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The map label for this gene is upp [H]

Identifier: 110834852

GI number: 110834852

Start: 2278685

End: 2279341

Strand: Reverse

Name: upp [H]

Synonym: ABO_1991

Alternate gene names: 110834852

Gene position: 2279341-2278685 (Counterclockwise)

Preceding gene: 110834853

Following gene: 110834851

Centisome position: 73.05

GC content: 56.32

Gene sequence:

>657_bases
ATGTTTATTGGTATCCAGGAGCCTGCCACCATGAGTGTCCATGAAATTCGCCATCCGTTGGTCCAACACAAGCTGGGGCT
GTTGCGCCAGAAGAGCTTGAGCACCCGTAGTTTTCGCCAGTTGACCTCTGAGGTGGGCAGCCTGTTGACCTACGAAGCCA
CTAGCGACTTGGTGCTGGAGGATTATCAGGTGGATACCTGGATGGGCAAGGCGCCAGCCCAGCGCATCCGGGGTAAAAAA
ATCACTGTGGTGCCTATTCTCCGGGCCGGATTGGGTATGCTGGATGGAGTGCTGGGATTGATCCCCAGCGCTAAAGTGAG
TGTGGTGGGGGTGTATCGGGATGAGACCACTCTGCAGCCGGTGGCCTATTTTGAGAAGCTGGCCCACGATATCGACGAGC
GCACGGCGCTAGTTATCGACCCCATGCTAGCCACCGGGGGCTCCATGCTGGCTTGCATCGACATGCTAAAAAAAGCCGGT
TGCACCCAGATTCGAGCTTTGGTGCTGGTGGCGGCGCCGGAAGGTATCCGTAAAGTCCAAGAAGCACACCCTGATGTGTC
TCTTTACACTGCTTCGGTGGATCAGGGTTTGAATGAGGACGGTTACATTATGCCGGGCCTGGGGGATGCCGGGGACAAGA
TTTTCGGCACCAAGTAG

Upstream 100 bases:

>100_bases
GTGTGAGGGGGCGTGCGGTGAAATGACACAGCGTGTGCACCGGTGACATTTGCGCTGTAATCGTCACAATATCGCTATTG
TTGGGGTGATCTGCGCCCCT

Downstream 100 bases:

>100_bases
CCGCGTGATGATTGCTAACAGGAGCTCCTTATGAGCCAGACCGGCGGATTCTGGAACTGGAAAACCATTCTTATTGGTGC
CCAGATGCTGTTTGTGGCTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MFIGIQEPATMSVHEIRHPLVQHKLGLLRQKSLSTRSFRQLTSEVGSLLTYEATSDLVLEDYQVDTWMGKAPAQRIRGKK
ITVVPILRAGLGMLDGVLGLIPSAKVSVVGVYRDETTLQPVAYFEKLAHDIDERTALVIDPMLATGGSMLACIDMLKKAG
CTQIRALVLVAAPEGIRKVQEAHPDVSLYTASVDQGLNEDGYIMPGLGDAGDKIFGTK

Sequences:

>Translated_218_residues
MFIGIQEPATMSVHEIRHPLVQHKLGLLRQKSLSTRSFRQLTSEVGSLLTYEATSDLVLEDYQVDTWMGKAPAQRIRGKK
ITVVPILRAGLGMLDGVLGLIPSAKVSVVGVYRDETTLQPVAYFEKLAHDIDERTALVIDPMLATGGSMLACIDMLKKAG
CTQIRALVLVAAPEGIRKVQEAHPDVSLYTASVDQGLNEDGYIMPGLGDAGDKIFGTK
>Mature_218_residues
MFIGIQEPATMSVHEIRHPLVQHKLGLLRQKSLSTRSFRQLTSEVGSLLTYEATSDLVLEDYQVDTWMGKAPAQRIRGKK
ITVVPILRAGLGMLDGVLGLIPSAKVSVVGVYRDETTLQPVAYFEKLAHDIDERTALVIDPMLATGGSMLACIDMLKKAG
CTQIRALVLVAAPEGIRKVQEAHPDVSLYTASVDQGLNEDGYIMPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=213, Percent_Identity=29.1079812206573, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI57863312, Length=213, Percent_Identity=29.1079812206573, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=67.7884615384615, Blast_Score=305, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=21.8905472636816, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=21.8905472636816, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=202, Percent_Identity=34.6534653465347, Blast_Score=111, Evalue=8e-26,
Organism=Drosophila melanogaster, GI45550449, Length=217, Percent_Identity=26.2672811059908, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573516, Length=217, Percent_Identity=26.2672811059908, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573514, Length=217, Percent_Identity=26.2672811059908, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573512, Length=217, Percent_Identity=26.2672811059908, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23659; Mature: 23659

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIGIQEPATMSVHEIRHPLVQHKLGLLRQKSLSTRSFRQLTSEVGSLLTYEATSDLVLE
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCCEEE
DYQVDTWMGKAPAQRIRGKKITVVPILRAGLGMLDGVLGLIPSAKVSVVGVYRDETTLQP
CEEHHHHCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHH
VAYFEKLAHDIDERTALVIDPMLATGGSMLACIDMLKKAGCTQIRALVLVAAPEGIRKVQ
HHHHHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHHHHHHEEECCHHHHHHH
EAHPDVSLYTASVDQGLNEDGYIMPGLGDAGDKIFGTK
HHCCCCEEEEEHHHCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MFIGIQEPATMSVHEIRHPLVQHKLGLLRQKSLSTRSFRQLTSEVGSLLTYEATSDLVLE
CEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEECCCCCCEEE
DYQVDTWMGKAPAQRIRGKKITVVPILRAGLGMLDGVLGLIPSAKVSVVGVYRDETTLQP
CEEHHHHCCCCHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHH
VAYFEKLAHDIDERTALVIDPMLATGGSMLACIDMLKKAGCTQIRALVLVAAPEGIRKVQ
HHHHHHHHHHHHHCCEEEECCHHHCCCHHHHHHHHHHHCCHHHHHHHHEEECCHHHHHHH
EAHPDVSLYTASVDQGLNEDGYIMPGLGDAGDKIFGTK
HHCCCCEEEEEHHHCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA