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The map label for this gene is folK [H]

Identifier: 110834917

GI number: 110834917

Start: 2344257

End: 2344769

Strand: Reverse

Name: folK [H]

Synonym: ABO_2056

Alternate gene names: 110834917

Gene position: 2344769-2344257 (Counterclockwise)

Preceding gene: 110834918

Following gene: 110834912

Centisome position: 75.15

GC content: 52.83

Gene sequence:

>513_bases
ATGCCTGACGTGTCTCAGGCTCAGGTATTTCTAAGCCTGGGCTCCAATATCGACCGTGAGCACAATATTAGCTCTGGGTT
AGATGCCCTAAAGCGGGCATTTTCCCCCTTGTCGATCAGCCCGGTGTACGAAAGTGAAGCGGTGGGTTTCGATGGTGATG
CCTTTTACAACCTAGTGGTGGGGCTGAAGACAGCCTTGAGTGTGGGAGAACTGGCTGCCTGTCTAAAAGAGATCGAAAAG
GAGCATGGTCGGGTGCGGGGCGAGAAAAAGTTTTCAAGCCGAACCTTGGATATTGATATTCTCACCTACAATGATTGTGT
GGGTGAGATAGAGGGTGTGCAGCTGCCCCGGGACGAAATTCTCAAGCATGCTTTTGTTCTAAAACCCCTGGTCGATCTGG
CCCCGGATGCCATGCACCCGCAAACCCGTGCATCCTACCGGGCATTGTTGGACGCGGCTGATTTCAGCGGGCAGAACTTA
TGGGTAGTGCCGTTCGGCGGCAAGAAACAATAG

Upstream 100 bases:

>100_bases
GAGTTCAGTGTGCCGTGGCTAAAATTGCGACTCAGCAAGCCGGGCGCTTTGCGCGGCGCCCGTGATGTGGGGGTGATCAT
TGAGCGGGGTGTGCGTCCCA

Downstream 100 bases:

>100_bases
TTTTTGTAGATTGCGTTAGCGACATGTCGGTGCAAACCGGCAGCTATCGGTAGGCCTGAGATGCAACGTGTTCCGTGCTG
TGTCTCTCAATACCAATGCG

Product: 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MPDVSQAQVFLSLGSNIDREHNISSGLDALKRAFSPLSISPVYESEAVGFDGDAFYNLVVGLKTALSVGELAACLKEIEK
EHGRVRGEKKFSSRTLDIDILTYNDCVGEIEGVQLPRDEILKHAFVLKPLVDLAPDAMHPQTRASYRALLDAADFSGQNL
WVVPFGGKKQ

Sequences:

>Translated_170_residues
MPDVSQAQVFLSLGSNIDREHNISSGLDALKRAFSPLSISPVYESEAVGFDGDAFYNLVVGLKTALSVGELAACLKEIEK
EHGRVRGEKKFSSRTLDIDILTYNDCVGEIEGVQLPRDEILKHAFVLKPLVDLAPDAMHPQTRASYRALLDAADFSGQNL
WVVPFGGKKQ
>Mature_169_residues
PDVSQAQVFLSLGSNIDREHNISSGLDALKRAFSPLSISPVYESEAVGFDGDAFYNLVVGLKTALSVGELAACLKEIEKE
HGRVRGEKKFSSRTLDIDILTYNDCVGEIEGVQLPRDEILKHAFVLKPLVDLAPDAMHPQTRASYRALLDAADFSGQNLW
VVPFGGKKQ

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=156, Percent_Identity=28.8461538461538, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18603; Mature: 18472

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDVSQAQVFLSLGSNIDREHNISSGLDALKRAFSPLSISPVYESEAVGFDGDAFYNLVV
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
GLKTALSVGELAACLKEIEKEHGRVRGEKKFSSRTLDIDILTYNDCVGEIEGVQLPRDEI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHH
LKHAFVLKPLVDLAPDAMHPQTRASYRALLDAADFSGQNLWVVPFGGKKQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
PDVSQAQVFLSLGSNIDREHNISSGLDALKRAFSPLSISPVYESEAVGFDGDAFYNLVV
CCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHH
GLKTALSVGELAACLKEIEKEHGRVRGEKKFSSRTLDIDILTYNDCVGEIEGVQLPRDEI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEEEEECCCCCCCCCCCCCHHHH
LKHAFVLKPLVDLAPDAMHPQTRASYRALLDAADFSGQNLWVVPFGGKKQ
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]