Click here to switch to the map view.

The map label for this gene is htpX [H]

Identifier: 110834770

GI number: 110834770

Start: 2185286

End: 2187181

Strand: Direct

Name: htpX [H]

Synonym: ABO_1909

Alternate gene names: 110834770

Gene position: 2185286-2187181 (Clockwise)

Preceding gene: 110834769

Following gene: 110834771

Centisome position: 70.04

GC content: 57.7

Gene sequence:

>1896_bases
ATGGATTTCTTTCAACACCAAGAACGAGCCCGCCGCAAAACCGGGCTGCTTGTTCTGTATTTCATCCTCGCGGTCATCGC
CATCGTGGTGTGTGTCAACCTGGCCTTGTTGCTGACGCTGTTCTGGGGAAACGTCCAGATCGTGCATGCTCACCAATGGC
TTGCACACCCCATCGTCCACTGGGTTACCGGCCTTACCCTGGCGGTTATGATCTTCGGCTGTCTGATTAAACTTTGGCAG
CTGCGCAACGGTGGTAAGGGCCTAGCGGACATGCTCGGTGCCCGCCACATTCCCATGGATAGCGTAGACATCAGCGAAAA
AAAGCTGATCAATGTGGTCGAGGAAATGAGTATTGCCTCGGGTATCCCCGCTCCCCAGCTCTATGTGCTGGACAAGGAAA
GCGGCATTAACGCTTTCGTAGCAGGCTTCCGCCCCTCGGAAACCGTGCTGGTGGTGACGCAGGGCACACTTAACGAGCTC
AATCGCGATGAGCTGCAAGGCGTTATCGCCCATGAGTTCAGCCATATTTTCAATGCCGACATGCGCCTGAACTTGCGCCT
GCTGGCCGTGCTTGCGGGCATTCTCGCACTAGGAAAAGTTGGCGAATACCTGATTCGCGGCCAACGCCGCTCTTCTTCTA
ACCGCAAAGGCGGTGGCGGGCTGGTGTTTGCCGGGCTGGCATTGATGGTTGTCGGTTATGTCGGGCTGTTCTTCGGACGC
CTGATTAAAGCGGCCATCTCCCGGCAGCGGGAGCTGTTGGCAGATGCCTCTGCCGTGCAATTCACCCGCAACCCGGCAGG
AATTGGCGGTGCACTGATTAAAATTCGCAACGGCAACGGCTCTCACTTAACCAGCCCCCACGCAGAAGACATGAGCCATA
TGTGTTTCGGCGAAACGTTACGTTTTCGCTGGCGCAACCTGCTAGGTACCCATCCACCACTGGACGAGCGACTCCGCGCC
CTAGGCAGCGACTGGGTGGCCCGTGCCCGTAGCCGAGCCCGTAATACCCTTAGCACCGCCACACACAGCAACCCCGAGAT
TCCTCAAGGAGCCTCAGCCTTCGCCGGCGGCAGCCTTAAGCCCACACGTAACGAAAACCCGCCAGCCGCCCCCTCACAAC
GTATTGGCACCGTAAGCGAACCCGATATGGGCTATGCCCGTAGCTTGTTGGAGACCATTCCTGACGATCTTCGACGCCAA
ACTCGCTCGCCCAAGTCGGCAGAGAATGTGCTCTACGCCCTGATACTTAGCGCGTCAAATAGCAGCACTGAAGCGCTGTT
GGCTGCATTAGATATCACAGGTCAACGACCCGCCTTAGTCACGCTAAGCAAGCAAATTCATGCCCAAGGTTCCCGTCTAC
GGCTACCGTTAATTGACTTAGCATTACCGGCGCTTAAACCGCTACCCGCCACTGACCGGGCACGGATCCTTACTCACCTG
ACCGCATTGATTGAGGTCGACGACCGTTACAGCTTTTTCGAATGGGCGCTAGTGGGATTAGCCCGCCAGCAACTCGGGGA
TCAATCCGGCAAGAATCGCCGCACCCGCTTCCGCCGCTATGGCGCACTGGCCGCAGAACTGCAATTGCTGTTCTCGGTAC
TGACTTGGGCCAGTGGCGCTGACGAGAAAGACGCACGTACTCTATTCCAGCTCAGCACCCACGGGCTTCTGCCCGCTGGC
CGCACCTTGCTGCCCCTAACACATTGTGGCAGCCACAAGCTCAGTAACGCCATTGAGCGCCTGGCCGACTTGTCTCCGCT
GCTCAAGGGGCCTGTTATTGATGCTGCGGCGGATCTGGTACTGGCCGATGGTAAAGTCCAGGTGCAGGAAGCAGAACTGC
TGCGCGCGGTATCCGCCCTGCTTGAGTGTCCCCTTCCGCCCCTGTTTAATCGCTAA

Upstream 100 bases:

>100_bases
CGGCGGATTATTCGGCAGCTTTAGCGAAGCCAAGCTGCTACAAATTGAGACCGAGCAGGCACGCAAGGCCGTGAACGTCA
GTTTCTAACCCGGCCTCGCC

Downstream 100 bases:

>100_bases
AGAGTTTCCGCAGCCCAACATTTGGGAAATAGGGAATACCAGCAAGGGGCCCTAACAGCCGCAGTGCCACAATACCTTTG
AGTTTGATTCCCTATTGCGC

Product: protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MDFFQHQERARRKTGLLVLYFILAVIAIVVCVNLALLLTLFWGNVQIVHAHQWLAHPIVHWVTGLTLAVMIFGCLIKLWQ
LRNGGKGLADMLGARHIPMDSVDISEKKLINVVEEMSIASGIPAPQLYVLDKESGINAFVAGFRPSETVLVVTQGTLNEL
NRDELQGVIAHEFSHIFNADMRLNLRLLAVLAGILALGKVGEYLIRGQRRSSSNRKGGGGLVFAGLALMVVGYVGLFFGR
LIKAAISRQRELLADASAVQFTRNPAGIGGALIKIRNGNGSHLTSPHAEDMSHMCFGETLRFRWRNLLGTHPPLDERLRA
LGSDWVARARSRARNTLSTATHSNPEIPQGASAFAGGSLKPTRNENPPAAPSQRIGTVSEPDMGYARSLLETIPDDLRRQ
TRSPKSAENVLYALILSASNSSTEALLAALDITGQRPALVTLSKQIHAQGSRLRLPLIDLALPALKPLPATDRARILTHL
TALIEVDDRYSFFEWALVGLARQQLGDQSGKNRRTRFRRYGALAAELQLLFSVLTWASGADEKDARTLFQLSTHGLLPAG
RTLLPLTHCGSHKLSNAIERLADLSPLLKGPVIDAAADLVLADGKVQVQEAELLRAVSALLECPLPPLFNR

Sequences:

>Translated_631_residues
MDFFQHQERARRKTGLLVLYFILAVIAIVVCVNLALLLTLFWGNVQIVHAHQWLAHPIVHWVTGLTLAVMIFGCLIKLWQ
LRNGGKGLADMLGARHIPMDSVDISEKKLINVVEEMSIASGIPAPQLYVLDKESGINAFVAGFRPSETVLVVTQGTLNEL
NRDELQGVIAHEFSHIFNADMRLNLRLLAVLAGILALGKVGEYLIRGQRRSSSNRKGGGGLVFAGLALMVVGYVGLFFGR
LIKAAISRQRELLADASAVQFTRNPAGIGGALIKIRNGNGSHLTSPHAEDMSHMCFGETLRFRWRNLLGTHPPLDERLRA
LGSDWVARARSRARNTLSTATHSNPEIPQGASAFAGGSLKPTRNENPPAAPSQRIGTVSEPDMGYARSLLETIPDDLRRQ
TRSPKSAENVLYALILSASNSSTEALLAALDITGQRPALVTLSKQIHAQGSRLRLPLIDLALPALKPLPATDRARILTHL
TALIEVDDRYSFFEWALVGLARQQLGDQSGKNRRTRFRRYGALAAELQLLFSVLTWASGADEKDARTLFQLSTHGLLPAG
RTLLPLTHCGSHKLSNAIERLADLSPLLKGPVIDAAADLVLADGKVQVQEAELLRAVSALLECPLPPLFNR
>Mature_631_residues
MDFFQHQERARRKTGLLVLYFILAVIAIVVCVNLALLLTLFWGNVQIVHAHQWLAHPIVHWVTGLTLAVMIFGCLIKLWQ
LRNGGKGLADMLGARHIPMDSVDISEKKLINVVEEMSIASGIPAPQLYVLDKESGINAFVAGFRPSETVLVVTQGTLNEL
NRDELQGVIAHEFSHIFNADMRLNLRLLAVLAGILALGKVGEYLIRGQRRSSSNRKGGGGLVFAGLALMVVGYVGLFFGR
LIKAAISRQRELLADASAVQFTRNPAGIGGALIKIRNGNGSHLTSPHAEDMSHMCFGETLRFRWRNLLGTHPPLDERLRA
LGSDWVARARSRARNTLSTATHSNPEIPQGASAFAGGSLKPTRNENPPAAPSQRIGTVSEPDMGYARSLLETIPDDLRRQ
TRSPKSAENVLYALILSASNSSTEALLAALDITGQRPALVTLSKQIHAQGSRLRLPLIDLALPALKPLPATDRARILTHL
TALIEVDDRYSFFEWALVGLARQQLGDQSGKNRRTRFRRYGALAAELQLLFSVLTWASGADEKDARTLFQLSTHGLLPAG
RTLLPLTHCGSHKLSNAIERLADLSPLLKGPVIDAAADLVLADGKVQVQEAELLRAVSALLECPLPPLFNR

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=220, Percent_Identity=28.6363636363636, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 68836; Mature: 68836

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFFQHQERARRKTGLLVLYFILAVIAIVVCVNLALLLTLFWGNVQIVHAHQWLAHPIVH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHH
WVTGLTLAVMIFGCLIKLWQLRNGGKGLADMLGARHIPMDSVDISEKKLINVVEEMSIAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GIPAPQLYVLDKESGINAFVAGFRPSETVLVVTQGTLNELNRDELQGVIAHEFSHIFNAD
CCCCCEEEEEECCCCCCEEEECCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHHHHHCCC
MRLNLRLLAVLAGILALGKVGEYLIRGQRRSSSNRKGGGGLVFAGLALMVVGYVGLFFGR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LIKAAISRQRELLADASAVQFTRNPAGIGGALIKIRNGNGSHLTSPHAEDMSHMCFGETL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
RFRWRNLLGTHPPLDERLRALGSDWVARARSRARNTLSTATHSNPEIPQGASAFAGGSLK
HHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PTRNENPPAAPSQRIGTVSEPDMGYARSLLETIPDDLRRQTRSPKSAENVLYALILSASN
CCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHEECCC
SSTEALLAALDITGQRPALVTLSKQIHAQGSRLRLPLIDLALPALKPLPATDRARILTHL
CCHHHHHHHHHCCCCCCEEEEEHHHHHCCCCEEECHHHHHHHHHCCCCCCCHHHHHHHHH
TALIEVDDRYSFFEWALVGLARQQLGDQSGKNRRTRFRRYGALAAELQLLFSVLTWASGA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEKDARTLFQLSTHGLLPAGRTLLPLTHCGSHKLSNAIERLADLSPLLKGPVIDAAADLV
CCHHHHHHHHHHHCCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHEE
LADGKVQVQEAELLRAVSALLECPLPPLFNR
EECCCEEHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDFFQHQERARRKTGLLVLYFILAVIAIVVCVNLALLLTLFWGNVQIVHAHQWLAHPIVH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHH
WVTGLTLAVMIFGCLIKLWQLRNGGKGLADMLGARHIPMDSVDISEKKLINVVEEMSIAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHC
GIPAPQLYVLDKESGINAFVAGFRPSETVLVVTQGTLNELNRDELQGVIAHEFSHIFNAD
CCCCCEEEEEECCCCCCEEEECCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHHHHHCCC
MRLNLRLLAVLAGILALGKVGEYLIRGQRRSSSNRKGGGGLVFAGLALMVVGYVGLFFGR
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LIKAAISRQRELLADASAVQFTRNPAGIGGALIKIRNGNGSHLTSPHAEDMSHMCFGETL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHH
RFRWRNLLGTHPPLDERLRALGSDWVARARSRARNTLSTATHSNPEIPQGASAFAGGSLK
HHHHHHHCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PTRNENPPAAPSQRIGTVSEPDMGYARSLLETIPDDLRRQTRSPKSAENVLYALILSASN
CCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHEECCC
SSTEALLAALDITGQRPALVTLSKQIHAQGSRLRLPLIDLALPALKPLPATDRARILTHL
CCHHHHHHHHHCCCCCCEEEEEHHHHHCCCCEEECHHHHHHHHHCCCCCCCHHHHHHHHH
TALIEVDDRYSFFEWALVGLARQQLGDQSGKNRRTRFRRYGALAAELQLLFSVLTWASGA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DEKDARTLFQLSTHGLLPAGRTLLPLTHCGSHKLSNAIERLADLSPLLKGPVIDAAADLV
CCHHHHHHHHHHHCCCCCCCCCEEEHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHEE
LADGKVQVQEAELLRAVSALLECPLPPLFNR
EECCCEEHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA