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The map label for this gene is mdtA [H]

Identifier: 110835608

GI number: 110835608

Start: 3109518

End: 3110666

Strand: Reverse

Name: mdtA [H]

Synonym: ABO_2747

Alternate gene names: 110835608

Gene position: 3110666-3109518 (Counterclockwise)

Preceding gene: 110835609

Following gene: 110835607

Centisome position: 99.7

GC content: 59.88

Gene sequence:

>1149_bases
ATGGCGCGGATTATCGCGGGGCTGGTGCTGTTAGTACTGGTGGGGGTTGCTGTGTGGTGGTTTTGGCCCACGGAACAGGC
GCCCATGGGCTCGCGCCCGCCGACGGCGGTGAACTTAGCGCCGAGTATCGAGCGTCCTCTCTATGACCGGGTAGAAGCTG
TGGGCACCGCTCGTGCTGCTCAGGCCGTTGTGCTGTTGGCAGAAGTACCAGGGCGGGTAGCGGAAATCCACTTCCAGCAG
GGTCAGCAAGTCACGCGCGGGCAATTGCTGGTGACCTTGGATGACCGCAACGCCCGCGCTGAACTCGCTCGCGCTGAAGC
GGAGTACCAGCGTGCCAAGGACGACTATCGTCGTGGCCAGCAATTGGTGGATCGGCGCGCCATTTCCCAGTCCGAGGTAG
ATACGTTCCGCACTACTTTGGAAGCCGCTGAAGCCAGCCGGGATGTCGCCCGCGCCAATTTCAGTGACCATACCATCCGC
GCCCCATTTGCCGGCGTGTTGGGTCTTCGACAGGTGGACCCTGGCGCTTATCTGCAGACCGGTGATCCGATCACGACGCT
GGATAATGTGGGGCATTTGGAAGTGGATTTCCAGATACCAGAACGCTACTTGGCTAAGTTGGCTGTTGGTTTGCCGGTGC
AGATCCGCAATTCAGCGTTTGAAAATCAGGCCTTTGAAGGGAGCATTACCCATCTGGATTCGCGAGTGAACAGTAGCAGC
CGTAGCCTCACTGTGCGTGCGCGATTGAATAATCCTCAGGGCCAGTTATTGCCTGGGCAGTTTTTGCGAGTGTCTGTGCA
ATTAGCGCAACGCGATGCCTTGCTGGTGCCGGAGCAGGCAGTTATCACCCAGGGCGCGCAGAGCTATGTGTTCACCGTGA
GCAAGGATAACCGGGCGCGGCGTCATCCGGTTACCTTGGGCGGGCGCCGTGATGGCTGGGTGGAAGTCACCAGTGGCCTA
ACGGATAAACCGGACGTAGTCGTCAATGGCCACTCCCGGCTCGGCAGCGGTCAGCCGGTAAAGGTGATTGATGATCCGGA
GGCATTGCTGCCCGGCCAGCGGGTGTTGCTGAACTCGGAGCCAGCAGACGATGCTCCCTTTGGGGAGCCGCAACCGAATG
ATTCGGCTGTTAATGAGGCGGCGGCATGA

Upstream 100 bases:

>100_bases
AGCGGTCCTTTAAGGCGTGCTACACATTGCTTGCATAATTTAACGTTACACTGATGTGCTTCAATCAGTCTCGGTTTGAA
TGAAAATAATGGAGAGTGGC

Downstream 100 bases:

>100_bases
TCCTGTCGGATGTTTCTATTAAACGACCGGTCTTTGCCACCGTTATCAGCCTGCTGATCGTGGTGTTTGGCGTTAGCGCC
TTGCTAAAATTGCCAATCCG

Product: RND efflux membrane fusion protein

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MARIIAGLVLLVLVGVAVWWFWPTEQAPMGSRPPTAVNLAPSIERPLYDRVEAVGTARAAQAVVLLAEVPGRVAEIHFQQ
GQQVTRGQLLVTLDDRNARAELARAEAEYQRAKDDYRRGQQLVDRRAISQSEVDTFRTTLEAAEASRDVARANFSDHTIR
APFAGVLGLRQVDPGAYLQTGDPITTLDNVGHLEVDFQIPERYLAKLAVGLPVQIRNSAFENQAFEGSITHLDSRVNSSS
RSLTVRARLNNPQGQLLPGQFLRVSVQLAQRDALLVPEQAVITQGAQSYVFTVSKDNRARRHPVTLGGRRDGWVEVTSGL
TDKPDVVVNGHSRLGSGQPVKVIDDPEALLPGQRVLLNSEPADDAPFGEPQPNDSAVNEAAA

Sequences:

>Translated_382_residues
MARIIAGLVLLVLVGVAVWWFWPTEQAPMGSRPPTAVNLAPSIERPLYDRVEAVGTARAAQAVVLLAEVPGRVAEIHFQQ
GQQVTRGQLLVTLDDRNARAELARAEAEYQRAKDDYRRGQQLVDRRAISQSEVDTFRTTLEAAEASRDVARANFSDHTIR
APFAGVLGLRQVDPGAYLQTGDPITTLDNVGHLEVDFQIPERYLAKLAVGLPVQIRNSAFENQAFEGSITHLDSRVNSSS
RSLTVRARLNNPQGQLLPGQFLRVSVQLAQRDALLVPEQAVITQGAQSYVFTVSKDNRARRHPVTLGGRRDGWVEVTSGL
TDKPDVVVNGHSRLGSGQPVKVIDDPEALLPGQRVLLNSEPADDAPFGEPQPNDSAVNEAAA
>Mature_381_residues
ARIIAGLVLLVLVGVAVWWFWPTEQAPMGSRPPTAVNLAPSIERPLYDRVEAVGTARAAQAVVLLAEVPGRVAEIHFQQG
QQVTRGQLLVTLDDRNARAELARAEAEYQRAKDDYRRGQQLVDRRAISQSEVDTFRTTLEAAEASRDVARANFSDHTIRA
PFAGVLGLRQVDPGAYLQTGDPITTLDNVGHLEVDFQIPERYLAKLAVGLPVQIRNSAFENQAFEGSITHLDSRVNSSSR
SLTVRARLNNPQGQLLPGQFLRVSVQLAQRDALLVPEQAVITQGAQSYVFTVSKDNRARRHPVTLGGRRDGWVEVTSGLT
DKPDVVVNGHSRLGSGQPVKVIDDPEALLPGQRVLLNSEPADDAPFGEPQPNDSAVNEAAA

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=380, Percent_Identity=26.8421052631579, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789929, Length=334, Percent_Identity=27.2455089820359, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1789665, Length=334, Percent_Identity=27.5449101796407, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081796, Length=368, Percent_Identity=27.1739130434783, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87081951, Length=244, Percent_Identity=25.4098360655738, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786668, Length=371, Percent_Identity=25.8760107816712, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41626; Mature: 41495

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIIAGLVLLVLVGVAVWWFWPTEQAPMGSRPPTAVNLAPSIERPLYDRVEAVGTARAA
CHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
QAVVLLAEVPGRVAEIHFQQGQQVTRGQLLVTLDDRNARAELARAEAEYQRAKDDYRRGQ
HHEEEEECCCCCEEEEEHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QLVDRRAISQSEVDTFRTTLEAAEASRDVARANFSDHTIRAPFAGVLGLRQVDPGAYLQT
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCEECCCCCEEEC
GDPITTLDNVGHLEVDFQIPERYLAKLAVGLPVQIRNSAFENQAFEGSITHLDSRVNSSS
CCCCCHHCCCCEEEEEEECHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHCCCCC
RSLTVRARLNNPQGQLLPGQFLRVSVQLAQRDALLVPEQAVITQGAQSYVFTVSKDNRAR
CEEEEEEEECCCCCCCCCCHHHEEEEEHHCCCCEECCCHHHHHCCCCEEEEEEECCCCCC
RHPVTLGGRRDGWVEVTSGLTDKPDVVVNGHSRLGSGQPVKVIDDPEALLPGQRVLLNSE
CCCEEECCCCCCCEEEECCCCCCCCEEEECCCCCCCCCCEEEECCCHHHCCCCEEEECCC
PADDAPFGEPQPNDSAVNEAAA
CCCCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure 
ARIIAGLVLLVLVGVAVWWFWPTEQAPMGSRPPTAVNLAPSIERPLYDRVEAVGTARAA
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
QAVVLLAEVPGRVAEIHFQQGQQVTRGQLLVTLDDRNARAELARAEAEYQRAKDDYRRGQ
HHEEEEECCCCCEEEEEHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
QLVDRRAISQSEVDTFRTTLEAAEASRDVARANFSDHTIRAPFAGVLGLRQVDPGAYLQT
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCEECCCCCEEEC
GDPITTLDNVGHLEVDFQIPERYLAKLAVGLPVQIRNSAFENQAFEGSITHLDSRVNSSS
CCCCCHHCCCCEEEEEEECHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHHHCCCCC
RSLTVRARLNNPQGQLLPGQFLRVSVQLAQRDALLVPEQAVITQGAQSYVFTVSKDNRAR
CEEEEEEEECCCCCCCCCCHHHEEEEEHHCCCCEECCCHHHHHCCCCEEEEEEECCCCCC
RHPVTLGGRRDGWVEVTSGLTDKPDVVVNGHSRLGSGQPVKVIDDPEALLPGQRVLLNSE
CCCEEECCCCCCCEEEECCCCCCCCEEEECCCCCCCCCCEEEECCCHHHCCCCEEEECCC
PADDAPFGEPQPNDSAVNEAAA
CCCCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA