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The map label for this gene is uraA [H]

Identifier: 110834851

GI number: 110834851

Start: 2277338

End: 2278654

Strand: Reverse

Name: uraA [H]

Synonym: ABO_1990

Alternate gene names: 110834851

Gene position: 2278654-2277338 (Counterclockwise)

Preceding gene: 110834852

Following gene: 110834849

Centisome position: 73.03

GC content: 55.05

Gene sequence:

>1317_bases
ATGAGCCAGACCGGCGGATTCTGGAACTGGAAAACCATTCTTATTGGTGCCCAGATGCTGTTTGTGGCTTTTGGTGCGAT
GGTGTTAATGCCGTTGCTCACAGGGCTGGACCCCAGCGTGGCGCTATTTACCGCGGGCTTGGGCACGCTGCTGTTTCAAT
GGATTACTCGGCGCTCTATTCCTGTCTTTCTCGCGTCCTCTTTTGTATTTGTGGCACCCATTTCCCATGCTGTGAAACAG
TGGGGGGTGCCAGCCACGATGGGGGCGCTGTTCTGCACTGCCGTGGTTTACGTGATTCTCGGAGTGTTAGTGAAATGGCG
GGGCCCGGGGTTTCTGCACCGGCTGATGCCGCCGGTAGTCACCGGCCCCATCATTATGGTGATTGGGCTGAGCTTGGCAC
CTACTGCGGTGAACTTTGCCATGGGCATGTCCGGTAATGGTGAGATGCAGATGTTTGCGTATGGGGATGCGCTGCTCGTT
TCCATGGTTTCCTTGTTGGTCACTATGTTGGTGGCGGCGCTGGGGCATGGTTTGTTCCGGCTATTACCCATTCTGTGCGG
AGTAGTTTCGGGCTATCTGACGGCCCTGGCCATGGGCATGGTGGATTTTTCCGGGGTGAATCAAGCGGGCTGGTTATCGG
TGCCGACCTTTATTGCTCCCACCTTTTATTGGCCCGCCATCCTGTTCATGATGCCGGTGGCACTGGCGCCGGCCATTGAG
CATGTAGGAGATGTGCTGGCGATCAGTAACGTGACCGGCAAAGACTATATTCGTAAGCCTGGGCTGCATCGCACGCTCAC
AGGCGATGGTGTGGCCAGCATGGTGGCGGCCTTGTTCGGTGGCCCACCTAATACCACTTATTCGGAAGTTACCGGTGCGG
TGATGTTGACCCGGGTGTTTAATCCGGTGGTAATGACCTGGACGGCGATCTTCGCCATCTTATTGGCCTTTATTGGCAAG
TTTGGGTTGTTACTACAGAGTATCCCCACCCCAGTGATGGGCGGAATTTTGATTCTTATGTTCGGCTCCATTGCGAGTGT
GGGCATGAATACCTTGATCAAGGCGCAGGTGGATCTTCATGCGCAACGTAATCTGGTCATTGTGGCGGTAACCTTGATTT
TCGGCATTGGCGGCATGGTCATGGGCAACGGCGACTTCACCCTGCAGGGTATTAGCCTATGCGGGTTGGTGGCGGTGCTC
CTGAATCAGGTGCTTCCCCATGCCCCCTTCATGGCCGATGATCTTCATGAAGAGCAGGAGTATGTTGATGACTTATTGGC
GCACGTGCGTAAAAAAGAGCGCGATGAGCGCACATGA

Upstream 100 bases:

>100_bases
TTTGAATGAGGACGGTTACATTATGCCGGGCCTGGGGGATGCCGGGGACAAGATTTTCGGCACCAAGTAGCCGCGTGATG
ATTGCTAACAGGAGCTCCTT

Downstream 100 bases:

>100_bases
TTCTGTTTTTATGAGGCGGTTGATCTGATGGTTGAATCGTCGAAATTAAAAGAATAGTTGTTCTGGGAAACGGTCAGGGC
TGAATGGCCATTGGCCGTTA

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSQTGGFWNWKTILIGAQMLFVAFGAMVLMPLLTGLDPSVALFTAGLGTLLFQWITRRSIPVFLASSFVFVAPISHAVKQ
WGVPATMGALFCTAVVYVILGVLVKWRGPGFLHRLMPPVVTGPIIMVIGLSLAPTAVNFAMGMSGNGEMQMFAYGDALLV
SMVSLLVTMLVAALGHGLFRLLPILCGVVSGYLTALAMGMVDFSGVNQAGWLSVPTFIAPTFYWPAILFMMPVALAPAIE
HVGDVLAISNVTGKDYIRKPGLHRTLTGDGVASMVAALFGGPPNTTYSEVTGAVMLTRVFNPVVMTWTAIFAILLAFIGK
FGLLLQSIPTPVMGGILILMFGSIASVGMNTLIKAQVDLHAQRNLVIVAVTLIFGIGGMVMGNGDFTLQGISLCGLVAVL
LNQVLPHAPFMADDLHEEQEYVDDLLAHVRKKERDERT

Sequences:

>Translated_438_residues
MSQTGGFWNWKTILIGAQMLFVAFGAMVLMPLLTGLDPSVALFTAGLGTLLFQWITRRSIPVFLASSFVFVAPISHAVKQ
WGVPATMGALFCTAVVYVILGVLVKWRGPGFLHRLMPPVVTGPIIMVIGLSLAPTAVNFAMGMSGNGEMQMFAYGDALLV
SMVSLLVTMLVAALGHGLFRLLPILCGVVSGYLTALAMGMVDFSGVNQAGWLSVPTFIAPTFYWPAILFMMPVALAPAIE
HVGDVLAISNVTGKDYIRKPGLHRTLTGDGVASMVAALFGGPPNTTYSEVTGAVMLTRVFNPVVMTWTAIFAILLAFIGK
FGLLLQSIPTPVMGGILILMFGSIASVGMNTLIKAQVDLHAQRNLVIVAVTLIFGIGGMVMGNGDFTLQGISLCGLVAVL
LNQVLPHAPFMADDLHEEQEYVDDLLAHVRKKERDERT
>Mature_437_residues
SQTGGFWNWKTILIGAQMLFVAFGAMVLMPLLTGLDPSVALFTAGLGTLLFQWITRRSIPVFLASSFVFVAPISHAVKQW
GVPATMGALFCTAVVYVILGVLVKWRGPGFLHRLMPPVVTGPIIMVIGLSLAPTAVNFAMGMSGNGEMQMFAYGDALLVS
MVSLLVTMLVAALGHGLFRLLPILCGVVSGYLTALAMGMVDFSGVNQAGWLSVPTFIAPTFYWPAILFMMPVALAPAIEH
VGDVLAISNVTGKDYIRKPGLHRTLTGDGVASMVAALFGGPPNTTYSEVTGAVMLTRVFNPVVMTWTAIFAILLAFIGKF
GLLLQSIPTPVMGGILILMFGSIASVGMNTLIKAQVDLHAQRNLVIVAVTLIFGIGGMVMGNGDFTLQGISLCGLVAVLL
NQVLPHAPFMADDLHEEQEYVDDLLAHVRKKERDERT

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=434, Percent_Identity=24.6543778801843, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI44680143, Length=438, Percent_Identity=24.4292237442922, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI44680148, Length=442, Percent_Identity=22.8506787330317, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI40316845, Length=442, Percent_Identity=22.8506787330317, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788843, Length=422, Percent_Identity=36.0189573459716, Blast_Score=261, Evalue=7e-71,
Organism=Escherichia coli, GI87081818, Length=410, Percent_Identity=35.8536585365854, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI87082181, Length=468, Percent_Identity=28.8461538461538, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1790087, Length=368, Percent_Identity=28.2608695652174, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082178, Length=313, Percent_Identity=27.7955271565495, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17558856, Length=175, Percent_Identity=29.7142857142857, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17542262, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71993493, Length=157, Percent_Identity=29.9363057324841, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17542260, Length=157, Percent_Identity=29.2993630573248, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21356175, Length=386, Percent_Identity=27.979274611399, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46771; Mature: 46640

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQTGGFWNWKTILIGAQMLFVAFGAMVLMPLLTGLDPSVALFTAGLGTLLFQWITRRSI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
PVFLASSFVFVAPISHAVKQWGVPATMGALFCTAVVYVILGVLVKWRGPGFLHRLMPPVV
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHH
TGPIIMVIGLSLAPTAVNFAMGMSGNGEMQMFAYGDALLVSMVSLLVTMLVAALGHGLFR
HCHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
LLPILCGVVSGYLTALAMGMVDFSGVNQAGWLSVPTFIAPTFYWPAILFMMPVALAPAIE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
HVGDVLAISNVTGKDYIRKPGLHRTLTGDGVASMVAALFGGPPNTTYSEVTGAVMLTRVF
HHHHHHHCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
NPVVMTWTAIFAILLAFIGKFGLLLQSIPTPVMGGILILMFGSIASVGMNTLIKAQVDLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQRNLVIVAVTLIFGIGGMVMGNGDFTLQGISLCGLVAVLLNQVLPHAPFMADDLHEEQE
CCCCHHHHHHHHHHHCCCEEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
YVDDLLAHVRKKERDERT
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]