Click here to switch to the map view.

The map label for this gene is msrA

Identifier: 113474274

GI number: 113474274

Start: 609071

End: 609604

Strand: Reverse

Name: msrA

Synonym: Tery_0394

Alternate gene names: 113474274

Gene position: 609604-609071 (Counterclockwise)

Preceding gene: 113474275

Following gene: 113474271

Centisome position: 7.87

GC content: 35.02

Gene sequence:

>534_bases
ATGTTAGATACAATAGTATTAGGTGGTGGATGCTTCTGGTGCGTAGAATCTGTCTTTTTATCTGTGGTGGGAGTAAAAGA
AGTAGAATCTGGTTATGCTGGAGGAAATACTAAAAATCCTGACTATAGGTCTATATGTTCTGGAAAAACTGGTCATGCTG
AGGTTGTCAAAGTTTCCTTTGACACTGAGAAAATATCACTGAGTCAAATCTTAGAAATATTTTTTGCAACTCACGACCCC
ACAACACCCAATAGACAAGGAAATGATGTTGGTACTCAGTATCGTTCAGTTGTTATGTGTCATTCCCAAGAACAAAAAGA
CATTGCTCAAGAAGTAATTTCGACCTTGGGTAATAATGGAACATTTGAAAATCCCATTGTAACTGAAGTAGTTGATTTGA
AGGATTATTATAGAGCTGAGGAATATCATCAAAACTATTTTAACAAGAATCCTTATCAACCTTATTGTGTATTTTCAATT
CCGCCAAAATTACAAAAACTCAAGAAATATTTCCCAGATCAAGTATCTGCCTAA

Upstream 100 bases:

>100_bases
CAAAGGCTGATAACTATCTTGATCTAAAACCTATTGCTCTGTAATCAGTTTACAATGAATATTGAATAGAGTTTAATACC
AAAGTTTGGAGATGACAATA

Downstream 100 bases:

>100_bases
ATACAGCTATTCGCCTAATAGGTTGTAATGTTTTATCTAAGGGGGTTTGCTCTCATTACCTAACCAAAAATAGGATTGAT
ATGACCAAACCCCTAGAGTT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MLDTIVLGGGCFWCVESVFLSVVGVKEVESGYAGGNTKNPDYRSICSGKTGHAEVVKVSFDTEKISLSQILEIFFATHDP
TTPNRQGNDVGTQYRSVVMCHSQEQKDIAQEVISTLGNNGTFENPIVTEVVDLKDYYRAEEYHQNYFNKNPYQPYCVFSI
PPKLQKLKKYFPDQVSA

Sequences:

>Translated_177_residues
MLDTIVLGGGCFWCVESVFLSVVGVKEVESGYAGGNTKNPDYRSICSGKTGHAEVVKVSFDTEKISLSQILEIFFATHDP
TTPNRQGNDVGTQYRSVVMCHSQEQKDIAQEVISTLGNNGTFENPIVTEVVDLKDYYRAEEYHQNYFNKNPYQPYCVFSI
PPKLQKLKKYFPDQVSA
>Mature_177_residues
MLDTIVLGGGCFWCVESVFLSVVGVKEVESGYAGGNTKNPDYRSICSGKTGHAEVVKVSFDTEKISLSQILEIFFATHDP
TTPNRQGNDVGTQYRSVVMCHSQEQKDIAQEVISTLGNNGTFENPIVTEVVDLKDYYRAEEYHQNYFNKNPYQPYCVFSI
PPKLQKLKKYFPDQVSA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=158, Percent_Identity=44.3037974683544, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI208609995, Length=158, Percent_Identity=44.3037974683544, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI208609993, Length=115, Percent_Identity=43.4782608695652, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=41.1764705882353, Blast_Score=131, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=30.1369863013699, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=159, Percent_Identity=38.9937106918239, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24664627, Length=164, Percent_Identity=32.3170731707317, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45553131, Length=158, Percent_Identity=32.2784810126582, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=32.1212121212121, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_TRIEI (Q119G2)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720335.1
- ProteinModelPortal:   Q119G2
- SMR:   Q119G2
- STRING:   Q119G2
- GeneID:   4241628
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0394
- NMPDR:   fig|203124.1.peg.2402
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   VFYHDEA
- PhylomeDB:   Q119G2
- ProtClustDB:   CLSK2316634
- BioCyc:   TERY203124:TERY_0394-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19865; Mature: 19865

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: ACT_SITE 11-11

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTIVLGGGCFWCVESVFLSVVGVKEVESGYAGGNTKNPDYRSICSGKTGHAEVVKVSF
CCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEC
DTEKISLSQILEIFFATHDPTTPNRQGNDVGTQYRSVVMCHSQEQKDIAQEVISTLGNNG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
TFENPIVTEVVDLKDYYRAEEYHQNYFNKNPYQPYCVFSIPPKLQKLKKYFPDQVSA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDTIVLGGGCFWCVESVFLSVVGVKEVESGYAGGNTKNPDYRSICSGKTGHAEVVKVSF
CCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEEEEC
DTEKISLSQILEIFFATHDPTTPNRQGNDVGTQYRSVVMCHSQEQKDIAQEVISTLGNNG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
TFENPIVTEVVDLKDYYRAEEYHQNYFNKNPYQPYCVFSIPPKLQKLKKYFPDQVSA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA