Click here to switch to the map view.

The map label for this gene is hyuA [H]

Identifier: 110835445

GI number: 110835445

Start: 2923960

End: 2925936

Strand: Direct

Name: hyuA [H]

Synonym: ABO_2584

Alternate gene names: 110835445

Gene position: 2923960-2925936 (Clockwise)

Preceding gene: 110835442

Following gene: 110835446

Centisome position: 93.71

GC content: 62.11

Gene sequence:

>1977_bases
ATGTCCGTCTCTTACTGGCTCGGCGTCGATACCGGCGGCACCTTTACTGACTTTGTTCTGCTAGGCGATGGCGAACCACG
CATCCACAAGGTGCTGTCCACGCCCGCGTCCCCGGAACAAGCCATCCTGCAAGGCATTCAGGAGCTGGGCCTGAGTGATG
CAATGGCCAGTGGGCAACTGGCCATTGTGCACGGCACCACCGTGGCCACCAACGCCGCCCTCGAAGGCAAGGGCGCTCGC
ACCTTATTGATTACCAATAACGGGCTGGAGGACATCCTCCGCATTGGCCGCCAAAACCGTCCAGAGCTCTATAATCTTAC
CCCGGCGAGTAACGCCTCGGCGGTGAGCCAGGTGCCCACCCTGGGCTGCCCGGCACGGCTCGATGCTGCTGGTAACACCG
TTACCGCGCTCACCGATAACGATATTGCCATCATACTGGCGGCGGTCCGTGAAATCGCTCCGGAGTCCATCGCCCTGTGC
CTGCTGTTCAGCTACCTGAACCCGGAGCACGAACAGCGGCTCAGCCAGGCTCTGCTCAGTGCCGGCTTTGCAGTGAGCCC
CTCGCACCAAATCTTACCTACTCGAGGCGAATACGAACGGGGCATGGCCACCTGGCTAAATGCTTGGCTCGCGCCGCGAG
TGGCGGATTACCTGCAACGCCTACAGCAGGCCACCAGCCCCGCTCCATTGGCCATCATGCAATCCCACGGTGGCACCATT
GCTTCCCAACAAGCCGCGAACCAAGCCGTCAATCTCCTATTGTCTGGGCCCGCCGGTGGGCTGGCCGCCGCTCAGCGGCT
AGGGCAACAACTGCAGCAGCCACACTTGATGACTTTCGACATGGGCGGCACCTCCACTGATGTTGCCTTGCTCGACGGGG
ATATCCGCCTAACCCAGCAGGGCCGCATCGGTCCTTATCCCGTGGCCGTGCCCATGGTAGACATGCACACCATCGGTGCC
GGAGGTGGCTCGCTAGCCTATGTGGATGAGGCTGGGCTACTGCACGTGGGGCCACACTCAGCCGGCGCCGATCCCGGCCC
CGCGTGCTACGGCAACGGCGGCCAACACGTCACAGTAACCGATGCCAATGTAGTACTGGGCCGGCTGCAACCAGACTTCG
CCCTGGGGGGCTCACTAACGCTGGATGTGGCTTGCGCTGAGCAGGCCATGGACCGGTTAGCCGTAGCCCTCAACCTGACA
CGTCAGCAAACCGCTGAAGGAGTACTGGCGCTAGCCAACGAACACATGACCCAAGCCCTGCGGGTGATCTCCATCCAGAA
GGGCTTCGATCCCGCTGACTTCGCGCTAATGAGCTTTGGCGGCGCCGGGGGACTGCACGTCTGTGCGCTGGCCGACAACC
TGGGCATGCCACGGGCCATTGTCCCGCAGCGGGCCGGCGTGCTGTCTGCCGAAGGGCTGGTATATGCCCCCCGTAAACGG
GAAATATTGCAGGCGCTGCCAGAATCCGCCGACGAAGACTCCCTGCGTGCACTCATCGTCCAGCTGCAACAGCAAGGCTC
AAATGAACTTATCGCGGAAGGCGTTAGCGCAGACCGCATCCAGCACCGGGTATTTGTAGATATGTGCTATCAAGGCCAGT
CCTCAGTGCTACAAATTGATTGGCACGAAGAACCGGCAGACCGGGTAAGCCGCTTCCATGCGGCTCACCAGCAACGTTTT
GGCCACCGGTTAGGGCTACCAGTACAGCAGGTTAACCTACGCATTCAAAGCCAGGCTTTGGCTACCCCGCCCACGCTGCC
CGACGGCCACACTCAAACCGCCAACCCCGAACGCCAAGCGACGCTGCCGGGTATCCGCACCGCGGTGGCCGTGTTCAGCC
GCGAAACACTGGGTGTAGGTCAACGCCTCACCGGCCCGGCCCTGATTTACGAAGCAGTGGGCACCACCTGGCTGGAAACG
GGCTGGACCGCGACGGTAAACCCGCAAGGGCACCTGTTGTTACAGCGCGACGCCTAG

Upstream 100 bases:

>100_bases
TTGCGCGGTCCCGAAGAGCGCGCTGGCGCTAGCTATGTTACCTTGCTGCCAGTTTTTTTGTCTTTCGCTGTCACCGTTCA
ACAGATAACTGCCCACTACT

Downstream 100 bases:

>100_bases
CGGGCCGCCCAGCCATCAGCCCATCGCCCCCTTTGGGCCCCTGATTGACCGTAAAGTCCGAATTTGACCTGCTTCGTGTC
TTCTATCTGCCATCACCGGT

Product: N-methylhydantoinase A

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: ORF2 [H]

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSVSYWLGVDTGGTFTDFVLLGDGEPRIHKVLSTPASPEQAILQGIQELGLSDAMASGQLAIVHGTTVATNAALEGKGAR
TLLITNNGLEDILRIGRQNRPELYNLTPASNASAVSQVPTLGCPARLDAAGNTVTALTDNDIAIILAAVREIAPESIALC
LLFSYLNPEHEQRLSQALLSAGFAVSPSHQILPTRGEYERGMATWLNAWLAPRVADYLQRLQQATSPAPLAIMQSHGGTI
ASQQAANQAVNLLLSGPAGGLAAAQRLGQQLQQPHLMTFDMGGTSTDVALLDGDIRLTQQGRIGPYPVAVPMVDMHTIGA
GGGSLAYVDEAGLLHVGPHSAGADPGPACYGNGGQHVTVTDANVVLGRLQPDFALGGSLTLDVACAEQAMDRLAVALNLT
RQQTAEGVLALANEHMTQALRVISIQKGFDPADFALMSFGGAGGLHVCALADNLGMPRAIVPQRAGVLSAEGLVYAPRKR
EILQALPESADEDSLRALIVQLQQQGSNELIAEGVSADRIQHRVFVDMCYQGQSSVLQIDWHEEPADRVSRFHAAHQQRF
GHRLGLPVQQVNLRIQSQALATPPTLPDGHTQTANPERQATLPGIRTAVAVFSRETLGVGQRLTGPALIYEAVGTTWLET
GWTATVNPQGHLLLQRDA

Sequences:

>Translated_658_residues
MSVSYWLGVDTGGTFTDFVLLGDGEPRIHKVLSTPASPEQAILQGIQELGLSDAMASGQLAIVHGTTVATNAALEGKGAR
TLLITNNGLEDILRIGRQNRPELYNLTPASNASAVSQVPTLGCPARLDAAGNTVTALTDNDIAIILAAVREIAPESIALC
LLFSYLNPEHEQRLSQALLSAGFAVSPSHQILPTRGEYERGMATWLNAWLAPRVADYLQRLQQATSPAPLAIMQSHGGTI
ASQQAANQAVNLLLSGPAGGLAAAQRLGQQLQQPHLMTFDMGGTSTDVALLDGDIRLTQQGRIGPYPVAVPMVDMHTIGA
GGGSLAYVDEAGLLHVGPHSAGADPGPACYGNGGQHVTVTDANVVLGRLQPDFALGGSLTLDVACAEQAMDRLAVALNLT
RQQTAEGVLALANEHMTQALRVISIQKGFDPADFALMSFGGAGGLHVCALADNLGMPRAIVPQRAGVLSAEGLVYAPRKR
EILQALPESADEDSLRALIVQLQQQGSNELIAEGVSADRIQHRVFVDMCYQGQSSVLQIDWHEEPADRVSRFHAAHQQRF
GHRLGLPVQQVNLRIQSQALATPPTLPDGHTQTANPERQATLPGIRTAVAVFSRETLGVGQRLTGPALIYEAVGTTWLET
GWTATVNPQGHLLLQRDA
>Mature_657_residues
SVSYWLGVDTGGTFTDFVLLGDGEPRIHKVLSTPASPEQAILQGIQELGLSDAMASGQLAIVHGTTVATNAALEGKGART
LLITNNGLEDILRIGRQNRPELYNLTPASNASAVSQVPTLGCPARLDAAGNTVTALTDNDIAIILAAVREIAPESIALCL
LFSYLNPEHEQRLSQALLSAGFAVSPSHQILPTRGEYERGMATWLNAWLAPRVADYLQRLQQATSPAPLAIMQSHGGTIA
SQQAANQAVNLLLSGPAGGLAAAQRLGQQLQQPHLMTFDMGGTSTDVALLDGDIRLTQQGRIGPYPVAVPMVDMHTIGAG
GGSLAYVDEAGLLHVGPHSAGADPGPACYGNGGQHVTVTDANVVLGRLQPDFALGGSLTLDVACAEQAMDRLAVALNLTR
QQTAEGVLALANEHMTQALRVISIQKGFDPADFALMSFGGAGGLHVCALADNLGMPRAIVPQRAGVLSAEGLVYAPRKRE
ILQALPESADEDSLRALIVQLQQQGSNELIAEGVSADRIQHRVFVDMCYQGQSSVLQIDWHEEPADRVSRFHAAHQQRFG
HRLGLPVQQVNLRIQSQALATPPTLPDGHTQTANPERQATLPGIRTAVAVFSRETLGVGQRLTGPALIYEAVGTTWLETG
WTATVNPQGHLLLQRDA

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0145

COG function: function code EQ; N-methylhydantoinase A/acetone carboxylase, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=727, Percent_Identity=30.8115543328748, Blast_Score=235, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI133901900, Length=707, Percent_Identity=26.7326732673267, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322634, Length=729, Percent_Identity=27.8463648834019, Blast_Score=218, Evalue=3e-57,
Organism=Drosophila melanogaster, GI45550492, Length=728, Percent_Identity=29.3956043956044, Blast_Score=259, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008040
- InterPro:   IPR002821 [H]

Pfam domain/function: PF05378 Hydant_A_N; PF01968 Hydantoinase_A [H]

EC number: 3.5.2.14

Molecular weight: Translated: 69584; Mature: 69453

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSYWLGVDTGGTFTDFVLLGDGEPRIHKVLSTPASPEQAILQGIQELGLSDAMASGQL
CCEEEEEEECCCCCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCE
AIVHGTTVATNAALEGKGARTLLITNNGLEDILRIGRQNRPELYNLTPASNASAVSQVPT
EEEECCEEEECCEECCCCCEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCCHHHHHCCC
LGCPARLDAAGNTVTALTDNDIAIILAAVREIAPESIALCLLFSYLNPEHEQRLSQALLS
CCCCCEECCCCCEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHH
AGFAVSPSHQILPTRGEYERGMATWLNAWLAPRVADYLQRLQQATSPAPLAIMQSHGGTI
CCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
ASQQAANQAVNLLLSGPAGGLAAAQRLGQQLQQPHLMTFDMGGTSTDVALLDGDIRLTQQ
HHHHHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCEEEEEC
GRIGPYPVAVPMVDMHTIGAGGGSLAYVDEAGLLHVGPHSAGADPGPACYGNGGQHVTVT
CCCCCCCEEECEEEEEEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCEEEEE
DANVVLGRLQPDFALGGSLTLDVACAEQAMDRLAVALNLTRQQTAEGVLALANEHMTQAL
EEEEEEECCCCCEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVISIQKGFDPADFALMSFGGAGGLHVCALADNLGMPRAIVPQRAGVLSAEGLVYAPRKR
HHHHHHCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEECCCEEECCHHH
EILQALPESADEDSLRALIVQLQQQGSNELIAEGVSADRIQHRVFVDMCYQGQSSVLQID
HHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHEEHHHHCCCCCEEEEE
WHEEPADRVSRFHAAHQQRFGHRLGLPVQQVNLRIQSQALATPPTLPDGHTQTANPERQA
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCEEEECHHCCCCCCCCCCCCCCCCCCCCC
TLPGIRTAVAVFSRETLGVGQRLTGPALIYEAVGTTWLETGWTATVNPQGHLLLQRDA
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEECCCCEEEECCCCCEEEEECC
>Mature Secondary Structure 
SVSYWLGVDTGGTFTDFVLLGDGEPRIHKVLSTPASPEQAILQGIQELGLSDAMASGQL
CEEEEEEECCCCCEEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHCCCCE
AIVHGTTVATNAALEGKGARTLLITNNGLEDILRIGRQNRPELYNLTPASNASAVSQVPT
EEEECCEEEECCEECCCCCEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCCHHHHHCCC
LGCPARLDAAGNTVTALTDNDIAIILAAVREIAPESIALCLLFSYLNPEHEQRLSQALLS
CCCCCEECCCCCEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHH
AGFAVSPSHQILPTRGEYERGMATWLNAWLAPRVADYLQRLQQATSPAPLAIMQSHGGTI
CCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
ASQQAANQAVNLLLSGPAGGLAAAQRLGQQLQQPHLMTFDMGGTSTDVALLDGDIRLTQQ
HHHHHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCEEEEEC
GRIGPYPVAVPMVDMHTIGAGGGSLAYVDEAGLLHVGPHSAGADPGPACYGNGGQHVTVT
CCCCCCCEEECEEEEEEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCEEEEE
DANVVLGRLQPDFALGGSLTLDVACAEQAMDRLAVALNLTRQQTAEGVLALANEHMTQAL
EEEEEEECCCCCEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVISIQKGFDPADFALMSFGGAGGLHVCALADNLGMPRAIVPQRAGVLSAEGLVYAPRKR
HHHHHHCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEECCCEEECCHHH
EILQALPESADEDSLRALIVQLQQQGSNELIAEGVSADRIQHRVFVDMCYQGQSSVLQID
HHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHEEHHHHCCCCCEEEEE
WHEEPADRVSRFHAAHQQRFGHRLGLPVQQVNLRIQSQALATPPTLPDGHTQTANPERQA
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCEEEECHHCCCCCCCCCCCCCCCCCCCCC
TLPGIRTAVAVFSRETLGVGQRLTGPALIYEAVGTTWLETGWTATVNPQGHLLLQRDA
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEECCCCEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]