVQKLFPKAQVTIGPWIENGFYYDFDTLESFTEADLKAIK
KEMVKIIKRNLPVIREEVSREEAKRRIEEIKEPYKLEILEDLEDPITIYHLGEDWWDLCAGPHIESTKQINPKAIELETV
AGAYWRGDETKAQLQRIYGTAWETPEQLTEYKRRKEEALKRNHRKLGKELGLFIFSDLVGPGLPLWTPKGTMLKNSLKDF
LQQEQLKRGYLPVDTPHIARIDLFKTSGHWQKYKEDMFPMMAEDEQAEALEQGFVLKPMNCPFHIQIYKNELRSYRELPI
RLAEFGTVYRHEKSGELGGLTRVRGFTQDDSHLFVTPEQLDAEFLSVVDLTLFVFKSLQLQNFKARLSFRDPNLDKYIGS
DEAWEKAEGAIRRAVEKMGMDHFEGIGEAAFYGPKLDFIFQDALEREWQLGTVQVDYNLPERFDLEYVAEDGTRKRPVMI
HRAPFGSLERLIGILIEEYAGDFPVWLAPTQVKLLPVNSEFWPFAQEVAEQMLQVGIRAEVDMSNERLGKLIRNAEKAKI
PIMAVVGAKEVESNSLSIRTRSTGELGSIPVMEVIQKMTKAIANYENF

Sequences:

>Translated_608_residues
MSSSESSSSPEKSEKIHLPRTSESQTLKKIRHTTSHVMAMAVQKLFPKAQVTIGPWIENGFYYDFDTLESFTEADLKAIK
KEMVKIIKRNLPVIREEVSREEAKRRIEEIKEPYKLEILEDLEDPITIYHLGEDWWDLCAGPHIESTKQINPKAIELETV
AGAYWRGDETKAQLQRIYGTAWETPEQLTEYKRRKEEALKRNHRKLGKELGLFIFSDLVGPGLPLWTPKGTMLKNSLKDF
LQQEQLKRGYLPVDTPHIARIDLFKTSGHWQKYKEDMFPMMAEDEQAEALEQGFVLKPMNCPFHIQIYKNELRSYRELPI
RLAEFGTVYRHEKSGELGGLTRVRGFTQDDSHLFVTPEQLDAEFLSVVDLTLFVFKSLQLQNFKARLSFRDPNLDKYIGS
DEAWEKAEGAIRRAVEKMGMDHFEGIGEAAFYGPKLDFIFQDALEREWQLGTVQVDYNLPERFDLEYVAEDGTRKRPVMI
HRAPFGSLERLIGILIEEYAGDFPVWLAPTQVKLLPVNSEFWPFAQEVAEQMLQVGIRAEVDMSNERLGKLIRNAEKAKI
PIMAVVGAKEVESNSLSIRTRSTGELGSIPVMEVIQKMTKAIANYENF
>Mature_607_residues
SSSESSSSPEKSEKIHLPRTSESQTLKKIRHTTSHVMAMAVQKLFPKAQVTIGPWIENGFYYDFDTLESFTEADLKAIKK
EMVKIIKRNLPVIREEVSREEAKRRIEEIKEPYKLEILEDLEDPITIYHLGEDWWDLCAGPHIESTKQINPKAIELETVA
GAYWRGDETKAQLQRIYGTAWETPEQLTEYKRRKEEALKRNHRKLGKELGLFIFSDLVGPGLPLWTPKGTMLKNSLKDFL
QQEQLKRGYLPVDTPHIARIDLFKTSGHWQKYKEDMFPMMAEDEQAEALEQGFVLKPMNCPFHIQIYKNELRSYRELPIR
LAEFGTVYRHEKSGELGGLTRVRGFTQDDSHLFVTPEQLDAEFLSVVDLTLFVFKSLQLQNFKARLSFRDPNLDKYIGSD
EAWEKAEGAIRRAVEKMGMDHFEGIGEAAFYGPKLDFIFQDALEREWQLGTVQVDYNLPERFDLEYVAEDGTRKRPVMIH
RAPFGSLERLIGILIEEYAGDFPVWLAPTQVKLLPVNSEFWPFAQEVAEQMLQVGIRAEVDMSNERLGKLIRNAEKAKIP
IMAVVGAKEVESNSLSIRTRSTGELGSIPVMEVIQKMTKAIANYENF

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=573, Percent_Identity=38.7434554973822, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI38570111, Length=572, Percent_Identity=38.4615384615385, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI20070344, Length=584, Percent_Identity=36.472602739726, Blast_Score=366, Evalue=1e-101,
Organism=Escherichia coli, GI1788013, Length=596, Percent_Identity=40.1006711409396, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1786392, Length=138, Percent_Identity=26.8115942028986, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71984184, Length=600, Percent_Identity=36, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71984192, Length=600, Percent_Identity=36, Blast_Score=392, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322112, Length=596, Percent_Identity=36.4093959731544, Blast_Score=379, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6322654, Length=397, Percent_Identity=35.7682619647355, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24583839, Length=586, Percent_Identity=40.1023890784983, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24583842, Length=586, Percent_Identity=40.1023890784983, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI28574141, Length=586, Percent_Identity=40.1023890784983, Blast_Score=429, Evalue=1e-120,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 70044; Mature: 69913

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSESSSSPEKSEKIHLPRTSESQTLKKIRHTTSHVMAMAVQKLFPKAQVTIGPWIENG
CCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCC
FYYDFDTLESFTEADLKAIKKEMVKIIKRNLPVIREEVSREEAKRRIEEIKEPYKLEILE
EEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DLEDPITIYHLGEDWWDLCAGPHIESTKQINPKAIELETVAGAYWRGDETKAQLQRIYGT
CCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
AWETPEQLTEYKRRKEEALKRNHRKLGKELGLFIFSDLVGPGLPLWTPKGTMLKNSLKDF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
LQQEQLKRGYLPVDTPHIARIDLFKTSGHWQKYKEDMFPMMAEDEQAEALEQGFVLKPMN
HHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHCCCEEEECC
CPFHIQIYKNELRSYRELPIRLAEFGTVYRHEKSGELGGLTRVRGFTQDDSHLFVTPEQL
CCEEEEEEHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCEEEECHHHH
DAEFLSVVDLTLFVFKSLQLQNFKARLSFRDPNLDKYIGSDEAWEKAEGAIRRAVEKMGM
HHHHHHHHHHHHHHHHHHHHHCHHEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHCC
DHFEGIGEAAFYGPKLDFIFQDALEREWQLGTVQVDYNLPERFDLEYVAEDGTRKRPVMI
HHHHCCCCHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCEEE
HRAPFGSLERLIGILIEEYAGDFPVWLAPTQVKLLPVNSEFWPFAQEVAEQMLQVGIRAE
EECCCHHHHHHHHHHHHHHCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCE
VDMSNERLGKLIRNAEKAKIPIMAVVGAKEVESNSLSIRTRSTGELGSIPVMEVIQKMTK
ECCCHHHHHHHHHCCHHCCCCEEEEECCHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHH
AIANYENF
HHHCCCCC
>Mature Secondary Structure 
SSSESSSSPEKSEKIHLPRTSESQTLKKIRHTTSHVMAMAVQKLFPKAQVTIGPWIENG
CCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCC
FYYDFDTLESFTEADLKAIKKEMVKIIKRNLPVIREEVSREEAKRRIEEIKEPYKLEILE
EEECHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
DLEDPITIYHLGEDWWDLCAGPHIESTKQINPKAIELETVAGAYWRGDETKAQLQRIYGT
CCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCC
AWETPEQLTEYKRRKEEALKRNHRKLGKELGLFIFSDLVGPGLPLWTPKGTMLKNSLKDF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
LQQEQLKRGYLPVDTPHIARIDLFKTSGHWQKYKEDMFPMMAEDEQAEALEQGFVLKPMN
HHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCHHHHHHHCCCEEEECC
CPFHIQIYKNELRSYRELPIRLAEFGTVYRHEKSGELGGLTRVRGFTQDDSHLFVTPEQL
CCEEEEEEHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCEEEECHHHH
DAEFLSVVDLTLFVFKSLQLQNFKARLSFRDPNLDKYIGSDEAWEKAEGAIRRAVEKMGM
HHHHHHHHHHHHHHHHHHHHHCHHEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHCC
DHFEGIGEAAFYGPKLDFIFQDALEREWQLGTVQVDYNLPERFDLEYVAEDGTRKRPVMI
HHHHCCCCHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCEEE
HRAPFGSLERLIGILIEEYAGDFPVWLAPTQVKLLPVNSEFWPFAQEVAEQMLQVGIRAE
EECCCHHHHHHHHHHHHHHCCCCCEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCE
VDMSNERLGKLIRNAEKAKIPIMAVVGAKEVESNSLSIRTRSTGELGSIPVMEVIQKMTK
ECCCHHHHHHHHHCCHHCCCCEEEEECCHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHH
AIANYENF
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]