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The map label for this gene is icd [H]

Identifier: 113473992

GI number: 113473992

Start: 98280

End: 99698

Strand: Direct

Name: icd [H]

Synonym: Tery_0071

Alternate gene names: 113473992

Gene position: 98280-99698 (Clockwise)

Preceding gene: 113473990

Following gene: 113473993

Centisome position: 1.27

GC content: 38.48

Gene sequence:

>1419_bases
ATGTACGAAAAAATAACCCCCCCAACCACAGGGTCTAAAGTCACTTTCAGTAACGGCCAACCCATCGTTCCCGACGACCC
TATTATCCCATTTATTAGGGGCGATGGTACTGGATTAGATTTGTGGCCAGCATCTCAAAAAGTCTTTGACGCAGCGATCG
CTACTGCCTATGGAGACAAACGCAAAATTAATTGGTTTAAAATCTACGCTGGTGATGAAGCGTGTGACAAATATGGCACT
TTCCAATATTTGCCGGAAGATACTCTAAATGCCATAAAAGAATATGGTATTGCCATTAAAGGTCCTTTAACAACACCCAT
AGGTGGAGGTATTCGTTCCCTAAATGTCGCATTGCGTCAAATTAATGATTTATATGCTTGTGTTCGTCCTTGTAGATATT
ACACGGGTACACCTTCTCCTCACAAAACACCGGAAAAATTAGATGTCATCATTTACCGGGAAAATACAGAAGATATTTAT
CTGGGAATAGAATGGCGCGAGGGAACTGATATTGCTAGCAAATTGATTGACATTTTAAATAAAGACTTAATTCCTGCTAC
TCTCGAACACGGCAAAAAGCAAATTCGCTTCGACTCTGGTATTGGTATTAAACCTGTAAGTAAAACTGGTTCCCAACGTT
TGGTTAAACGTGCTATTCAAAATGCTTTGCGTTTACCTAAGTCCAAACAAATGGTAACTTTGGTACATAAAGGTAATATT
ATGAAGTACACCGAAGGCGCATTTCGTGACTGGGGTTATGAGTTAGCAACTACAGAATTTCGTCAAGAATGTGTCACTGA
AAGAGAATCTTGGATTCTTTCTAATAAAGAGGAAAACCTTAATATTAGTAGTGAGGAAAATTCTCGAAAAATTGACCCTG
GTTATGATGCTTTAACACCAGAAAAACAAGCAGAAATTTGCCAAGAAGTTGAGGATGTATTGGCAGCTATTTGGGATAGT
CATGGGCATGGAAAATGGAAAGAGAAAATCATGGTAAATGACCGAATTGCTGATAGTATTTTCCAACAAATTCAAACTCG
ACCAGAGGAGTATTCTATTCTGGCAACTATGAATTTGAATGGGGATTATTTATCCGACGCAGCAGCAGCTATTGTTGGTG
GTTTAGGTATGGGTCCAGGTGCTAATATTGGTGATAAATGTGCTATTTTTGAAGCCACTCATGGTACTGCTCCAAAACAC
GCAGGTTTAGATAGAGTAAACCCTGGTTCTTTAATTCTTTCTGGTGTAATGATGTTAGAATATATAGGCTGGCAAGAAGC
TGCAGATTTGATTAAAAAAGGTATTGAGATTTCTATTTCTAATGGTGAGGTAACTTATGATTTAGCAAGATTAATGGAAC
CATCTGTGCCGGCTTTGAAATGTTCTGAGTTTGCTGATGCAATTATCAAGCATTTTTAA

Upstream 100 bases:

>100_bases
AAAAAAATCTTATGTATATTTCAAAATATGTCATTATACATTGATAATCTGGACACAAAAGCATATATTTTACTCCAAAC
TATCAAGAAACTATCAAGGT

Downstream 100 bases:

>100_bases
AGATTAAAATCAAGAAAAATTGTGAAAGTTTAGAGGTTGAGAAAATAGGTATTGTCTGAGGATTAATATCATGTCTTAAA
AACTTTTATATATTTTGAAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MYEKITPPTTGSKVTFSNGQPIVPDDPIIPFIRGDGTGLDLWPASQKVFDAAIATAYGDKRKINWFKIYAGDEACDKYGT
FQYLPEDTLNAIKEYGIAIKGPLTTPIGGGIRSLNVALRQINDLYACVRPCRYYTGTPSPHKTPEKLDVIIYRENTEDIY
LGIEWREGTDIASKLIDILNKDLIPATLEHGKKQIRFDSGIGIKPVSKTGSQRLVKRAIQNALRLPKSKQMVTLVHKGNI
MKYTEGAFRDWGYELATTEFRQECVTERESWILSNKEENLNISSEENSRKIDPGYDALTPEKQAEICQEVEDVLAAIWDS
HGHGKWKEKIMVNDRIADSIFQQIQTRPEEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDKCAIFEATHGTAPKH
AGLDRVNPGSLILSGVMMLEYIGWQEAADLIKKGIEISISNGEVTYDLARLMEPSVPALKCSEFADAIIKHF

Sequences:

>Translated_472_residues
MYEKITPPTTGSKVTFSNGQPIVPDDPIIPFIRGDGTGLDLWPASQKVFDAAIATAYGDKRKINWFKIYAGDEACDKYGT
FQYLPEDTLNAIKEYGIAIKGPLTTPIGGGIRSLNVALRQINDLYACVRPCRYYTGTPSPHKTPEKLDVIIYRENTEDIY
LGIEWREGTDIASKLIDILNKDLIPATLEHGKKQIRFDSGIGIKPVSKTGSQRLVKRAIQNALRLPKSKQMVTLVHKGNI
MKYTEGAFRDWGYELATTEFRQECVTERESWILSNKEENLNISSEENSRKIDPGYDALTPEKQAEICQEVEDVLAAIWDS
HGHGKWKEKIMVNDRIADSIFQQIQTRPEEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDKCAIFEATHGTAPKH
AGLDRVNPGSLILSGVMMLEYIGWQEAADLIKKGIEISISNGEVTYDLARLMEPSVPALKCSEFADAIIKHF
>Mature_472_residues
MYEKITPPTTGSKVTFSNGQPIVPDDPIIPFIRGDGTGLDLWPASQKVFDAAIATAYGDKRKINWFKIYAGDEACDKYGT
FQYLPEDTLNAIKEYGIAIKGPLTTPIGGGIRSLNVALRQINDLYACVRPCRYYTGTPSPHKTPEKLDVIIYRENTEDIY
LGIEWREGTDIASKLIDILNKDLIPATLEHGKKQIRFDSGIGIKPVSKTGSQRLVKRAIQNALRLPKSKQMVTLVHKGNI
MKYTEGAFRDWGYELATTEFRQECVTERESWILSNKEENLNISSEENSRKIDPGYDALTPEKQAEICQEVEDVLAAIWDS
HGHGKWKEKIMVNDRIADSIFQQIQTRPEEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDKCAIFEATHGTAPKH
AGLDRVNPGSLILSGVMMLEYIGWQEAADLIKKGIEISISNGEVTYDLARLMEPSVPALKCSEFADAIIKHF

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=444, Percent_Identity=28.1531531531532, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI28178838, Length=132, Percent_Identity=31.0606060606061, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4758582, Length=114, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787381, Length=474, Percent_Identity=51.0548523206751, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1788101, Length=119, Percent_Identity=33.6134453781513, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081683, Length=136, Percent_Identity=33.0882352941176, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71986051, Length=241, Percent_Identity=31.5352697095436, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25144293, Length=107, Percent_Identity=36.4485981308411, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17505779, Length=101, Percent_Identity=35.6435643564356, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322097, Length=140, Percent_Identity=37.8571428571429, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324709, Length=232, Percent_Identity=29.3103448275862, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324291, Length=121, Percent_Identity=33.8842975206612, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24661184, Length=446, Percent_Identity=30.2690582959641, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24643268, Length=274, Percent_Identity=29.5620437956204, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24643270, Length=248, Percent_Identity=31.4516129032258, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 52320; Mature: 52320

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEKITPPTTGSKVTFSNGQPIVPDDPIIPFIRGDGTGLDLWPASQKVFDAAIATAYGDK
CCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
RKINWFKIYAGDEACDKYGTFQYLPEDTLNAIKEYGIAIKGPLTTPIGGGIRSLNVALRQ
CCCEEEEEEECCHHHHHCCCEEECCHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHH
INDLYACVRPCRYYTGTPSPHKTPEKLDVIIYRENTEDIYLGIEWREGTDIASKLIDILN
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHC
KDLIPATLEHGKKQIRFDSGIGIKPVSKTGSQRLVKRAIQNALRLPKSKQMVTLVHKGNI
CCCCHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCE
MKYTEGAFRDWGYELATTEFRQECVTERESWILSNKEENLNISSEENSRKIDPGYDALTP
EEECCCHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCC
EKQAEICQEVEDVLAAIWDSHGHGKWKEKIMVNDRIADSIFQQIQTRPEEYSILATMNLN
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECHHHHHHHHHHHHCCCCCEEEEEEEECC
GDYLSDAAAAIVGGLGMGPGANIGDKCAIFEATHGTAPKHAGLDRVNPGSLILSGVMMLE
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
YIGWQEAADLIKKGIEISISNGEVTYDLARLMEPSVPALKCSEFADAIIKHF
HHCHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYEKITPPTTGSKVTFSNGQPIVPDDPIIPFIRGDGTGLDLWPASQKVFDAAIATAYGDK
CCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
RKINWFKIYAGDEACDKYGTFQYLPEDTLNAIKEYGIAIKGPLTTPIGGGIRSLNVALRQ
CCCEEEEEEECCHHHHHCCCEEECCHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHH
INDLYACVRPCRYYTGTPSPHKTPEKLDVIIYRENTEDIYLGIEWREGTDIASKLIDILN
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHC
KDLIPATLEHGKKQIRFDSGIGIKPVSKTGSQRLVKRAIQNALRLPKSKQMVTLVHKGNI
CCCCHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCE
MKYTEGAFRDWGYELATTEFRQECVTERESWILSNKEENLNISSEENSRKIDPGYDALTP
EEECCCHHHHCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCC
EKQAEICQEVEDVLAAIWDSHGHGKWKEKIMVNDRIADSIFQQIQTRPEEYSILATMNLN
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEECHHHHHHHHHHHHCCCCCEEEEEEEECC
GDYLSDAAAAIVGGLGMGPGANIGDKCAIFEATHGTAPKHAGLDRVNPGSLILSGVMMLE
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
YIGWQEAADLIKKGIEISISNGEVTYDLARLMEPSVPALKCSEFADAIIKHF
HHCHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8169222; 11759840 [H]