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The map label for this gene is pyrFE [H]

Identifier: 113474256

GI number: 113474256

Start: 578538

End: 580040

Strand: Reverse

Name: pyrFE [H]

Synonym: Tery_0376

Alternate gene names: 113474256

Gene position: 580040-578538 (Counterclockwise)

Preceding gene: 113474261

Following gene: 113474255

Centisome position: 7.48

GC content: 33.33

Gene sequence:

>1503_bases
ATGAACTTTTTTGATAAGCTACTAACTAGCATAGAAAAGAACCAAAGTTTACTTTATCTGGAATTAGACCCTAATCCAGA
AAGTTTACCCAAACAAGCTGAGGGTAAAAATATTCCAGCAAAATATTTGCTTCTTAAACATCCAGAAAAAGATAATCAAG
AACTAATTCAAGATTGGTGGGAATGGCTCCATTTTTTAATAACTCAAACAGAAAAATATGTATGTGCTTATAAACTTTCT
TTAGGCTATTATCAATCTTTCGGCATACCAGGTTTACAACTACTTCAGCAAACCCTAAAAACTATTCCTTCTGAAATTCC
AATTATCTTAGATGCTAAACACAGTGACTTAAAAACAAGCACAGTATTTGCTCAGTCTATATTTGCAGATTTGCAAGTAG
ATGCTTGTACAATTTTACCCTATACAGGATTTGATTTAGTTGTACCTTTTTTACTTTATCCAGGTAAAGCAGTTTTTCTA
CTTTGTGCCACAGCAAATGCTTCAGCAGGAGTATTACAACAATATCCTAATCAAGAGCAACCTCTTTATTTGAAATTAGT
AGTAGAAGCTCAAAGATGGGCAACACCAGAAAAACTAGGTTTTGAAGTAGGAATAATGCCAGATATCCTAGGCAAAATCA
GACAAGTTGCTCCAGAAAGACTAATACTAATTCAAGGGGATATAGCAGAAGAAAATGATATTAATAATCCCCAAAAATTA
AATCAACTTTTAGCTGCTGGTTTGAATATTAATGGTGAAGGATTACTTTTACCAATACCACCAAAATTATTAGGAACTGC
AGAACCTAAGACTGCTATTAAAAGTTTAATAAGCACGATAAATGAACAACGTCTAAAGATGGTTAAAGGTAGTCCAACTT
GTGAATTGTGGTTGCCAGATATTTGTTTTTTACAACATCAACCACACCGGGATTTAATCTTACAACTTTATAATCTTGGC
TGTATTATTTTTGGCGATCATGTACAAGCATCGGGAGCTATTTTTCCCTACTATATAGACTTAAGAAAAATCATCTCAAT
TCCCCAAATATTCCATAAAATTGTTACTGCTTATGCTGAAATTATCCAGAATTTGGAATTTGATAGAATTGCAGGTATTC
CCTATGGTTCATTGCCCACTGCAACAGGTTTAGCTTTACATCTAGAACGCCCAATGATATTTCCTCGCAAAGAGGTAAAA
GCTTATGGTACTGGCCGATTAATTGAAGGCCATTTTCAACCAGGGGAAAAAATTGTAGTTGTGGATGATATTATGATTAC
TGGTAATAGTGTAATGGAGGGAGCAGAGAAACTAAAATCAGTGGGATTAAAAGTAGAAGATATTGTTGTATTTATTGACC
ATGAACGAGGAGTAAAGGATAAGTTACAAGACCATGGATATCTAGGTCACTCAGTATTGACTTTGACAGAAATTGCTCAA
ACTTTATATGAGTCTAACAAGATTAATTATGAACAATTTAATATCCTAAAAAATCATCATTAA

Upstream 100 bases:

>100_bases
AATTTCCGATTATAATCCAGTTTCTGCCTAACTCCTAAAACAATTATAATATCATATAATTTTAAATAATTACATAACTA
AAAAAGCAGAATAAAAAATC

Downstream 100 bases:

>100_bases
ATCCGATGCTATTTCCGCAAATATACTAATTTATAGTGGATGTCAAAAAGAGGTAATTAAACAAATTACAAGTCAGAAAG
TATAAGTTTTTCTTGTGATA

Product: bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein

Products: NA

Alternate protein names: Orotidine 5'-phosphate decarboxylase; OMP decarboxylase; OMPDCase; OMPdecase; Orotate phosphoribosyltransferase; OPRT; OPRTase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MNFFDKLLTSIEKNQSLLYLELDPNPESLPKQAEGKNIPAKYLLLKHPEKDNQELIQDWWEWLHFLITQTEKYVCAYKLS
LGYYQSFGIPGLQLLQQTLKTIPSEIPIILDAKHSDLKTSTVFAQSIFADLQVDACTILPYTGFDLVVPFLLYPGKAVFL
LCATANASAGVLQQYPNQEQPLYLKLVVEAQRWATPEKLGFEVGIMPDILGKIRQVAPERLILIQGDIAEENDINNPQKL
NQLLAAGLNINGEGLLLPIPPKLLGTAEPKTAIKSLISTINEQRLKMVKGSPTCELWLPDICFLQHQPHRDLILQLYNLG
CIIFGDHVQASGAIFPYYIDLRKIISIPQIFHKIVTAYAEIIQNLEFDRIAGIPYGSLPTATGLALHLERPMIFPRKEVK
AYGTGRLIEGHFQPGEKIVVVDDIMITGNSVMEGAEKLKSVGLKVEDIVVFIDHERGVKDKLQDHGYLGHSVLTLTEIAQ
TLYESNKINYEQFNILKNHH

Sequences:

>Translated_500_residues
MNFFDKLLTSIEKNQSLLYLELDPNPESLPKQAEGKNIPAKYLLLKHPEKDNQELIQDWWEWLHFLITQTEKYVCAYKLS
LGYYQSFGIPGLQLLQQTLKTIPSEIPIILDAKHSDLKTSTVFAQSIFADLQVDACTILPYTGFDLVVPFLLYPGKAVFL
LCATANASAGVLQQYPNQEQPLYLKLVVEAQRWATPEKLGFEVGIMPDILGKIRQVAPERLILIQGDIAEENDINNPQKL
NQLLAAGLNINGEGLLLPIPPKLLGTAEPKTAIKSLISTINEQRLKMVKGSPTCELWLPDICFLQHQPHRDLILQLYNLG
CIIFGDHVQASGAIFPYYIDLRKIISIPQIFHKIVTAYAEIIQNLEFDRIAGIPYGSLPTATGLALHLERPMIFPRKEVK
AYGTGRLIEGHFQPGEKIVVVDDIMITGNSVMEGAEKLKSVGLKVEDIVVFIDHERGVKDKLQDHGYLGHSVLTLTEIAQ
TLYESNKINYEQFNILKNHH
>Mature_500_residues
MNFFDKLLTSIEKNQSLLYLELDPNPESLPKQAEGKNIPAKYLLLKHPEKDNQELIQDWWEWLHFLITQTEKYVCAYKLS
LGYYQSFGIPGLQLLQQTLKTIPSEIPIILDAKHSDLKTSTVFAQSIFADLQVDACTILPYTGFDLVVPFLLYPGKAVFL
LCATANASAGVLQQYPNQEQPLYLKLVVEAQRWATPEKLGFEVGIMPDILGKIRQVAPERLILIQGDIAEENDINNPQKL
NQLLAAGLNINGEGLLLPIPPKLLGTAEPKTAIKSLISTINEQRLKMVKGSPTCELWLPDICFLQHQPHRDLILQLYNLG
CIIFGDHVQASGAIFPYYIDLRKIISIPQIFHKIVTAYAEIIQNLEFDRIAGIPYGSLPTATGLALHLERPMIFPRKEVK
AYGTGRLIEGHFQPGEKIVVVDDIMITGNSVMEGAEKLKSVGLKVEDIVVFIDHERGVKDKLQDHGYLGHSVLTLTEIAQ
TLYESNKINYEQFNILKNHH

Specific function: Catalyzes the decarboxylation of orotidine monophosphate (OMP) to uridine monophosphate (UMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=189, Percent_Identity=40.7407407407407, Blast_Score=151, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17508631, Length=184, Percent_Identity=36.4130434782609, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17554964, Length=188, Percent_Identity=33.5106382978723, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17933654, Length=181, Percent_Identity=35.3591160220994, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011995
- InterPro:   IPR001754
- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase; PF00156 Pribosyltran [H]

EC number: =4.1.1.23; =2.4.2.10 [H]

Molecular weight: Translated: 56278; Mature: 56278

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFDKLLTSIEKNQSLLYLELDPNPESLPKQAEGKNIPAKYLLLKHPEKDNQELIQDWW
CCHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
EWLHFLITQTEKYVCAYKLSLGYYQSFGIPGLQLLQQTLKTIPSEIPIILDAKHSDLKTS
HHHHHHHHCCCCEEEEEEEEHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
TVFAQSIFADLQVDACTILPYTGFDLVVPFLLYPGKAVFLLCATANASAGVLQQYPNQEQ
HHHHHHHHHHCEECEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCCCC
PLYLKLVVEAQRWATPEKLGFEVGIMPDILGKIRQVAPERLILIQGDIAEENDINNPQKL
CEEEEEEEEHHHCCCHHHCCEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHH
NQLLAAGLNINGEGLLLPIPPKLLGTAEPKTAIKSLISTINEQRLKMVKGSPTCELWLPD
HHHHHHCCCCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
ICFLQHQPHRDLILQLYNLGCIIFGDHVQASGAIFPYYIDLRKIISIPQIFHKIVTAYAE
CHHHCCCCCHHHHHHHHHCCEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
IIQNLEFDRIAGIPYGSLPTATGLALHLERPMIFPRKEVKAYGTGRLIEGHFQPGEKIVV
HHHCCCHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCEEECCCCCCCEEEE
VDDIMITGNSVMEGAEKLKSVGLKVEDIVVFIDHERGVKDKLQDHGYLGHSVLTLTEIAQ
EEEEEECCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHH
TLYESNKINYEQFNILKNHH
HHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MNFFDKLLTSIEKNQSLLYLELDPNPESLPKQAEGKNIPAKYLLLKHPEKDNQELIQDWW
CCHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
EWLHFLITQTEKYVCAYKLSLGYYQSFGIPGLQLLQQTLKTIPSEIPIILDAKHSDLKTS
HHHHHHHHCCCCEEEEEEEEHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
TVFAQSIFADLQVDACTILPYTGFDLVVPFLLYPGKAVFLLCATANASAGVLQQYPNQEQ
HHHHHHHHHHCEECEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHCCCCCC
PLYLKLVVEAQRWATPEKLGFEVGIMPDILGKIRQVAPERLILIQGDIAEENDINNPQKL
CEEEEEEEEHHHCCCHHHCCEEECCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHH
NQLLAAGLNINGEGLLLPIPPKLLGTAEPKTAIKSLISTINEQRLKMVKGSPTCELWLPD
HHHHHHCCCCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
ICFLQHQPHRDLILQLYNLGCIIFGDHVQASGAIFPYYIDLRKIISIPQIFHKIVTAYAE
CHHHCCCCCHHHHHHHHHCCEEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHH
IIQNLEFDRIAGIPYGSLPTATGLALHLERPMIFPRKEVKAYGTGRLIEGHFQPGEKIVV
HHHCCCHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCEEECCCCCCCEEEE
VDDIMITGNSVMEGAEKLKSVGLKVEDIVVFIDHERGVKDKLQDHGYLGHSVLTLTEIAQ
EEEEEECCCHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHH
TLYESNKINYEQFNILKNHH
HHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]